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2024-04-26 21:32:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007300 7287 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens breast cancer 1, early onset (BRCA1), transcript
variant 2, mRNA.
ACCESSION NM_007300
VERSION NM_007300.3 GI:237681118
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7287)
AUTHORS Orban,T.I. and Olah,E.
TITLE Emerging roles of BRCA1 alternative splicing
JOURNAL MP, Mol. Pathol. 56 (4), 191-197 (2003)
PUBMED 12890739
REMARK Review article
REFERENCE 2 (bases 1 to 7287)
AUTHORS Orban,T.I. and Olah,E.
TITLE Expression profiles of BRCA1 splice variants in asynchronous and in
G1/S synchronized tumor cell lines
JOURNAL Biochem. Biophys. Res. Commun. 280 (1), 32-38 (2001)
PUBMED 11162473
REFERENCE 3 (bases 1 to 7287)
AUTHORS Paterson,J.W.
TITLE BRCA1: a review of structure and putative functions
JOURNAL Dis. Markers 13 (4), 261-274 (1998)
PUBMED 9553742
REMARK Review article
REFERENCE 4 (bases 1 to 7287)
AUTHORS Xu,C.F., Chambers,J.A., Nicolai,H., Brown,M.A., Hujeirat,Y.,
Mohammed,S., Hodgson,S., Kelsell,D.P., Spurr,N.K., Bishop,D.T. and
Solomon,E.
TITLE Mutations and alternative splicing of the BRCA1 gene in UK
breast/ovarian cancer families
JOURNAL Genes Chromosomes Cancer 18 (2), 102-110 (1997)
PUBMED 9115959
REFERENCE 5 (bases 1 to 7287)
AUTHORS Wilson,C.A., Payton,M.N., Elliott,G.S., Buaas,F.W., Cajulis,E.E.,
Grosshans,D., Ramos,L., Reese,D.M., Slamon,D.J. and Calzone,F.J.
TITLE Differential subcellular localization, expression and biological
toxicity of BRCA1 and the splice variant BRCA1-delta11b
JOURNAL Oncogene 14 (1), 1-16 (1997)
PUBMED 9010228
REFERENCE 6 (bases 1 to 7287)
AUTHORS Thakur,S., Zhang,H.B., Peng,Y., Le,H., Carroll,B., Ward,T., Yao,J.,
Farid,L.M., Couch,F.J., Wilson,R.B. and Weber,B.L.
TITLE Localization of BRCA1 and a splice variant identifies the nuclear
localization signal
JOURNAL Mol. Cell. Biol. 17 (1), 444-452 (1997)
PUBMED 8972225
REFERENCE 7 (bases 1 to 7287)
AUTHORS Lu,M., Conzen,S.D., Cole,C.N. and Arrick,B.A.
TITLE Characterization of functional messenger RNA splice variants of
BRCA1 expressed in nonmalignant and tumor-derived breast cells
JOURNAL Cancer Res. 56 (20), 4578-4581 (1996)
PUBMED 8840964
REFERENCE 8 (bases 1 to 7287)
AUTHORS Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
Arteaga,C.L., King,M.C. and Jensen,R.A.
TITLE Growth retardation and tumour inhibition by BRCA1
JOURNAL Nat. Genet. 12 (3), 298-302 (1996)
PUBMED 8589721
REMARK Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE 9 (bases 1 to 7287)
AUTHORS Xu,C.F., Brown,M.A., Chambers,J.A., Griffiths,B., Nicolai,H. and
Solomon,E.
TITLE Distinct transcription start sites generate two forms of BRCA1 mRNA
JOURNAL Hum. Mol. Genet. 4 (12), 2259-2264 (1995)
PUBMED 8634696
REFERENCE 10 (bases 1 to 7287)
AUTHORS Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
TITLE A strong candidate for the breast and ovarian cancer susceptibility
gene BRCA1
JOURNAL Science 266 (5182), 66-71 (1994)
PUBMED 7545954
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL701927.1, BC115037.1,
U14680.1, AC135721.4, BC072418.1, BU617173.1 and BU679389.1.
