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2024-04-18 11:40:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012414 7329 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens RAB3 GTPase activating protein subunit 2
(non-catalytic) (RAB3GAP2), mRNA.
ACCESSION NM_012414
VERSION NM_012414.3 GI:209977033
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7329)
AUTHORS Handley,M.T. and Aligianis,I.A.
TITLE RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf
syndromes
JOURNAL Biochem. Soc. Trans. 40 (6), 1394-1397 (2012)
PUBMED 23176487
REMARK GeneRIF: Micro syndrome has been associated with causative
mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18.
Martsolf syndrome has been associated with a mutation in RAB3GAP2.
[Review]
Review article
REFERENCE 2 (bases 1 to 7329)
AUTHORS Borck,G., Wunram,H., Steiert,A., Volk,A.E., Korber,F., Roters,S.,
Herkenrath,P., Wollnik,B., Morris-Rosendahl,D.J. and Kubisch,C.
TITLE A homozygous RAB3GAP2 mutation causes Warburg Micro syndrome
JOURNAL Hum. Genet. 129 (1), 45-50 (2011)
PUBMED 20967465
REMARK GeneRIF: functionally severe RAB3GAP2 mutations cause Warburg Micro
syndrome while hypomorphic RAB3GAP2 mutations can result in the
milder Martsolf phenotype
REFERENCE 3 (bases 1 to 7329)
AUTHORS Niwa,S., Tanaka,Y. and Hirokawa,N.
TITLE KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic
regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD
JOURNAL Nat. Cell Biol. 10 (11), 1269-1279 (2008)
PUBMED 18849981
REMARK GeneRIF: KIF1Bbeta- and KIF1A-mediated axonal transport of
presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner
through MADD.
REFERENCE 4 (bases 1 to 7329)
AUTHORS Ng,E.L. and Tang,B.L.
TITLE Rab GTPases and their roles in brain neurons and glia
JOURNAL Brain Res Rev 58 (1), 236-246 (2008)
PUBMED 18485483
REMARK GeneRIF: Data show that at chemical synapses, Rab3 performs
specific functions in synpatic vesicle exocytosis.
Review article
REFERENCE 5 (bases 1 to 7329)
AUTHORS Aligianis,I.A., Morgan,N.V., Mione,M., Johnson,C.A., Rosser,E.,
Hennekam,R.C., Adams,G., Trembath,R.C., Pilz,D.T., Stoodley,N.,
Moore,A.T., Wilson,S. and Maher,E.R.
TITLE Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic
subunit in a kindred with Martsolf syndrome
JOURNAL Am. J. Hum. Genet. 78 (4), 702-707 (2006)
PUBMED 16532399
REFERENCE 6 (bases 1 to 7329)
AUTHORS Aligianis,I.A., Johnson,C.A., Gissen,P., Chen,D., Hampshire,D.,
Hoffmann,K., Maina,E.N., Morgan,N.V., Tee,L., Morton,J.,
Ainsworth,J.R., Horn,D., Rosser,E., Cole,T.R., Stolte-Dijkstra,I.,
Fieggen,K., Clayton-Smith,J., Megarbane,A., Shield,J.P.,
Newbury-Ecob,R., Dobyns,W.B., Graham,J.M. Jr., Kjaer,K.W.,
Warburg,M., Bond,J., Trembath,R.C., Harris,L.W., Takai,Y.,
Mundlos,S., Tannahill,D., Woods,C.G. and Maher,E.R.
TITLE Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro
syndrome
JOURNAL Nat. Genet. 37 (3), 221-223 (2005)
PUBMED 15696165
REFERENCE 7 (bases 1 to 7329)
AUTHORS Lehner,B. and Sanderson,C.M.
TITLE A protein interaction framework for human mRNA degradation
JOURNAL Genome Res. 14 (7), 1315-1323 (2004)
PUBMED 15231747
REFERENCE 8 (bases 1 to 7329)
AUTHORS Nagano,F., Sasaki,T., Fukui,K., Asakura,T., Imazumi,K. and Takai,Y.
