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2024-04-27 09:08:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007297 7132 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens breast cancer 1, early onset (BRCA1), transcript
variant 3, mRNA.
ACCESSION NM_007297
VERSION NM_007297.3 GI:237681120
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7132)
AUTHORS Orban,T.I. and Olah,E.
TITLE Emerging roles of BRCA1 alternative splicing
JOURNAL MP, Mol. Pathol. 56 (4), 191-197 (2003)
PUBMED 12890739
REMARK Review article
REFERENCE 2 (bases 1 to 7132)
AUTHORS Orban,T.I. and Olah,E.
TITLE Expression profiles of BRCA1 splice variants in asynchronous and in
G1/S synchronized tumor cell lines
JOURNAL Biochem. Biophys. Res. Commun. 280 (1), 32-38 (2001)
PUBMED 11162473
REFERENCE 3 (bases 1 to 7132)
AUTHORS Paterson,J.W.
TITLE BRCA1: a review of structure and putative functions
JOURNAL Dis. Markers 13 (4), 261-274 (1998)
PUBMED 9553742
REMARK Review article
REFERENCE 4 (bases 1 to 7132)
AUTHORS Xu,C.F., Chambers,J.A., Nicolai,H., Brown,M.A., Hujeirat,Y.,
Mohammed,S., Hodgson,S., Kelsell,D.P., Spurr,N.K., Bishop,D.T. and
Solomon,E.
TITLE Mutations and alternative splicing of the BRCA1 gene in UK
breast/ovarian cancer families
JOURNAL Genes Chromosomes Cancer 18 (2), 102-110 (1997)
PUBMED 9115959
REFERENCE 5 (bases 1 to 7132)
AUTHORS Wilson,C.A., Payton,M.N., Elliott,G.S., Buaas,F.W., Cajulis,E.E.,
Grosshans,D., Ramos,L., Reese,D.M., Slamon,D.J. and Calzone,F.J.
TITLE Differential subcellular localization, expression and biological
toxicity of BRCA1 and the splice variant BRCA1-delta11b
JOURNAL Oncogene 14 (1), 1-16 (1997)
PUBMED 9010228
REFERENCE 6 (bases 1 to 7132)
AUTHORS Thakur,S., Zhang,H.B., Peng,Y., Le,H., Carroll,B., Ward,T., Yao,J.,
Farid,L.M., Couch,F.J., Wilson,R.B. and Weber,B.L.
TITLE Localization of BRCA1 and a splice variant identifies the nuclear
localization signal
JOURNAL Mol. Cell. Biol. 17 (1), 444-452 (1997)
PUBMED 8972225
REFERENCE 7 (bases 1 to 7132)
AUTHORS Lu,M., Conzen,S.D., Cole,C.N. and Arrick,B.A.
TITLE Characterization of functional messenger RNA splice variants of
BRCA1 expressed in nonmalignant and tumor-derived breast cells
JOURNAL Cancer Res. 56 (20), 4578-4581 (1996)
PUBMED 8840964
REFERENCE 8 (bases 1 to 7132)
AUTHORS Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
Arteaga,C.L., King,M.C. and Jensen,R.A.
TITLE Growth retardation and tumour inhibition by BRCA1
JOURNAL Nat. Genet. 12 (3), 298-302 (1996)
PUBMED 8589721
REMARK Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE 9 (bases 1 to 7132)
AUTHORS Xu,C.F., Brown,M.A., Chambers,J.A., Griffiths,B., Nicolai,H. and
Solomon,E.
TITLE Distinct transcription start sites generate two forms of BRCA1 mRNA
JOURNAL Hum. Mol. Genet. 4 (12), 2259-2264 (1995)
PUBMED 8634696
REFERENCE 10 (bases 1 to 7132)
AUTHORS Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
TITLE A strong candidate for the breast and ovarian cancer susceptibility
gene BRCA1
JOURNAL Science 266 (5182), 66-71 (1994)
PUBMED 7545954
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC072418.1, U14680.1,
BU617173.1 and BU679389.1.
On May 16, 2009 this sequence version replaced gi:63252874.
