2024-04-19 12:15:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012096 6061 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), mRNA. ACCESSION NM_012096 VERSION NM_012096.2 GI:124494248 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6061) AUTHORS Ogawa,A., Yamazaki,Y., Nakamori,M., Takahashi,T., Kurashige,T., Hiji,M., Nagano,Y., Yamawaki,T. and Matsumoto,M. TITLE Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study JOURNAL Brain Res. 1494, 118-124 (2013) PUBMED 23246927 REMARK GeneRIF: neurons with APPL1-positive granules were restricted to the CA1 area and subiculum, areas associated with hippocampal vulnerability, suggesting a possible link between the perisomatic accumulation of APPL1 and Alzheimer's disease. REFERENCE 2 (bases 1 to 6061) AUTHORS King,G.J., Stockli,J., Hu,S.H., Winnen,B., Duprez,W.G., Meoli,C.C., Junutula,J.R., Jarrott,R.J., James,D.E., Whitten,A.E. and Martin,J.L. TITLE Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase JOURNAL J. Biol. Chem. 287 (49), 40996-41006 (2012) PUBMED 23055524 REMARK GeneRIF: analysis of APPL1 and APPL2 proteins and their interaction with Rab REFERENCE 3 (bases 1 to 6061) AUTHORS Chen,Q., Liu,W.Y., Zhao,Z., Xie,Y. and Han,B.S. TITLE [Expression and significance of Rab5a and APPL1 in breast cancer] JOURNAL Zhonghua Zhong Liu Za Zhi 34 (11), 838-841 (2012) PUBMED 23291133 REMARK GeneRIF: Rab5a and APPL1 are overexpressed in breast cancer, and are positively correlated with the HER-2 expression. REFERENCE 4 (bases 1 to 6061) AUTHORS Hupalowska,A., Pyrzynska,B. and Miaczynska,M. TITLE APPL1 regulates basal NF-kappaB activity by stabilizing NIK JOURNAL J. Cell. Sci. 125 (PT 17), 4090-4102 (2012) PUBMED 22685329 REMARK GeneRIF: APPL1 regulates basal NF-kappaB activity by modulating the stability of NIK, which affects the activation of p65. REFERENCE 5 (bases 1 to 6061) AUTHORS Liu,M., Zhou,L., Wei,L., Villarreal,R., Yang,X., Hu,D., Riojas,R.A., Holmes,B.M., Langlais,P.R., Lee,H. and Dong,L.Q. TITLE Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes JOURNAL J. Biol. Chem. 287 (31), 26087-26093 (2012) PUBMED 22685300 REMARK GeneRIF: APPL1 is a novel target in endoplasmic reticulum (ER) stress-induced insulin resistance and PKCalpha is the kinase mediating ER stress-induced phosphorylation of APPL1 at Ser(430). REFERENCE 6 (bases 1 to 6061) AUTHORS Nechamen,C.A., Thomas,R.M., Cohen,B.D., Acevedo,G., Poulikakos,P.I., Testa,J.R. and Dias,J.A. TITLE Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling JOURNAL Biol. Reprod. 71 (2), 629-636 (2004) PUBMED 15070827 REMARK GeneRIF: APPL1 is a potential interactor with FSHR REFERENCE 7 (bases 1 to 6061) AUTHORS Miaczynska,M., Christoforidis,S., Giner,A., Shevchenko,A., Uttenweiler-Joseph,S., Habermann,B., Wilm,M., Parton,R.G. and Zerial,M. TITLE APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment JOURNAL Cell 116 (3), 445-456 (2004) PUBMED 15016378 REMARK GeneRIF: identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 and APPL2, two Rab5 effectors REFERENCE 8 (bases 1 to 6061) AUTHORS Yang,L., Lin,H.K., Altuwaijri,S., Xie,S., Wang,L. and Chang,C. TITLE APPL suppresses androgen receptor transactivation via potentiating Akt activity JOURNAL J. Biol. Chem. 278 (19), 16820-16827 (2003) PUBMED 12621049 REFERENCE 9 (bases 1 to 6061) AUTHORS Liu,J., Yao,F., Wu,R., Morgan,M., Thorburn,A., Finley,R.L. Jr. and Chen,Y.Q. TITLE Mediation of the DCC apoptotic signal by DIP13 alpha JOURNAL J. Biol. Chem. 277 (29), 26281-26285 (2002) PUBMED 12011067 REFERENCE 10 (bases 1 to 6061) AUTHORS Mitsuuchi,Y., Johnson,S.W., Sonoda,G., Tanno,S., Golemis,E.A. and Testa,J.R. TITLE Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 JOURNAL Oncogene 18 (35), 4891-4898 (1999) PUBMED 10490823 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC028599.2, AF169797.1 and AC093928.2. On Feb 6, 2007 this sequence version replaced gi:6912241. Summary: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028599.2, AF169797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-215 BC028599.2 1-215 216-3804 AF169797.1 127-3715 3805-6061 AC093928.2 100969-103225 FEATURES Location/Qualifiers source 1..6061 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p21.1-p14.3" gene 1..6061 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1" /db_xref="GeneID:26060" /db_xref="HGNC:24035" /db_xref="HPRD:05053" /db_xref="MIM:604299" exon 1..201 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 130 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:7643644" variation 134 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:375189154" CDS 148..2277 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="signaling adaptor protein DIP13alpha; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; AKT2 interactor; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; dip13-alpha" /codon_start=1 /product="DCC-interacting protein 13-alpha" /protein_id="NP_036228.1" /db_xref="GI:6912242" /db_xref="CCDS:CCDS2882.1" /db_xref="GeneID:26060" /db_xref="HGNC:24035" /db_xref="HPRD:05053" /db_xref="MIM:604299" /translation="
