Home |
Help |
Advanced search
2024-04-20 13:25:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012114 3153 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens caspase 14, apoptosis-related cysteine peptidase
(CASP14), mRNA.
ACCESSION NM_012114
VERSION NM_012114.2 GI:312596938
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3153)
AUTHORS Yamamoto,M., Miyai,M., Matsumoto,Y., Tsuboi,R. and Hibino,T.
TITLE Kallikrein-related peptidase-7 regulates caspase-14 maturation
during keratinocyte terminal differentiation by generating an
intermediate form
JOURNAL J. Biol. Chem. 287 (39), 32825-32834 (2012)
PUBMED 22825846
REMARK GeneRIF: regulation of procaspase-14 maturation during terminal
differentiation is a unique two-step process involving KLK7 and an
activation intermediate of caspase-14.
REFERENCE 2 (bases 1 to 3153)
AUTHORS Park,C., Han,S., Lee,K.M., Choi,J.Y., Song,N., Jeon,S., Park,S.K.,
Ahn,H.S., Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E. and
Kang,D.
TITLE Association between CASP7 and CASP14 genetic polymorphisms and the
risk of childhood leukemia
JOURNAL Hum. Immunol. 73 (7), 736-739 (2012)
PUBMED 22548721
REMARK GeneRIF: genetic polynorphism is associated with the risk of
childhood leukemia
REFERENCE 3 (bases 1 to 3153)
AUTHORS Al-Shabrawey,M., Ahmad,S., Megyerdi,S., Othman,A., Baban,B.,
Palenski,T.L., Shin,E.S., Gurel,Z., Hsu,S. and Sheibani,N.
TITLE Caspase-14: a novel caspase in the retina with a potential role in
diabetic retinopathy
JOURNAL Mol. Vis. 18, 1895-1906 (2012)
PUBMED 22876114
REMARK GeneRIF: Caspase-14 might play a significant role in the
pathogenesis of diabetic retinopathy by accelerating retinal
endothelial and epithelial cells death.
REFERENCE 4 (bases 1 to 3153)
AUTHORS Asselin-Labat,M.L., Sutherland,K.D., Vaillant,F., Gyorki,D.E.,
Wu,D., Holroyd,S., Breslin,K., Ward,T., Shi,W., Bath,M.L., Deb,S.,
Fox,S.B., Smyth,G.K., Lindeman,G.J. and Visvader,J.E.
TITLE Gata-3 negatively regulates the tumor-initiating capacity of
mammary luminal progenitor cells and targets the putative tumor
suppressor caspase-14
JOURNAL Mol. Cell. Biol. 31 (22), 4609-4622 (2011)
PUBMED 21930782
REMARK GeneRIF: A strong association was evident between GATA-3 and
caspase-14 expression in preinvasive ductal carcinoma in situ
samples, where GATA-3 also displayed prognostic significance
REFERENCE 5 (bases 1 to 3153)
AUTHORS Fang,H.Y., Chen,C.Y., Hung,M.F., Hsiao,Y.T., Chiang,T.C., Lin,T.Y.,
Chang,H.W., Chow,K.C. and Ko,W.J.
TITLE Caspase-14 is an anti-apoptotic protein targeting
apoptosis-inducing factor in lung adenocarcinomas
JOURNAL Oncol. Rep. 26 (2), 359-369 (2011)
PUBMED 21567094
REMARK GeneRIF: Casp-14 overexpression correlated with tumor stage, cell
differentiation and lymphovascular involvement, suggesting that
casp-14 was associated with tumor cell growth and metastatic
potential.
REFERENCE 6 (bases 1 to 3153)
AUTHORS Eckhart,L., Ban,J., Fischer,H. and Tschachler,E.
TITLE Caspase-14: analysis of gene structure and mRNA expression during
keratinocyte differentiation
JOURNAL Biochem. Biophys. Res. Commun. 277 (3), 655-659 (2000)
PUBMED 11062009
REFERENCE 7 (bases 1 to 3153)
AUTHORS Ahmad,M., Srinivasula,S.M., Hegde,R., Mukattash,R.,
Fernandes-Alnemri,T. and Alnemri,E.S.
TITLE Identification and characterization of murine caspase-14, a new
member of the caspase family
JOURNAL Cancer Res. 58 (22), 5201-5205 (1998)
PUBMED 9823333
REFERENCE 8 (bases 1 to 3153)
AUTHORS Hu,S., Snipas,S.J., Vincenz,C., Salvesen,G. and Dixit,V.M.
TITLE Caspase-14 is a novel developmentally regulated protease
JOURNAL J. Biol. Chem. 273 (45), 29648-29653 (1998)
PUBMED 9792675
REFERENCE 9 (bases 1 to 3153)
AUTHORS Van de Craen,M., Van Loo,G., Pype,S., Van Criekinge,W., Van den
brande,I., Molemans,F., Fiers,W., Declercq,W. and Vandenabeele,P.
