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2024-04-26 01:49:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012424 4206 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1
(RPS6KC1), transcript variant 1, mRNA.
ACCESSION NM_012424 NM_058253
VERSION NM_012424.3 GI:209915589
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4206)
AUTHORS Liu,L., Yang,C., Yuan,J., Chen,X., Xu,J., Wei,Y., Yang,J., Lin,G.
and Yu,L.
TITLE RPK118, a PX domain-containing protein, interacts with
peroxiredoxin-3 through pseudo-kinase domains
JOURNAL Mol. Cells 19 (1), 39-45 (2005)
PUBMED 15750338
REMARK GeneRIF: findings indicate that RPK118 is a PRDX3-binding protein
that may be involved in transporting PRDX3 from the cytoplasm to
its mitochondrial site of function or to other membrane structures
via endosome trafficking.
REFERENCE 2 (bases 1 to 4206)
AUTHORS Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
Sanderson,C.M.
TITLE Analysis of a high-throughput yeast two-hybrid system and its use
to predict the function of intracellular proteins encoded within
the human MHC class III region
JOURNAL Genomics 83 (1), 153-167 (2004)
PUBMED 14667819
REFERENCE 3 (bases 1 to 4206)
AUTHORS Hayashi,S., Okada,T., Igarashi,N., Fujita,T., Jahangeer,S. and
Nakamura,S.
TITLE Identification and characterization of RPK118, a novel sphingosine
kinase-1-binding protein
JOURNAL J. Biol. Chem. 277 (36), 33319-33324 (2002)
PUBMED 12077123
REMARK GeneRIF: cloning and characterization of RPK118 as a sphingosine
kinase-1-binding protein
REFERENCE 4 (bases 1 to 4206)
AUTHORS Zhang,H., Yu,L., Mao,N., Fu,Q., Tu,Q., Gao,J. and Zhao,S.
TITLE Cloning, characterization, and chromosome mapping of RPS6KC1, a
novel putative member of the ribosome protein S6 kinase family, to
chromosome 12q12-q13.1
JOURNAL Genomics 61 (3), 314-318 (1999)
PUBMED 10552933
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB060692.1 and AF477978.1.
On Oct 23, 2008 this sequence version replaced gi:19923722.
##Evidence-Data-START##
Transcript exon combination :: AF477978.1, BC104769.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-131 DB060692.1 1-131
132-4206 AF477978.1 122-4196
FEATURES Location/Qualifiers
source 1..4206
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q41"
gene 1..4206
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="ribosomal protein S6 kinase, 52kDa, polypeptide 1"
/db_xref="GeneID:26750"
/db_xref="HGNC:10439"
/db_xref="HPRD:10204"
exon 1..264
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 10
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:182912293"
variation 59
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace=""
/replace="c"
/db_xref="dbSNP:111922819"
misc_feature 118..120
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="upstream in-frame stop codon"
variation 132
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:4951476"
CDS 160..3360
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/EC_number="2.7.11.1"
/note="isoform a is encoded by transcript variant 1;
ribosomal protein S6 kinase delta-1; S6K-delta-1;
SPHK1-binding protein; 52 kDa ribosomal protein S6 kinase;
ribosomal S6 kinase-like protein with two PSK domains 118
kDa protein"
/codon_start=1
/product="ribosomal protein S6 kinase delta-1 isoform a"
/protein_id="NP_036556.2"
/db_xref="GI:19923723"
/db_xref="CCDS:CCDS1513.1"
/db_xref="GeneID:26750"
/db_xref="HGNC:10439"
/db_xref="HPRD:10204"
/translation="
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
"
misc_feature 190..543
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="The phosphoinositide binding Phox Homology domain
of RPK118-like proteins; Region: PX_RPK118_like; cd07287"
/db_xref="CDD:132820"
misc_feature order(316..324,406..411,451..453)
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="phosphoinositide binding site [chemical binding];
other site"
/db_xref="CDD:132820"
misc_feature <946..1095
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="MIT: domain contained within Microtubule
Interacting and Trafficking molecules. This MIT domain
sub-family is found in sorting nexin 15 and related
proteins. The molecular function of the MIT domain is
unclear; Region: MIT_SNX15; cd02677"
/db_xref="CDD:30298"
misc_feature <949..1080
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="Microtubule Interacting and Trafficking molecule
domain; Region: MIT; smart00745"
/db_xref="CDD:197854"
misc_feature 1180..>1437
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(1180..1194,1204..1206,1243..1245,1249..1251,
1321..1323,1369..1380,1390..1392,1396..1398)
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(1180..1194,1204..1206,1243..1245,1249..1251,
1321..1323,1369..1380,1390..1392)
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature 1426..1428
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96S38.2); phosphorylation site"
misc_feature 1426..1428
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1438..1440
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96S38.2); phosphorylation site"
misc_feature 1438..1440
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature <2782..3327
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature <2842..3327
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="Catalytic domain of the Protein Serine/Threonine
Kinases, RPK118 and similar proteins; Region:
STKc_RPK118_like; cd05576"
/db_xref="CDD:173667"
misc_feature order(2944..2946,2950..2952,2956..2961,2965..2967,
2995..3000,3007..3009,3040..3057,3136..3138,3154..3156,
3163..3165)
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="active site"
/db_xref="CDD:173667"
misc_feature order(2944..2946,2950..2952,2956..2958,3007..3009,
3040..3057,3136..3138,3154..3156,3163..3165)
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173667"
misc_feature 2995..3057
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173667"
variation 201
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:376722820"
variation 210
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:370328339"