On May 16, 2009 this sequence version replaced gi:63252877.
Summary: This gene encodes a nuclear phosphoprotein that plays a
role in maintaining genomic stability, and it also acts as a tumor
suppressor. The encoded protein combines with other tumor
suppressors, DNA damage sensors, and signal transducers to form a
large multi-subunit protein complex known as the BRCA1-associated
genome surveillance complex (BASC). This gene product associates
with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus
plays a role in transcription, DNA repair of double-stranded
breaks, and recombination. Mutations in this gene are responsible
for approximately 40% of inherited breast cancers and more than 80%
of inherited breast and ovarian cancers. Alternative splicing plays
a role in modulating the subcellular localization and physiological
function of this gene. Many alternatively spliced transcript
variants, some of which are disease-associated mutations, have been
described for this gene, but the full-length natures of only some
of these variants has been described. A related pseudogene, which
is also located on chromosome 17, has been identified. [provided by
RefSeq, May 2009].
Transcript Variant: This variant (2) includes an alternate in-frame
exon and an alternate in-frame splice site in the central coding
region, compared to variant 1. The encoded isoform (2) is longer
than isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC115037.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025088 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-110 AL701927.1 1-110
111-1807 BC115037.1 16-1712
1808-3780 U14680.1 1695-3667
3781-4539 BC115037.1 3686-4444
4540-4540 U14680.1 4427-4427
4541-4612 BC115037.1 4446-4517
4613-4613 AC135721.4 80044-80044
4614-4874 BC115037.1 4519-4779
4875-5887 U14680.1 4699-5711
5888-6636 BC072418.1 2401-3149
6637-7268 BU617173.1 19-650 c
7269-7287 BU679389.1 1-19 c
FEATURES Location/Qualifiers
source 1..7287
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
gene 1..7287
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="breast cancer 1, early onset"
/db_xref="GeneID:672"
/db_xref="HGNC:1100"
/db_xref="MIM:113705"
exon 1..213
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 87
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace=""
/replace="t"
/db_xref="dbSNP:8176075"
misc_feature 93
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="alternative transcription start site"
STS 184..1651
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/db_xref="UniSTS:482866"
misc_feature 209..211
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="upstream in-frame stop codon"
exon 214..312
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
CDS 233..5887
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="isoform 2 is encoded by transcript variant 2;
BRCA1/BRCA2-containing complex, subunit 1; RING finger
protein 53; breast cancer type 1 susceptibility protein;
breast and ovarian cancer susceptibility protein 1;
protein phosphatase 1, regulatory subunit 53; breast and
ovarian cancer sususceptibility protein 1"
/codon_start=1
/product="breast cancer type 1 susceptibility protein
isoform 2"
/protein_id="NP_009231.2"
/db_xref="GI:237681119"
/db_xref="CCDS:CCDS11456.2"
/db_xref="GeneID:672"
/db_xref="HGNC:1100"
/db_xref="MIM:113705"
/translation="
MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDSHIHGQRNNSMFSKRPREHISVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY
"
misc_feature 290..427
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 299..436
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(302..304,311..313,347..349,353..355,362..364,
371..373,413..415,422..424)
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 572..574
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 1154..1156
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by AURKA; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 1262..1753
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Serine-rich domain associated with BRCT; Region:
BRCT_assoc; pfam12820"
/db_xref="CDD:193295"
misc_feature 1415..1417
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 1424..1426
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 1499..1501
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 2195..3166
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Ethylene insensitive 3; Region: EIN3; pfam04873"
/db_xref="CDD:191117"
misc_feature 2312..2314
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 2489..2491
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 3194..3196
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CHEK2; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 3659..3661
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 3863..3865
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 3881..3883
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 3884..3886
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 4070..4072
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4214..4216
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 4238..4240
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 4256..4258
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P38398.2); phosphorylation site"
misc_feature 4391..4393
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4412..4414
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by ATR, in vitro; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4421..4504
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P38398.2);
Region: Interaction with PALB2"
misc_feature 4499..4501
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4664..4666
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4865..4867
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 5582..5821
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Breast Cancer Suppressor Protein (BRCA1),
carboxy-terminal domain. The BRCT domain is found within
many DNA damage repair and cell cycle checkpoint proteins.