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA
" misc_feature 148..1431 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UKG1.1); Region: Required for RAB5A binding" misc_feature 205..849 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1; Region: BAR_APPL1; cd07631" /db_xref="CDD:153315" misc_feature order(205..207,280..285,502..504,508..510,517..519, 535..537,583..585,592..594,601..603,607..609,619..621, 664..666) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="putative membrane interaction site; other site" /db_xref="CDD:153315" misc_feature order(232..234,241..246,256..258,265..267,274..279, 286..288,316..321,325..330,337..342,346..351,358..360, 412..414,703..705,712..717,721..723,736..741,745..750, 757..762,766..771,778..783,787..792,802..804,811..813) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:153315" misc_feature 985..1263 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="Pleckstrin homology (PH) domain; Region: PH; cd00821" /db_xref="CDD:176270" misc_feature order(985..999,1006..1014,1039..1059,1066..1077, 1108..1122,1132..1137,1138..1143,1168..1188,1201..1218, 1231..1263) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="core domain; other site" /db_xref="CDD:176270" misc_feature order(1009..1011,1039..1041,1045..1053) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="putative lipid binding motif; other site" /db_xref="CDD:176270" misc_feature 1342..1344 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q9UKG1.1); phosphorylation site" misc_feature 1348..1350 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q9UKG1.1); phosphorylation site" misc_feature 1348..1350 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1348..1350 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1354..1389 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UKG1.1); Region: F&H" misc_feature 1375..1377 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PKA; propagated from UniProtKB/Swiss-Prot (Q9UKG1.1); phosphorylation site" misc_feature 1642..2028 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="Phosphotyrosine-binding (PTB) domain; Region: PTB; cd00934" /db_xref="CDD:176276" misc_feature order(1642..1668,1765..1818,1831..1839,1849..1875, 1891..1917,1948..1974,1987..2028) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="PTB core; other site" /db_xref="CDD:176276" misc_feature order(1642..1668,1765..1818,1831..1839,1849..1875, 1891..1917,1948..1974,1987..2028) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="PH-like core; other site" /db_xref="CDD:176276" misc_feature order(1861..1869,1873..1875,1993..1995,2005..2007, 2014..2016,2026..2028) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="peptide binding site [polypeptide binding]; other site" /db_xref="CDD:176276" misc_feature order(1861..1863,1912..1914,1948..1950) /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /note="phosphotyrosine binding site [chemical binding]; other site" /db_xref="CDD:176276" misc_feature 2218..2220 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" variation 183 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:79282761" exon 202..300 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 216 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:11544592" variation 235 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:368795074" variation 254 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:188131823" variation 291 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:112114640" exon 301..360 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 347 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:141978531" exon 361..432 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 361 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:201654453" variation 366 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:150282222" variation 403 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:147166062" variation 408 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:111715039" variation 423 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:371500847" variation 425 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:145538605" exon 433..520 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 443 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:147750872" variation 445 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:376685561" variation 460 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:142276532" variation 470 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:4381906" variation 475 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:369970448" variation 476 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:201464226" exon 521..562 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 524 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:377601621" variation 541 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:199855351" variation 542 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:370934737" variation 