GGRNA Home | Help | Advanced search

2020-10-24 07:07:16, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_012418               1690 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens fascin homolog 2, actin-bundling protein, retinal
            (Strongylocentrotus purpuratus) (FSCN2), transcript variant 1,
            mRNA.
ACCESSION   NM_012418
VERSION     NM_012418.3  GI:268838146
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Schafer,C., Faust,U., Kirchgessner,N., Merkel,R. and Hoffmann,B.
  TITLE     The filopodium: a stable structure with highly regulated repetitive
            cycles of elongation and persistence depending on the actin
            cross-linker fascin
  JOURNAL   Cell Adh Migr 5 (5), 431-438 (2011)
   PUBMED   21975552
  REMARK    GeneRIF: The filopodium: a stable structure with highly regulated
            repetitive cycles of elongation and persistence depending on the
            actin cross-linker fascin
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Chan,C., Jankova,L., Fung,C.L., Clarke,C., Robertson,G.,
            Chapuis,P.H., Bokey,L., Lin,B.P., Dent,O.F. and Clarke,S.
  TITLE     Fascin expression predicts survival after potentially curative
            resection of node-positive colon cancer
  JOURNAL   Am. J. Surg. Pathol. 34 (5), 656-666 (2010)
   PUBMED   20410808
  REMARK    GeneRIF: Fascin expression predicts survival after potentially
            curative resection of node-positive colon cancer.
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Chen,S.F., Lin,C.Y., Chang,Y.C., Li,J.W., Fu,E., Chang,F.N.,
            Lin,Y.L. and Nieh,S.
  TITLE     Effects of small interfering RNAs targeting Fascin on gene
            expression in oral cancer cells
  JOURNAL   J. Oral Pathol. Med. 38 (9), 722-730 (2009)
   PUBMED   19473443
  REMARK    GeneRIF: expression may play an essential role in regulation of
            progression of oral squamous cell carcinoma and contributes to the
            event of epithelial-mesenchymal transition in the early
            aggressiveness of OSCC
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Hsu,K.F., Lin,C.K., Yu,C.P., Tzao,C., Lee,S.C., Lee,Y.Y., Tsai,W.C.
            and Jin,J.S.
  TITLE     Cortactin, fascin, and survivin expression associated with
            clinicopathological parameters in esophageal squamous cell
            carcinoma
  JOURNAL   Dis. Esophagus 22 (5), 402-408 (2009)
   PUBMED   19207554
  REMARK    GeneRIF: Higher fascin scores correlated positively with tumor
            differentiation of esophageal SqCC. Significantly worse prognosis
            in patients with high scores of fascin, poor differentiation, T4
            stage, positive for lymph node metastasis and distant metastasis
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Kostopoulou,E., Daponte,A., Terzis,A., Nakou,M., Chiotoglou,I.,
            Theodosiou,D., Chatzichristodoulou,C., Messinis,I.E. and
            Koukoulis,G.
  TITLE     Fascin in ovarian epithelial tumors
  JOURNAL   Histol. Histopathol. 23 (8), 935-944 (2008)
   PUBMED   18498068
  REMARK    GeneRIF: In ovarian tumors fascin is associated with certain
            features of increased tumor aggressiveness.
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Wada,Y., Abe,T., Itabashi,T., Sato,H., Kawamura,M. and Tamai,M.
  TITLE     Autosomal dominant macular degeneration associated with 208delG
            mutation in the FSCN2 gene
  JOURNAL   Arch. Ophthalmol. 121 (11), 1613-1620 (2003)
   PUBMED   14609921
  REMARK    GeneRIF: The 208delG mutation in the FSCN2 gene produces not only
            autosomal dominant retinitis pigmentosa but also ADMD (autosomal
            dominant macular degeneration)
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Wada,Y., Abe,T., Takeshita,T., Sato,H., Yanashima,K. and Tamai,M.
  TITLE     Mutation of human retinal fascin gene (FSCN2) causes autosomal
            dominant retinitis pigmentosa
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 42 (10), 2395-2400 (2001)
   PUBMED   11527955
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Saishin,Y., Ishikawa,R., Ugawa,S., Guo,W., Ueda,T., Morimura,H.,
            Kohama,K., Shimizu,H., Tano,Y. and Shimada,S.
  TITLE     Retinal fascin: functional nature, subcellular distribution, and
            chromosomal localization
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 41 (8), 2087-2095 (2000)
   PUBMED   10892848
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Tubb,B.E., Bardien-Kruger,S., Kashork,C.D., Shaffer,L.G.,
            Ramagli,L.S., Xu,J., Siciliano,M.J. and Bryan,J.
  TITLE     Characterization of human retinal fascin gene (FSCN2) at 17q25:
            close physical linkage of fascin and cytoplasmic actin genes
  JOURNAL   Genomics 65 (2), 146-156 (2000)
   PUBMED   10783262
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Bardien-Kruger,S., Greenberg,J., Tubb,B., Bryan,J., Queimado,L.,
            Lovett,M. and Ramesar,R.S.
