2024-03-29 22:58:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012279 3089 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens zinc finger protein 346 (ZNF346), mRNA. ACCESSION NM_012279 VERSION NM_012279.2 GI:38570153 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3089) AUTHORS Yang,M., Wu,S., Jia,J. and May,W.S. TITLE JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1 JOURNAL Cell Cycle 10 (14), 2390-2399 (2011) PUBMED 21715977 REMARK GeneRIF: JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ's dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo. REFERENCE 2 (bases 1 to 3089) AUTHORS Chen,T., Brownawell,A.M. and Macara,I.G. TITLE Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5 JOURNAL Mol. Cell. Biol. 24 (15), 6608-6619 (2004) PUBMED 15254228 REMARK GeneRIF: JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism REFERENCE 3 (bases 1 to 3089) AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and Wiemann,S. TITLE Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing JOURNAL EMBO Rep. 1 (3), 287-292 (2000) PUBMED 11256614 REFERENCE 4 (bases 1 to 3089) AUTHORS Yang,M., May,W.S. and Ito,T. TITLE JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization JOURNAL J. Biol. Chem. 274 (39), 27399-27406 (1999) PUBMED 10488071 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988061.1, AK026627.1, AL359576.1 and AK024650.1. On Dec 1, 2003 this sequence version replaced gi:6912439. Summary: The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK026627.1, BC007775.2 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-138 CB988061.1 28-165 139-1607 AK026627.1 123-1591 1608-2299 AL359576.1 1572-2263 2300-3089 AK024650.1 95-884 FEATURES Location/Qualifiers source 1..3089 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5q35.2" gene 1..3089 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="zinc finger protein 346" /db_xref="GeneID:23567" /db_xref="HGNC:16403" /db_xref="HPRD:05606" /db_xref="MIM:605308" exon 1..218 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" misc_feature 26..28 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="upstream in-frame stop codon" CDS 44..928 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="double-stranded RNA-binding zinc finger protein JAZ; just another zinc finger protein" /codon_start=1 /product="zinc finger protein 346" /protein_id="NP_036411.1" /db_xref="GI:6912440" /db_xref="CCDS:CCDS4409.1" /db_xref="GeneID:23567" /db_xref="HGNC:16403" /db_xref="HPRD:05606" /db_xref="MIM:605308" /translation="
MEYPAPATVQAADGGAAGPYSSSELLEGQEPDGVRFDRERARRLWEAVSGAQPVGREEVEHMIQKNQCLFTNTQCKVCCALLISESQKLAHYQSKKHANKVKRYLAIHGMETLKGETKKLDSDQKSSRSKDKNQCCPICNMTFSSPVVAQSHYLGKTHAKNLKLKQQSTKVEALHQNREMIDPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKLKLMARYGRLADPAVTDFPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTVASSLGQIPMQRQPIQKDSTTLED
" misc_feature 254..355 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="Zinc-finger double-stranded RNA-binding; Region: zf-C2H2_jaz; cl09952" /db_xref="CDD:209110" misc_feature 446..535 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="U1-like zinc finger; Region: ZnF_U1; smart00451" /db_xref="CDD:197732" misc_feature 587..691 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /note="U1-like zinc finger; Region: ZnF_U1; smart00451" /db_xref="CDD:197732" variation 79 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:146045012" variation 84 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:377522993" variation 108 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:370147753" variation 146 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:374427722" variation 212 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:377548604" variation 214 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:370780368" exon 219..322 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 223 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:115113508" variation 280 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:200491700" variation 302..303 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="g" /db_xref="dbSNP:34893256" variation 317..318 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="g" /db_xref="dbSNP:35799524" exon 323..415 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 354 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="t" /db_xref="dbSNP:146699341" variation 393 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:375973385" variation 394 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:201590699" exon 416..560 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 474 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:373293858" variation 485 