GGRNA Home | Help | Advanced search

2024-03-29 06:55:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_013229               7171 bp    mRNA    linear   PRI 26-MAY-2013
DEFINITION  Homo sapiens apoptotic peptidase activating factor 1 (APAF1),
            transcript variant 1, mRNA.
ACCESSION   NM_013229
VERSION     NM_013229.2  GI:32483365
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7171)
  AUTHORS   Yuan,S., Topf,M., Reubold,T.F., Eschenburg,S. and Akey,C.W.
  TITLE     Changes in Apaf-1 conformation that drive apoptosome assembly
  JOURNAL   Biochemistry 52 (13), 2319-2327 (2013)
   PUBMED   23521171
  REMARK    GeneRIF: Apaf-1 conformational changes during apoptosome assembly.
REFERENCE   2  (bases 1 to 7171)
  AUTHORS   Li,T., Zeng,L., Gao,W., Cui,M.Z., Fu,X. and Xu,X.
  TITLE     PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial
            apoptotic pathway independent of Bcl-2 family proteins
  JOURNAL   Biochim. Biophys. Acta 1832 (3), 453-474 (2013)
   PUBMED   23207240
  REMARK    GeneRIF: Data indicate that the formation of cytochrome c-Apaf-1
            apoptosome and the presence of Smac are absolutely required for
            PSAP-induced apoptosis.
REFERENCE   3  (bases 1 to 7171)
  AUTHORS   Andreev,D.E., Dmitriev,S.E., Zinovkin,R., Terenin,I.M. and
            Shatsky,I.N.
  TITLE     The 5' untranslated region of Apaf-1 mRNA directs translation under
            apoptosis conditions via a 5' end-dependent scanning mechanism
  JOURNAL   FEBS Lett. 586 (23), 4139-4143 (2012)
   PUBMED   23085065
  REMARK    GeneRIF: The 5' untranslated region of Apaf-1 mRNA directs
            translation under apoptosis conditions via a 5' end-dependent
            scanning mechanism.
REFERENCE   4  (bases 1 to 7171)
  AUTHORS   Zang,Y.S., Zhong,Y.F., Fang,Z., Li,B. and An,J.
  TITLE     MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin
            via negative regulation of Apaf-1 expression
  JOURNAL   Cancer Gene Ther. 19 (11), 773-778 (2012)
   PUBMED   22996741
  REMARK    GeneRIF: Both the silencing of miR-155 and the overexpression
            Apaf-1 greatly increased the sensitivity of A549 cells to
            cisplatin.
REFERENCE   5  (bases 1 to 7171)
  AUTHORS   Wang,J., Xiao,X., Zhang,Y., Shi,D., Chen,W., Fu,L., Liu,L., Xie,F.,
            Kang,T., Huang,W. and Deng,W.
  TITLE     Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling
            by melatonin to inhibit proliferation and induce apoptosis in
            breast cancer cells
  JOURNAL   J. Pineal Res. 53 (1), 77-90 (2012)
   PUBMED   22335196
  REMARK    GeneRIF: melatonin inhibits cell proliferation and induces
            apoptosis in MDA-MB-361 breast cancer cells in vitro by
            simultaneously suppressing the COX-2/PGE2, p300/NF-kappaB, and
            PI3K/Akt/signaling and activating the Apaf-1/caspase-dependent
            apoptotic pathway.
REFERENCE   6  (bases 1 to 7171)
  AUTHORS   Srinivasula,S.M., Ahmad,M., Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
  JOURNAL   Mol. Cell 1 (7), 949-957 (1998)
   PUBMED   9651578
REFERENCE   7  (bases 1 to 7171)
  AUTHORS   Hu,Y., Benedict,M.A., Wu,D., Inohara,N. and Nunez,G.
  TITLE     Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent
            caspase-9 activation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (8), 4386-4391 (1998)
   PUBMED   9539746
REFERENCE   8  (bases 1 to 7171)
  AUTHORS   Pan,G., O'Rourke,K. and Dixit,V.M.
  TITLE     Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
  JOURNAL   J. Biol. Chem. 273 (10), 5841-5845 (1998)
   PUBMED   9488720
REFERENCE   9  (bases 1 to 7171)
  AUTHORS   Li,P., Nijhawan,D., Budihardjo,I., Srinivasula,S.M., Ahmad,M.,
            Alnemri,E.S. and Wang,X.
