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2020-10-26 18:35:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_012115               6821 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript
            variant 1, mRNA.
ACCESSION   NM_012115
VERSION     NM_012115.3  GI:212549780
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6821)
  AUTHORS   Yang,X.C., Sabath,I., Debski,J., Kaus-Drobek,M., Dadlez,M.,
            Marzluff,W.F. and Dominski,Z.
  TITLE     A complex containing the CPSF73 endonuclease and other
            polyadenylation factors associates with U7 snRNP and is recruited
            to histone pre-mRNA for 3'-end processing
  JOURNAL   Mol. Cell. Biol. 33 (1), 28-37 (2013)
   PUBMED   23071092
  REMARK    GeneRIF: FLASH/Lsm11 complex bind a unique combination of
            polyadenylation factors
REFERENCE   2  (bases 1 to 6821)
  AUTHORS   Lee,K.D., Pai,M.Y., Hsu,C.C., Chen,C.C., Chen,Y.L., Chu,P.Y.,
            Lee,C.H., Chen,L.T., Chang,J.Y., Huang,T.H., Hsiao,S.H. and
            Leu,Y.W.
  TITLE     Targeted Casp8AP2 methylation increases drug resistance in
            mesenchymal stem cells and cancer cells
  JOURNAL   Biochem. Biophys. Res. Commun. 422 (4), 578-585 (2012)
   PUBMED   22595458
  REMARK    GeneRIF: These data demonstrate that methylation within the
            Casp8AP2 promoter correlates with the development of drug
            resistance and might serve as a biomarker and treatment target for
            drug resistance in cancer cells.
REFERENCE   3  (bases 1 to 6821)
  AUTHORS   De Cola,A., Bongiorno-Borbone,L., Bianchi,E., Barcaroli,D.,
            Carletti,E., Knight,R.A., Di Ilio,C., Melino,G., Sette,C. and De
            Laurenzi,V.
  TITLE     FLASH is essential during early embryogenesis and cooperates with
            p73 to regulate histone gene transcription
  JOURNAL   Oncogene 31 (5), 573-582 (2012)
   PUBMED   21725362
  REMARK    GeneRIF: Data show that show that the transcription factor p73
            binds to Flice-Associated Huge Protein (FLASH) and is part of the
            complex that regulates histone gene transcription.
REFERENCE   4  (bases 1 to 6821)
  AUTHORS   Chen,S., Evans,H.G. and Evans,D.R.
  TITLE     FLASH knockdown sensitizes cells to Fas-mediated apoptosis via
            down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip
            short
  JOURNAL   PLoS ONE 7 (3), E32971 (2012)
   PUBMED   22427918
  REMARK    GeneRIF: FLASH knockdown in HT1080 mutant cells defective in p53
            did not significantly accelerate Fas mediated apoptosis indicating
            that the effect was dependent on functional p53.
REFERENCE   5  (bases 1 to 6821)
  AUTHORS   Hummon,A.B., Pitt,J.J., Camps,J., Emons,G., Skube,S.B., Huppi,K.,
            Jones,T.L., Beissbarth,T., Kramer,F., Grade,M.,
            Difilippantonio,M.J., Ried,T. and Caplen,N.J.
  TITLE     Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional
            deregulation of the replication-dependent histone genes and
            extensive effects on the transcriptome of colorectal cancer cells
  JOURNAL   Mol. Cancer 11, 1 (2012)
   PUBMED   22216762
  REMARK    GeneRIF: This study further defines the role CASP8AP2/FLASH plays
            in the regulating expression of the replication-dependent histones
            and shows that its LOF results in broad and reproducible effects on
            the transcriptome of colorectal cancer cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6821)
  AUTHORS   Jun,J.I., Chung,C.W., Lee,H.J., Pyo,J.O., Lee,K.N., Kim,N.S.,
            Kim,Y.S., Yoo,H.S., Lee,T.H., Kim,E. and Jung,Y.K.
  TITLE     Role of FLASH in caspase-8-mediated activation of NF-kappaB:
            dominant-negative function of FLASH mutant in NF-kappaB signaling
            pathway
  JOURNAL   Oncogene 24 (4), 688-696 (2005)
   PUBMED   15592525
  REMARK    GeneRIF: endogenous caspase-8 mediates tumor necrosis
            factor-alpha-induced activation of NF-kappaB via FLASH
REFERENCE   7  (bases 1 to 6821)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J. Biol. Chem. 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   8  (bases 1 to 6821)
  AUTHORS   Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
            Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
  TITLE     FLASH coordinates NF-kappa B activity via TRAF2
  JOURNAL   J. Biol. Chem. 276 (27), 25073-25077 (2001)
   PUBMED   11340079
REFERENCE   9  (bases 1 to 6821)
  AUTHORS   Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
  TITLE     Apoptosis. Searching for FLASH domains
  JOURNAL   Nature 401 (6754), 662 (1999)
   PUBMED   10537104
REFERENCE   10 (bases 1 to 6821)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP363682.1, BC132830.1 and
            AF154415.1.
