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2020-10-26 19:19:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_013233               3288 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens serine threonine kinase 39 (STK39), mRNA.
ACCESSION   NM_013233
VERSION     NM_013233.2  GI:115430251
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Ponce-Coria,J., Gagnon,K.B. and Delpire,E.
  TITLE     Calcium-binding protein 39 facilitates molecular interaction
            between Ste20p proline alanine-rich kinase and oxidative stress
            response 1 monomers
  JOURNAL   Am. J. Physiol., Cell Physiol. 303 (11), C1198-C1205 (2012)
   PUBMED   23034389
  REMARK    GeneRIF: SPAK and OSR1, which are oftencoexpressed in cells can
            form functional heterodimers.
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Vavolizza,R.D., Schmeidler,J., Ramoz,N., Buxbaum,J.D., Smith,C.J.
            and Silverman,J.M.
  TITLE     The effect of an autism-associated polymorphism in the STK39 gene
            on the autism symptom domains
  JOURNAL   J Autism Dev Disord 42 (2), 319-320 (2012)
   PUBMED   21442361
  REMARK    GeneRIF: our results suggest no significant assocation between any
            of the core autism symptom domains or the four additional
            previously identified familial features and the rs1807984 SNP on
            the STK39 gene.
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Yan,Y., Laroui,H., Ingersoll,S.A., Ayyadurai,S., Charania,M.,
            Yang,S., Dalmasso,G., Obertone,T.S., Nguyen,H., Sitaraman,S.V. and
            Merlin,D.
  TITLE     Overexpression of Ste20-related proline/alanine-rich kinase
            exacerbates experimental colitis in mice
  JOURNAL   J. Immunol. 187 (3), 1496-1505 (2011)
   PUBMED   21705622
  REMARK    GeneRIF: SPAK increases intestinal epithelial permeability; both
            SPAK-transfected Caco2-cells and SPAK transgenic mice exhibit loss
            of intestinal barrier function and homeostasis in inflammatory
            bowel disease.
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Richardson,C., Sakamoto,K., de los Heros,P., Deak,M.,
            Campbell,D.G., Prescott,A.R. and Alessi,D.R.
  TITLE     Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent
            and -independent pathways
  JOURNAL   J. Cell. Sci. 124 (PT 5), 789-800 (2011)
   PUBMED   21321328
  REMARK    GeneRIF: Data demonstrate that hypotonic low-chloride conditions
            that activate the WNK1-SPAK and OSR1 pathway promote
            phosphorylation of NKCC2 isoforms.
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Yang,D., Li,Q., So,I., Huang,C.L., Ando,H., Mizutani,A., Seki,G.,
            Mikoshiba,K., Thomas,P.J. and Muallem,S.
  TITLE     IRBIT governs epithelial secretion in mice by antagonizing the
            WNK/SPAK kinase pathway
  JOURNAL   J. Clin. Invest. 121 (3), 956-965 (2011)
   PUBMED   21317537
  REMARK    GeneRIF: IRBIT opposes the effects of WNKs and SPAK by recruiting
            PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring
            their cell surface expression, in addition to stimulating their
            activities
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Moriguchi,T., Urushiyama,S., Hisamoto,N., Iemura,S., Uchida,S.,
            Natsume,T., Matsumoto,K. and Shibuya,H.
  TITLE     WNK1 regulates phosphorylation of cation-chloride-coupled
            cotransporters via the STE20-related kinases, SPAK and OSR1
  JOURNAL   J. Biol. Chem. 280 (52), 42685-42693 (2005)
   PUBMED   16263722
  REMARK    GeneRIF: WNK1 and SPAK/OSR1 mediate the hypotonic stress signaling
            pathway to cation-chloride-coupled cotransporters
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Piechotta,K., Garbarini,N., England,R. and Delpire,E.
  TITLE     Characterization of the interaction of the stress kinase SPAK with
            the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a
            scaffolding role of the kinase
  JOURNAL   J. Biol. Chem. 278 (52), 52848-52856 (2003)
   PUBMED   14563843
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Dowd,B.F. and Forbush,B.