The unique diversity of this domain superfamily allows
BRCT modules to interact forming homo...; Region: BRCT;
cd00027"
/db_xref="CDD:28909"
misc_feature order(5627..5629,5639..5641,5648..5650,5657..5659,
5663..5665)
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28909"
misc_feature order(5804..5806,5816..5818)
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="BRCT sequence motif; other site"
/db_xref="CDD:28909"
exon 313..366
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 367..444
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 445..533
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 534..673
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 674..779
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 686
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286288"
variation 710
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625285"
variation 760
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:34545365"
exon 780..825
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 826..902
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 903..4328
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
STS 909..1077
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454227"
/db_xref="UniSTS:157424"
variation 925
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625298"
variation 949
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:56310439"
STS 996..1234
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454278"
/db_xref="UniSTS:157425"
variation 997
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625299"
variation 1154
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55767801"
STS 1159..1436
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454349"
/db_xref="UniSTS:157426"
variation 1201
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:45586033"
variation 1247
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55842957"
STS 1299..1543
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454353"
/db_xref="UniSTS:157427"
STS 1465..1730
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454372"
/db_xref="UniSTS:157428"
STS 1685..1947
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454381"
/db_xref="UniSTS:157429"
variation 1773
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="g"
/db_xref="dbSNP:56100707"
STS 1844..2087
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454417"
/db_xref="UniSTS:157430"
variation 1963
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897678"
STS 2031..2329
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454421"
/db_xref="UniSTS:157431"
variation 2081
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:45564238"
variation 2110
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176154"
variation 2204
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55932871"
STS 2255..2510
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454425"
/db_xref="UniSTS:157432"
STS 2394..2617
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454429"
/db_xref="UniSTS:157433"
STS 2561..2830
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454433"
/db_xref="UniSTS:157434"
variation 2721..2722
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace=""
/replace="aa"
/db_xref="dbSNP:273899685"
STS 2748..3061
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454437"
/db_xref="UniSTS:157435"
variation 2757
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897684"
variation 2763
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:56051266"
STS 2774..3016
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC13918P1"
/db_xref="UniSTS:270877"
STS 3013..3318
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454441"
/db_xref="UniSTS:157436"
variation 3198
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:4986848"
STS 3284..3661
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454446"
/db_xref="UniSTS:157437"
variation 3443
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:41293445"
STS 3526..3850
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454450"