            On Nov 13, 2008 this sequence version replaced gi:16306505.
            
            Summary: This protein is highly similar to FLASH, a mouse apoptotic
            protein identified by its interaction with the death-effector
            domain (DED) of caspase 8. Studies of FLASH protein suggested that
            this protein may be a component of the death-inducing signaling
            complex that includes Fas receptor, Fas-binding adapter FADD, and
            caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
            Alternative splicing results in multiple transcript variants
            encoding the same protein.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154415.1, BC132830.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BP363682.1         1-153
            154-6722            BC132830.1         1-6569
            6723-6821           AF154415.1         6684-6782
FEATURES             Location/Qualifiers
     source          1..6821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..6821
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:1510"
                     /db_xref="HPRD:06048"
                     /db_xref="MIM:606880"
     variation       4
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375731771"
     variation       10
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368340936"
     variation       24
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:183190155"
     variation       46
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150333903"
     variation       65
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73752810"
     variation       70
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:137975335"
     variation       92
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143660157"
     variation       105
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367700022"
     variation       183
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113121473"
     misc_feature    212..214
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="upstream in-frame stop codon"
     variation       227
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371341158"
     CDS             236..6184
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="FLICE associated huge; CASP8 associated protein 2;
                     FLICE-associated huge protein; human FLASH; FLASH homolog
                     RIP25"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_036247.1"
                     /db_xref="GI:6912288"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:1510"
                     /db_xref="HPRD:06048"
                     /db_xref="MIM:606880"
                     /translation="
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR
"
     misc_feature    239..241
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (Q9UKL3.1); acetylation site"
     misc_feature    293..295
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UKL3.1); phosphorylation site"
     misc_feature    4067..4069
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    5282..5296
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 1 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5360..6181
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: NCOA2-binding"
     misc_feature    5444..5458
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 2 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5615..5629
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 3 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5981..6175
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     variation       244
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371635635"
     variation       283
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35891026"
     variation       286
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376288172"
     variation       311
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377117590"
     variation       380
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138471825"
     variation       397
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374871939"
     variation       409
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369309364"
     variation       514
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369328"
     variation       583
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375845338"
     variation       586
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370454326"
     variation       730
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191794738"
     variation       746
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375746744"
     variation       752
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371046529"
     variation       827
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79485882"
     variation       867
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199979891"
     variation       888
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:115337779"
     variation       890
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374867724"
     variation       898
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182729426"
     variation       907
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372111972"
     variation       921
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377049861"
     variation       944
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368353175"
     variation       945
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202238236"
     variation       963
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376835324"
     variation       980
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369918159"
     variation       1005
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371653827"
     variation       1006
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116832209"
     variation       1023
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200917530"
     variation       1045
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201596073"
     variation       1047
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369118984"
     variation       1105
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3734656"
     variation       1106
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376169756"
     variation       1107
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369927994"
     variation       1129
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373400557"
     variation       1144
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377422956"
     variation       1214
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200248550"
     variation       1236
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374722055"
     variation       1264
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9444715"
     variation       1282
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370574439"
     variation       1292
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375447849"
     variation       1340
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368346657"
     variation       1351
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372317117"
     variation       1399
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374277382"
     variation       1495