TITLE Identification of a new caspase homologue: caspase-14
JOURNAL Cell Death Differ. 5 (10), 838-846 (1998)
PUBMED 10203698
REFERENCE 10 (bases 1 to 3153)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK313992.1, AC004699.1 and
BM840054.1.
On Nov 24, 2010 this sequence version replaced gi:6912285.
Summary: This gene encodes a member of the cysteine-aspartic acid
protease (caspase) family. Sequential activation of caspases plays
a central role in the execution-phase of cell apoptosis. Caspases
exist as inactive proenzymes which undergo proteolytic processing
at conserved aspartic residues to produce two subunits, large and
small, that dimerize to form the active enzyme. This caspase has
been shown to be processed and activated by caspase 8 and caspase
10 in vitro, and by anti-Fas agonist antibody or TNF-related
apoptosis inducing ligand in vivo. The expression and processing of
this caspase may be involved in keratinocyte terminal
differentiation, which is important for the formation of the skin
barrier. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: EU502748.1, AK313992.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025090 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-941 AK313992.1 1-941
942-2868 AC004699.1 16787-18713
2869-3153 BM840054.1 1-285
FEATURES Location/Qualifiers
source 1..3153
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.1"
gene 1..3153
/gene="CASP14"
/note="caspase 14, apoptosis-related cysteine peptidase"
/db_xref="GeneID:23581"
/db_xref="HGNC:1502"
/db_xref="HPRD:05788"
/db_xref="MIM:605848"
exon 1..166
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
STS 165..941
/gene="CASP14"
/db_xref="UniSTS:481629"
exon 167..239
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 168
/gene="CASP14"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:140414099"
variation 174
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:372983776"
misc_feature 183..185
/gene="CASP14"
/note="upstream in-frame stop codon"
variation 187
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:186830696"
variation 199
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:376448347"
variation 202
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:370925265"
variation 203
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:199721592"
variation 210
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:376949640"
CDS 213..941
/gene="CASP14"
/note="caspase 14, apoptosis-related cysteine protease;
caspase-14; CASP-14"
/codon_start=1
/product="caspase-14 precursor"
/protein_id="NP_036246.1"
/db_xref="GI:6912286"
/db_xref="CCDS:CCDS12323.1"
/db_xref="GeneID:23581"
/db_xref="HGNC:1502"
/db_xref="HPRD:05788"
/db_xref="MIM:605848"
/translation="
MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ
"
mat_peptide 213..650
/gene="CASP14"
/product="caspase-14, large subunit"
misc_feature 243..938
/gene="CASP14"
/note="Caspase, interleukin-1 beta converting enzyme (ICE)
homologues; Cysteine-dependent aspartate-directed
proteases that mediate programmed cell death (apoptosis).
Caspases are synthesized as inactive zymogens and
activated by proteolysis of the peptide...; Region: CASc;
cd00032"
/db_xref="CDD:28914"
misc_feature order(297..299,480..482,600..602,621..623,738..755,
765..770)
/gene="CASP14"
/note="substrate pocket [chemical binding]; other site"
/db_xref="CDD:28914"
misc_feature order(477..479,606..608)
/gene="CASP14"
/note="active site"
/db_xref="CDD:28914"
misc_feature order(624..626,693..698,717..719,726..728,735..737,
804..806,822..824,840..842,888..890,903..908,912..914,
921..926)
/gene="CASP14"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28914"
misc_feature order(627..629,690..692)
/gene="CASP14"
/note="proteolytic cleavage site; other site"
/db_xref="CDD:28914"
mat_peptide 651..938
/gene="CASP14"
/product="caspase-14, small subunit"
misc_feature 666..668
/gene="CASP14"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:00253"
variation 223
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:201635146"
variation 225
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:77227419"
variation 226
/gene="CASP14"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:142817732"
variation 228
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:200016650"
exon 240..389
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 246
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:144989590"
variation 248
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:367920999"
variation 261
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:147396237"
variation 264
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:372522700"
variation 281
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:61731994"
variation 299
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:112772421"
variation 304
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:150848274"
variation 308
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:139270509"
variation 318
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:149977168"
variation 335
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:201108070"
variation 342
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:61731993"
variation 386
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755277"
variation 389
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:112231728"
exon 390..615
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 395
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:377160369"
variation 405
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:182103308"
variation 424
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:370807238"
variation 425
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:142030951"
variation 426
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143807360"
variation 429
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143735207"
variation 435
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:375587132"
variation 436
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:146833428"
variation 437