  TITLE     PASK (proline-alanine-rich STE20-related kinase), a regulatory
            kinase of the Na-K-Cl cotransporter (NKCC1)
  JOURNAL   J. Biol. Chem. 278 (30), 27347-27353 (2003)
   PUBMED   12740379
  REMARK    GeneRIF: roles in phosphorylation and activation of the Na-K-Cl
            cotransporter (NKCC1)
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Qi,H., Labrie,Y., Grenier,J., Fournier,A., Fillion,C. and Labrie,C.
  TITLE     Androgens induce expression of SPAK, a STE20/SPS1-related kinase,
            in LNCaP human prostate cancer cells
  JOURNAL   Mol. Cell. Endocrinol. 182 (2), 181-192 (2001)
   PUBMED   11514053
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Johnston,A.M., Naselli,G., Gonez,L.J., Martin,R.M., Harrison,L.C.
            and DeAizpurua,H.J.
  TITLE     SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
  JOURNAL   Oncogene 19 (37), 4290-4297 (2000)
   PUBMED   10980603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF099989.1, AC016723.11 and
            BF516344.1.
            On Sep 30, 2006 this sequence version replaced gi:7019542.
            
            Summary: This gene encodes a serine/threonine kinase that is
            thought to function in the cellular stress response pathway. The
            kinase is activated in response to hypotonic stress, leading to
            phosphorylation of several cation-chloride-coupled cotransporters.
            The catalytically active kinase specifically activates the p38 MAP
            kinase pathway, and its interaction with p38 decreases upon
            cellular stress, suggesting that this kinase may serve as an
            intermediate in the response to cellular stress. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099989.1, AF030403.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AF099989.1         2-52
            52-309              AF099989.1         65-322
            310-2228            AF099989.1         329-2247
            2229-3119           AC016723.11        170127-171017       c
            3120-3288           BF516344.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..3288
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="serine threonine kinase 39"
                     /db_xref="GeneID:27347"
                     /db_xref="HGNC:17717"
                     /db_xref="MIM:607648"
     exon            1..368
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     STS             133..1825
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /db_xref="UniSTS:482333"
     CDS             161..1798
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /EC_number="2.7.11.1"
                     /note="serine threonine kinase 39 (STE20/SPS1 homolog,
                     yeast); Ste20-like protein kinase; small intestine
                     SPAK-like kinase; proline-alanine-rich STE20-related
                     kinase; ste-20-related kinase; serine/threonine-protein
                     kinase 39"
                     /codon_start=1
                     /product="STE20/SPS1-related proline-alanine-rich protein
                     kinase"
                     /protein_id="NP_037365.2"
                     /db_xref="GI:115430252"
                     /db_xref="CCDS:CCDS42770.1"
                     /db_xref="GeneID:27347"
                     /db_xref="HGNC:17717"
                     /db_xref="MIM:607648"
                     /translation="
MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS
"
     misc_feature    341..1171
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinases, Oxidative stress response kinase and
                     Ste20-related proline alanine-rich kinase; Region:
                     STKc_OSR1_SPAK; cd06610"
                     /db_xref="CDD:173726"
     misc_feature    347..1171
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(365..379,389..391,428..430,434..436,524..526,
                     572..583,590..595,602..604,734..736,740..751,755..757,
                     788..790,797..799,854..865,869..871,953..955,980..982)
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="active site"
                     /db_xref="CDD:173726"
     misc_feature    order(365..379,389..391,428..430,434..436,524..526,
                     572..583,590..595,602..604,740..742,746..751,755..757,
                     788..790)
