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2024-03-29 07:36:14, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_012119               2343 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens cyclin-dependent kinase 20 (CDK20), transcript variant
            2, mRNA.
ACCESSION   NM_012119
VERSION     NM_012119.4  GI:282402173
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Mumert,M., Dubuc,A., Wu,X., Northcott,P.A., Chin,S.S., Pedone,C.A.,
            Taylor,M.D. and Fults,D.W.
  TITLE     Functional genomics identifies drivers of medulloblastoma
            dissemination
  JOURNAL   Cancer Res. 72 (19), 4944-4953 (2012)
   PUBMED   22875024
  REMARK    GeneRIF: Data indicate that expression of ERAS, LHX1, and CCRK is
            increased in aggressive subgroups of medulloblastomas.
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Feng,H., Cheng,A.S., Tsang,D.P., Li,M.S., Go,M.Y., Cheung,Y.S.,
            Zhao,G.J., Ng,S.S., Lin,M.C., Yu,J., Lai,P.B., To,K.F. and
            Sung,J.J.
  TITLE     Cell cycle-related kinase is a direct androgen receptor-regulated
            gene that drives beta-catenin/T cell factor-dependent
            hepatocarcinogenesis
  JOURNAL   J. Clin. Invest. 121 (8), 3159-3175 (2011)
   PUBMED   21747169
  REMARK    GeneRIF: Cell cycle-related kinase is a direct androgen
            receptor-regulated gene that drives beta-catenin/T cell
            factor-dependent hepatocarcinogenesis
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   An,X., Ng,S.S., Xie,D., Zeng,Y.X., Sze,J., Wang,J., Chen,Y.C.,
            Chow,B.K., Lu,G., Poon,W.S., Kung,H.F., Wong,B.C. and Lin,M.C.
  TITLE     Functional characterisation of cell cycle-related kinase (CCRK) in
            colorectal cancer carcinogenesis
  JOURNAL   Eur. J. Cancer 46 (9), 1752-1761 (2010)
   PUBMED   20466538
  REMARK    GeneRIF: results suggest for the first time that CCRK is involved
            in colorectal cancer carcinogenesis and G1/S cell cycle transition
            by regulating Cdk2, cyclin E and Rb.
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Wu,G.Q., Xie,D., Yang,G.F., Liao,Y.J., Mai,S.J., Deng,H.X., Sze,J.,
            Guan,X.Y., Zeng,Y.X., Lin,M.C. and Kung,H.F.
  TITLE     Cell cycle-related kinase supports ovarian carcinoma cell
            proliferation via regulation of cyclin D1 and is a predictor of
            outcome in patients with ovarian carcinoma
  JOURNAL   Int. J. Cancer 125 (11), 2631-2642 (2009)
   PUBMED   19672860
  REMARK    GeneRIF: Overexpression of CCRK is associated with ovarian
            carcinoma.
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M.,
            Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J.
  TITLE     Cyclin-dependent kinases: a family portrait
  JOURNAL   Nat. Cell Biol. 11 (11), 1275-1276 (2009)
   PUBMED   19884882
REFERENCE   6  (bases 1 to 2343)
  AUTHORS   Qiu,H., Dai,H., Jain,K., Shah,R., Hong,C., Pain,J., Tian,B.,
            Vatner,D.E., Vatner,S.F. and Depre,C.
  TITLE     Characterization of a novel cardiac isoform of the cell
            cycle-related kinase that is regulated during heart failure
  JOURNAL   J. Biol. Chem. 283 (32), 22157-22165 (2008)
   PUBMED   18508765
REFERENCE   7  (bases 1 to 2343)
  AUTHORS   Wohlbold,L., Larochelle,S., Liao,J.C., Livshits,G., Singer,J.,
            Shokat,K.M. and Fisher,R.P.
  TITLE     The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK
            supports cell proliferation but has no intrinsic CDK-activating
            kinase (CAK) activity
  JOURNAL   Cell Cycle 5 (5), 546-554 (2006)
   PUBMED   16552187
  REMARK    GeneRIF: Depletion of PNQALRE by >80% due to RNA interference
            (RNAi) impairs cell proliferation, but fails to arrest the cell
            cycle at a discrete point.