549 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:201150623" exon 563..621 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 576 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:140443720" variation 588 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:370998865" variation 593 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:146571495" exon 622..768 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 624 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:144751041" variation 718 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:200733439" exon 769..851 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 777 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:369824923" variation 844 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:143447963" variation 848 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:143408452" variation 849 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:372306303" exon 852..1010 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 864 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:147175597" variation 869 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:201812017" variation 887 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:369018187" variation 895 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:200911734" variation 897 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:184540761" variation 923 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:368783056" variation 947 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:144008669" variation 950 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:373408408" variation 960 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:149863724" variation 983 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:189403986" exon 1011..1199 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1015 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:148516206" variation 1041 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:201123189" variation 1059 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:201817839" variation 1102 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:62251990" variation 1128 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:113411736" variation 1149 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:61735096" variation 1162 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:371202748" variation 1181 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:141281784" variation 1188 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:140294967" exon 1200..1242 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1207 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:371514647" variation 1236 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:34321969" exon 1243..1299 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1261 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:199964053" exon 1300..1394 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1319 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:374776755" variation 1329 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:181789799" variation 1353 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:34128429" variation 1382 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:199533180" exon 1395..1577 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1409 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:35776173" variation 1432 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:148780624" variation 1442 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:150911867" variation 1468 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:201500452" variation 1481 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:370121993" variation 1485 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:144211678" variation 1532 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:140080512" exon 1578..1630 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1579 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:200151001" variation 1580 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:142763260" exon 1631..1805 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1658 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:368758377" variation 1720 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:375592616" exon 1806..1842 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1833 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:375073314" exon 1843..1989 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 1846 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:76731092" variation 1905 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="t" /db_xref="dbSNP:188070352" variation 1916 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:369533275" variation 1923 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:142605137" exon 1990..2040 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 2000 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:372104157" variation 