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2020-10-24 07:16:52, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_012381               2586 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens origin recognition complex, subunit 3 (ORC3),
            transcript variant 2, mRNA.
ACCESSION   NM_012381
VERSION     NM_012381.3  GI:308737001
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat. Res. 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Enjuanes,A., Benavente,Y., Bosch,F., Martin-Guerrero,I.,
            Colomer,D., Perez-Alvarez,S., Reina,O., Ardanaz,M.T., Jares,P.,
            Garcia-Orad,A., Pujana,M.A., Montserrat,E., de Sanjose,S. and
            Campo,E.
  TITLE     Genetic variants in apoptosis and immunoregulation-related genes
            are associated with risk of chronic lymphocytic leukemia
  JOURNAL   Cancer Res. 68 (24), 10178-10186 (2008)
   PUBMED   19074885
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   DeRosse,P., Lencz,T., Burdick,K.E., Siris,S.G., Kane,J.M. and
            Malhotra,A.K.
  TITLE     The genetics of symptom-based phenotypes: toward a molecular
            classification of schizophrenia
  JOURNAL   Schizophr Bull 34 (6), 1047-1053 (2008)
   PUBMED   18628273
  REMARK    GeneRIF: Lifetime severity of positive symptoms was significantly
            (P = 2.50 x 10(-5)) associated with a SNP within the origin
            recognition complex subunit 3-like (ORC3L) gene, a gene implicated
            in synaptic plasticity.
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Siddiqui,K. and Stillman,B.
  TITLE     ATP-dependent assembly of the human origin recognition complex
  JOURNAL   J. Biol. Chem. 282 (44), 32370-32383 (2007)
   PUBMED   17716973
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Izumi,M., Yanagi,K., Mizuno,T., Yokoi,M., Kawasaki,Y., Moon,K.Y.,
            Hurwitz,J., Yatagai,F. and Hanaoka,F.
  TITLE     The human homolog of Saccharomyces cerevisiae Mcm10 interacts with
            replication factors and dissociates from nuclease-resistant nuclear
            structures in G(2) phase
  JOURNAL   Nucleic Acids Res. 28 (23), 4769-4777 (2000)
   PUBMED   11095689
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Thome,K.C., Dhar,S.K., Quintana,D.G., Delmolino,L., Shahsafaei,A.
            and Dutta,A.
  TITLE     Subsets of human origin recognition complex (ORC) subunits are
            expressed in non-proliferating cells and associate with non-ORC
            proteins
  JOURNAL   J. Biol. Chem. 275 (45), 35233-35241 (2000)
   PUBMED   10954718
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Herbig,U., Marlar,C.A. and Fanning,E.
  TITLE     The Cdc6 nucleotide-binding site regulates its activity in DNA
            replication in human cells
  JOURNAL   Mol. Biol. Cell 10 (8), 2631-2645 (1999)
   PUBMED   10436018
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Pinto,S., Quintana,D.G., Smith,P., Mihalek,R.M., Hou,Z.H.,
            Boynton,S., Jones,C.J., Hendricks,M., Velinzon,K.,
            Wohlschlegel,J.A., Austin,R.J., Lane,W.S., Tully,T. and Dutta,A.
  TITLE     latheo encodes a subunit of the origin recognition complex and
            disrupts neuronal proliferation and adult olfactory memory when
            mutant
  JOURNAL   Neuron 23 (1), 45-54 (1999)
   PUBMED   10402192
  REMARK    GeneRIF: Functional studies of the Drosophila homolog
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Tugal,T., Zou-Yang,X.H., Gavin,K., Pappin,D., Canas,B.,
            Kobayashi,R., Hunt,T. and Stillman,B.
  TITLE     The Orc4p and Orc5p subunits of the Xenopus and human origin
            recognition complex are related to Orc1p and Cdc6p
  JOURNAL   J. Biol. Chem. 273 (49), 32421-32429 (1998)
   PUBMED   9829972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC395106.1, AF125507.1 and
            BM971022.1.