  TITLE     Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9
            complex initiates an apoptotic protease cascade
  JOURNAL   Cell 91 (4), 479-489 (1997)
   PUBMED   9390557
REFERENCE   10 (bases 1 to 7171)
  AUTHORS   Zou,H., Henzel,W.J., Liu,X., Lutschg,A. and Wang,X.
  TITLE     Apaf-1, a human protein homologous to C. elegans CED-4,
            participates in cytochrome c-dependent activation of caspase-3
  JOURNAL   Cell 90 (3), 405-413 (1997)
   PUBMED   9267021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF013263.1, AF134397.1 and
            AC011248.8.
            On Jul 9, 2003 this sequence version replaced gi:7108332.
            
            Summary: This gene encodes a cytoplasmic protein that initiates
            apoptosis. This protein contains several copies of the WD-40
            domain, a caspase recruitment domain (CARD), and an ATPase domain
            (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an
            oligomeric apoptosome. The apoptosome binds and cleaves caspase 9
            preproprotein, releasing its mature, activated form. Activated
            caspase 9 stimulates the subsequent caspase cascade that commits
            the cell to apoptosis. Alternative splicing results in several
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate splice site
            in the coding region but maintains the reading frame, compared to
            variant 3. Variant 1 encodes isoform a, which is shorter than
            isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC150255.1, AB007873.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AF013263.1         1-577
            578-4291            AF134397.1         1-3714
            4292-5296           AF013263.1         4163-5167
            5297-5297           AC011248.8         25332-25332         c
            5298-6717           AF013263.1         5169-6588
            6718-6718           AC011248.8         23911-23911         c
            6719-6738           AF013263.1         6590-6609
            6739-6739           AC011248.8         23890-23890         c
            6740-7171           AF013263.1         6611-7042
FEATURES             Location/Qualifiers
     source          1..7171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23"
     gene            1..7171
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="apoptotic peptidase activating factor 1"
                     /db_xref="GeneID:317"
                     /db_xref="HGNC:576"
                     /db_xref="HPRD:03755"
                     /db_xref="MIM:602233"
     exon            1..536
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       20
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367782321"
     variation       38
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116501350"
     variation       68
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371572763"
     variation       69
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:113577911"
     variation       90
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11109556"
     variation       94
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113907867"
     variation       106
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74619561"
     variation       134
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192062352"
     variation       249
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2118851"
     variation       293
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139550753"
     variation       390
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2118852"
     exon            537..715
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       567
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:111232069"
     misc_feature    569..571
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="upstream in-frame stop codon"
     CDS             578..4291
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="isoform a is encoded by transcript variant 1;
                     apoptotic protease-activating factor 1"
                     /codon_start=1
                     /product="apoptotic protease-activating factor 1 isoform
                     a"
                     /protein_id="NP_037361.1"
                     /db_xref="GI:7108333"
                     /db_xref="CCDS:CCDS55862.1"
                     /db_xref="GeneID:317"
                     /db_xref="HGNC:576"
                     /db_xref="HPRD:03755"
                     /db_xref="MIM:602233"
                     /translation="
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
"
     misc_feature    596..853
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="Caspase activation and recruitment domain similar
                     to that found in Apoptotic Protease-Activating Factor 1;
                     Region: CARD_APAF1; cd08323"
                     /db_xref="CDD:176737"
     misc_feature    order(644..649,656..661,665..670,686..688,695..697)
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="APAF1-Caspase9 interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:176737"
     misc_feature    920..1279
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="AAA ATPase domain; Region: AAA_16; pfam13191"
                     /db_xref="CDD:205372"
     misc_feature    929..1786
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="NB-ARC domain; Region: NB-ARC; pfam00931"
                     /db_xref="CDD:201512"
     misc_feature    1154..1156
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1256..1258
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1286..1288
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2363..3274
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:29257"
     misc_feature    2381..2500
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-1"
     misc_feature    order(2384..2386,2438..2440,2450..2452,2468..2473,
                     2507..2512,2564..2566,2576..2578,2594..2599,2633..2638,
                     2693..2695,2708..2710,2726..2731,2768..2770,2819..2821,
                     2834..2836,2852..2857,2930..2935,2987..2989,2999..3001,
                     3014..3019,3056..3061,3110..3112,3125..3127,3143..3148,
                     3182..3187,3239..3241,3251..3253,3269..3274)
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="structural tetrad; other site"
                     /db_xref="CDD:29257"
     misc_feature    2450..3643