/db_xref="UniSTS:157438"
variation 3548
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:45599040"
STS 3796..4084
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1"
/db_xref="UniSTS:262743"
STS 3799..4072
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454454"
/db_xref="UniSTS:157439"
STS 3808..4067
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P3"
/db_xref="UniSTS:272805"
variation 3816
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897685"
STS 3901..4196
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="G60034"
/db_xref="UniSTS:137300"
STS 3909..4067
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P2"
/db_xref="UniSTS:272804"
STS 3973..4181
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454458"
/db_xref="UniSTS:157440"
STS 4109..4326
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454462"
/db_xref="UniSTS:157441"
variation 4225
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="g"
/db_xref="dbSNP:70953658"
exon 4329..4417
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 4418..4589
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4450
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:1800707"
exon 4590..4655
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 4656..4779
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4766
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="c"
/db_xref="dbSNP:111034213"
exon 4780..4970
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4800
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:56335406"
variation 4905
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:70953659"
variation 4939
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897692"
exon 4971..5281
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4978
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:55688400"
variation 5153
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176219"
variation 5167
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555992"
variation 5232
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:28897694"
exon 5282..5369
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5370..5447
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5395
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:45519437"
exon 5448..5488
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5452
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:28897697"
exon 5489..5572
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5573..5627
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5621
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:1800757"
exon 5628..5701
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5702..5762
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5728
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:4438367"
exon 5763..7270
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5766
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:70953662"
STS 5809..5944
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P11"
/db_xref="UniSTS:272801"
variation 5866
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:28897699"
variation 5929
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:273902777"
STS 5935..6172
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="RH79896"
/db_xref="UniSTS:90392"
variation 6159
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176317"
variation 6308
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:8176318"
STS 6437..7266
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1_4046"
/db_xref="UniSTS:464465"
STS 6617..6696
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="D5S1597E"
/db_xref="UniSTS:151019"
variation 6668
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:8176319"
variation 6781
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:1060920"
variation 6787
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:1060921"
variation 7174
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:12516"
variation 7219
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176320"
polyA_signal 7245..7250
