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2024-03-29 18:56:41, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_012250               2360 bp    mRNA    linear   PRI 29-JUN-2013
DEFINITION  Homo sapiens related RAS viral (r-ras) oncogene homolog 2 (RRAS2),
            transcript variant 1, mRNA.
ACCESSION   NM_012250
VERSION     NM_012250.5  GI:293597516
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M. and Green,R.C.
  CONSRTM   The GENAROADS Consortium, and The Alzheimer's Disease Neuroimaging
            Initiative
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement (2013) In press
   PUBMED   23535033
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Lee,J.H., Pyon,J.K., Lee,S.H., Lee,Y.J., Kang,S.G., Kim,C.H.,
            Kim,D.W., Nam,H.S., Park,Y.H., Jeong,D.J. and Cho,M.K.
  TITLE     Greater expression of TC21/R-ras2 in highly aggressive malignant
            skin cancer
  JOURNAL   Int. J. Dermatol. 50 (8), 956-960 (2011)
   PUBMED   21781067
  REMARK    GeneRIF: This article is the first study demonstrating expression
            of TC21 in human skin malignant tumors and suggests that TC21 is
            more expressed in highly aggressive skin tumors.
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Kim,J.M., Park,S.K., Yang,J.J., Shin,E.S., Lee,J.Y., Yun,J.Y.,
            Kim,J.S., Park,S.S. and Jeon,B.S.
  TITLE     SNPs in axon guidance pathway genes and susceptibility for
            Parkinson's disease in the Korean population
  JOURNAL   J. Hum. Genet. 56 (2), 125-129 (2011)
   PUBMED   21085126
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Luo,H., Hao,X., Ge,C., Zhao,F., Zhu,M., Chen,T., Yao,M., He,X. and
            Li,J.
  TITLE     TC21 promotes cell motility and metastasis by regulating the
            expression of E-cadherin and N-cadherin in hepatocellular carcinoma
  JOURNAL   Int. J. Oncol. 37 (4), 853-859 (2010)
   PUBMED   20811707
  REMARK    GeneRIF: Suggest that TC21 promotes cell motility and metastasis by
            regulating the expression of E-cadherin and N-cadherin in
            hepatocellular carcinoma and is associated with tumor progression
            and poor prognosis in HCC.
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Calvo,F. and Crespo,P.
  TITLE     Structural and spatial determinants regulating TC21 activation by
            RasGRF family nucleotide exchange factors
  JOURNAL   Mol. Biol. Cell 20 (20), 4289-4302 (2009)
   PUBMED   19692568
  REMARK    GeneRIF: RasGRF GEFs can activate TC21 in all sublocalizations
            except the Golgi complex. Farnesylated TC21 can be activated by
            RasGRF1 & RasGRF2, but geranylgeranylated TC21 is unresponsive to
            RasGRF2.
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Ehrhardt,G.R., Leslie,K.B., Lee,F., Wieler,J.S. and Schrader,J.W.
  TITLE     M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of
            a constitutively active mutant results in factor-independent growth
            of an interleukin-3-dependent cell line
  JOURNAL   Blood 94 (7), 2433-2444 (1999)
   PUBMED   10498616
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Linnemann,T., Geyer,M., Jaitner,B.K., Block,C., Kalbitzer,H.R.,
            Wittinghofer,A. and Herrmann,C.
  TITLE     Thermodynamic and kinetic characterization of the interaction
            between the Ras binding domain of AF6 and members of the Ras
            subfamily
  JOURNAL   J. Biol. Chem. 274 (19), 13556-13562 (1999)
   PUBMED   10224125
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Rosario,M., Paterson,H.F. and Marshall,C.J.
  TITLE     Activation of the Raf/MAP kinase cascade by the Ras-related protein
            TC21 is required for the TC21-mediated transformation of NIH 3T3
            cells
  JOURNAL   EMBO J. 18 (5), 1270-1279 (1999)
   PUBMED   10064593
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Chan,A.M., Miki,T., Meyers,K.A. and Aaronson,S.A.