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="FOG: WD40 repeat [General function prediction
                     only]; Region: COG2319"
                     /db_xref="CDD:32473"
     misc_feature    2507..2626
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-2"
     misc_feature    2633..2758
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-3"
     misc_feature    2765..2884
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-4"
     misc_feature    2930..3052
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-5"
     misc_feature    3050..4273
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="FOG: WD40 repeat [General function prediction
                     only]; Region: COG2319"
                     /db_xref="CDD:32473"
     misc_feature    3056..3175
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-6"
     misc_feature    3182..3274
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 1-7"
     misc_feature    3272..3307
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: Interpropeller linker (By similarity)"
     misc_feature    3308..3418
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-1"
     misc_feature    3419..3538
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-2"
     misc_feature    3425..4246
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:29257"
     misc_feature    order(3476..3478,3488..3490,3506..3511,3545..3550,
                     3602..3604,3614..3616,3632..3637,3668..3673,3722..3724,
                     3734..3736,3752..3757,3794..3796,3845..3847,3860..3862,
                     3878..3883,3917..3922,3974..3976,3986..3988,4004..4009,
                     4043..4045,4070..4072,4121..4123,4148..4153,4187..4192,
                     4244..4246)
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="structural tetrad; other site"
                     /db_xref="CDD:29257"
     misc_feature    3545..3664
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-3"
     misc_feature    3668..3784
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-4"
     misc_feature    3791..3910
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-5"
     misc_feature    3917..4036
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-6"
     misc_feature    4067..4180
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-7"
     misc_feature    4181..4288
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14727.2);
                     Region: WD 2-8"
     variation       615
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373035647"
     variation       635
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368174559"
     variation       648
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150457288"
     variation       686
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372259373"
     variation       711
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145226502"
     variation       713
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199944569"
     exon            716..872
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       757
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200621810"
     variation       784
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:202065446"
     variation       793
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373040331"
     variation       804
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376597105"
     variation       848
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139951279"
     variation       851
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141352935"
     variation       864
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150823984"
     exon            873..1070
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       883
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139274870"
     variation       909
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150005477"
     variation       927
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147700706"
     variation       975
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200533513"
     variation       1002
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377171914"
     variation       1021
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370625919"
     variation       1022
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76680641"
     variation       1043
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113035658"
     variation       1054
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144787055"
     variation       1059
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147932236"
     exon            1071..1254
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1092
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200830441"
     variation       1103
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370928764"
     variation       1117
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143842243"
     variation       1145
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374500915"
     variation       1156
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151139898"
     variation       1195
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146505676"
     variation       1242
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141157255"
     variation       1247
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368744142"
     exon            1255..1367
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1325
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145270473"
     variation       1349
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199783677"
     variation       1351
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111885484"
     exon            1368..1499
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1403
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144728788"
     variation       1408
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138616141"
     variation       1442
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201562861"
     variation       1454
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149321598"
     variation       1455
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189237320"
     variation       1481
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192898520"
     variation       1491
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369909924"
     exon            1500..1738
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1516