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
polyA_site 7270
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
ORIGIN
gtaccttgatttcgtattctgagaggctgctgcttagcggtagccccttggtttccgtggcaacggaaaagcgcgggaattacagataaattaaaactgcgactgcgcggcgtgagctcgctgagacttcctggacgggggacaggctgtggggtttctcagataactgggcccctgcgctcaggaggccttcaccctctgctctgggtaaagttcattggaacagaaagaaatggatttatctgctcttcgcgttgaagaagtacaaaatgtcattaatgctatgcagaaaatcttagagtgtcccatctgtctggagttgatcaaggaacctgtctccacaaagtgtgaccacatattttgcaaattttgcatgctgaaacttctcaaccagaagaaagggccttcacagtgtcctttatgtaagaatgatataaccaaaaggagcctacaagaaagtacgagatttagtcaacttgttgaagagctattgaaaatcatttgtgcttttcagcttgacacaggtttggagtatgcaaacagctataattttgcaaaaaaggaaaataactctcctgaacatctaaaagatgaagtttctatcatccaaagtatgggctacagaaaccgtgccaaaagacttctacagagtgaacccgaaaatccttccttgcaggaaaccagtctcagtgtccaactctctaaccttggaactgtgagaactctgaggacaaagcagcggatacaacctcaaaagacgtctgtctacattgaattgggatctgattcttctgaagataccgttaataaggcaacttattgcagtgtgggagatcaagaattgttacaaatcacccctcaaggaaccagggatgaaatcagtttggattctgcaaaaaaggctgcttgtgaattttctgagacggatgtaacaaatactgaacatcatcaacccagtaataatgatttgaacaccactgagaagcgtgcagctgagaggcatccagaaaagtatcagggtagttctgtttcaaacttgcatgtggagccatgtggcacaaatactcatgccagctcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaaaaggctgaattctgtaataaaagcaaacagcctggcttagcaaggagccaacataacagatgggctggaagtaaggaaacatgtaatgataggcggactcccagcacagaaaaaaaggtagatctgaatgctgatcccctgtgtgagagaaaagaatggaataagcagaaactgccatgctcagagaatcctagagatactgaagatgttccttggataacactaaatagcagcattcagaaagttaatgagtggttttccagaagtgatgaactgttaggttctgatgactcacatgatggggagtctgaatcaaatgccaaagtagctgatgtattggacgttctaaatgaggtagatgaatattctggttcttcagagaaaatagacttactggccagtgatcctcatgaggctttaatatgtaaaagtgaaagagttcactccaaatcagtagagagtaatattgaagacaaaatatttgggaaaacctatcggaagaaggcaagcctccccaacttaagccatgtaactgaaaatctaattataggagcatttgttactgagccacagataatacaagagcgtcccctcacaaataaattaaagcgtaaaaggagacctacatcaggccttcatcctgaggattttatcaagaaagcagatttggcagttcaaaagactcctgaaatgataaatcagggaactaaccaaacggagcagaatggtcaagtgatgaatattactaatagtggtcatgagaataaaacaaaaggtgattctattcagaatgagaaaaatcctaacccaatagaatcactcgaaaaagaatctgctttcaaaacgaaagctgaacctataagcagcagtataagcaatatggaactcgaattaaatatccacaattcaaaagcacctaaaaagaataggctgaggaggaagtcttctaccaggcatattcatgcgcttgaactagtagtcagtagaaatctaagcccacctaattgtactgaattgcaaattgatagttgttctagcagtgaagagataaagaaaaaaaagtacaaccaaatgccagtcaggcacagcagaaacctacaactcatggaaggtaaagaacctgcaactggagccaagaagagtaacaagccaaatgaacagacaagtaaaagacatgacagcgatactttcccagagctgaagttaacaaatgcacctggttcttttactaagtgttcaaataccagtgaacttaaagaatttgtcaatcctagccttccaagagaagaaaaagaagagaaactagaaacagttaaagtgtctaataatgctgaagaccccaaagatctcatgttaagtggagaaagggttttgcaaactgaaagatctgtagagagtagcagtatttcattggtacctggtactgattatggcactcaggaaagtatctcgttactggaagttagcactctagggaaggcaaaaacagaaccaaataaatgtgtgagtcagtgtgcagcatttgaaaaccccaagggactaattcatggttgttccaaagataatagaaatgacacagaaggctttaagtatccattgggacatgaagttaaccacagtcgggaaacaagcatagaaatggaagaaagtgaacttgatgctcagtatttgcagaatacattcaaggtttcaaagcgccagtcatttgctccgttttcaaatccaggaaatgcagaagaggaatgtgcaacattctctgcccactctgggtccttaaagaaacaaagtccaaaagtcacttttgaatgtgaacaaaaggaagaaaatcaaggaaagaatgagtctaatatcaagcctgtacagacagttaatatcactgcaggctttcctgtggttggtcagaaagataagccagttgataatgccaaatgtagtatcaaaggaggctctaggttttgtctatcatctcagttcagaggcaacgaaactggactcattactccaaataaacatggacttttacaaaacccatatcgtataccaccactttttcccatcaagtcatttgttaaaactaaatgtaagaaaaatctgctagaggaaaactttgaggaacattcaatgtcacctgaaagagaaatgggaaatgagaacattccaagtacagtgagcacaattagccgtaataacattagagaaaatgtttttaaagaagccagctcaagcaatattaatgaagtaggttccagtactaatgaagtgggctccagtattaatgaaataggttccagtgatgaaaacattcaagcagaactaggtagaaacagagggccaaaattgaatgctatgcttagattaggggttttgcaacctgaggtctataaacaaagtcttcctggaagtaattgtaagcatcctgaaataaaaaagcaagaatatgaagaagtagttcagactgttaatacagatttctctccatatctgatttcagataacttagaacagcctatgggaagtagtcatgcatctcaggtttgttctgagacacctgatgacctgttagatgatggtgaaataaaggaagatactagttttgctgaaaatgacattaaggaaagttctgctgtttttagcaaaagcgtccagaaaggagagcttagcaggagtcctagccctttcacccatacacatttggctcagggttaccgaagaggggccaagaaattagagtcctcagaagagaacttatctagtgaggatgaagagcttccctgcttccaacacttgttatttggtaaagtaaacaatataccttctcagtctactaggcatagcaccgttgctaccgagtgtctgtctaagaacacagaggagaatttattatcattgaagaatagcttaaatgactgcagtaaccaggtaatattggcaaaggcatctcaggaacatcaccttagtgaggaaacaaaatgttctgctagcttgttttcttcacagtgcagtgaattggaagacttgactgcaaatacaaacacccaggatcctttcttgattggttcttccaaacaaatgaggcatcagtctgaaagccagggagttggtctgagtgacaaggaattggtttcagatgatgaagaaagaggaacgggcttggaagaaaataatcaagaagagcaaagcatggattcaaacttaggtgaagcagcatctgggtgtgagagtgaaacaagcgtctctgaagactgctcagggctatcctctcagagtgacattttaaccactcagcagagggataccatgcaacataacctgataaagctccagcaggaaatggctgaactagaagctgtgttagaacagcatgggagccagccttctaacagctacccttccatcataagtgactcttctgcccttgaggacctgcgaaatccagaacaaagcacatcagaaaaagattcgcatatacatggccaaaggaacaactccatgttttctaaaaggcctagagaacatatatcagtattaacttcacagaaaagtagtgaataccctataagccagaatccagaaggcctttctgctgacaagtttgaggtgtctgcagatagttctaccagtaaaaataaagaaccaggagtggaaaggtcatccccttctaaatgcccatcattagatgataggtggtacatgcacagttgctctgggagtcttcagaatagaaactacccatctcaagaggagctcattaaggttgttgatgtggaggagcaacagctggaagagtctgggccacacgatttgacggaaacatcttacttgccaaggcaagatctagagggaaccccttacctggaatctggaatcagcctcttctctgatgaccctgaatctgatccttctgaagacagagccccagagtcagctcgtgttggcaacataccatcttcaacctctgcattgaaagttccccaattgaaagttgcagaatctgcccagagtccagctgctgctcatactactgatactgctgggtataatgcaatggaagaaagtgtgagcagggagaagccagaattgacagcttcaacagaaagggtcaacaaaagaatgtccatggtggtgtctggcctgaccccagaagaatttatgctcgtgtacaagtttgccagaaaacaccacatcactttaactaatctaattactgaagagactactcatgttgttatgaaaacagatgctgagtttgtgtgtgaacggacactgaaatattttctaggaattgcgggaggaaaatgggtagttagctatttctgggtgacccagtctattaaagaaagaaaaatgctgaatgagcatgattttgaagtcagaggagatgtggtcaatggaagaaaccaccaaggtccaaagcgagcaagagaatcccaggacagaaagatcttcagggggctagaaatctgttgctatgggcccttcaccaacatgcccacagatcaactggaatggatggtacagctgtgtggtgcttctgtggtgaaggagctttcatcattcacccttggcacaggtgtccacccaattgtggttgtgcagccagatgcctggacagaggacaatggcttccatgcaattgggcagatgtgtgaggcacctgtggtgacccgagagtgggtgttggacagtgtagcactctaccagtgccaggagctggacacctacctgataccccagatcccccacagccactactgactgcagccagccacaggtacagagccacaggaccccaagaatgagcttacaaagtggcctttccaggccctgggagctcctctcactcttcagtccttctactgtcctggctactaaatattttatgtacatcagcctgaaaaggacttctggctatgcaagggtcccttaaagattttctgcttgaagtctcccttggaaatctgccatgagcacaaaattatggtaatttttcacctgagaagattttaaaaccatttaaacgccaccaattgagcaagatgctgattcattatttatcagccctattctttctattcaggctgttgttggcttagggctggaagcacagagtggcttggcctcaagagaatagctggtttccctaagtttacttctctaaaaccctgtgttcacaaaggcagagagtcagacccttcaatggaaggagagtgcttgggatcgattatgtgacttaaagtcagaatagtccttgggcagttctcaaatgttggagtggaacattggggaggaaattctgaggcaggtattagaaatgaaaaggaaacttgaaacctgggcatggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggcagatcactggaggtcaggagttcgaaaccagcctggccaacatggtgaaaccccatctctactaaaaatacagaaattagccggtcatggtggtggacacctgtaatcccagctactcaggtggctaaggcaggagaatcacttcagcccgggaggtggaggttgcagtgagccaagatcataccacggcactccagcctgggtgacagtgagactgtggctcaaaaaaaaaaaaaaaaaaaggaaaatgaaactagaagagatttctaaaagtctgagatatatttgctagatttctaaagaatgtgttctaaaacagcagaagattttcaagaaccggtttccaaagacagtcttctaattcctcattagtaataagtaaaatgtttattgttgtagctctggtatataatccattcctcttaaaatataagacctctggcatgaatatttcatatctataaaatgacagatcccaccaggaaggaagctgttgctttctttgaggtgatttttttcctttgctccctgttgctgaaaccatacagcttcataaataattttgcttgctgaaggaagaaaaagtgtttttcataaacccattatccaggactgtttatagctgttggaaggactaggtcttccctagcccccccagtgtgcaagggcagtgaagacttgattgtacaaaatacgttttgtaaatgttgtgctgttaacactgcaaataaacttggtagcaaacacttccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:672 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:672 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: NAS
GeneID:672 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
GeneID:672 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:672 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:672 -> Molecular function: GO:0015631 [tubulin binding] evidence: NAS
GeneID:672 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
GeneID:672 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS
GeneID:672 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: IDA
GeneID:672 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: TAS