REFERENCE   8  (bases 1 to 2343)
  AUTHORS   Liu,Y., Wu,C. and Galaktionov,K.
  TITLE     p42, a novel cyclin-dependent kinase-activating kinase in mammalian
            cells
  JOURNAL   J. Biol. Chem. 279 (6), 4507-4514 (2004)
   PUBMED   14597612
  REMARK    GeneRIF: identification of p42, a novel cyclin-dependent
            kinase-activating kinase (CAK) activity in human cells; p42 is
            essential for the phosphorylation of Thr-160 and activation of CDK2
            and is indispensable for cell growth
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB469301.1, CB992644.1,
            AK075325.1, AY904367.1, AL353572.13, AI479563.1 and BM982394.1.
            On Dec 30, 2009 this sequence version replaced gi:89903016.
            
            Summary: The protein encoded by this gene contains a kinase domain
            most closely related to the cyclin-dependent protein kinases. The
            encoded kinase may activate cyclin-dependent kinase 2 and is
            involved in cell growth. Alternatively spliced transcript variants
            encoding distinct isoforms have been reported. [provided by RefSeq,
            Dec 2009].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035013.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB469301.1         1-18
            19-409              CB992644.1         28-418
            410-456             AK075325.1         202-248
            457-457             AY904367.1         123-123
            458-1543            AK075325.1         250-1335
            1544-2140           AL353572.13        64637-65233         c
            2141-2328           AI479563.1         1-188               c
            2329-2343           BM982394.1         2-16                c
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..2343
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="cyclin-dependent kinase 20"
                     /db_xref="GeneID:23552"
                     /db_xref="HGNC:21420"
                     /db_xref="HPRD:13010"
                     /db_xref="MIM:610076"
     exon            1..409
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       108
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:28364934"
     misc_feature    188..190
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="upstream in-frame stop codon"
     CDS             335..1312
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /EC_number="2.7.11.22"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     division protein kinase 20; CAK-kinase p42; CDK-activating
                     kinase p42; cyclin-kinase-activating kinase p42;
                     cyclin-dependent protein kinase H; cell cycle-related
                     kinase"
                     /codon_start=1
                     /product="cyclin-dependent kinase 20 isoform 2"
                     /protein_id="NP_036251.2"
                     /db_xref="GI:30795215"
                     /db_xref="CCDS:CCDS6677.1"
                     /db_xref="GeneID:23552"
                     /db_xref="HGNC:21420"
                     /db_xref="HPRD:13010"
                     /db_xref="MIM:610076"
                     /translation="
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG
"
     misc_feature    335..1135
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="cyclin-dependent kinase A; Provisional; Region:
                     PLN00009"
                     /db_xref="CDD:177649"
     misc_feature    341..1138
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Cell Cycle-Related Kinase; Region: STKc_CCRK; cd07832"
                     /db_xref="CDD:173736"
     misc_feature    order(362..373,386..388,425..427,431..433,482..484,
                     527..529,575..586,593..595,599..604,713..715,719..721,
                     725..730,734..736,767..769,776..778,815..817,821..832,
                     887..889)
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="active site"
                     /db_xref="CDD:173736"
     misc_feature    order(362..373,386..388,425..427,431..433,527..529,
                     575..586,593..595,602..604,725..730,734..736,767..769)
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173736"
     misc_feature    order(482..484,599..601,713..715,719..721,776..778,
                     815..817,821..832,887..889)
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173736"
     misc_feature    order(764..799,812..835)
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173736"
     exon            410..523
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     exon            524..712
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       591