variation 216
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:373786068"
variation 223
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:144865741"
variation 230
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:368815923"
exon 265..300
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 283
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:56087470"
exon 301..421
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 322
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:373067977"
variation 354
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:148829724"
variation 376
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:202093150"
variation 384
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:376028316"
variation 405
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:371532539"
variation 411
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:200039706"
exon 422..537
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 444
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:56056039"
variation 445
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:56032860"
variation 474
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:201673972"
variation 499
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:200402765"
variation 502
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:374091106"
exon 538..631
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 618
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:201312117"
variation 619
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:146013577"
exon 632..994
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 678
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:200064577"
variation 695
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:367564641"
STS 706..858
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/standard_name="RH91832"
/db_xref="UniSTS:88042"
variation 713
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:375756109"
variation 742
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:372834454"
variation 749
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:377208928"
variation 769
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:141240814"
variation 776
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:191838083"
variation 781
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:139296657"
variation 787
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:77602608"
variation 815
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:199560994"
variation 818
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:369704036"
variation 838
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:372361416"
variation 854
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:376958657"
variation 927
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:150727119"
variation 931
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:144929190"
variation 940
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:147945661"
exon 995..1110
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 1009
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:368914061"
variation 1012
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:148984854"
variation 1031
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:374003961"
variation 1041
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:200954000"
variation 1055
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:370851168"
exon 1111..1203
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 1115
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:56369827"
variation 1149
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:373867090"
variation 1150
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:367794519"
variation 1161
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:144315266"
variation 1175
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:376318262"
variation 1194
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:202123122"
exon 1204..1251
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 1213
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:77163540"
variation 1225
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:372177529"
exon 1252..1384
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 1275
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:183071790"
variation 1284
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:138630226"
variation 1297
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:148124485"
variation 1303
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:375560038"
variation 1309
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:372891671"
variation 1379
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:116671995"
variation 1380
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:202015199"
exon 1385..2980
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 1430
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:56183862"
variation 1442
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:376486080"
variation 1471
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:139398884"
variation 1475
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:200446126"
variation 1480
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:370571049"
variation 1578
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:145337135"
variation 1583
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:183778510"
variation 1607
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:4307536"
variation 1622
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:144042840"
variation 1625
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:186781395"
variation 1628
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:140824568"
variation 1632
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:144593105"
variation 1639
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:139942392"
variation 1645
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:367579615"