GeneID:672 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:672 -> Biological process: GO:0006301 [postreplication repair] evidence: IDA
GeneID:672 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:672 -> Biological process: GO:0006302 [double-strand break repair] evidence: TAS
GeneID:672 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:672 -> Biological process: GO:0006359 [regulation of transcription from RNA polymerase III promoter] evidence: TAS
GeneID:672 -> Biological process: GO:0006633 [fatty acid biosynthetic process] evidence: IEA
GeneID:672 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:672 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: TAS
GeneID:672 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: TAS
GeneID:672 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:672 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP
GeneID:672 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:672 -> Biological process: GO:0010212 [response to ionizing radiation] evidence: IMP
GeneID:672 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS
GeneID:672 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:672 -> Biological process: GO:0034446 [substrate adhesion-dependent cell spreading] evidence: IDA
GeneID:672 -> Biological process: GO:0035066 [positive regulation of histone acetylation] evidence: IDA
GeneID:672 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: TAS
GeneID:672 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:672 -> Biological process: GO:0043627 [response to estrogen stimulus] evidence: IDA
GeneID:672 -> Biological process: GO:0045717 [negative regulation of fatty acid biosynthetic process] evidence: IMP
GeneID:672 -> Biological process: GO:0045739 [positive regulation of DNA repair] evidence: IMP
GeneID:672 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:672 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
GeneID:672 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: TAS
GeneID:672 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:672 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:672 -> Biological process: GO:0046600 [negative regulation of centriole replication] evidence: NAS
GeneID:672 -> Biological process: GO:0051571 [positive regulation of histone H3-K4 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0051573 [negative regulation of histone H3-K9 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0051865 [protein autoubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0070512 [positive regulation of histone H4-K20 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0071158 [positive regulation of cell cycle arrest] evidence: IDA
GeneID:672 -> Biological process: GO:0071681 [cellular response to indole-3-methanol] evidence: IDA
GeneID:672 -> Biological process: GO:0085020 [protein K6-linked ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:2000145 [regulation of cell motility] evidence: IDA
GeneID:672 -> Biological process: GO:2000617 [positive regulation of histone H3-K9 acetylation] evidence: IDA
GeneID:672 -> Biological process: GO:2000620 [positive regulation of histone H4-K16 acetylation] evidence: IDA
GeneID:672 -> Cellular component: GO:0000151 [ubiquitin ligase complex] evidence: NAS
GeneID:672 -> Cellular component: GO:0001726 [ruffle] evidence: IDA
GeneID:672 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:672 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:672 -> Cellular component: GO:0005694 [chromosome] evidence: ISS
GeneID:672 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:672 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
GeneID:672 -> Cellular component: GO:0008274 [gamma-tubulin ring complex] evidence: NAS
GeneID:672 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0031436 [BRCA1-BARD1 complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0031941 [filamentous actin] evidence: IDA
GeneID:672 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0070531 [BRCA1-A complex] evidence: IDA
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