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75673851"
     variation       1539
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74395498"
     variation       1572
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187658864"
     variation       1577
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372268202"
     variation       1578
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374708182"
     variation       1587
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202104748"
     variation       1591
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34701151"
     variation       1607
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201785439"
     variation       1666
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192787612"
     variation       1759
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369303003"
     variation       1785
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200323558"
     variation       1841
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376777596"
     variation       1847
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370049023"
     variation       1853
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374581994"
     variation       1903
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377395999"
     variation       1913
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370348129"
     variation       1951
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370445193"
     variation       1953
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200220681"
     variation       1975
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377095494"
     variation       2025
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370562618"
     variation       2103
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375044202"
     variation       2105
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368459977"
     variation       2151
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372157483"
     variation       2173
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374796247"
     variation       2174
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139622677"
     variation       2198
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367672377"
     variation       2200
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371194420"
     variation       2215
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375013992"
     variation       2221
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368221756"
     variation       2237
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201489639"
     variation       2257
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376398807"
     variation       2290
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369747236"
     variation       2305
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374435750"
     variation       2347
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373095386"
     variation       2371
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185478571"
     variation       2385
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369938492"
     variation       2438
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199531988"
     variation       2482
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376213760"
     variation       2502
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370683344"
     variation       2532
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:189475790"
     variation       2607
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:118038939"
     variation       2619
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377330360"
     variation       2626
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3799895"
     variation       2632
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370853193"
     variation       2642
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374310883"
     variation       2667
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373335807"
     variation       2758
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191911199"
     variation       2767
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201271265"
     variation       2773
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368553205"
     variation       2799
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371069501"
     variation       2838
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184335133"
     variation       2858
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201494268"
     variation       2912
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202224866"
     variation       2952
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137945652"
     variation       2985
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199818755"
     variation       3089
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201306147"
     variation       3104
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368026528"
     variation       3124..3125
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34572105"
     variation       3150
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117850701"
     variation       3174
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149473817"
     variation       3191
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201974982"
     variation       3195
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376299045"
     variation       3214
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369795421"
     variation       3231
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114897724"
     variation       3297
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375785540"
     variation       3363
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369132664"
     variation       3394
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370730058"
     STS             3623..3779
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="STS-H50583"
                     /db_xref="UniSTS:2284"
     variation       3638
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373329038"
     variation       3675
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064002"
     variation       3703
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143076875"
     variation       3740
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182864217"
     variation       3867
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41273333"
     variation       3893
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:116614248"
     variation       3947
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201597048"
     variation       3949
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199918891"
     variation       3951
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73752819"
     variation       3954
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201506096"
     variation       3982
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376295745"
     variation       3989
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200866261"
     variation       3990
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374748337"
     variation       4006
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369576046"