  TITLE     Refinement of the RP17 locus for autosomal dominant retinitis
            pigmentosa, construction of a YAC contig and investigation of the
            candidate gene retinal fascin
  JOURNAL   Eur. J. Hum. Genet. 7 (3), 332-338 (1999)
   PUBMED   10234509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA059324.1, AF030165.1 and
            AC139149.6.
            On Nov 19, 2009 this sequence version replaced gi:116295252.
            
            Summary: This gene encodes a member of the fascin protein family.
            Fascins crosslink actin into filamentous bundles within dynamic
            cell extensions. This family member is proposed to play a role in
            photoreceptor disk morphogenesis. A mutation in this gene results
            in one form of autosomal dominant retinitis pigmentosa and macular
            degeneration. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 2,
            resulting in a shorter protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030165.1, BC126295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025086, ERS025091 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AA059324.1         1-5
            6-98                AF030165.1         1-93
            99-107              AC139149.6         2925-2933           c
            108-1690            AF030165.1         103-1685
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25"
     gene            1..1690
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="fascin homolog 2, actin-bundling protein, retinal
                     (Strongylocentrotus purpuratus)"
                     /db_xref="GeneID:25794"
                     /db_xref="HGNC:3960"
                     /db_xref="HPRD:06366"
                     /db_xref="MIM:607643"
     exon            1..967
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /inference="alignment:Splign:1.39.8"
     variation       5
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112158827"
     STS             85..1661
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /db_xref="UniSTS:486070"
     misc_feature    88..90
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="upstream in-frame stop codon"
     STS             96..1665
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /db_xref="UniSTS:482429"
     variation       103
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2075720"
     variation       117
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372264376"
     CDS             142..1620
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fascin-2"
                     /codon_start=1
                     /product="fascin-2 isoform 1"
                     /protein_id="NP_036550.1"
                     /db_xref="GI:6912626"
                     /db_xref="CCDS:CCDS45811.1"
                     /db_xref="GeneID:25794"
                     /db_xref="HGNC:3960"
                     /db_xref="HPRD:06366"
                     /db_xref="MIM:607643"
                     /translation="
MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGQGTAVLLRSSHLGRYLSAEEDGRVACEAEQPGRDCRFLVLPQPDGRWVLRSEPHGRFFGGTEDQLSCFATAVSPAELWTVHLAIHPQAHLLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSRRYCLKSCDSRYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIHATATQVSANTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGKDEEFTLKLINRPILVLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYRIRGRDGGFWYTGSHGSVCSDGERAEDFVFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGTALWEY
"
     misc_feature    178..540
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    256..258
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    553..903
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    640..642
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    913..1269
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    994..996
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    1282..1617
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    1363..1365
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     variation       171
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377034060"
     variation       189
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199668780"
     variation       190
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137853900"
     variation       197
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201652340"
     variation       205
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368996304"
     variation       206
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200258773"
     variation       213
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:376633374"
     variation       228
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377085709"
     variation       253
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370432174"
     variation       271
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200925863"
     variation       279
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376138127"
     variation       287
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200600577"
     variation       291
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:184519759"
     variation       308
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374436472"
     variation       323
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368665227"
     variation       351
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199599072"
     variation       364
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201226132"
     variation       368
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376532437"
     variation       392
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373682711"
     variation       398..401
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace=""
                     /replace="gtga"
                     /db_xref="dbSNP:144080430"
     variation       400..401
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:368451922"
     variation       450
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34126129"
     variation       474
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117946784"
     variation       481
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202158770"
     variation       498
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189437871"
     variation       501
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372408296"
     variation       521
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377179386"
     variation       522
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34454351"
     variation       538
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373996403"
     variation       553
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143796236"
     variation       557
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369192058"
     variation       577
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372751268"
     variation       587
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181961770"
     variation       594
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73367596"
     variation       608
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200503363"
     variation       609
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199752482"
     variation       611
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199574936"
     variation       618
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371033160"
     variation       627
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375636321"
     variation       628
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367599003"
     variation       633
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370382419"
     variation       634
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112994063"
     variation       657
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375067866"
     variation       660
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368029027"
     variation       679
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200332556"
     variation       715
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377025075"
     variation       729
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368621796"
     variation       736
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372191222"
     variation       737
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201632465"