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:61731992"
variation 446
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:61750055"
variation 447
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143520169"
variation 467
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:150953711"
variation 480
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:368748073"
variation 534
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:372381877"
variation 540
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:140739098"
variation 543
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:369011733"
variation 570
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:372679035"
variation 584
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:376689987"
variation 595
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:150080919"
variation 601
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:138947421"
exon 616..732
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 622
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:142853060"
variation 626
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:147008615"
variation 627
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:138149294"
variation 628
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:146305677"
variation 629
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:201448178"
variation 661
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:370502147"
variation 680
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:113252599"
variation 713
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:78345508"
variation 714
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:148526551"
variation 724
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:141847530"
variation 726
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:373831493"
exon 733..836
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 734
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:146048182"
variation 741
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:140182507"
variation 748
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:185297693"
variation 784
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:143950047"
variation 785
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:139574706"
variation 789
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:146875225"
variation 792
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:139724524"
variation 811
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:150030379"
variation 818
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:371374933"
exon 837..3145
/gene="CASP14"
/inference="alignment:Splign:1.39.8"
variation 842
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:200722004"
variation 844
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:199893602"
variation 846
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:200139686"
variation 853
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:376759468"
variation 880
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:144959721"
variation 892
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:149050628"
variation 893
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:61750056"
variation 919
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:147759883"
variation 931
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:141111994"
variation 939
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:202225537"
variation 941
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:202004752"
variation 945
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:202048131"
variation 977..980
/gene="CASP14"
/replace=""
/replace="ttct"
/db_xref="dbSNP:142912238"
variation 1029
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:111682561"
variation 1038
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574685"
variation 1129
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574686"
variation 1169
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:61637857"
variation 1177
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143941999"
variation 1188
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574687"
variation 1324
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:114641232"
variation 1330
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:73926368"
variation 1359
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:188221732"
variation 1360..1361
/gene="CASP14"
/replace=""
/replace="tg"
/db_xref="dbSNP:34773644"
variation 1367
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:7246853"
variation 1380
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:375639504"
variation 1486
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:181045695"
variation 1489
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:187166972"
variation 1543
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:140547221"
variation 1721
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:367870775"
variation 1738
/gene="CASP14"
/replace=""
/replace="a"
/db_xref="dbSNP:150563804"
variation 1836
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181309"
variation 1842
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:150420196"
variation 1875
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:138232102"
variation 1893
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:148864648"
variation 1995
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143557180"
variation 2113
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:143730439"
variation 2131..2132
/gene="CASP14"
/replace=""
/replace="c"
/db_xref="dbSNP:35530560"
variation 2255..2256
/gene="CASP14"
/replace=""
/replace="t"
/db_xref="dbSNP:35095152"
variation 2264
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:192295730"
variation 2265
/gene="CASP14"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:3181310"
variation 2368
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:183250741"
variation 2384
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:16980273"