            On Oct 15, 2010 this sequence version replaced gi:32483366.
            
            Summary: The origin recognition complex (ORC) is a highly conserved
            six subunits protein complex essential for the initiation of the
            DNA replication in eukaryotic cells. Studies in yeast demonstrated
            that ORC binds specifically to origins of replication and serves as
            a platform for the assembly of additional initiation factors such
            as Cdc6 and Mcm proteins. The protein encoded by this gene is a
            subunit of the ORC complex. Studies of a similar gene in Drosophila
            suggested a possible role of this protein in neuronal proliferation
            and olfactory memory. Alternatively spliced transcript variants
            encoding distinct isoforms have been reported for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks three nts in an
            alternate splicing site in the 3' coding, as compared to variant 1.
            The translation reading frame remains the same, and the resulting
            isoform (2) lacks an internal aa, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093535.1, AK222795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                DC395106.1         1-67
            68-2563             AF125507.1         1-2496
            2564-2586           BM971022.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.3-q16.1"
     gene            1..2586
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /note="origin recognition complex, subunit 3"
                     /db_xref="GeneID:23595"
                     /db_xref="HGNC:8489"
                     /db_xref="HPRD:05398"
                     /db_xref="MIM:604972"
     exon            1..126
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       21
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307387"
     misc_feature    28..30
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /note="upstream in-frame stop codon"
     variation       35
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146601654"
     variation       68
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201438682"
     variation       88..89
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:28381461"
     variation       91..92
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:2307367"
     variation       101
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2307368"
     CDS             103..2238
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     origin recognition complex, subunit 3 honolog; homolog of
                     latheo, Drosophila; origin recognition complex subunit
                     Latheo"
                     /codon_start=1
                     /product="origin recognition complex subunit 3 isoform 2"
                     /protein_id="NP_036513.2"
                     /db_xref="GI:32483367"
                     /db_xref="CCDS:CCDS43486.1"
                     /db_xref="GeneID:23595"
                     /db_xref="HGNC:8489"
                     /db_xref="HPRD:05398"
                     /db_xref="MIM:604972"
                     /translation="
MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
"
     misc_feature    157..1134
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /note="Origin recognition complex (ORC) subunit 3
                     N-terminus; Region: ORC3_N; pfam07034"
                     /db_xref="CDD:148572"
     misc_feature    169..171
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UBD5.1); phosphorylation site"
     misc_feature    724..726
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1648..1650
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UBD5.1); phosphorylation site"
     misc_feature    1648..1650
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       114
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376418108"
     variation       116
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375214415"
     variation       120
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149941248"
     exon            127..181
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       159
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201861328"
     variation       168
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144122164"
     variation       178
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148696846"
     exon            182..279
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       234
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371874111"
     variation       235
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142044709"
     variation       258
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146668920"
     variation       267
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200996438"
     exon            280..424
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       304
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144040713"
     variation       343
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78910923"
     variation       347
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368053556"
     variation       356
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371584444"
     variation       365
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112186214"
     variation       378
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74364970"
     variation       379
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201924978"
     variation       382
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2307365"
     variation       410
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150252172"
     exon            425..529
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       429
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145851270"
     variation       431
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149010963"
     variation       457
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373085430"
     variation       464
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78632433"
     variation       465
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143632999"
     variation       466
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202154049"
     variation       479
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2307371"
     variation       481