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144643655"
     variation       1537
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199648389"
     variation       1621
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57171247"
     variation       1639
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201932795"
     variation       1670
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141824871"
     variation       1677
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201629052"
     exon            1739..1906
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1744
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368597507"
     variation       1745
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371118366"
     variation       1792
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147249307"
     variation       1803
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140772800"
     variation       1818..1819
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34602753"
     variation       1840
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374998401"
     variation       1844
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368429786"
     variation       1845
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201872620"
     variation       1871
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144721573"
     variation       1880
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:75622772"
     variation       1882
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376806366"
     variation       1894
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139378273"
     variation       1901
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371633206"
     variation       1905
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150056794"
     exon            1907..2038
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       1938
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76732147"
     variation       1953
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145393515"
     variation       1968
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369544125"
     variation       1980
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373209321"
     variation       1981
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149223130"
     variation       2025
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143963802"
     exon            2039..2152
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2106
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146424586"
     exon            2153..2337
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2174
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372400613"
     variation       2183
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376175905"
     variation       2219
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202243082"
     variation       2283
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11613534"
     variation       2298
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199975148"
     variation       2308
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371417225"
     variation       2325
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:61758870"
     exon            2338..2464
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2356
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144715006"
     variation       2378
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371897242"
     variation       2379
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375182344"
     variation       2400
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61758871"
     variation       2418
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73142307"
     variation       2419
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369089258"
     variation       2463
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140327382"
     exon            2465..2590
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2539
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372738633"
     exon            2591..2722
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2591
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200295459"
     variation       2617
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376958146"
     variation       2652
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375497407"
     variation       2674
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111760682"
     exon            2723..2848
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2732
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371871697"
     variation       2745
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371385003"
     variation       2750
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150355642"
     variation       2760
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138068283"
     variation       2778
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372234984"
     variation       2818
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200562772"
     exon            2849..3010
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       2860
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368374940"
     variation       2873
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138526583"
     variation       2889
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:117235991"
     variation       2927
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181546874"
     variation       2942
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139083690"
     variation       2944
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372032284"
     variation       2958
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375207439"
     variation       2959
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202216630"
     variation       2965
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143097832"
     variation       3007
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144749677"
     exon            3011..3139
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3040
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369768631"
     variation       3046
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374560085"
     variation       3054
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200461221"
     variation       3055