variation 2393
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:114140983"
variation 2462
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:3181311"
variation 2465..2466
/gene="CASP14"
/replace=""
/replace="g"
/db_xref="dbSNP:35504145"
variation 2486..2487
/gene="CASP14"
/replace=""
/replace="t"
/db_xref="dbSNP:139740414"
variation 2492
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:112071153"
variation 2494
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:3181312"
variation 2499
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:76470759"
variation 2510..2511
/gene="CASP14"
/replace=""
/replace="g"
/db_xref="dbSNP:34239715"
variation 2576..2577
/gene="CASP14"
/replace=""
/replace="c"
/db_xref="dbSNP:200174349"
variation 2577
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:73518130"
variation 2662
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181313"
variation 2702
/gene="CASP14"
/replace="g"
/replace="t"
/db_xref="dbSNP:371752487"
variation 2734
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181314"
variation 2735
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:115565964"
variation 2747
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:16980277"
variation 2767
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:114786558"
variation 2834
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:11671298"
variation 2884
/gene="CASP14"
/replace="a"
/replace="c"
/db_xref="dbSNP:11671325"
variation 2900
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:75700653"
variation 2936
/gene="CASP14"
/replace="c"
/replace="g"
/db_xref="dbSNP:112714229"
variation 2942..2943
/gene="CASP14"
/replace=""
/replace="ct"
/db_xref="dbSNP:201234475"
variation 2948
/gene="CASP14"
/replace="a"
/replace="g"
/db_xref="dbSNP:118148528"
variation 2973
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:141157621"
variation 3005
/gene="CASP14"
/replace="a"
/replace="t"
/db_xref="dbSNP:16980279"
variation 3081
/gene="CASP14"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:77468598"
variation 3096
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:150737028"
polyA_signal 3121..3126
/gene="CASP14"
variation 3127
/gene="CASP14"
/replace="c"
/replace="t"
/db_xref="dbSNP:76111697"
polyA_site 3145
/gene="CASP14"
ORIGIN
atagaccaggcttctcaggagaaaccccgggagattccacactgtcagccccttctccaagatcagtacgtgggcctgactcctcctcggtgcccagctcagtattggcaactaggagagtagtgagattgaacttggccttgaggaacagctgcctctagagttggatcagacaagggtgctgagagccgggactcacaaccaaaggagaaatgagcaatccgcggtctttggaagaggagaaatatgatatgtcaggtgcccgcctggccctaatactgtgtgtcaccaaagcccgggaaggttccgaagaagacctggatgctctggaacacatgtttcggcagctgagattcgaaagcaccatgaaaagagaccccactgccgagcaattccaggaagagctggaaaaattccagcaggccatcgattcccgggaagatcccgtcagttgtgccttcgtggtactcatggctcacgggagggaaggcttcctcaagggagaagatggggagatggtcaagctggagaatctcttcgaggccctgaacaacaagaactgccaggccctgcgagctaagcccaaggtgtacatcatacaggcctgtcgaggagaacaaagggaccccggtgaaacagtaggtggagatgagattgtgatggtcatcaaagacagcccacaaaccatcccaacatacacagatgccttgcacgtttattccacggtagagggatacatcgcctaccgacatgatcagaaaggctcatgctttatccagaccctggtggatgtgttcacgaagaggaaaggacatatcttggaacttctgacagaggtgacccggcggatggcagaagcagagctggttcaagaaggaaaagcaaggaaaacgaaccctgaaatccaaagcaccctccggaaacggctgtatctgcagtagaagtagaaagaccaggaggagctttccttccagcattctttctgtctcacagaaatttagaggcagctcttacctctccccaagatcttctgttcccaaggccaaatggcacccagtttcttttccatcacacccttcatgcaggtcctcctgtccttattagagcaagccagccaaaacttagcacaaggcatggtggcaacattaacatcacctccctcaggctggactttctatctttattaatgcaaccgaagagacctaagagtgcattcacttatcccactttctgttcctgtggtcttctttctcccatgaagcagaaactggataaagctcaagattttccatagacaaaccaaagcccactcatcccctcctaccccaatccaacctctgctggctcctgcatctcacttggaggtcaaacctcctcctgaggccaatgcattcccaacttccagttctttcctttaccctggagagttagtaaggtaagaaccattctttctctccaaaaccactcctccttggctggcaagttggtgtcctaactccgttctcttcctagctcatggcctctctagataataaagttgtctcctcctttctggatctcttcctcctaacacccctcccctgaaaccctggactctgccctctctccaagaaaatccatctattcaactattcttgcattcaattactctaaatgagagcgtgttggagctatggcaaattccctgttgtcaccttgctattttgcagacaacataatatttaacctctcataaccagagaggttaaataatttgtcaaatgcaatacagtaagacagaggcaaggacaaggtttgacttccagcccagcctcttttccacaacctgctaaatcctgatccatctgaaaacttttctaattagtgaagatgactaataaaaattttccctatctccaaggtaggagctttctggaagtttctagaaattttcaataaccaccagccaaggttacctccaggtaaccttgcagcaccaggctggaagtcagatcggcttcactatcttccaactctacagcctgtatctctccatccccagctttgacctttcctgctcaagtaacctacgggcacatccagcgtcactaaaaactcagggcttttcttcccggttactcctccaagcgttccctggtatcctcaacctcagatcccaggttcagatttctgcagtcaatctatgacccctctcttcttgcatccttcatatgccaccagacaccatgcccagtccagcctgattttgaaacaactttcatgccggtcttctcttccctgacatgttactgtccaggctcaagtcctcagcttctcatatctgcatctttgcaaccaacttcctcccttgcctctctgcttttccatcccacttttcatgtgtcctccataccatctataacagtgatctccctggaacactcaagaagacacaacataccatattatttaaagaccagggtactggacagtggctcacacctgtattcccgactttgagagtctgaagcgggaggatcacttgaggccaggagttaagagaccagcctgggcaacacagcaagaccctgtctctaaaaaaaaaaattaattaactgggtatggtggcacatgcctgtagtcccagctactcaggaggctgaggtgggaggatgacttgagcccaggagtttgaggctgcaaggagctatgatcatgccagtgcatcccagctctaggtgagacagtgagatccggtctccaaaataaatcaatcaatcaaataaagaccaaagtcaaaccgcacatcaggatctctcacacccttccaattttgccatctaccagcacttagctaaacccatctcccatctcttccaccatgaattcactctttcaaaaaggctaatgtcttcttactcacccttgcctctaagcctttgctatcaccatttcccccaagctggagggccctccctctccctttacccctcttccactacctcccacccctactttttccagaaagccatttcctctcttttttctgattgatccttccctctcacccaggattagatgctggaaatgaccacttctggagggcagggaacaagcccttaatctgcataatgagtgttcaataaacagttgtcaaactttgaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23581 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IEA
GeneID:23581 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:23581 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:23581 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:23581 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:23581 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:23581 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:23581 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:23581 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.