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143881974"
     variation       489
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369815671"
     variation       491
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77689062"
     variation       507
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373119034"
     variation       517
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146526621"
     variation       521
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141851921"
     exon            530..681
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       533
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141721711"
     variation       570
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150567304"
     variation       611
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112741742"
     variation       613
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61756140"
     variation       616
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139602020"
     variation       650
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149324991"
     variation       655..656
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35309297"
     exon            682..815
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       686
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146286747"
     variation       687
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369385539"
     variation       745
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199698250"
     variation       751
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2307389"
     variation       775
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200682425"
     variation       781
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199789475"
     variation       802
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367552239"
     exon            816..975
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       841
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2307374"
     variation       852
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377330226"
     variation       884
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146446780"
     variation       891
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201301884"
     variation       912
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367965463"
     variation       933
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148643475"
     variation       962
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307381"
     variation       969
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151302588"
     exon            976..1089
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1049
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140577831"
     variation       1070
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150481408"
     variation       1089
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2307363"
     exon            1090..1223
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1096
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61753612"
     variation       1112
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147755470"
     variation       1134
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368361212"
     variation       1165
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200762592"
     exon            1224..1287
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1227
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200082103"
     variation       1238
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142333103"
     variation       1243
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201077859"
     variation       1259
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146416983"
     variation       1264
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200211835"
     variation       1267
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2307372"
     exon            1288..1404
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1289
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376650812"
     variation       1295
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371509958"
     variation       1378
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138599697"
     exon            1405..1484
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1420
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201209204"
     variation       1444
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139108147"
     variation       1476
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143108637"
     exon            1485..1618
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1493
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371508516"
     variation       1501
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148245971"
     variation       1544
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9353493"
     variation       1553
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202114121"
     variation       1594
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307393"
     variation       1608
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201278306"
     variation       1610
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146268634"
     exon            1619..1695
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1630
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200525076"
     variation       1639
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369225174"
     variation       1640
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199578553"
     variation       1647
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373490954"
     variation       1651
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199748447"
     variation       1686
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201594291"
     exon            1696..1793
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1697
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138153363"
     variation       1756
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142321378"
     exon            1794..1935
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1827
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370934198"
     variation       1864
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307370"