     variation       4036
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367664392"
     variation       4049
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370073401"
     variation       4051
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374343288"
     variation       4079
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186180164"
     variation       4086
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148256815"
     variation       4095
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375610839"
     variation       4102
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141249173"
     variation       4128
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372787304"
     variation       4129
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375991831"
     variation       4172
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370120781"
     variation       4192
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371257885"
     variation       4198
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374774067"
     variation       4251
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369180336"
     variation       4257
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78396072"
     variation       4288
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147437828"
     variation       4295
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376211225"
     variation       4372
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369714914"
     variation       4405
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373655186"
     variation       4540
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376852526"
     variation       4622
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139736386"
     variation       4623
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143016644"
     variation       4627
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371559146"
     variation       4661
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190118214"
     variation       4773
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75601500"
     variation       4828
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60966143"
     variation       4876
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200433993"
     variation       4933..4950
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="gacatctttgcccagaca"
                     /db_xref="dbSNP:202116886"
     variation       4938
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202101805"
     variation       4940
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200213073"
     variation       4946
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201189413"
     variation       4949
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202111256"
     variation       4951
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199694900"
     variation       4952
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200862023"
     variation       4953
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201534830"
     variation       4954
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199515704"
     variation       5073
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139983441"
     variation       5102
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150022229"
     variation       5126
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369757511"
     variation       5152
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368260598"
     variation       5170
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371881005"
     variation       5183
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111766212"
     variation       5202
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375182927"
     variation       5210
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3799896"
     variation       5213
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372893351"
     variation       5270..5271
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34373654"
     variation       5277
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374695928"
     variation       5285
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200556402"
     variation       5357
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369072391"
     variation       5358
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371594163"
     variation       5373
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199714955"
     variation       5377
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369451328"
     variation       5395
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200853389"
     variation       5418
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377357235"
     variation       5439
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369858460"
     variation       5441
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:117650507"
     variation       5461
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377396142"
     variation       5472
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370442854"
     variation       5533
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374893112"
     variation       5539
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377482246"
     variation       5544
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73752820"
     variation       5554
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374232968"
     variation       5561
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368605777"
     variation       5571
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371085535"
     variation       5602
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374618973"
     variation       5635
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368658707"
     STS             5637..5874
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="SHGC-52865"
                     /db_xref="UniSTS:38874"
     variation       5656
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371166110"
     variation       5660
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200564116"
     variation       5750
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201549866"
     variation       5753
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200157861"
     variation       5841
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1062121"
     variation       5886
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199771380"
     variation       5912
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182937785"
     variation       5933
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367942163"
     variation       5967
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372229978"
     variation       6050
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369939894"
     variation       6066
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200753477"
     variation       6100
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374433157"
     variation       6185
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370975833"
     variation       6210
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376095529"
     variation       6220
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367794675"