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:202040011" variation 493 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:199787330" variation 496 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:200470136" variation 518 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:139233067" exon 561..746 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 575 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:375159608" variation 615 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:111663248" variation 628 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:376968170" variation 629 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:201400452" variation 637 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:41275291" variation 644 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:199731522" variation 655 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:373775962" variation 678 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:370460147" variation 689 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:367611427" variation 721 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:370077874" variation 734 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:144916400" exon 747..840 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 810 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:146769030" variation 821 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:368577314" exon 841..3086 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /inference="alignment:Splign:1.39.8" variation 853 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:113725454" variation 863 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:149109025" variation 867 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:143189601" variation 930 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:151183135" variation 1067 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:144050595" variation 1169 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:13356308" variation 1179 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:188295559" variation 1255 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:148675773" variation 1285 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:142342588" variation 1342 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:181805572" variation 1454 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="c" /db_xref="dbSNP:185732634" variation 1550 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="c" /db_xref="dbSNP:201597490" variation 1560 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:190193734" variation 1621 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="t" /db_xref="dbSNP:371081332" variation 1652 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:181743835" variation 1806 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:2456167" variation 1840 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:151281957" variation 1849 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="c" /db_xref="dbSNP:139245841" variation 1885 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:251848" variation 1961 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:186307396" variation 1984 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:190330034" variation 2111 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:145366452" STS 2135..2282 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /standard_name="SGC32143" /db_xref="UniSTS:69125" STS 2152..2309 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /standard_name="D5S2863" /db_xref="UniSTS:16915" variation 2187..2188 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="tg" /replace="tgtgtg" /db_xref="dbSNP:146386684" variation 2188..2189 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="g" /replace="gt" /replace="tg" /db_xref="dbSNP:11377166" variation 2211..2212 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="c" /db_xref="dbSNP:168489" variation 2211..2212 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="g" /db_xref="dbSNP:377584121" variation 2211 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:28392170" variation 2212..2213 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="a" /replace="c" /db_xref="dbSNP:35976285" variation 2223 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:180732483" polyA_signal 2275..2280 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" polyA_site 2298 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /experiment="experimental evidence, no additional details recorded" variation 2309 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="g" /replace="t" /db_xref="dbSNP:142648749" STS 2395..3071 