Summary: This gene encodes a nuclear phosphoprotein that plays a
role in maintaining genomic stability, and it also acts as a tumor
suppressor. The encoded protein combines with other tumor
suppressors, DNA damage sensors, and signal transducers to form a
large multi-subunit protein complex known as the BRCA1-associated
genome surveillance complex (BASC). This gene product associates
with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus
plays a role in transcription, DNA repair of double-stranded
breaks, and recombination. Mutations in this gene are responsible
for approximately 40% of inherited breast cancers and more than 80%
of inherited breast and ovarian cancers. Alternative splicing plays
a role in modulating the subcellular localization and physiological
function of this gene. Many alternatively spliced transcript
variants, some of which are disease-associated mutations, have been
described for this gene, but the full-length natures of only some
of these variants has been described. A related pseudogene, which
is also located on chromosome 17, has been identified. [provided by
RefSeq, May 2009].
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
portion of the 5' coding region and uses a downstream translational
start codon, compared to variant 1. The encoded isoform (3) is
shorter at the N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-274 BC072418.1 1-274
275-5732 U14680.1 254-5711
5733-6481 BC072418.1 2401-3149
6482-7113 BU617173.1 19-650 c
7114-7132 BU679389.1 1-19 c
FEATURES Location/Qualifiers
source 1..7132
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
gene 1..7132
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="breast cancer 1, early onset"
/db_xref="GeneID:672"
/db_xref="HGNC:1100"
/db_xref="MIM:113705"
exon 1..175
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 55
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace=""
/replace="t"
/db_xref="dbSNP:8176075"
misc_feature 61
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="alternative transcription start site"
STS 152..1559
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/db_xref="UniSTS:482866"
exon 176..274
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
misc_feature 273..275
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="upstream in-frame stop codon"
exon 275..352
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
CDS 282..5732
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="isoform 3 is encoded by transcript variant 3;
BRCA1/BRCA2-containing complex, subunit 1; RING finger
protein 53; breast cancer type 1 susceptibility protein;
breast and ovarian cancer susceptibility protein 1;
protein phosphatase 1, regulatory subunit 53; breast and
ovarian cancer sususceptibility protein 1"
/codon_start=1
/product="breast cancer type 1 susceptibility protein
isoform 3"
/protein_id="NP_009228.2"
/db_xref="GI:237681121"
/db_xref="CCDS:CCDS11459.2"
/db_xref="GeneID:672"
/db_xref="HGNC:1100"
/db_xref="MIM:113705"
/translation="
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY
"
misc_feature 1170..1661
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Serine-rich domain associated with BRCT; Region:
BRCT_assoc; pfam12820"
/db_xref="CDD:193295"
misc_feature 2103..3074
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Ethylene insensitive 3; Region: EIN3; pfam04873"
/db_xref="CDD:191117"
misc_feature 5427..5666
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Breast Cancer Suppressor Protein (BRCA1),
carboxy-terminal domain. The BRCT domain is found within
many DNA damage repair and cell cycle checkpoint proteins.