2002 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:199932677" variation 2035 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:142229340" exon 2041..2130 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" variation 2045 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:138693457" variation 2073 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:183787750" variation 2087 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:375301727" variation 2108 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:144769112" exon 2131..6061 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /inference="alignment:Splign:1.39.8" STS 2163..2252 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="D3S2814E" /db_xref="UniSTS:150850" variation 2165 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:138485817" variation 2219 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:201646423" variation 2222 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="t" /db_xref="dbSNP:200390978" variation 2223 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:146152896" variation 2246 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:11544593" variation 2257 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:144975113" variation 2258 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:142166154" variation 2261 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:368624059" variation 2278 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:371334982" variation 2284 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:375766377" variation 2289 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:200910570" variation 2293 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:377335362" variation 2301 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:368090122" variation 2412..2413 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="a" /db_xref="dbSNP:200042046" variation 2496 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:111851979" STS 2668..2834 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="RH99000" /db_xref="UniSTS:83920" variation 2778 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:145153328" variation 2779 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:116632536" variation 2789 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:148727696" variation 2834 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:184839280" variation 3033 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:144495926" variation 3112 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:9830276" variation 3144 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:189516135" variation 3171 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:116325625" variation 3398 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:192043658" variation 3565 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:374362658" variation 3732 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="c" /db_xref="dbSNP:201068461" variation 3732 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:1046545" variation 3776 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="g" /db_xref="dbSNP:189683917" variation 3785 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:372351070" variation 3805 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:3204124" variation 3813..3814 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="ca" /db_xref="dbSNP:141358272" variation 3814..3815 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="ac" /db_xref="dbSNP:375829258" variation 3816 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="a" /db_xref="dbSNP:200698271" variation 4104 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:181271716" variation 4135 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:3210546" variation 4411 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:186691326" variation 4433 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:17735233" variation 4453 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:371581244" variation 4481 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="c" /db_xref="dbSNP:200677787" variation 4582 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:189112925" variation 4659 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:113879374" variation 4688..4689 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="actt" /db_xref="dbSNP:375522993" variation 4691 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:78324425" variation 4745 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:147859645" variation 4819..4820 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="taga" /db_xref="dbSNP:10670620" variation 4820..4821 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="taga" /db_xref="dbSNP:36096411" variation 4822..4823 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="atag" /db_xref="dbSNP:373258411" variation 4825 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:141456042" variation 4881 