     variation       6257
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11752373"
     variation       6324
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368628751"
     variation       6332
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112756481"
     variation       6370
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371344448"
     variation       6529
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372563597"
     variation       6549
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370145460"
     STS             6578..6719
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="RH47433"
                     /db_xref="UniSTS:49695"
     variation       6659
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142161883"
     variation       6726..6727
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:71864478"
     polyA_signal    6785..6790
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
     polyA_site      6811
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
ORIGIN      
aaaggaaccgggttgtcttgggccgggcagggcgggtaagttgtcgtaggggcccggtccgtgagggactgctaaggaagaggctgcatggcgcggtagtcccccgagtggaggtcggctgcccctgggaaaccagagagtcggagggagtccatctggagcggccaagtaggtcggggaagggccgcgcctgacgtctggccgcaggtggtgactctcaaaaggaaataggatcatggcagcagatgatgacaatggtgatggaacaagtttatttgatgtcttttctgcttctcctcttaagaacaatgatgaaggctcactggacatatacgctgggttggacagtgctgtttctgacagcgcttccaaatcctgtgtaccatcaagaaattgtttggacttatatgaagagatcctgactgaagaaggaactgcaaaggaggcaacatataatgatttgcaagtagaatatggaaaatgtcaactacaaatgaaagagctgatgaaaaaatttaaagaaatacagacacagaatttcagcttaataaacgaaaaccagtctcttaagaagaatatttcagcacttatcaaaactgccagagtggaaataaaccgcaaggatgaagaaataagtaatcttcaccaaagattgtctgagtttccacattttcgaaataatcataaaactgcaaggacatttgatacagttaaaacaaaagatcttaaatctagatctccacatttggatgattgttcaaagactgatcacagagctaaaagtgatgtttctaaagatgtacatcatagcacttcactgccaaatctggaaaaggaaggaaaaccacattctgataaaaggagtacttcacatttacctacatctgttgagaaacactgcactaatggtgtttggtcacgttctcattatcaggttggcgagggtagctcaaatgaggatagtagaagaggaagaaaagatattagacatagccagtttaacagaggaactgaaagagtacgaaaagacttaagtactggctgtggtgatggtgaaccaaggatattggaggctagtcaaaggctacaaggacatcctgagaaatatggtaaaggtgaaccaaagactgaaagcaaaagttcgaagtttaaaagtaactcagattctgactataaaggtgaacgcattaactcttcttgggagaaagagacccctggagaaaggtcacacagtcgagtagactctcaaagtgacaaaaaactagaaagacaaagtgaaagatcacaaaatataaataggaaagaagttaaatcacaagacaaagaagaaagaaaagttgatcaaaaacctaaatcagtagtaaaggaccaagatcactggagaagatctgaacgagcatcacttcctcattccaagaatgaaataacattttctcataattcaagtaaataccatctagaagagagaagaggatgggaagattgtaaaagagacaagagtgtaaacagtcatagttttcaagatggaagatgtccatcttctctttcaaacagtagaactcacaaaaacattgactctaaggaagttgatgccatgcatcagtgggaaaatacacctttaaaagcagaaagacatagaactgaagataagaggaaaagagaacaagaaagcaaagaagaaaataggcatattagaaatgaaaaaagagtacctacagaacatttgcagaagactaataaggaaactaagaaaaccactactgatttaaagaaacagaatgaaccaaagactgataagggagaagtccttgataatggtgtttctgaaggagcagataataaagagcttgcaatgaaagctgagagtggtccaaatgaaacaaaaaacaaggacctaaaattgagttttatgaaaaaattgaacttaactctttctcctgctaaaaagcaacctgtttcccaggataatcagcataaaataactgatattcccaagtccagtggtgtatgtgattcagagtcttcaatgcaagttaaaacagtggcatatgttccctccataagtgaacatatcttgggggaagcagctgtcagtgaacataccatgggggaaaccaagtcaacgttattggaaccaaaggttgctcttctagcagtgactgaacccaggatcggtatctcagaaaccaacaaggaagacgaaaatagtttgttagttaggtctgttgacaatactatgcattgtgaagagcccatttgtggtacagagacttccttcccatctcctatggaaatacaacagacagaatccttgtttccatcaacaggaatgaaacaaaccattaataatggaagggcagcagctcctgtggtaatggatgtattacaaacagatgtgtctcaaaactttggcttggaattggataccaaaagaaatgataattcagattattgtggtatttctgaaggtatggagatgaaggtggcactttcaacaacagtgagtgaaaccactgaaagcattttgcagccttcaattgaggaagctgatattttgccaataatgctttcagaagataataacccaaaatttgagccttctgttatagttacaccactggttgagagtaagtcgtgtcatctggagccttgcttacctaaagagactctagattcttcacttcagcagactgagttaatggaccacagaatggcaactggtgaaacaaactcagtatatcatgatgatgataactcggttttgagcattgaccttaatcacctgagacctattccagaagccatcagtcctctgaatagtccagtgagacctgtagcaaaagttcttagaaatgaaagcccacctcaagttccagtgtataataacagtcataaagatgtgtttttaccaaattcagctcattctacctctaagagtcagtctgatctcaataaggaaaatcaaaagccaatttacaaatctgacaaatgtacagaagcagacacatgtaagaattcaccattagatgaattagaagaaggagaaattagaagtgatagtgaaacatctaaaccacaagaaagttttgaaaaaaattccaaacgtagagtgtcagctgatgtgcggaagtcaaagactatcccacgacgtgggaaaagtactgtgtgtttagataaagacagtaggaaaacacatgtaagaatccatcagaccaataacaaatggaataaaagacctgataaatctagcagatcttcaaaaacagagaagaaagataaagtgatgagcacttccagcttggaaaaaatagttccaattattgctgtaccctcttctgaacaagagatcatgcacatgttacgaatgataagaaaacatgtaagaaaaaattatatgaaattcaaggcaaaattttcattaatacaatttcacagaattattgagtcagcaattttgagttttacatctttaattaaacatctcaacttacacaaaatctctaagtcagtgactaccttacagaagaatctctgtgatattatagagtctaaacttaagcaagttaaaaagaatggcatagttgatcgtttatttgaacagcaactaccagatatgaaaaaaaaattgtggaagtttgtagatgaccaacttgattatttgtttgcaaagcttaagaaaatcttagtatgtgattccaaaagctttggaagagatagtgatgaaggcaaacttgaaaaaacaagtaaacagaatgcacagtattcaaatagtcagaaaaggagtgtggacaactccaacagagaattgctgaaagaaaaattatcaaaatcagaagaccctgttcattataagtctttagtgggatgtaaaaaatctgaggaaaattatcaagaccaaaataactccagtattaacactgtaaagcatgacattaaaaaaaattttaacatctgctttgataatataaagaactctcaatccgaagagcgctccttggaagtacactgtccaagcaccccaaagtcagaaaaaaacgaaggaagcagcatagaggatgcacagacatcccagcatgcaactttgaagccagaacgaagtttcgagattcttaccgaacagcaagcatcgagccttacttttaatttagtgagtgatgcacaaatgggtgaaatatttaaaagtttgttgcaaggttctgatcttttagacagcagtgttaactgtactgaaaaaagtgagtgggagttaaagactccagagaagcagctgctagagactcttaagtgcgagtctataccagcttgtacaacagaagagctagtttcaggggtggcttctccatgtcctaaaatgattagtgatgataattggtcattattatcatctgaaaaaggtccatctctgtcttcagggctttcattgccggttcatcctgatgtgttggatgaaagttgtatgtttgaagtgtctactaacctacctttaagtaaagataatgtgtgtagtgtagaaaagagcaagccctgcgtttcttccatacttcttgaagatctagcagtctctttaacagtaccatcgcctctgaagtcagatggtcatctcagttttttaaagcctgatatgtcgtccagttcaactcctgaagaagtcattagtgctcattttagtgaagatgccttacttgaggaagaggatgcatctgagcaagatattcatttagctctggagtctgataattcaagcagtaaatcaagttgttcttcttcctggacaagccgatctgttgctccaggctttcagtaccaccctaatctacctatgcatgccgtcataatggaaaagtccaatgatcatttcattgtgaaaatacgacgtgcaacaccatctacctcttctggccttaaacagagtatgatgcctgatgaattattgacatctttgcccagacatggaaaggaagctgatgaaggaccagagaaagaatatatttcatgtcaga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//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9994 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:9994 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
            GeneID:9994 -> Molecular function: GO:0005123 [death receptor binding] evidence: TAS
            GeneID:9994 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9994 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Molecular function: GO:0016505 [peptidase activator activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Molecular function: GO:0032184 [SUMO polymer binding] evidence: IDA
            GeneID:9994 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:9994 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IMP
            GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:9994 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
            GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: ISS
            GeneID:9994 -> Biological process: GO:0036337 [Fas signaling pathway] evidence: IMP
            GeneID:9994 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
            GeneID:9994 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:9994 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0016605 [PML body] evidence: IDA

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