  TITLE     A human oncogene of the RAS superfamily unmasked by expression cDNA
            cloning
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7558-7562 (1994)
   PUBMED   8052619
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol. Cell. Biol. 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP206589.1, AK313976.1,
            AK309683.1, BQ023701.1, AA873016.1 and BQ020351.1.
            On Apr 3, 2010 this sequence version replaced gi:156713449.
            
            Summary: This gene encodes a member of the R-Ras subfamily of
            Ras-like small GTPases. The encoded protein associates with the
            plasma membrane and may function as a signal transducer. This
            protein may play an important role in activating signal
            transduction pathways that control cell proliferation. Mutations in
            this gene are associated with the growth of certain tumors.
            Pseudogenes of this gene are found on chromosomes 1 and 2.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013106.1, AK313976.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP206589.1         4-4
            2-929               AK313976.1         1-928
            930-1163            AK309683.1         737-970
            1164-1516           BQ023701.1         13-365              c
            1517-1928           AA873016.1         1-412               c
            1929-2360           BQ020351.1         1-432               c
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..2360
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="related RAS viral (r-ras) oncogene homolog 2"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:17271"
                     /db_xref="HPRD:02518"
                     /db_xref="MIM:600098"
     exon            1..422
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     CDS             315..929
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="isoform a is encoded by transcript variant 1;
                     ras-like protein TC21; teratocarcinoma oncogene"
                     /codon_start=1
                     /product="ras-related protein R-Ras2 isoform a"
                     /protein_id="NP_036382.2"
                     /db_xref="GI:21361416"
                     /db_xref="CCDS:CCDS7814.1"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:17271"
                     /db_xref="HPRD:02518"
                     /db_xref="MIM:600098"
                     /translation="
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF
"
     misc_feature    351..842
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="R-Ras2/TC21, M-Ras/R-Ras3; Region: M_R_Ras_like;
                     cd04145"
                     /db_xref="CDD:133345"
     misc_feature    354..926
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="Ras-like protein; Provisional; Region: PTZ00369"
                     /db_xref="CDD:240385"
     misc_feature    375..398
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="G1 box; other site"
                     /db_xref="CDD:133345"
     misc_feature    order(378..383,522..527)
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="putative GDI interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133345"
     misc_feature    order(384..401,435..440,693..698,702..704,783..788)
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133345"
     misc_feature    order(396..401,441..443,447..449,465..470,507..512,
                     516..518,522..527,789..791)
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133345"
     misc_feature    441..467
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P62070.1);
                     Region: Effector region (By similarity)"
     misc_feature    order(444..449,459..470)
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="putative effector interaction site; other site"
                     /db_xref="CDD:133345"
     misc_feature    444..467
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="Switch I region; other site"
                     /db_xref="CDD:133345"
     misc_feature    450..452
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="G2 box; other site"
                     /db_xref="CDD:133345"
     misc_feature    516..527
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="G3 box; other site"
                     /db_xref="CDD:133345"
     misc_feature    522..578
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="Switch II region; other site"
                     /db_xref="CDD:133345"
     misc_feature    693..704
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="G4 box; other site"
                     /db_xref="CDD:133345"
     misc_feature    783..791