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377621175"
     variation       3079
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61742041"
     variation       3121
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74485890"
     exon            3140..3265
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3156
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145807191"
     variation       3159
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139940389"
     variation       3225
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61757705"
     variation       3236
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199525775"
     exon            3266..3385
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3378
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146420669"
     exon            3386..3502
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3396
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201911170"
     variation       3405
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:140836008"
     variation       3406
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143246247"
     variation       3475
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145497334"
     variation       3496
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148854272"
     exon            3503..3628
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3522
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201541593"
     variation       3549
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201122276"
     variation       3551
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367942061"
     variation       3595
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143528358"
     variation       3611
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372125027"
     variation       3618
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77127123"
     exon            3629..3748
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3643
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142269091"
     variation       3656
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146238655"
     variation       3665
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139016212"
     exon            3749..3874
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3778
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143961269"
     variation       3829
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139786967"
     exon            3875..4000
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       3891
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138188210"
     variation       3968
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201678092"
     variation       3976
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149589840"
     exon            4001..4144
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       4018
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144336881"
     variation       4022
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184890158"
     variation       4045
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368589663"
     variation       4072
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140151475"
     exon            4145..7158
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /inference="alignment:Splign:1.39.8"
     variation       4192
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201917086"
     variation       4217
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201029707"
     variation       4222
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369751053"
     variation       4226
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142230441"
     variation       4240
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372861046"
     variation       4267
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375449857"
     variation       4284
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369724536"
     variation       4294
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:118102803"
     variation       4295
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375966404"
     variation       4497
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147973432"
     variation       4578
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17227606"
     variation       4626
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376693352"
     variation       4659
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370287396"
     variation       4717
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:115805629"
     variation       4757
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:187945549"
     variation       4857
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116884285"
     variation       4858
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368133650"
     variation       4884..4885
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:376965258"
     STS             4901..5003
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="D11S2921"
                     /db_xref="UniSTS:152074"
     STS             4908..5295
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="PMC156606P1"
                     /db_xref="UniSTS:271408"
     STS             4908..4997
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="PMC156606P1"
                     /db_xref="UniSTS:271408"
     variation       4928
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372020077"
     variation       4947
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111382335"
     STS             4963..5049
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       4969
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192421145"
     variation       4985
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185285999"
     STS             4990..5363
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="GDB:313557"
                     /db_xref="UniSTS:8230"
     variation       5048
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12307986"
     variation       5078
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187456676"
     STS             5112..5417
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     STS             5112..5281
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     variation       5122
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:4450213"
     STS             5125..5388