TITLE Molecular cloning and characterization of the noncatalytic subunit
of the Rab3 subfamily-specific GTPase-activating protein
JOURNAL J. Biol. Chem. 273 (38), 24781-24785 (1998)
PUBMED 9733780
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA379077.1, AB020646.2,
BC131573.1, AL117631.1, BX483077.1, AC103590.2 and N93244.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 28, 2008 this sequence version replaced gi:19923789.
Summary: The protein encoded by this gene belongs to the RAB3
protein family, members of which are involved in regulated
exocytosis of neurotransmitters and hormones. This protein forms
the Rab3 GTPase-activating complex with RAB3GAP1, where it
constitutes the regulatory subunit, whereas the latter functions as
the catalytic subunit. This gene has the highest level of
expression in the brain, consistent with it having a key role in
neurodevelopment. Mutations in this gene are associated with
Martsolf syndrome.[provided by RefSeq, Oct 2009].
##Evidence-Data-START##
Transcript exon combination :: AF255648.1, BC036513.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-164 DA379077.1 1-164
165-892 AB020646.2 1-728
893-3251 BC131573.1 776-3134
3252-5125 AB020646.2 3088-4961
5126-5145 AL117631.1 2175-2194
5146-5645 BX483077.1 3-502
5646-7288 AC103590.2 201273-202915 c
7289-7329 N93244.1 1-41 c
FEATURES Location/Qualifiers
source 1..7329
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q41"
gene 1..7329
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/note="RAB3 GTPase activating protein subunit 2
(non-catalytic)"
/db_xref="GeneID:25782"
/db_xref="HGNC:17168"
/db_xref="HPRD:11471"
/db_xref="MIM:609275"
exon 1..279
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
misc_feature 126..128
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/note="upstream in-frame stop codon"
CDS 165..4346
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/note="rab3 GTPase-activating protein 150 kDa subunit;
RGAP-iso; rab3-GAP p150; rab3-GAP regulatory subunit"
/codon_start=1
/product="rab3 GTPase-activating protein non-catalytic
subunit"
/protein_id="NP_036546.2"
/db_xref="GI:19923790"
/db_xref="CCDS:CCDS31028.1"
/db_xref="GeneID:25782"
/db_xref="HGNC:17168"
/db_xref="HPRD:11471"
/db_xref="MIM:609275"
/translation="
MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEPEEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKTKSPNLDLVETEIKELILDIKYPATKKQALESILASERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLDTPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYEKDVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANEERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISIVELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLAHHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQTKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLALHLIEAVEAISLPSL
"
misc_feature 1512..1514
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H2M9.1); phosphorylation site"
misc_feature 2865..2867
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9H2M9.1); phosphorylation site"
exon 280..344
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 345..468
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 469..550
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 551..598
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 599..674
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 675..776
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 777..876
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 877..975
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 976..1124
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1125..1204
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1205..1294