     variation       769
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376778677"
     variation       774
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75815349"
     variation       786
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372547724"
     variation       804
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374822744"
     variation       812
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369222151"
     variation       815
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75057462"
     variation       817
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372923979"
     variation       832
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150620080"
     variation       843
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371255330"
     variation       844
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199541595"
     variation       859
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370156011"
     variation       866
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78593950"
     variation       873
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34797307"
     variation       879
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34567655"
     variation       905
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370581176"
     variation       920
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374814454"
     variation       924
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368281226"
     variation       941..942
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:372385538"
     variation       946
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372447325"
     variation       947
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201099468"
     variation       949
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374441955"
     variation       950
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368603459"
     variation       961
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372368597"
     variation       965
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374697213"
     exon            968..1124
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /inference="alignment:Splign:1.39.8"
     variation       970
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181420326"
     variation       1008
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368687488"
     variation       1009
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373043784"
     variation       1028
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376328590"
     variation       1107
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367734858"
     variation       1108
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186367879"
     exon            1125..1246
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /inference="alignment:Splign:1.39.8"
     variation       1166
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374441539"
     variation       1188
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73369203"
     variation       1192
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371223700"
     variation       1193
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374338872"
     variation       1197
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367827022"
     variation       1198
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144409045"
     variation       1210
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376890749"
     variation       1222
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202063383"
     variation       1227
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368154602"
     variation       1233
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188142101"
     variation       1236
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201346660"
     variation       1240
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200938099"
     variation       1241
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370080793"
     variation       1246
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376938035"
     exon            1247..1414
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /inference="alignment:Splign:1.39.8"
     variation       1265
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183485967"
     variation       1290
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371446245"
     variation       1307
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201628937"
     variation       1325
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367604773"
     variation       1329
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370208434"
     variation       1330
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375077430"
     variation       1362
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367955776"
     variation       1368
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1802103"
     variation       1371
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182593453"
     exon            1415..1670
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /inference="alignment:Splign:1.39.8"
     variation       1439
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186619653"
     variation       1450
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368990075"
     variation       1470
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372555456"
     variation       1513
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374827376"
     variation       1587
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143561119"
     polyA_signal    1648..1653
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
     polyA_site      1670
                     /gene="FSCN2"
                     /gene_synonym="RFSN; RP30"
ORIGIN      
gcaggcagggggttcgtgacgccggctgggtctgggggctgtgggccagccgagccgacccgggcttctgggggaccgcgggggccgtgagcactcagagggcgcatcccaggcccctccggggacccggccagcctgaagatgccgacgaacggcctgcaccaggtgctgaagatccagtttggcctcgtcaacgacactgaccgctacctgacagctgagagcttcggcttcaaggtcaatgcctcggcacccagcctcaagaggaagcagacctgggtgctggaacccgacccaggacaaggcacggctgtgctgctccgcagcagccacctgggccgctacctgtcggcagaagaggacgggcgcgtggcctgtgaggcagagcagccgggccgtgactgccgcttcctggtcctgccgcagccagatgggcgctgggtgctgcggtccgagccgcacggccgcttcttcggaggcaccgaggaccagctgtcctgcttcgccacagccgtttccccggccgagctgtggaccgtgcacctggccatccacccgcaggcccacctgctgagcgtgagccggcggcgctacgtgcacctgtgcccgcgggaggacgagatggccgcagacggagacaagccctggggcgtggacgccctcctcaccctcatcttccggagccgacggtactgcctcaagtcctgtgacagccgctacctgcgcagcgacggccgtctggtctgggagcctgagccccgtgcctgctacacgctggagttcaaggcgggcaagctggccttcaaggactgcgacggccactacctggcacccgtggggcccgcaggcaccctcaaggccggccgaaacacgcgacctggcaaggatgagctctttgatctggaggagagtcacccacaggtggtgctggtggctgccaaccaccgctacgtctctgtgcggcaaggggtcaacgtctcagccaatcaggatgatgaactagaccacgagaccttcctgatgcaaattgaccaggagacaaagaagtgcaccttctattccagcactgggggctactggaccctggtcacccatgggggcattcacgccacagccacacaagtttctgccaacaccatgtttgagatggagtggcgtggccggcgggtagcactcaaagccagcaacgggcgctacgtgtgcatgaagaagaatgggcagctggcggctatcagcgattttgtcggcaaggacgaagagttcaccctcaagctcatcaaccggcccatcctggtgctgcgcggcctggacggcttcgtctgccaccaccgcggctccaaccagctggacaccaaccgctccgtctacgacgtcttccacctgagcttcagcgacggcgcctaccggatccgaggccgcgacggagggttctggtacacgggcagccacggcagcgtgtgcagcgacggcgaacgcgccgaggacttcgtcttcgagttccgtgagcgcggccgcctggccatccgcgcccggagcggcaagtacctgcgcggcggcgcctcgggcctgctgcgggccgatgccgacgccccggccgggaccgcgctttgggagtactgaggccgcgcccagaccagcctgtcgcgcattaaaaccgtgtctctcccgcaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:25794 -> Molecular function: GO:0003779 [actin binding] evidence: ISS
            GeneID:25794 -> Molecular function: GO:0030674 [protein binding, bridging] evidence: IEA
            GeneID:25794 -> Molecular function: GO:0051015 [actin filament binding] evidence: ISS
            GeneID:25794 -> Biological process: GO:0007601 [visual perception] evidence: TAS
            GeneID:25794 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
            GeneID:25794 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: ISS
            GeneID:25794 -> Biological process: GO:0051017 [actin filament bundle assembly] evidence: TAS
            GeneID:25794 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:25794 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: ISS
            GeneID:25794 -> Cellular component: GO:0032420 [stereocilium] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.