variation 1657
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:150362956"
variation 1709
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:143588119"
variation 1719
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:139110232"
variation 1725
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:371309599"
variation 1745
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:143902583"
variation 1781
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:144668404"
variation 1795
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:35281247"
variation 1819
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:200113819"
variation 1820
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:368605950"
variation 1841
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:17020314"
variation 1848
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:140672126"
variation 1883
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:56060894"
variation 1884
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:371947868"
variation 1962
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:199765911"
variation 1968
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:199708203"
variation 1984
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:182116576"
variation 1992
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:113176399"
variation 2020
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:187036422"
variation 2074
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:200457587"
variation 2099
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:201311957"
variation 2180
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:143609307"
variation 2185
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:76987106"
variation 2225
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:201317387"
variation 2268
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:142188661"
variation 2332
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:368836189"
variation 2399
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:200816287"
variation 2402
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:185451843"
variation 2462
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:145921318"
variation 2517
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:141637651"
variation 2551
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:372285935"
variation 2629
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:138148824"
variation 2631
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:199581175"
variation 2667
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:375818673"
variation 2718
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:34080597"
variation 2726
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:185611165"
variation 2735
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:144436274"
variation 2751
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:373138975"
variation 2784
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:377265201"
variation 2793
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:189351169"
variation 2817
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:369229582"
variation 2852
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:199577296"
variation 2853
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:139892453"
variation 2861
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:145246683"
variation 2862
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:149870413"
variation 2869
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:61751035"
variation 2935
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:180891474"
variation 2943
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:367715701"
exon 2981..3070
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 2997
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:145118748"
variation 3023
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:377432736"
variation 3038
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:370222314"
variation 3045
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:147823242"
variation 3056
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:376274594"
exon 3071..3153
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
exon 3154..3249
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 3189
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="g"
/replace="t"
/db_xref="dbSNP:368418495"
variation 3191
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:143714274"
variation 3192
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:34661072"
variation 3197
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:371668209"
variation 3205
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:139038185"
variation 3234
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:373927574"
variation 3244
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:367780807"
exon 3250..4191
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/inference="alignment:Splign:1.39.8"
variation 3319
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:201703424"
variation 3322
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:193921071"
variation 3362
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:138424811"
variation 3382
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:200862433"
variation 3383
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:200434642"
variation 3489
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:186353531"
variation 3491
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:149939613"
variation 3507
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:112017651"
variation 3509
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:190195331"
variation 3519
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:144935605"
variation 3530
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="c"
/db_xref="dbSNP:370963120"
variation 3553