The unique diversity of this domain superfamily allows
BRCT modules to interact forming homo...; Region: BRCT;
cd00027"
/db_xref="CDD:28909"
misc_feature order(5472..5474,5484..5486,5493..5495,5502..5504,
5508..5510)
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="Dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28909"
misc_feature order(5649..5651,5661..5663)
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="BRCT sequence motif; other site"
/db_xref="CDD:28909"
exon 353..441
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 442..581
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 582..687
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 594
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286288"
variation 618
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625285"
variation 668
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:34545365"
exon 688..733
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 734..810
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 811..4236
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
STS 817..985
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454227"
/db_xref="UniSTS:157424"
variation 833
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625298"
variation 857
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:56310439"
STS 904..1142
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454278"
/db_xref="UniSTS:157425"
variation 905
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:62625299"
variation 1062
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55767801"
STS 1067..1344
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454349"
/db_xref="UniSTS:157426"
variation 1109
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:45586033"
variation 1155
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55842957"
STS 1207..1451
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454353"
/db_xref="UniSTS:157427"
STS 1373..1638
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454372"
/db_xref="UniSTS:157428"
STS 1593..1855
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454381"
/db_xref="UniSTS:157429"
variation 1681
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="g"
/db_xref="dbSNP:56100707"
STS 1752..1995
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454417"
/db_xref="UniSTS:157430"
variation 1871
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897678"
STS 1939..2237
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454421"
/db_xref="UniSTS:157431"
variation 1989
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:45564238"
variation 2018
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176154"
variation 2112
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:55932871"
STS 2163..2418
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454425"
/db_xref="UniSTS:157432"
STS 2302..2525
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454429"
/db_xref="UniSTS:157433"
STS 2469..2738
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454433"
/db_xref="UniSTS:157434"
variation 2629..2630
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace=""
/replace="aa"
/db_xref="dbSNP:273899685"
STS 2656..2969
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454437"
/db_xref="UniSTS:157435"
variation 2665
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897684"
variation 2671
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:56051266"
STS 2682..2924
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC13918P1"
/db_xref="UniSTS:270877"
STS 2921..3226
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454441"
/db_xref="UniSTS:157436"
variation 3106
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:4986848"
STS 3192..3569
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454446"
/db_xref="UniSTS:157437"
variation 3351
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:41293445"
STS 3434..3758
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454450"
/db_xref="UniSTS:157438"
variation 3456
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:45599040"
STS 3704..3992
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1"
/db_xref="UniSTS:262743"
STS 3707..3980
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454454"
/db_xref="UniSTS:157439"
STS 3716..3975
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P3"
/db_xref="UniSTS:272805"
variation 3724
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897685"
STS 3809..4104
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="G60034"
/db_xref="UniSTS:137300"
STS 3817..3975
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P2"
/db_xref="UniSTS:272804"