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173726"
     misc_feature    order(374..379,734..736,740..748,797..799,854..865,
                     869..871,953..955,980..982)
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173726"
     misc_feature    order(785..826,845..871)
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173726"
     misc_feature    1085..1087
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC/PRKCQ; propagated from
                     UniProtKB/Swiss-Prot (Q9UEW8.3); phosphorylation site"
     misc_feature    1085..1087
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[10]
                     /db_xref="HPRD:02710"
     misc_feature    1127..1129
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[10]
                     /db_xref="HPRD:02710"
     misc_feature    1205..1207
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q9UEW8.3); acetylation site"
     misc_feature    1238..1258
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UEW8.3);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    1268..1270
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UEW8.3); phosphorylation site"
     misc_feature    1268..1270
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1271..1273
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UEW8.3); phosphorylation site"
     misc_feature    1313..1315
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UEW8.3); phosphorylation site"
     misc_feature    1313..1315
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1319..1333
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UEW8.3);
                     Region: Caspase cleavage related site"
     misc_feature    1514..1609
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /note="Oxidative-stress-responsive kinase 1 C terminal;
                     Region: OSR1_C; pfam12202"
                     /db_xref="CDD:204847"
     exon            369..481
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            482..590
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            591..732
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            733..788
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            789..898
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            899..1000
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1001..1134
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1135..1183
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1184..1249
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     variation       1220
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802105"
     exon            1250..1372
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1373..1402
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1403..1465
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1466..1536
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1537..1589
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1590..1658
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1659..1723
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     exon            1724..3274
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /inference="alignment:Splign:1.39.8"
     STS             1797..1952
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /standard_name="RH68427"
                     /db_xref="UniSTS:31029"
     polyA_site      1979
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
     variation       2452
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1061471"
     variation       2682
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3769428"
     STS             2855..3023
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /standard_name="RH99072"
                     /db_xref="UniSTS:85155"
     variation       3065
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3769429"
     polyA_signal    3250..3255
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
     polyA_site      3274
                     /gene="STK39"
                     /gene_synonym="DCHT; PASK; SPAK"
ORIGIN      
gctccctcccctcctagctggcttcggcggggacggcggcggcggcggcgggcggggagggcgtgcgccggccgagaggtgtcggcggcgaggcaaaggaagtttcaagtggaaggtcgtccgtcggccggcgcgtcctcctgctctcctccgcagcatcatggcggagccgagcggctcgcccgtgcacgtccagcttccccagcaggcggccccggtgacagcggcggcggcggcggccccggcggccgcgacagcagcgccggccccggcagctcccgcggccccggccccggccccggccccggcggcacaggctgtcggctggcccatctgcagggacgcgtacgagctgcaggaggttatcggcagtggagctactgctgtggttcaggcagccctatgcaaacccaggcaagaacgtgtagcaataaaacggatcaacttggaaaaatgccagaccagtatggatgaactattaaaagaaattcaagccatgagtcagtgcagccatcccaacgtagtgacctattacacctcttttgtggtcaaagatgaactttggctggtcatgaaattactaagtggaggttcaatgttggatatcataaaatacattgtcaaccgaggagaacacaagaatggagttctggaagaggcaataatagcaacaattcttaaagaggttttggaaggcttagactatctacacagaaacggtcagattcacagggatttgaaagctggtaatattcttctgggtgaggatggttcagtacaaatagcagattttggggtaagtgcgttcctagcaacagggggtgatgttacccgaaataaagtaagaaaaacattcgttggcaccccatgttggatggctcctgaagtcatggaacaggtgagaggctatgacttcaaggctgacatgtggagttttggaataactgccattgaattagcaacaggagcagcgccttatcacaaatatcctcccatgaaagtgttaatgttgactttgcaaaatgatccacccactttggaaacaggggtagaggataaagaaatgatgaaaaagtacggcaagtcctttagaaaattactttcactgtgtcttcagaaagatccttccaaaaggcccacagcagcagaacttttaaaatgcaaattcttccagaaagccaagaacagagagtacctgattgagaagctgcttacaagaacaccagacatagcccaaagagccaaaaaggtaagaagagttcctgggtcaagtggtcaccttcataaaaccgaagacggggactgggagtggagtgacgacgagatggatgagaagagcgaagaagggaaagcagctttttctcaggaaaagtcacgaagagtaaaagaagaaaatccagagattgcagtgagtgccagcaccatccccgaacaaatacagtccctctctgtgcacgactctcagggcccacccaatgctaatgaagactacagagaagcttcttcttgtgccgtgaacctcgttttgagattaagaaactccagaaaggaacttaatgacatacgatttgagtttactccaggaagagatacagcagatggtgtatctcaggagctcttctctgctggcttggtggatggtcacgatgtagttatagtggctgctaatttacagaagattgtagatgatcccaaagctttaaaaacattgacatttaagttggcttctggctgtgatgggtcggagattcctgatgaagtgaagctgattgggtttgctcagttgagtgtcagctgatgtatgtcccttgatgtcaccctgatctgtcatgccccaccgccacccctactcccttcaaccctccctctttctgcccatttcctcccaccccctcactcccatttcctagcaaaatcagaagattgtgaagaggccggcttcaacaaaatgggataaaaaaataattttttaaaacttacaacactccgagttctgctttattctctagcaatccacagtacaagaacaagcaaatgccacagctgcacgactgttgctcatttttccaaaagctatttaatattcttagcaatcaatttggatatcccttaagtgaaaagaatctgaaatacactcaggtggtcttatttattggcaacaaaaggaattttctatccagaagcctatttctcctttcattgttgttatttctgttataatactttaattgtacatctgacaatactgcctcttttatgttgtatttagaaattaatatacttataaaattaagatttattagccaaacttgaattctagttttaaaactgactgtgaattttatttttcatatatttatgcattacacaccttagctataagaaaaaaagggttttgattatatgcttcttgcagttaatctcgttatttaaacaaaaagttttgggtctgtctttggagtatttgtaacttctaaattttgaaatgactgaattaggaatttggatgcttattcttttagtctgtttgcctaaaaaccaatttacaatctgactgtctcttgggagagggaggtgccttgcaaactttcacattaagaatgtgcctgaggctgctttactctggaatagtctcagatctaaaatttcctctatataaggtggcatatgttaagttttgcttcattggaccgtttagaatgctatgtaaaatgttgccattctgttagattgctaactatatacccatctctgatttggctctccttaagtgataggatttgttattctaaaggtgataaacttgaaaatatcagaatctgagttttacttgaaattttgcagaatacccaggtggagtgaaaattggaagggttttgtgcaatgactaaaaggtaaaacgctgttaaggttcaagaatcaatactttcaacccaagtagccctctgcttgactgtatattatggaactagtaaaccttaggattttgaaaattggagtctaatctttcaaggaggtgggctcccaggatggtaccattgctctttcctagctaaccctagatatggcagctctttaatgtacttcaaaaagcaaatatatattactaaggaaaaaaagttatttataattgccttgtcataattgttaaggtgttctagagccatttgcatacaatttaatgtaatttcattccattctattgtttacacaacgattactcgaagatgactgcaaaggtaaaaggaaaataaaagtgtattgcacaatgagaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:27347 -> Molecular function: GO:0004702 [receptor signaling protein serine/threonine kinase activity] evidence: NAS
            GeneID:27347 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS
            GeneID:27347 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
            GeneID:27347 -> Biological process: GO:0006468 [protein phosphorylation] evidence: NAS
            GeneID:27347 -> Biological process: GO:0006950 [response to stress] evidence: NAS
            GeneID:27347 -> Biological process: GO:0023014 [signal transduction by phosphorylation] evidence: NAS
            GeneID:27347 -> Biological process: GO:0043268 [positive regulation of potassium ion transport] evidence: IEA
            GeneID:27347 -> Biological process: GO:0050727 [regulation of inflammatory response] evidence: IEA
            GeneID:27347 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:27347 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
            GeneID:27347 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
            GeneID:27347 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IEA
            GeneID:27347 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_037365 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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