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:3087684" variation 4929 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:371244585" variation 4940 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:74543077" variation 5127 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:11544594" variation 5139 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:146976259" variation 5173 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="c" /db_xref="dbSNP:17791685" variation 5188..5189 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="a" /db_xref="dbSNP:142729232" STS 5212..5363 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="G38326" /db_xref="UniSTS:6873" STS 5231..5333 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="D11S2921" /db_xref="UniSTS:152074" STS 5285..5387 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="D8S2278" /db_xref="UniSTS:473906" variation 5291 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:376177891" STS 5293..5382 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="D8S2279" /db_xref="UniSTS:473907" variation 5341 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:180969939" variation 5344 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:12497949" STS 5364..5466 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="D11S3114" /db_xref="UniSTS:152207" variation 5440 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:186157021" variation 5499 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:79755068" variation 5523 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:1913302" variation 5538 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="g" /replace="t" /db_xref="dbSNP:3186496" variation 5653..5654 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="" /replace="at" /db_xref="dbSNP:369482277" variation 5734 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:190912996" STS 5822..5986 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /standard_name="SHGC-77071" /db_xref="UniSTS:4301" variation 5853 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="c" /replace="t" /db_xref="dbSNP:9883699" variation 5867 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" /replace="a" /replace="g" /db_xref="dbSNP:140757143" polyA_signal 6022..6027 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" polyA_site 6043 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" polyA_site 6061 /gene="APPL1" /gene_synonym="APPL; DIP13alpha" ORIGIN
gctcggcgcctggagaaggctgtgcgggcggggacggctgcagcccttgccggagagggcgggccggggtcagctgcggcgggcgggccggcgcggggagctgtgggcggcagctgcgtctcctgccaccgccctccctccgccacgatgccggggatcgacaagctgcccatcgaggagacgctggaggacagcccgcagacaaggtctttactaggtgtatttgaagaagatgccacagctatttccaactatatgaaccagttgtatcaagctatgcatcggatttatgatgcacagaatgaattaagtgcagcaacacacctgacctcaaaacttttaaaagaatatgaaaaacagcgttttccattgggaggtgatgatgaagttatgagctctacattgcaacagttttcaaaagttatagatgagcttagctcttgtcatgcagtgctttcaactcaacttgctgatgccatgatgttccccattacccagtttaaagaaagagatctgaaagaaatactaacattaaaggaagtatttcagattgcaagtaatgatcatgatgctgcgattaatagatatagccgtttatcaaaaaaaagagaaaatgacaaggtgaagtatgaagtaacagaagatgtgtacacatccagaaagaaacaacaccagaccatgatgcattatttttgtgcattaaatactcttcagtacaagaagaaaatagcattgttagaacctctacttgggtacatgcaagctcagataagtttctttaagatgggttctgaaaatcttaatgaacaactggaagaatttttagctaatattggaacaagcgttcagaatgttcgcagggaaatggacagtgatatagagaccatgcaacagacaatagaggatttggaagtagccagtgatcccttatatgtgcctgacccagaccccaccaaatttcctgttaatcgaaatttaacccgaaaggctggataccttaatgctaggaataaaacaggcttggtgtcatctacctgggacagacagttttacttcacgcagggtggaaatttaatgagtcaggcccgtggggatgtagcaggaggcctggccatggacatagacaactgttcagtgatggctgtggactgtgaagacagacgatattgttttcagatcacctctttcgatggaaaaaaatcttcaattttgcaagcagagagtaaaaaagatcatgaagagtggatctgtacaataaacaacatatctaaacaaatatacttaagtgaaaatccagaggaaactgctgcacgagtaaatcaatcagctctggaagctgtcactccttccccatctttccagcagaggcacgagagcctgcggccagcagcaggacaatctcggccaccgacagctcgaaccagcagttcaggatccttaggatctgagtctacaaatttggctgccctctctctagattctcttgttgccccagacaccccaatacagtttgacataatttctcctgtgtgtgaagatcagcctggccaggcaaaagcctttggccagggaggcaggcgtacaaatccatttggagaatctggaggaagtacaaaatctgaaactgaagattctattcttcatcagttatttattgtccgattccttggttcaatggaggtgaaatcagatgaccatccagatgttgtttatgaaactatgcgccaaatcttagctgcccgggccatccataacatctttcgtatgacagaatcgcatttattagtcacttgtgactgtttaaagttaattgatccacagacacaagttacaaggctcacgtttccattaccttgtgtagttttgtatgctacacaccaggaaaataagcgcctttttggatttgttcttcggacatcaagcgggagaagtgaaagtaatctgtcatcagtctgctatatatttgagtcaaacaatgagggggaaaagatatgtgattctgttggactggcaaaacagatagctttgcatgctgaactggatcgtagggcatcagaaaaacaaaaagaaatagagagagtaaaagagaagcaacagaaagaactcaataaacaaaaacagattgaaaaggacttggaagaacaaagtcggttgatagctgcttccagtagaccaaaccaagccagtagtgaggggcagtttgttgtccttagcagtagccagtcagaagagagtgatttgggagaaggaggaaagaagagagaatcagaagcataagcttatacttttggtagatattcccccttggaatttgacagtttctatggtgaaatggcagaaggtaacaactatgttgaaatatcaaggaggagattaagctttatatttgcttatttgttgtagctacattttaaaaaaaagattgaacttgatgacttaggtttgcattgatcttttttcccccttaaacataatgtactatgtattaacatctaaaggaaacctgctcatctccctgaagcagactgctgaggaattacatttgctcaagaattttttccgtcaaattgtgaacttttaattcttgcattgtaattggctgtgtccataagaaatcatttattcttcaggcttagacattcatggatatgcttttctttcattaggaacattttgctggtgatgaggaagcatttagctgaataagtttaaagccctttatacagagaattctacaagtttgcaaatattttaacaatattaaatgtgcaatagaacttttataaaataattagaacagagattttacagttaaggtttcaaattgtggcaggtggtactgttgatctcagggtactttctgggattgctcacatttctctaatgtactgcacttgatgccagtaggaaagaagcttaagtgtcttcagttcaagattgatagagcccttggcattttattatcacattcttagttctcaggttgggacttcaattactgctgcagagcagtagtggttaaaaataagatattggaatttattaaaagatttttgttcaatacattttagattaggattgacaagtaaagatactgctatggaatgatacattgtattttctgcattgtgtgaaatagtttttattgaaagtcaagtgacatttcaaaagaagttctataacaattatgtttcatgcttaaagtaaaaattcccagagtttagtttagaaaatgtaatcttttaaatttcagactgatatattcccagtattttcataatgccatgttttgataaagtactgaatcaccactttatatccacaaaggcaaataactaatgtatgataatagaataatttgcactaattattgtaaatatgtctactcttcaaatgagtaaaaggtccaattttgtgaaagattgaaaatgaattgaatgcctagtagagtataggagaagttgaccaaggaaggatttaacctggtgccaaggttaaaataacatttctctactgcctattgtttatgttaaaccttaattttttttctgtaatcacttttaacactgctaatagaaattatgttttcatgtgtttcacatgaaaaagtatatatatacaaagttaatatagtgggtaaaatactttacatagtcacacatttacaaatttttcaagaggttagccactaagactttaataattttacaagggaaaaagcctttttttttctttgatatacagttttttcttcttagttctgcattagaaatggcatctgttttaggtctcaaaatataactcagctgtttcacactgtatatgtacattgttttctgtaggaataggataatgatatataggatcatgatattccttctatccatgtgccaaatgggtgtaatgtttatttactgatgctttatgttaccaaaacatacagtaaaaaagtagaaatttatgaaatacttttgataaaaagtttattttgtgcttaccaaaaggaatgctttcacaatagtgtatcagttcttttgttttgttaaagttggaatttattctgttgccagcatttaagtagtcatggcaagtcctgtttttaagaccttttggagactggagctttctgttccattaagtcttttgtttatactacaaattgtcacctcacttagttcagatgaaatctgttactctacaaggaaggtgttcatcattaggaggcagctttactaagctggtgctttgcatggtagcaagtgctgccctttatcagcaccctgggtcatagtgtaggctagagttaaggcactggcagacttagggatgctggacagacctgtagttcgttttaagtcatgttcacaggaatttctacaataataaacccatcatctccataggtcagatcgaagtgcattccaatgctaaatagaagttatgagtgggtttaacaattttagatgattcagcttttgttccattactgttgaactatatgaactattccattactgcagagatttaagtatctgttttaataagctctttttgttatttaaaggctgcccatgggtttctgcctagtggtaaagctgattgttaccctcctttgaaatcccttctagttctgagatgctttgagggtaactggattcgattttgggatatcttttctcacattcagacttacacttaatggtgttagaaatcaacaaaactcctttttaaaaagaaaagatattaagcctgcctacttctacaatgcattctgttacctatttgaacagtatgtttgtaactatggcaatgaagtcagtagataggaaaccagttattccttctacctttaaaaattttgagaacttgccaaccagggattaaagctattatcttgaacagagtccctaaagctagtctagtttttgccacatctgcaatgattattgtttaatttcaaaagaatcctcaggctctacaatctaggggtggtaaatgtgtttccactatacttgggaaaaggtcagtaggatgtgcatcctagggaagataaaatcgtatatggtaaaggcatttgagttaattttgcattatatctaggaaccatattatttaaaatttgaatcctattaatgctgagagatcctaagagctagtatgttgtaaaacctgccacctgaataaaatgaaaaaaaaagtgtttttttgagacagagtcttgctctgttgcccaggctggagtgcagtggtgtgatcttgggtcactgcaaactccgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggaccacaggggcccaccaccgcgcccggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaggatgttctcgatctcctgacctcatgatccgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgtgcccggccctaaaatgaaattattaatgttggttctgaaacagcctcttagcattcagattgtattttaaatacttaaacacaccaattgtagaaagcaaccctttatttttagcaagtttggtttactcttctcccatgagattttgtctttctacattaactagtaagacataaagatttgaaactggaactatattatactttttaaccaatctctgtggcttcactcatgaaatttacttcagttaatatgagactgggggttaagttgtaactaatatgcaaaattgctttgtatatttggtgattttgtaatgtaagtgaattgattcttatttcactgatactattaatcatgcagtgtacaattcaaaatcatgcaatgtttcactttagaattggatttgaagaactcgactttatgtgatcatggtattggtatacatgtggggtggagaacttattttttcattttgtcacaataggtatatactgacaaggcttcaggaaaaaagttgttagaagattttttaatgtataataaagtccatgatttttgtacagtgttttttaatgaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:26060 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:26060 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA GeneID:26060 -> Molecular function: GO:0043422 [protein kinase B binding] evidence: IPI GeneID:26060 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:26060 -> Biological process: GO:0007049 [cell cycle] evidence: IEA GeneID:26060 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:26060 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:26060 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS GeneID:26060 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:26060 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS GeneID:26060 -> Biological process: GO:0046324 [regulation of glucose import] evidence: IMP GeneID:26060 -> Biological process: GO:0090003 [regulation of establishment of protein localization to plasma membrane] evidence: IMP GeneID:26060 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:26060 -> Cellular component: GO:0005737 [cytoplasm] evidence: IC GeneID:26060 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:26060 -> Cellular component: GO:0010008 [endosome membrane] evidence: IDA GeneID:26060 -> Cellular component: GO:0010008 [endosome membrane] evidence: TAS GeneID:26060 -> Cellular component: GO:0012506 [vesicle membrane] evidence: IDA GeneID:26060 -> Cellular component: GO:0016581 [NuRD complex] evidence: IDA GeneID:26060 -> Cellular component: GO:0031901 [early endosome membrane] evidence: IEA
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