     variation       1886
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61747273"
     variation       1933
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375586431"
     exon            1936..2052
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       1954
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370143904"
     variation       1961
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139494209"
     STS             1970..2110
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /standard_name="STS-H99257"
                     /db_xref="UniSTS:38099"
     variation       1978
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28381545"
     variation       1982
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201741907"
     variation       2007
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144517793"
     exon            2053..2132
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       2053
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374112561"
     variation       2101
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148557057"
     variation       2130
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200865515"
     exon            2133..2569
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /inference="alignment:Splign:1.39.8"
     variation       2138
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188446659"
     STS             2149..2568
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /standard_name="ORC3L_9379"
                     /db_xref="UniSTS:471702"
     variation       2194
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146518052"
     STS             2200..2370
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /standard_name="RH68856"
                     /db_xref="UniSTS:39128"
     variation       2263
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376580990"
     variation       2269
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368993527"
     variation       2278
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371602431"
     variation       2321
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2307380"
     variation       2339
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190350143"
     variation       2343
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307392"
     variation       2380
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2307369"
     variation       2426
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149980633"
     variation       2446
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28381552"
     variation       2450
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145220662"
     polyA_signal    2539..2544
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
     variation       2540
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74984361"
     variation       2549
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149159300"
     polyA_site      2569
                     /gene="ORC3"
                     /gene_synonym="LAT; LATHEO; ORC3L"
ORIGIN      
caatcaaggagccgtgtggctcgccactaacctctgccctgcagccgcgagggcgcgcgggaaatcccgagtgcatctggaatacgcagagtcagtaagaccatggctacgtcctcgatgtctaagggttgctttgtttttaagccaaactccaaaaagagaaagatctctctgccaatagaggactattttaacaaagggaaaaatgagcctgaggacagtaagcttcgattcgaaacttatcagttgatatggcagcagatgaaatctgaaaatgagcgactacaagaggaattaaataaaaacttgtttgacaatctgattgaatttctgcaaaaatcacattctggattccagaagaattcaagagacttgggcggtcaaataaaactcagagaaattccaactgctgctcttgttcttggtgtgaatgtcacagatcatgatttgacattcggaagtctaacagaggcccttcagaataatgtcacaccatatgtagtctcattgcaagctaaagattgtccagatatgaaacattttttgcaaaagttgatctcacagttgatggactgctgtgtagatataaaatccaaagaggaggaaagtgttcacgtcacccaaagaaagacacattattcaatggattcactttccagttggtatatgactgtcacacagaagacggacccaaaaatgctaagcaaaaaaaggactacttctagccaatggcagtctcctcctgttgtcgttatcttgaaggatatggaaagctttgccacaaaagtactacaagacttcataattatcagcagtcaacatctccatgaatttccactaatactcatttttggaatagccacatctcctattatcatccaccgattgcttcctcatgcagtatcatctctattgtgcatagaactgttccaatctttgtcttgtaaggagcacctgactacggtactcgataagctacttcttacaactcagtttccctttaaaataaatgaaaaagtattacaggttctgaccaacatctttttgtatcatgatttctcagttcaaaactttataaaaggacttcagctttctctattagagcatttctattcccagcccttaagtgtcctgtgctgtaatcttccagaagccaaaagaagaataaattttttatcaaataatcaatgtgaaaacatccgacgtctaccatcttttaggaggtacgtggaaaagcaagcttcagaaaagcaagttgcgctcttgaccaatgagagatatttgaaggaggaaacacaattattactagaaaacctgcatgtttatcatatgaattacttcctggttttgagatgtcttcataagttcacctcttctcttcccaagtatccactaggtcgacagatcagagagttgtactgtacatgtttagaaaagaacatatgggattcagaggagtatgcatcagtcttgcagctgctgaggatgttggcaaaggatgaactgatgaccatacttgagaaatgtttcaaggtttttaagtcttattgtgaaaaccaccttggcagcacagctaagagaatagaggagttcctggcccagtttcagagcctcgatgaaaccaaagaggaagaagatgcttctgggtcacagccaaaggggcttcagaagacagacctctatcatcttcagaagtccttattggaaatgaaggagttaagaagaagtaagaagcaaaccaaatttgaagtactcagagaaaatgttgtgaacttcattgactgtctagtgagagaataccttctgcctcctgagacacagcctctccatgaggtggtgtacttcagtgctgcccatgcccttcgtgagcatttaaatgctgctccgcgaattgccctccatactgcactcaacaatccttactattatctcaagaatgaagcactgaaaagcgaagaaggctgcattccgaatatcgccccagacatctgcatagcatacaaactgcacctagagtgtagcaggctcatcaacctcgtggactggtcagaggcttttgcaacagttgtgacagctgctgaaaaaatggatgcaaattctgcaacctcagaagaaatgaatgaaattatccatgctcggtttattagagctgtttctgaactagaacttttaggatttataaaacctaccaaacagaagactgaccatgtggcaagactaacatggggaggctgctagaaagcaaataagcaaagccagaactatcacatttagcttaagagaaaaaggtgaccagtcatatttacatatattagaggagcctgttttgttgagaagataaatgtgtaacccccattgatgtttaaccagaaaagtacattgctaaccccaaacaggcatgtatcaaaacacctgtggagtactttagactccaacaaataataatgtaactaaaactgctcacacattttactgtactttccaaagtcattactaaattgtgagtaaatcattcttgaacttagagtatgtaaatgtaataaattccgttatccaggagtataaattaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:23595 -> Molecular function: GO:0003688 [DNA replication origin binding] evidence: TAS
            GeneID:23595 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:23595 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:23595 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:23595 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
            GeneID:23595 -> Cellular component: GO:0000808 [origin recognition complex] evidence: IDA
            GeneID:23595 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:23595 -> Cellular component: GO:0005664 [nuclear origin of replication recognition complex] evidence: IDA

by @meso_cacase at DBCLS
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