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /note="G5 box; other site"
                     /db_xref="CDD:133345"
     misc_feature    870..872
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P62070.1); phosphorylation site"
     misc_feature    870..872
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            423..510
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     exon            511..613
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     exon            614..722
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     exon            723..841
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     exon            842..2346
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /inference="alignment:Splign:1.39.8"
     variation       1053
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8570"
     polyA_signal    1497..1502
                     /gene="RRAS2"
                     /gene_synonym="TC21"
     polyA_site      1516
                     /gene="RRAS2"
                     /gene_synonym="TC21"
     variation       1559
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370703532"
     STS             1686..1880
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /standard_name="RH40056"
                     /db_xref="UniSTS:85592"
     STS             2212..2321
                     /gene="RRAS2"
                     /gene_synonym="TC21"
                     /standard_name="RH80353"
                     /db_xref="UniSTS:92463"
     polyA_signal    2321..2326
                     /gene="RRAS2"
                     /gene_synonym="TC21"
     polyA_site      2346
                     /gene="RRAS2"
                     /gene_synonym="TC21"
ORIGIN      
cagacggccatttgtggcggcgctggaggctgcgttcggcaggcgctgcggagacgcgtagaggagcgcgccccccggccgctgccgcccctggcccgtgccgtcaccccgcttctccgcgcctcgggcggtacccagccagtccccagcgccgcgctaccgcgctgaccggccctccagacgcctcccggtacccgggaccccagcccggccgctcgcccgcagcccgccggccgcacacgtccccggagccgggcctagggcgggcggcagcggcggctcggcgcagtcaggctgggctctgtagcgtccccatggccgcggccggctggcgggacggctccggccaggagaagtaccggctcgtggtggtcggcgggggcggcgtgggcaagtcggcgctcaccatccagttcatccagtcctattttgtaacggattatgatccaaccattgaagattcttacacaaagcagtgtgtgatagatgacagagcagcccggctagatattttggatacagcaggacaagaagagtttggagccatgagagaacagtatatgaggactggcgaaggcttcctgttggtcttttcagtcacagatagaggcagttttgaagaaatctataagtttcaaagacagattctcagagtaaaggatcgtgatgagttcccaatgattttaattggtaataaagcagatctggatcatcaaagacaggtaacacaggaagaaggacaacagttagcacggcagcttaaggtaacatacatggaggcatcagcaaagattaggatgaatgtagatcaagctttccatgaacttgtccgggttatcaggaaatttcaagagcaggaatgtcctccttcaccagaaccaacacggaaagaaaaagacaagaaaggctgccattgtgtcattttctagaatcccttcagttttagctaccaacggccaggaaaagccctcatcttctctttctctcctcagtttacatcttgttggtacctttctagccttagacaaatgatcaccatgttagccttagacgaagaagctggctagtcctttctgtgaagctaatacaatggtcatttccagacaaatttaaaggaaacactaaggctgcttcaaagattatctgattcctttaaaatatatgtctatatacacagacatgctctttttttaagtgcttacattttaatagagatgaatcagttttggaatctaagctgtttgccaagctgaagctacaggttgtgaaataatttttaacttttggaatcatactgcctactgttactctaaatagaaatatagggttttttttaatgtgaatttttgcctatctttaaacatttcaatgtcagcctttgttaaccttaaatacactgaattgaatctacaaaagtgaaccatctcagacctttactgatactacaacttttgttttctgatggccaaaataccaaatgcctgttgtatttatggattaaaaactgcttataaaaccctgtgttactactcctactcttggagatgataatattctatgtggtcaaatatttggactcatttaggacttagatatttcagtgtacttgattttttaatttaactctttttcacagccacgctaagggtaaaaaggaataatttccttctgtcttccttttcaagtatttctgggtaagggattcaaaaaactaaaactgtttttgtttgtaatataaaatatggaattgatctttccagggtcagagatgattaatgtttttgctatatacttttatacattattttcttatcaaactagttaacaagtatttttatatgtttgtaagcagatatgctttcatagcataccttgtgtatatgtaaagataagtatttaattctcactgttcacttttaactgacaaagaaaaacaagtggaaactacagaaactgtggtagaacttttacttgctggtctggtcttggttgtacccatctttggccagtcacataactactcaagaaaccttcccaatagagtacaacaggatgagactctgaaatcactttcagtattccctgctagatattgattgttatttcaagtattaagtgtaagcttttaatggataattagtataactgtggatggcatctgattttgtttttaattctgtggattgtgtttaagcaattcaatagtatgttcctgattttgagatgctaagtggtattgcacagttgtcactttatcaagtgtgtacaacagtcccatgaagtttatagagcatacccttgtatagcttcaggtgctagaattaaaattgatctgttatcacaagaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:22800 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
            GeneID:22800 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:22800 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
            GeneID:22800 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: IEA
            GeneID:22800 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IEA
            GeneID:22800 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: NAS
            GeneID:22800 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA

by @meso_cacase at DBCLS
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