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28364953"
     variation       619
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3750491"
     exon            713..834
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       743
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28364955"
     exon            835..958
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       886
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28364959"
     exon            959..1114
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       1113
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28364963"
     exon            1115..2333
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /inference="alignment:Splign:1.39.8"
     variation       1465
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3750492"
     variation       1754
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28364970"
     STS             1902..2050
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /standard_name="WIAF-2079"
                     /db_xref="UniSTS:8848"
     STS             1950..2115
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /standard_name="A005E17"
                     /db_xref="UniSTS:40615"
     variation       2117
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28364971"
     polyA_signal    2142..2147
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
     polyA_site      2163
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
     polyA_signal    2300..2305
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
     polyA_site      2333
                     /gene="CDK20"
                     /gene_synonym="CCRK; CDCH; P42; PNQALRE"
ORIGIN      
gggggcgggggcagataggaggtgcctgctgtcatcgttccgtgggccctgctgcgggcacgctctcggcgcatgcgttttttatgcgggattaagcttgctgctgcgtgacagcggagggctaggaaaaggcgcagtggggcccggagctgtcacccctgactcgacgcagcttccgttctcctggtgacgtcgcctacaggaaccgccccagtggtcagctgccgcgctgttgctaggcaacagcgtgcgagctcagatcagcgtggggtggaggagaagtggagtttggaagttcaggggcacaggggcacaggcccacgactgcagcgggatggaccagtactgcatcctgggccgcatcggggagggcgcccacggcatcgtcttcaaggccaagcacgtggagactggcgagatagttgccctcaagaaggtggccctaaggcggttggaggacggcttccctaaccaggccctgcgggagattaaggctctgcaggagatggaggacaatcagtatgtggtacaactgaaggctgtgttcccacacggtggaggctttgtgctggcctttgagttcatgctgtcggatctggccgaggtggtgcgccatgcccagaggccactagcccaggcacaggtcaagagctacctgcagatgctgctcaagggtgtcgccttctgccatgccaacaacattgtacatcgggacctgaaacctgccaacctgctcatcagcgcctcaggccagctcaagatagcggactttggcctggctcgagtcttttccccagacggcagccgcctctacacacaccaggtggccaccaggtctgtgggctgcatcatgggggagctgttgaatgggtccccccttttcccgggcaagaacgatattgaacagctttgctatgtgcttcgcatcttgggcaccccaaaccctcaagtctggccggagctcactgagctgccggactacaacaagatctcctttaaggagcaggtgcccatgcccctggaggaggtgctgcctgacgtctctccccaggcattggatctgctgggtcaattccttctctaccctcctcaccagcgcatcgcagcttccaaggctctcctccatcagtacttcttcacagctcccctgcctgcccatccatctgagctgccgattcctcagcgtctagggggacctgcccccaaggcccatccagggcccccccacatccatgacttccacgtggaccggcctcttgaggagtcgctgttgaacccagagctgattcggcccttcatcctggaggggtgagaagttggccctggtcccgtctgcctgctcctcaggaccactcagtccacctgttcctctgccacctgcctggcttcaccctccaaggcctccccatggccacagtgggcccacaccacaccctgccccttagcccttgcgagggttggtctcgaggcagaggtcatgttcccagccaagagtatgagaacatccagtcgagcagaggagattcatggcctgtgctcggtgagccttaccttctgtgtgctactgacgtacccatcaggacagtgagctctgctgccagtcaaggcctgcatatgcagaatgacgatgcctgccttggtgctgcttccccgagtgctgcctcctggtcaaggagaagtgcagagagtaaggtgtccttatgttggaaactcaagtggaaggaagatttggtttggttttattctcagagccattaaacactagttcagtatgtgagatatagattctaaaaacctcaggtggctctgccttatgtctgttcctccttcatttctctcaagggaaatggctaaggtggcattgtctcatggctctcgtttttggggtcatggggagggtagcaccaggcatagccacttttgccctgagggactcctgtgtacttcacatcactgagcactcatttagaagtgagggagacagaagtctaggcccagggatggctccagttggggatccagcaggagaccctctgcacatgaggctggtttaccaacatctactccctcaggatgagcgtgagccagaagcagctgtgtatttaaggaaacaagcgttcctggaattaatttataaatttaataaatcccaatataatcccagctagtgctttttccttattataatttgataaggtgattataaaagatacatggaaggaagtggaaccagatgcagaagaggaaatgatggaaggacttacggtatcagataccaatatttaaaagtttgtataataataaagagtatgattgtggttcaaggataaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:23552 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
            GeneID:23552 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:23552 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:23552 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:23552 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:23552 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:23552 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:23552 -> Cellular component: GO:0005929 [cilium] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_036251 -> EC 2.7.11.22

by @meso_cacase at DBCLS
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