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:115294298"
variation 3568
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:180936383"
variation 3612
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="g"
/db_xref="dbSNP:140447631"
variation 3692
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:185923099"
variation 3848
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="t"
/db_xref="dbSNP:373951158"
variation 3865
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:191616855"
STS 3955..4169
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/standard_name="SHGC-76324"
/db_xref="UniSTS:45386"
variation 3957
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:144192461"
variation 3987
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="a"
/replace="g"
/db_xref="dbSNP:41307658"
variation 4003
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace="c"
/replace="t"
/db_xref="dbSNP:9970974"
STS 4032..4161
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/standard_name="WI-14762"
/db_xref="UniSTS:46448"
variation 4038..4041
/gene="RPS6KC1"
/gene_synonym="humS6PKh1; RPK118"
/replace=""
/replace="tctt"
/db_xref="dbSNP:146197405"
ORIGIN
ggaagcagagctgtgcagctgaggcgccgccgtggagccgccttggagccaccgccccctcgccgcttcgccgctgcgttggggaacctggaccgcggcggcgccgggtttccctcatgatcccgggcgggtggcggcggcggcagaggcggcgggaggatgacctcttaccgggagcggagtgccgacctggcccgtttctacactgtcaccgagccccagcgacacccgaggggctacacagtatataaggtcaccgcccgggttgtttcacgaagaaatccagaggatgtccaggagataattgtatggaagagatacagtgattttaagaaactacacaaagaactatggcaaattcacaaaaacttattccgacattcagagttgtttcctccatttgctaaaggaatagtgtttgggcgatttgatgaaactgttatcgaagagagaagacaatgtgctgaagacctgctacagttctctgccaatattcctgctctttacaatagtaaacagcttgaagactttttcaagggtggaataattaatgatagttctgaattaattggtcctgctgaagctcactcagattccctcattgatacctttcctgagtgtagtacggaaggcttctccagtgacagtgatctggtatctcttactgttgatgtggattctcttgctgagttagatgatggaatggcttccaatcaaaattctcccattagaacttttggtctcaatctttcttcggattcttcagcactaggggctgttgcttctgacagtgaacagagcaaaacagaagaagaacgggaaagtcgtagcctctttcctggcagtttaaagccgaagcttggcaagagagattatttggagaaagcaggagaattaataaagctggctttaaaaaaggaagaagaagacgactatgaagctgcttctgatttttataggaagggagttgatttactcctagaaggtgttcaaggagagtcaagccctacccgtcgagaagctgtgaagagaagaacagccgagtacctcatgcgggcagaaagtatctctagtctttatgggaaacctcagcttgatgatgtatctcagcctccaggatcactaagttcaaggcccctttggaacctaaggagccctgccgaggagctgaaggccttcagagtccttggggtgattgacaaggttttacttgtaatggacacaaggacagaacagactttcattttaaaaggtctaaggaaaagcagtgaatacagcaggaacagaaagaccatcatcccccgctgtgtgcccaacatggtgtgtctgcataagtacatcatctctgaggagtcagtatttcttgtgctgcagcatgcggaaggtggcaaactgtggtcatatatcagtaaatttctaaacagaagtcctgaagaaagctttgacatcaaggaagtgaaaaaacctacacttgcaaaagttcacctgcagcagccaacttctagtcctcaggacagcagtagctttgaatccagaggaagtgatggtggaagcatgcttaaagctctgcctttgaagagtagtcttactccaagttctcaagatgacagcaaccaggaagatgatggccaagatagctctccaaagtggccagattctggttcaagttcagaagaagaatgtactactagttatttaacattatgcaatgaatatgggcaagaaaagattgaaccagggtctttgaatgaggagcccttcatgaagactgaagggaatggtgttgatacaaaagctattaaaagcttcccagcacaccttgctgctgacagtgacagccccagcacacagctgagagctcacgagctgaagttcttccccaacgatgacccagaagcagttagttctccaagaacatcagattccctcagtagatcaaaaaatagccccatggaattctttaggatagacagtaaggatagcgcaagtgaactcctgggacttgactttggagaaaaattgtatagtctaaaatcagaacctttgaaaccattctttactcttccagatggagacagtgcttctaggagttttaatactagtgaaagcaaggtagagtttaaagctcaggacaccattagcaggggctcagatgactcagtgccagttatttcatttaaagatgctgcttttgatgatgtcagtggtactgatgaaggaagacctgatcttcttgtaaatttacctggtgaattggagtcaacaagagaagctgcagcaatgggacctactaagtttacacaaactaatatagggataatagaaaataaactcttggaagcccctgatgttttatgcctcaggcttagtactgaacaatgccaagcacatgaggagaaaggcatagaggaactgagtgatccctctgggcccaaatcctatagtataacagagaaacactatgcacaggaggatcccaggatgttatttgtagcagctgttgatcatagtagttcaggagatatgtctttgttacccagctcagatcctaagtttcaaggacttggagtggttgagtcagcagtaactgcaaacaacacagaagaaagcttattccgtatttgtagtccactctcaggtgctaatgaatatattgcaagcacagacactttaaaaacagaagaagtattgctgtttacagatcagactgatgatttggctaaagaggaaccaacttctttattccagagagactctgagactaagggtgaaagtggtttagtgctagaaggagacaaggaaatacatcagatttttgaggaccttgataaaaaattagcactagcctccaggttttacatcccagagggctgcattcaaagatgggcagctgaaatggtggtagcccttgatgctttacatagagagggaattgtgtgccgcgatttgaacccaaacaacatcttattgaatgatagaggacacattcagctaacgtattttagcaggtggagtgaggttgaagattcctgtgacagcgatgccatagagagaatgtactgtgccccagaggttggagcaatcactgaagaaactgaagcctgtgattggtggagtttgggtgctgtcctctttgaacttctcactggcaagactctggttgaatgccatccagcaggaataaatactcacactactttgaacatgccagaatgtgtctctgaagaggctcgctcactcattcaacagctcttgcagttcaatcctctggaacgacttggtgctggagttgctggtgttgaagatatcaaatctcatccattttttacccctgtggattgggcagaactgatgagatgaacgtaatgcagggttatcttcacacattctgatcttctctgtgacaggcatctccagcactgaggcacctctgactcacagttacttatggagcaccaaagcatttggataaagaccgttataggaaatgggggggaaatggctaaaagagaacaattcgtttacaattacaagatattagctaattgtgccaggggctgttatatacatatatacacaaccaaggtgtgatctgaatttaatccacatttggtgttgcagatgagttgtaaagccaactgaaagagttccttcaagaagttcctctgataggaagctagaagtgtagaatgaagttttacttgacagaaggacctttacatggcagctaacagtgctttttgctgaccaggattggtttatatgattaaattaatatttgcttaataatacactaaaagtatatgaacaatgtcatcaatgaaacttaaaagcgagaaaaaagaatatacacataatttctgacggaaaacctgtaccctgatgctgtataatgtatgttgaatgtggtcccagattatttctgtaagaagacactccatgttgtcagctttgtactctttgttgatactgcttatttagagaagggttcatataaacactcactctgtgtcttcaacagcatctttctttccccatctttctattttctgcaccctctgcttgttccctcatattctgttcttccgactcctgctaacacacatgcaacaaaaaagggaagggagtgcttatttccctttgtgtaaggactaagaaatcatgatatcaaataaacatggtgaaacattaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:26750 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:26750 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:26750 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:26750 -> Molecular function: GO:0035091 [phosphatidylinositol binding] evidence: IEA
GeneID:26750 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:26750 -> Cellular component: GO:0005769 [early endosome] evidence: IDA
GeneID:26750 -> Cellular component: GO:0016020 [membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_036556 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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