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="L17791"
                     /db_xref="UniSTS:42740"
     variation       5177
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375602833"
     variation       5194
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188204280"
     variation       5199
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140030216"
     variation       5272
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192992501"
     variation       5297
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1131019"
     variation       5304
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143208155"
     variation       5378
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12829605"
     variation       5410
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184748337"
     variation       5463
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188259081"
     variation       5476
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180779783"
     variation       5643
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11296996"
     variation       5706
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139964896"
     variation       5761
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145416277"
     variation       5779
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183510672"
     variation       5948..5949
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:374060808"
     variation       5948
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:6538881"
     variation       5949
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6538882"
     variation       5975
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187010424"
     variation       6005
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191552272"
     variation       6020..6021
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35746294"
     variation       6049
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145263832"
     variation       6132
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142293344"
     variation       6189
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151008594"
     variation       6213
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111495253"
     variation       6239
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181602728"
     variation       6267
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140896989"
     variation       6304
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73142318"
     variation       6647..6648
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:371739358"
     variation       6668
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60760345"
     variation       6718
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1131020"
     variation       6739
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1131021"
     variation       6819
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116928965"
     STS             6889..7049
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /standard_name="RH69665"
                     /db_xref="UniSTS:12332"
     variation       6918
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186272491"
     variation       6936
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116289685"
     variation       6966..6967
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:201081099"
     variation       6969
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:12159"
     variation       6973
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:3834481"
     variation       7007
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113354620"
     polyA_signal    7128..7133
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
     variation       7144
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140352209"
     polyA_site      7158
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
ORIGIN      
aagaagaggtagcgagtggacgtgactgctctatcccgggcaaaagggatagaaccagaggtggggagtctgggcagtcggcgacccgcgaagacttgaggtgccgcagcggcatccggagtagcgccgggctccctccggggtgcagccgccgtcgggggaagggcgccacaggccgggaagacctcctccctttgtgtccagtagtggggtccaccggagggcggcccgtgggccgggcctcaccgcggcgctccgggactgtggggtcaggctgcgttgggtggacgcccacctcgccaaccttcggaggtccctgggggtcttcgtgcgccccggggctgcagagatccaggggaggcgcctgtgaggcccggacctgccccggggcgaagggtatgtggcgagacagagccctgcacccctaattcccggtggaaaactcctgttgccgtttccctccaccggcctggagtctcccagtcttgtcccggcagtgccgccctccccactaagacctaggcgcaaaggcttggctcatggttgacagctcagagagagaaagatctgagggaagatggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatcaagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagaggaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgatacttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatataaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtgtaaggacagtcctgtgtgaaggtggagtaccacagaggccagttgtttttgtcacaaggaagaagctggtgaatgcaattcagcagaagctctccaaattgaaaggtgaaccaggatgggtcaccatacatggaatggcaggctgtgggaagtctgtattagctgcagaagctgttagagatcattcccttttagaaggttgtttcccagggggagtgcattgggtttcagttgggaaacaagacaaatctgggcttctgatgaaactgcagaatctttgcacacggttggatcaggatgagagtttttcccagaggcttccacttaatattgaagaggctaaagaccgtctccgcattctgatgcttcgcaaacacccaaggtctctcttgatcttggatgatgtttgggactcttgggtgttgaaagcttttgacagtcagtgtcagattcttcttacaaccagagacaagagtgttacagattcagtaatgggtcctaaatatgtagtccctgtggagagttccttaggaaaggaaaaaggacttgaaattttatccctttttgttaatatgaagaaggcagatttgccagaacaagctcatagtattataaaagaatgtaaaggctctccccttgtagtatctttaattggtgcacttttacgtgattttcccaatcgctgggagtactacctcaaacagcttcagaataagcagtttaagagaataaggaaatcttcgtcttatgattatgaggctctagatgaagccatgtctataagtgttgaaatgctcagagaagacatcaaagattattacacagatctttccatccttcagaaggacgttaaggtgcctacaaaggtgttatgtattctctgggacatggaaactgaagaagttgaagacatactgcaggagtttgtaaataagtctcttttattctgtgatcggaatggaaagtcgtttcgttattatttacatgatcttcaagtagattttcttacagagaagaattgcagccagcttcaggatctacataagaagataatcactcagtttcagagatatcaccagccgcatactctttcaccagatcaggaagactgtatgtattggtacaactttctggcctatcacatggccagtgccaagatgcacaaggaactttgtgctttaatgttttccctggattggattaaagcaaaaacagaacttgtaggccctgctcatctgattcatgaatttgtggaatacagacatatactagatgaaaaggattgtgcagtcagtgagaattttcaggagtttttatctttaaatggacaccttcttggacgacagccatttcctaatattgtacaactgggtctctgtgagccggaaacttcagaagtttatcagcaagctaagctgcaggccaagcaggaggtcgataatggaatgctttacctggaatggataaacaaaaaaaacatcacgaatctttcccgcttagttgtccgcccccacacagatgctgtttaccatgcctgcttttctgaggatggtcagagaatagcttcttgtggagctgataaaaccttacaggtgttcaaagctgaaacaggagagaaacttctagaaatcaaggctcatgaggatgaagtgctttgttgtgcattctctacagatgacagatttatagcaacctgctcagtggataaaaaagtgaagatttggaattctatgactggggaactagtacacacctatgatgagcactcagagcaagtcaattgctgccatttcaccaacagtagtcatcatcttctcttagccactgggtcaagtgactgcttcctcaaactttgggatttgaatcaaaaagaatgtcgaaataccatgtttggtcatacaaattcagtcaatcactgcagattttcaccagatgataagcttttggctagttgttcagctgatggaaccttaaagctttgggatgcgacatcagcaaatgagaggaaaagcattaatgtgaaacagttcttcctaaatttggaggaccctcaagaggatatggaagtgatagtgaagtgttgttcgtggtctgctgatggtgcaaggataatggtggcagcaaaaaataaaatctttctttttgacattcatactagtggcctattgggagaaatccacacgggccatcacagcaccatccagtactgtgacttctccccacaaaaccatttggcagtggttgctttgtcccagtactgtgtagagttgtggaatacagactcacgttcaaaggtggctgattgcagaggacatttaagttgggttcatggtgtgatgttttctcctgatggatcatcatttttgacatcttctgatgaccagacaatcaggctctgggagacaaagaaagtatgtaagaactctgctgtaatgttaaagcaagaagtagatgttgtgtttcaagaaaatgaagtgatggtccttgcagttgaccatataagacgtctgcaactcattaatggaagaacaggtcagattgattatctgactgaagctcaagttagctgctgttgcttaagtccacatcttcagtacattgcatttggagatgaaaatggagccattgagattttagaacttgtaaacaatagaatcttccagtccaggtttcagcacaagaaaactgtatggcacatccagttcacagccgatgagaagactcttatttcaagttctgatgatgctgaaattcaggtatggaattggcaattggacaaatgtatctttctacgaggccatcaggaaacagtgaaagactttagactcttgaaaaattcaagactgctttcttggtcatttgatggaacagtgaaggtatggaatattattactggaaataaagaaaaagactttgtctgtcaccagggtacagtactttcttgtgacatttctcacgatgctaccaagttttcatctacctctgctgacaagactgcaaagatctggagttttgatctccttttgccacttcatgaattgaggggccacaacggctgtgtgcgctgctctgccttctctgtggacagtaccctgctggcaacgggagatgacaatggagaaatcaggatatggaatgtctcaaacggtgagcttcttcatttgtgtgctccgctttcagaagaaggagctgctacccatggaggctgggtgactgacctttgcttttctccagatggcaaaatgcttatctctgctggaggatatattaagtggtggaacgttgtcactggggaatcctcacagaccttctacacaaatggaaccaatcttaagaaaatacacgtgtcccctgacttcaaaacatatgtgactgtggataatcttggtattttatatattttacagactttagaataaaatagttaagcattaatgtagttgaactttttaaatttttgaattggaaaaaaattctaatgaaaccctgatatcaactttttataaagctcttaattgttgtgcagtattgcattcattacaaaagtgtttgtggttggatgaataatattaatgtagctttttcccaaatgaacatacctttaatcttgtttttcatgatcatcattaacagtttgtccttaggatgcaaatgaaaatgtgaatacataccttgttgtactgttggtaaaattctgtcttgatgcattcaaaatggttgacataattaatgagaagaatttggaagaaattggtattttaatactgtctgtatttattactgttatgcaggctgtgcctcagggtagcagtggcctgctttttgaaccacacttaccccaagggggttttgttctcctaaatacaatcttagaggttttttgcactctttaaatttgctttaaaaatattgtgtctgtgtgcatagtctgcagcatttcctttaattgactcaataagtgagtcttggatttagcaggcccccccaccttttttttttgtttttggagacagagtcttgctttgttgccaggctggagtgcagtggcgcgatctcggctcaccacaatcgctgcctcctgggttcaagcaattctcctgcctcagcctcccgagtagctgggactacaggtgtgcgcacatgccaggctaatttttgtatttttagtagagacggggtttcaccatgttggccgggatggtctcgatctcttgacctcatgatctacccgccttggcctcccaaagtgctgagattacaggcgtgagccaccgtgcctggccaggccccttctcttttaatggagacagggtcttgcactatcacccaggctggagtgcagtggcataatcatacctcattgcagcctcagactcctgggttcaagcaatcctcctgcctcagcctcccaagtagctgagactacaggcacgagccaccacacccagctaatttttaagttttcttgtagagacagggtctcactatgttgtctaggctggtcttgaactcttggcctcaagtaatcctcctgcctcagcctcccaaagtgttgggattgcagatatgagccactggcctggccttcagcagttctttttgtgaagtaaaacttgtatgttggaaagagtagattttattggtctacccttttctcactgtagctgctggcagccctgtgccatatctggactctagttgtcagtatctgagttggacactattcctgctccctcttgtttcttacatatcagacttcttacttgaatgaaacctgatctttcctaatcctcacttttttcttttttaaaaagcagtttctccactgctaaatgttagtcattgaggtggggccaattttaatcataagccttaataagatttttctaagaaatgtgaaatagaacaattttcatctaattccatttacttttagatgaatggcattgtgaatgccattcttttaatgaatttcaagagaattctctggttttctgtgtaattccagatgagtcactgtaactctagaagattaaccttccagccaacctattttcctttcccttgtctctctcatcctcttttccttccttctttcctttctcttcttttatctccaaggttaatcaggaaaaatagcttttgacaggggaaaaaactcaataactagctatttttgacctcctgatcaggaactttagttgaagcgtaaatctaaagaaacattttctctgaaatatattattaagggcaatggagataaattaatagtagatgtggttcccagaaaatataatcaaaattcaaagattttttttgtttctgtaactggaactaaatcaaatgattactagtgttaatagtagataacttgtttttattgttggtgcatattagtataactgtggggtaggtcggggagagggtaagggaatagatcactcagatgtattttagataagctatttagcctttgatggaatcataaatacagtgaatacaatcctttgcattgttaaggaggttttttgtttttaaatggtgggtcaaggagctagtttacaggcttactgtgatttaagcaaatgtgaaaagtgaaaccttaattttatcaaaagaaatttctgtaaatggtatgtctccttagaatacccaaatcataattttatttgtacacactgttaggggctcatctcatgtaggcagagtataaagtattaccttttggaattaaaagccactgactgttataaagtataacaacacacatcaggttttaaaaagccttgaatggcccttgtcttaaaaagaaattaggagccaggtgcggtggcacgtgcctgtaatcccagctccttgggaggctaagacaggaggattccttgagccctggagtttgagtccagcctgggtgacatagcaagaccctgtcttaaaagaaaaatgggaagaaagacaaggtaacatgaagaaagaagagatacctagtatgatggagctgcaaatttcatggcagttcatgcagtcggtcaagaggaggattttgttttgtagtttgcagatgagcatttctaaagcattttcccttgctgtatttttttgtattataaattacattggacttcatatatataatttttttttacattatatgtctcttgtatgttttgaaactcttgtatttatgatatagcttatatgatttttttgccttggtatacattttaaaatatgaatttaaaaaatttttgtaaaaataaaattcacaaaattgttttgaaaaacaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:317 -> Molecular function: GO:0000166 [nucleotide binding] evidence: TAS
            GeneID:317 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:317 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:317 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: NAS
            GeneID:317 -> Molecular function: GO:0042802 [identical protein binding] evidence: IEA
            GeneID:317 -> Molecular function: GO:0043531 [ADP binding] evidence: IEA
            GeneID:317 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
            GeneID:317 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: IEA
            GeneID:317 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:317 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
            GeneID:317 -> Biological process: GO:0006952 [defense response] evidence: IEA
            GeneID:317 -> Biological process: GO:0007399 [nervous system development] evidence: TAS
            GeneID:317 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: IDA
            GeneID:317 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: TAS
            GeneID:317 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
            GeneID:317 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:317 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
            GeneID:317 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:317 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:317 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:317 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:317 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:317 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:317 -> Cellular component: GO:0043293 [apoptosome] evidence: IDA
            GeneID:317 -> Cellular component: GO:0043293 [apoptosome] evidence: TAS

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.