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /standard_name="ZNF346__4826" /db_xref="UniSTS:468821" variation 2434 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:59157655" variation 2591 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="t" /db_xref="dbSNP:6887893" variation 2650 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:146915315" variation 2810 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:12655218" variation 2980 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="c" /replace="g" /db_xref="dbSNP:145810091" variation 3003 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="t" /db_xref="dbSNP:371265500" variation 3008 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:148987780" variation 3011 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="g" /db_xref="dbSNP:6893089" variation 3028 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="a" /replace="t" /db_xref="dbSNP:372315667" polyA_site 3086 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" variation 3086 /gene="ZNF346" /gene_synonym="JAZ; Zfp346" /replace="" /replace="aa" /db_xref="dbSNP:74355837" ORIGIN
aggcgcctgagaggctctctaccggtgagggtttgcggggaagatggagtatcccgcgccggccacggtgcaggccgcggacggcggagcggccgggccttacagcagctcggagttgctggagggccaggagccggacggggtgcgctttgaccgcgagagggcgcgccgcctgtgggaagccgtgtccggtgcccagccggtgggtagagaggaagtggagcacatgatccagaagaaccaatgtctcttcaccaacacccagtgtaaggtttgctgcgccttgcttatttctgagtcccagaagctggcacattaccagagcaaaaaacatgccaacaaagtgaagagatacctagcaatccatggaatggagacattaaagggggaaacgaagaagctagactcagatcagaagagcagcagaagcaaagacaagaaccagtgctgccccatctgtaacatgaccttttcctcccctgtcgtggcccagtcgcactacctggggaagacccacgcaaagaacttaaagctgaagcagcagtccactaaggtggaagccttgcaccagaatagagagatgatagacccagacaagttctgcagcctctgccatgcaactttcaacgaccctgtcatggctcaacaacattatgtgggcaagaaacacagaaaacaggagaccaagctcaaactaatggcacgctatgggcggctggcggaccctgctgtcactgactttccagctggaaagggctacccctgcaaaacatgtaagatagtgctgaactccatagaacagtaccaagctcatgtcagcggcttcaaacacaagaaccagtcaccaaaaacagtggcatcatccctgggccagattccaatgcaaaggcaacccattcagaaagactcaaccaccttggaagactagaggtgattctgcccagcatcccatattgggccagccatgagccagcttcccgtgactgctcagcccttggctccctcttgctcgttgttctcaccaggaaagtacacgggcctgaggcaggattgggccacagacagcctctcattggtccgggctaattcactcctgctgctcccctttggcaggggtcctgtaggtcatgacaggggaggcaagggtattgagagactcggggtctcgcggggtggtagtttggagggtggctttccccatttcccaacccctctgggccttaggtgctgaggcccctgccacctgtctttcctctaaaggtcagttttgggccagttcttgcaactaaagagcagagatctctctgggccctagacatttccagcaaaacctggaactttcatgccaaacctggggcagggcaggaaacagaggaaatggctgcaacatgggagcttggagctaatacgacactctgccttcccccagaaggtgcaggctttcctgagtcttagaccagatatggccagttgcgcaggtttctgccaactgtgaagtatcctcctggagcagtgacacaatcttggcggagcattgctacccccgctgccccctccacagttcctgaatggtgctaaggatctgcagcagttggcaacgagctggggctgggggcggcctccatgtccactgagatcataggacactccaatggggatgggacctttcccctcctccatcagaggtgctctgaccctaggttacacgggaaagtgccccacatgcaagtctccctgagggttctgcccctaaaggcagactgcctcatgcccgctagctgtgaggttcattgctaccctcggccctactagccctctcttcccccttgtgcagcggaccacttgcccagtttgctgtggtgctagccttccccatcatccaccgggtgatttctgggtcccagggaaagaaagagagagctgatgcaggtttctacagtgaggaacaggcgtttcccaggccccacacccagatttctctatctttgctgtgttttatggcctgggactgagtccacacggatagatttttccttgtaaccttgagacgagaattccaaggagtgtcaccatcagaggcttctcttcattgtgtcaaagaagcccctagctgctctcgtggcctccttcccccactccctatcccttcacctgtgaaatgcctttgctttgcatattgtgtgtggatgtgtgtgtgtgtgtgtgtgtgtttgtgtgtatgtgtgtgcttctgtgtgtgcctaatgctctgtctcttggtcactgaagcatccaaataaagaatttccctcatgggccagactacaacttaacagacctagggttttgagccatattgccattggatctagtatgtctgtcttgacccctcacccccaccccattcagacctcagtagtccccagtagtcactttaggagttgggacagagtcgagcaccctgtgaaagtctcccttgagttcaggtgccctgaactcagtacagcctcatcttctcatccaccaccttctcctgcttctcctgtcacatagggcctcatgaaggtctttaaagggtttaagctggggatctgctttatgtttgagagaactgttctggctgttatgtaaaggagtgcagggaggggcaggaaaggagacaaggaggccagtatggacactgtgtccagtatggctttccaggctaatcacttagggcagagacccagccttattcatctctacttcctgatgtccatagtggtgtgtcatgaatttttattgaatgaacaaatgaggtgtatgaggagagatggttttctcctgctcagctcttacacagtgataggtttgttccatgggacttatcataggcctggtgattcttgaaagagcatttttcatgactcaaaaatgagctgagaaggagtgttatggccaggtgcggcgtcatgcacctatagtcccagctgctcaggaggctaaggcagaaagaccattcaagcccaggagttccagcctgaagtatgctgtgatcatgcctgtgaataaccactgcactccagccagggcaacataacaagactctatctaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:23567 -> Molecular function: GO:0003725 [double-stranded RNA binding] evidence: IDA GeneID:23567 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:23567 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:23567 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:23567 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:23567 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:23567 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
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