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1295..1434
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1435..1651
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1652..1795
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1796..1878
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1879..1943
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 1944..2034
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2035..2162
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2163..2376
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
variation 2252
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2577126"
exon 2377..2474
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2475..2580
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2581..2741
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2742..2970
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 2971..3144
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3145..3251
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3252..3318
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3319..3389
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3390..3425
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3426..3500
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3501..3719
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
variation 3659
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:11547779"
exon 3720..3809
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 3810..4031
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
STS 3900..4019
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="SHGC-76387"
/db_xref="UniSTS:82456"
variation 4006
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34081806"
exon 4032..4190
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
exon 4191..7329
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/inference="alignment:Splign:1.39.8"
polyA_signal 4467..4472
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
polyA_site 4503
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
variation 4750
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1059140"
STS 4864..4991
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="SHGC-76377"
/db_xref="UniSTS:52533"
STS 4925..5110
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="A005E47"
/db_xref="UniSTS:45249"
STS 5282..5471
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="SHGC-24046"
/db_xref="UniSTS:43137"
STS 5458..5619
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="RH45736"
/db_xref="UniSTS:92727"
STS 7124..7273
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
/standard_name="RH69283"
/db_xref="UniSTS:60635"
polyA_signal 7286..7291
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
polyA_site 7304
/gene="RAB3GAP2"
/gene_synonym="p150; RAB3-GAP150; RAB3GAP150;
RP11-568G11.1; WARBM2"
ORIGIN
gcagtactcggagacagcggacccgtgtcagtgacagcttccggtttggtttctccgccttctgcttggctagagctattggggctcggtggcggccgcagtggggtggagggggcagggcgtggtgaggtaaggtgagtgccgtagtggggttccctggagccatggcctgctccattgtccagttctgctacttccaggacctccaggccgcccgggacttcctctttcctcacctgcgggaggagatcctcagcggcgccttgcggagggaccccagtaaatcaacagactgggaagatgatggttggggagcatgggaagaaaatgaaccacaagaacctgaagaagaaggaaatacttgcaaaacacaaaaaacttcctggctccaagattgtgttttatccttatctccaaccaatgatcttatggtgatagctcgagagcaaaaagctgtatttctagtgccaaaatggaaatatagtgataaaggaaaggaagaaatgcaatttgctgttggctggagtggttccttaaatgtcgaagaaggggaatgtgtaaccagtgctctatgtatcccactagcaagccaaaagaggagttccactgggcgtcctgactggacctgcattgtggtgggttttacttcaggttatgtacgcttctacactgagaatggtgtgctcttgcttgcacagcttttgaatgaggacccagtacttcaacttaaatgcagaacctatgaaataccacgacatcccggcgtgactgagcagaatgaagagttgagtatcttatatccagctgccattgtgactattgatggatttagcctttttcaatctcttcgtgcttgtcgaaatcaggtagcaaaagctgcagcatcaggcaatgagaacatacaaccaccaccattagcttataagaaatggggtctacaagatattgacactattattgatcatgctagtgttggtattatgactctgtccccctttgatcaaatgaagactgcctccaatataggtggatttaatgcagcaattaaaaatagtccacctgccatgtctcagtatatcactgtagggtccaatccatttactggcttcttctatgctttagagggaagcacacaaccattattatcccatgttgcactagcagttgcaagtaaactcacttctgctttatttaatgctgccagtggttggcttggttggaaaagtaagcacgaagaagaagctgtccaaaagcaaaagccgaaggttgagccagctaccccattagctgtaagatttggacttccagattctagacgccatggtgaaagcatatgtctgtctccatgtaacacactggcagcagtaacagatgatttcggcagagttattttattggatgtagctagaggaattgcaatacgcatgtggaaagggtaccgcgacgcacaaattggatggattcaaactgtagaggacctccatgaaagagtgccagaaaaggcagatttttccccctttggaaattctcagggtccaagtcgagtagctcaattccttgtgatctatgcgccaagaaggggaattttagaagtgtggagcacacagcagggacctagagtaggagctttcaatgtggggaagcactgcaggctgctgtatcctggctataaaataatgggtttaaataatgttaccagtcagagttggcagccacagacttatcagatctgtctggttgatccagtgtctggaagtgtgaaaacagtgaacgttcccttccatttagcactgagtgataagaagagtgaacgagccaaggatatgcacctagtgaagaaactagcagccttactgaaaacaaaatctcccaatcttgatttggttgaaacagaaataaaggaattaattcttgatattaaataccctgcaaccaaaaaacaagctttggaaagcattttggcaagtgaacgtttaccattttcttgccttagaaacatcactcagactttaatggacactttaaaaagtcaagaacttgagtctgttgatgaaggattgctacagttttgtgccaataaactaaaactgctgcaactctatgagtctgtcagtcaattaaattcccttgattttcatttagacacaccattctctgataatgacttggctctgttactaaggcttgatgaaaaagaactgcttaagctccaggcattactagagaaatataagcaagagaacaccaggacaaatgttcgattttctgatgataaagatggtgtgttgcctgtaaaaacattcttggaatatttagaatatgaaaaggatgtgctcaacataaagaaaataagtgaagaggaatatgtggctttaggtagtttctttttttggaagtgtttgcatggagaaagctccactgaggatatgtgtcacactttggagtcggctggtcttagccctcagctgttgttgtctctgctcctgagtgtttggctttcaaaggaaaaggatattttggataaaccacagtcaatctgctgtcttcataccatgctgtccctcctgagcaagatgaaagtggccatcgatgagacctgggattctcagtctgtgtccccatggtggcagcagatgcgcacagcctgtattcagtctgagaacaatggagccgctctgttgtctgcgcatgttgggcattctgttgctgcacagatatcaaacaacatgacagagaaaaaattttcccaaacagttttgggtgctgattcagaggccctcactgattcctgggaggcactttctcttgacactgagtactggaaactccttctgaaacagctggaggattgtctcatacttcagactctgcttcacagcaaagggaacactcagacctccaaagtgtcatcactgcaggctgagccacttccaaggctttctgttaaaaagttattagaaggaggaaaaggtggcattgcagacagtgtagccaagtggatatttaaacaggacttcagccctgaagtattaaaactggctaatgaagaaagagatgcagaaaacccagatgaacccaaagaaggtgttaacagaagtttccttgaggtatcagagatggagatggacttaggagccataccagacttactgcatttagcctatgagcagtttccttgtagccttgagctcgatgtcttgcatgcacattgctgctgggagtacgttgttcagtggaataaagatccagaggaagcacgtttttttgttaggtcaatagaacacttgaagcaaatatttaatgcacatgttcaaaatggcattgcactgatgatgtggaatacgttcttagttaaaagattttctgctgctacatacttaatggataaggttggaaaatcaccaaaagataggttatgccgaagggatgtgggaatgagtgacacagcaatgacatctttcctcggctcctgtttggatcttcttcagatcttaatggaggcagatgttagcagggatgaaatacaggtgcctgtgctggatactgaggatgcgtggctctccgtggaaggaccaatctccatagtggaactggcccttgaacagaagcacatccactacccactggtggagcaccactccatcctgtgctccatcttgtatgcagtcatgaggttttctctgaagaccgtgaagccactttcactttttgacagtaagggaaaaaatgcatttttcaaagacctaacttcaattcagttattacctagtggggaaatggatccaaattttatttctgtacgacaacagttcttattgaaagttgtcagtgcagctgtccaggcccaacattcagccacaaaggtcaaagatcccacagaagaggccacacccactccttttgggaaagaccaagattggccagctctagctgtggatttagcccatcaccttcaagttagtgaagatgttgttagaaggcattatgtgggggaactatacaactatggagttgaccacttaggagaagaggccattctacaggttcatgacaaagaggtccttgcctctcagctgctggtgctcacggggcaaaggctggctcatgcgcttctccacacccagacaaaagaaggaatggagctgcttgccagacttccacccacactgtgtacttggctgaaagcaatggacccccaggaccttcaaaacactgaagtgccaattgcaacaacagctaaactagtaaataaagtaattgagcttttaccagaaaaacatgggcaatatggtctagccttacacctcattgaagctgtggaagccatatctcttccttctttatgacacttacctactggaaatagtctaaaattatgattataacatgaagtagtgcatggttattttacatagtaagacctggaattttatgggaaaagtatgtctttttttttccttttgtaaaataaataaaagtatatacaacttttaaaaagtgcaaccctggctaaattccactcctttggttaatactgaagataaaatataaacaaatgtcaactctgttataattaatacagatgttttactgtttatttctaattcaaacacttaagtagctttattgttaaactttgctatttaaaattggttataatttagattatgttcttataagattctatatttcctatctaaaatgttgttgtaattcaatttaaatgtgttcatgtacagtccccatcagtagcgtatagaacaccccactctcctttagtaaatgttgagaaaatgcctttgttgtcatgctccaaatcccacactgggctgccacctgggagttctggataccgaaaggttcctttcccagaggttctgctgttgccatcagaggaggatgaccgtgcttgaggaggaagaatgggttcaagatcatcatattcatcagaaggggacactaaatagaacccttaacctgttgtacttgccaaaattgagaatcagagatgtgtaaaatgcagcaaattaattataatgtaagttaagatttgctttttgccaagttgcaaagttgtatccacatcaggtcactgtaaaaatgtattatcttgtaaaacttatgtaaaaaaaaaaaaaaaaaaaaggcaaagatactaaaaattttaagtccgactttatttttcctacaagtgtttagaaatgcttctgggatttgctaatattatctgtccttgggaacagtattgaaaaaactgcttagtggtattacagctttagcaaacctacctcacagctgggatgagaggataaaatacaactaattttgtaccctatagtgcctagagcagtccaagtgctaaataaatatttactgattaaaaccaaactatagctactcgggaggctggaggaggatcgcttgagcccaggagtttgaggccattctgggcaatatagcaagaccctgtctcgaaaaaaaaaaaaaaaagaaaaaaccaaactaaccaaaactctgtaaaagagtgctttgagctctacaaataccaagtatttattgtggtatatttttagaatgtagccatacagtgtaattatgggtatctgtcatggatcacaattattattcatagtaagtcattgtgatacagaagtttgtttcttcacttccccttaagaagccaactatagtaatcatgcaaagttgaggagtatgtccttcagggatataaaaagaaaaacaaatctgttttttgagctaaaagagcacatccaaacaagaatttaactggctaaaatttagtaattactgttaagtaactatcaaacttgaaatcttacaagataaatggttaagatgtcttgagtatttgggatgggggcctgtgagtctgattgagacatacattttacagagtagcagcactggaaagggctagtccaacctcccagcctctgcttgggtctccgctgccccagccacacacatcctagaattcttgtaaacatatctggctctgtgttaacagtcacttgttatatgttttctaagagattagttcttcctgtgatttttccaagtacgctgaaagtagtagtatgaacttaaggaggctagtcaaagaaacttggagttataggtatttttaaagaataaatcctcaattccatcatcacttggcggggagggggcacttattaagcattttagataataaaactggttaagcttactctggtagaacagacaatcaaatctggggattgctgagaacaataataagctgaagtatggctcacagaatcctaacacaaatcattaagtctctagttagatttgttatcctaaaatttttcatagaattttaaaatctaattctgacttgtatggttaagaaaagcagttaaatattttactacttatcaagggcttttaaaataaataaatctgattgataggaagaaaggcaaataaatacctatgtagacattctataataacaaagagccatagatgataaaggaattagattttaatgtagaatgggtggtttctgaaacaaaggtatgtggtactttgtagttattgatgagaagccagtaaccagtagtgttttcctagatatatgcccaccctcacacaactttcttcattaacaaacattaaatatgcatttgtatcttattaaattatattgtataatgctgaaggaaaacaaaaagtgttcaaataatcataacttctacattacaggttctgtttagatgcagaactagaggggccagggtaaatgtagataaagagatatatagcaccatgcttcttaatgcttcatacttttgcaaacagaaaaaaaaagttttacttttattataaaacttcatctatggtcaaagtaaacactgttacatttaaattgctttttaaaaacaattgcgatctaaaaagtcaaaaatctgaaatttaataatatgagacttacactgaatataatgttcatttagaagttgctgtggtccacttcatttataaggaacaaatatttttacagtacactatagcaacagcaaaagccctctctcaccctgataggaatgggtttgctgggtgtctagaagttagattcctgctgaatagaattagccatccttaaaagattttaatccaatactgaactgtttataaaatgctttctctattgtaatgtactgtaagtagtgaaattctgtatatactgctattttctgtctgttcattgttgtgaacttcttatgtatattagtgaaataaattttcagctttcatgttgtttcctaaacattcataagt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25782 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IEA
GeneID:25782 -> Molecular function: GO:0008047 [enzyme activator activity] evidence: TAS
GeneID:25782 -> Molecular function: GO:0030234 [enzyme regulator activity] evidence: ISS
GeneID:25782 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: ISS
GeneID:25782 -> Biological process: GO:0006886 [intracellular protein transport] evidence: TAS
GeneID:25782 -> Biological process: GO:0043085 [positive regulation of catalytic activity] evidence: TAS
GeneID:25782 -> Biological process: GO:0043087 [regulation of GTPase activity] evidence: ISS
GeneID:25782 -> Biological process: GO:0043547 [positive regulation of GTPase activity] evidence: TAS
GeneID:25782 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:25782 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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