STS 3881..4089
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454458"
/db_xref="UniSTS:157440"
STS 4017..4234
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454462"
/db_xref="UniSTS:157441"
variation 4133
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="g"
/db_xref="dbSNP:70953658"
exon 4237..4325
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 4326..4497
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4358
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:1800707"
exon 4498..4624
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4611
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="c"
/db_xref="dbSNP:111034213"
exon 4625..4815
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4645
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:56335406"
variation 4750
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:70953659"
variation 4784
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897692"
exon 4816..5126
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 4823
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:55688400"
variation 4998
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176219"
variation 5012
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555992"
variation 5077
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:28897694"
exon 5127..5214
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5215..5292
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5240
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:45519437"
exon 5293..5333
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5297
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:28897697"
exon 5334..5417
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5418..5472
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5466
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:1800757"
exon 5473..5546
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
exon 5547..5607
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5573
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:4438367"
exon 5608..7115
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:1.39.8"
variation 5611
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:70953662"
STS 5654..5789
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P11"
/db_xref="UniSTS:272801"
variation 5711
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:28897699"
variation 5774
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:273902777"
STS 5780..6017
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="RH79896"
/db_xref="UniSTS:90392"
variation 6004
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176317"
variation 6153
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="g"
/replace="t"
/db_xref="dbSNP:8176318"
STS 6282..7111
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1_4046"
/db_xref="UniSTS:464465"
STS 6462..6541
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="D5S1597E"
/db_xref="UniSTS:151019"
variation 6513
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:8176319"
variation 6626
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:1060920"
variation 6632
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="t"
/db_xref="dbSNP:1060921"
variation 7019
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="c"
/replace="t"
/db_xref="dbSNP:12516"
variation 7064
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176320"
polyA_signal 7090..7095
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
polyA_site 7115
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
ORIGIN
cttagcggtagccccttggtttccgtggcaacggaaaagcgcgggaattacagataaattaaaactgcgactgcgcggcgtgagctcgctgagacttcctggacgggggacaggctgtggggtttctcagataactgggcccctgcgctcaggaggccttcaccctctgctctggttcattggaacagaaagaaatggatttatctgctcttcgcgttgaagaagtacaaaatgtcattaatgctatgcagaaaatcttagagtgtcccatctgattttgcatgctgaaacttctcaaccagaagaaagggccttcacagtgtcctttatgtaagaatgatataaccaaaaggagcctacaagaaagtacgagatttagtcaacttgttgaagagctattgaaaatcatttgtgcttttcagcttgacacaggtttggagtatgcaaacagctataattttgcaaaaaaggaaaataactctcctgaacatctaaaagatgaagtttctatcatccaaagtatgggctacagaaaccgtgccaaaagacttctacagagtgaacccgaaaatccttccttgcaggaaaccagtctcagtgtccaactctctaaccttggaactgtgagaactctgaggacaaagcagcggatacaacctcaaaagacgtctgtctacattgaattgggatctgattcttctgaagataccgttaataaggcaacttattgcagtgtgggagatcaagaattgttacaaatcacccctcaaggaaccagggatgaaatcagtttggattctgcaaaaaaggctgcttgtgaattttctgagacggatgtaacaaatactgaacatcatcaacccagtaataatgatttgaacaccactgagaagcgtgcagctgagaggcatccagaaaagtatcagggtagttctgtttcaaacttgcatgtggagccatgtggcacaaatactcatgccagctcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaaaaggctgaattctgtaataaaagcaaacagcctggcttagcaaggagccaacataacagatgggctggaagtaaggaaacatgtaatgataggcggactcccagcacagaaaaaaaggtagatctgaatgctgatcccctgtgtgagagaaaagaatggaataagcagaaactgccatgctcagagaatcctagagatactgaagatgttccttggataacactaaatagcagcattcagaaagttaatgagtggttttccagaagtgatgaactgttaggttctgatgactcacatgatggggagtctgaatcaaatgccaaagtagctgatgtattggacgttctaaatgaggtagatgaatattctggttcttcagagaaaatagacttactggccagtgatcctcatgaggctttaatatgtaaaagtgaaagagttcactccaaatcagtagagagtaatattgaagacaaaatatttgggaaaacctatcggaagaaggcaagcctccccaacttaagccatgtaactgaaaatctaattataggagcatttgttactgagccacagataatacaagagcgtcccctcacaaataaattaaagcgtaaaaggagacctacatcaggccttcatcctgaggattttatcaagaaagcagatttggcagttcaaaagactcctgaaatgataaatcagggaactaaccaaacggagcagaatggtcaagtgatgaatattactaatagtggtcatgagaataaaacaaaaggtgattctattcagaatgagaaaaatcctaacccaatagaatcactcgaaaaagaatctgctttcaaaacgaaagctgaacctataagcagcagtataagcaatatggaactcgaattaaatatccacaattcaaaagcacctaaaaagaataggctgaggaggaagtcttctaccaggcatattcatgcgcttgaactagtagtcagtagaaatctaagcccacctaattgtactgaattgcaaattgatagttgttctagcagtgaagagataaagaaaaaaaagtacaaccaaatgccagtcaggcacagcagaaacctacaactcatggaaggtaaagaacctgcaactggagccaagaagagtaacaagccaaatgaacagacaagtaaaagacatgacagcgatactttcccagagctgaagttaacaaatgcacctggttcttttactaagtgttcaaataccagtgaacttaaagaatttgtcaatcctagccttccaagagaagaaaaagaagagaaactagaaacagttaaagtgtctaataatgctgaagaccccaaagatctcatgttaagtggagaaagggttttgcaaactgaaagatctgtagagagtagcagtatttcattggtacctggtactgattatggcactcaggaaagtatctcgttactggaagttagcactctagggaaggcaaaaacagaaccaaataaatgtgtgagtcagtgtgcagcatttgaaaaccccaagggactaattcatggttgttccaaagataatagaaatgacacagaaggctttaagtatccattgggacatgaagttaaccacagtcgggaaacaagcatagaaatggaagaaagtgaacttgatgctcagtatttgcagaatacattcaaggtttcaaagcgccagtcatttgctccgttttcaaatccaggaaatgcagaagaggaatgtgcaacattctctgcccactctgggtccttaaagaaacaaagtccaaaagtcacttttgaatgtgaacaaaaggaagaaaatcaaggaaagaatgagtctaatatcaagcctgtacagacagttaatatcactgcaggctttcctgtggttggtcagaaagataagccagttgataatgccaaatgtagtatcaaaggaggctctaggttttgtctatcatctcagttcagaggcaacgaaactggactcattactccaaataaacatggacttttacaaaacccatatcgtataccaccactttttcccatcaagtcatttgttaaaactaaatgtaagaaaaatctgctagaggaaaactttgaggaacattcaatgtcacctgaaagagaaatgggaaatgagaacattccaagtacagtgagcacaattagccgtaataacattagagaaaatgtttttaaagaagccagctcaagcaatattaatgaagtaggttccagtactaatgaagtgggctccagtattaatgaaataggttccagtgatgaaaacattcaagcagaactaggtagaaacagagggccaaaattgaatgctatgcttagattaggggttttgcaacctgaggtctataaacaaagtcttcctggaagtaattgtaagcatcctgaaataaaaaagcaagaatatgaagaagtagttcagactgttaatacagatttctctccatatctgatttcagataacttagaacagcctatgggaagtagtcatgcatctcaggtttgttctgagacacctgatgacctgttagatgatggtgaaataaaggaagatactagttttgctgaaaatgacattaaggaaagttctgctgtttttagcaaaagcgtccagaaaggagagcttagcaggagtcctagccctttcacccatacacatttggctcagggttaccgaagaggggccaagaaattagagtcctcagaagagaacttatctagtgaggatgaagagcttccctgcttccaacacttgttatttggtaaagtaaacaatataccttctcagtctactaggcatagcaccgttgctaccgagtgtctgtctaagaacacagaggagaatttattatcattgaagaatagcttaaatgactgcagtaaccaggtaatattggcaaaggcatctcaggaacatcaccttagtgaggaaacaaaatgttctgctagcttgttttcttcacagtgcagtgaattggaagacttgactgcaaatacaaacacccaggatcctttcttgattggttcttccaaacaaatgaggcatcagtctgaaagccagggagttggtctgagtgacaaggaattggtttcagatgatgaagaaagaggaacgggcttggaagaaaataatcaagaagagcaaagcatggattcaaacttaggtgaagcagcatctgggtgtgagagtgaaacaagcgtctctgaagactgctcagggctatcctctcagagtgacattttaaccactcagcagagggataccatgcaacataacctgataaagctccagcaggaaatggctgaactagaagctgtgttagaacagcatgggagccagccttctaacagctacccttccatcataagtgactcttctgcccttgaggacctgcgaaatccagaacaaagcacatcagaaaaagcagtattaacttcacagaaaagtagtgaataccctataagccagaatccagaaggcctttctgctgacaagtttgaggtgtctgcagatagttctaccagtaaaaataaagaaccaggagtggaaaggtcatccccttctaaatgcccatcattagatgataggtggtacatgcacagttgctctgggagtcttcagaatagaaactacccatctcaagaggagctcattaaggttgttgatgtggaggagcaacagctggaagagtctgggccacacgatttgacggaaacatcttacttgccaaggcaagatctagagggaaccccttacctggaatctggaatcagcctcttctctgatgaccctgaatctgatccttctgaagacagagccccagagtcagctcgtgttggcaacataccatcttcaacctctgcattgaaagttccccaattgaaagttgcagaatctgcccagagtccagctgctgctcatactactgatactgctgggtataatgcaatggaagaaagtgtgagcagggagaagccagaattgacagcttcaacagaaagggtcaacaaaagaatgtccatggtggtgtctggcctgaccccagaagaatttatgctcgtgtacaagtttgccagaaaacaccacatcactttaactaatctaattactgaagagactactcatgttgttatgaaaacagatgctgagtttgtgtgtgaacggacactgaaatattttctaggaattgcgggaggaaaatgggtagttagctatttctgggtgacccagtctattaaagaaagaaaaatgctgaatgagcatgattttgaagtcagaggagatgtggtcaatggaagaaaccaccaaggtccaaagcgagcaagagaatcccaggacagaaagatcttcagggggctagaaatctgttgctatgggcccttcaccaacatgcccacagatcaactggaatggatggtacagctgtgtggtgcttctgtggtgaaggagctttcatcattcacccttggcacaggtgtccacccaattgtggttgtgcagccagatgcctggacagaggacaatggcttccatgcaattgggcagatgtgtgaggcacctgtggtgacccgagagtgggtgttggacagtgtagcactctaccagtgccaggagctggacacctacctgataccccagatcccccacagccactactgactgcagccagccacaggtacagagccacaggaccccaagaatgagcttacaaagtggcctttccaggccctgggagctcctctcactcttcagtccttctactgtcctggctactaaatattttatgtacatcagcctgaaaaggacttctggctatgcaagggtcccttaaagattttctgcttgaagtctcccttggaaatctgccatgagcacaaaattatggtaatttttcacctgagaagattttaaaaccatttaaacgccaccaattgagcaagatgctgattcattatttatcagccctattctttctattcaggctgttgttggcttagggctggaagcacagagtggcttggcctcaagagaatagctggtttccctaagtttacttctctaaaaccctgtgttcacaaaggcagagagtcagacccttcaatggaaggagagtgcttgggatcgattatgtgacttaaagtcagaatagtccttgggcagttctcaaatgttggagtggaacattggggaggaaattctgaggcaggtattagaaatgaaaaggaaacttgaaacctgggcatggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggcagatcactggaggtcaggagttcgaaaccagcctggccaacatggtgaaaccccatctctactaaaaatacagaaattagccggtcatggtggtggacacctgtaatcccagctactcaggtggctaaggcaggagaatcacttcagcccgggaggtggaggttgcagtgagccaagatcataccacggcactccagcctgggtgacagtgagactgtggctcaaaaaaaaaaaaaaaaaaaggaaaatgaaactagaagagatttctaaaagtctgagatatatttgctagatttctaaagaatgtgttctaaaacagcagaagattttcaagaaccggtttccaaagacagtcttctaattcctcattagtaataagtaaaatgtttattgttgtagctctggtatataatccattcctcttaaaatataagacctctggcatgaatatttcatatctataaaatgacagatcccaccaggaaggaagctgttgctttctttgaggtgatttttttcctttgctccctgttgctgaaaccatacagcttcataaataattttgcttgctgaaggaagaaaaagtgtttttcataaacccattatccaggactgtttatagctgttggaaggactaggtcttccctagcccccccagtgtgcaagggcagtgaagacttgattgtacaaaatacgttttgtaaatgttgtgctgttaacactgcaaataaacttggtagcaaacacttccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:672 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:672 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: NAS
GeneID:672 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
GeneID:672 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:672 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:672 -> Molecular function: GO:0015631 [tubulin binding] evidence: NAS
GeneID:672 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:672 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
GeneID:672 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS
GeneID:672 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: IDA
GeneID:672 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: TAS
GeneID:672 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:672 -> Biological process: GO:0006301 [postreplication repair] evidence: IDA
GeneID:672 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:672 -> Biological process: GO:0006302 [double-strand break repair] evidence: TAS
GeneID:672 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:672 -> Biological process: GO:0006359 [regulation of transcription from RNA polymerase III promoter] evidence: TAS
GeneID:672 -> Biological process: GO:0006633 [fatty acid biosynthetic process] evidence: IEA
GeneID:672 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:672 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: TAS
GeneID:672 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: TAS
GeneID:672 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:672 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP
GeneID:672 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:672 -> Biological process: GO:0010212 [response to ionizing radiation] evidence: IMP
GeneID:672 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS
GeneID:672 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:672 -> Biological process: GO:0034446 [substrate adhesion-dependent cell spreading] evidence: IDA
GeneID:672 -> Biological process: GO:0035066 [positive regulation of histone acetylation] evidence: IDA
GeneID:672 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: TAS
GeneID:672 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:672 -> Biological process: GO:0043627 [response to estrogen stimulus] evidence: IDA
GeneID:672 -> Biological process: GO:0045717 [negative regulation of fatty acid biosynthetic process] evidence: IMP
GeneID:672 -> Biological process: GO:0045739 [positive regulation of DNA repair] evidence: IMP
GeneID:672 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:672 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
GeneID:672 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: TAS
GeneID:672 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:672 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:672 -> Biological process: GO:0046600 [negative regulation of centriole replication] evidence: NAS
GeneID:672 -> Biological process: GO:0051571 [positive regulation of histone H3-K4 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0051573 [negative regulation of histone H3-K9 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0051865 [protein autoubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:0070512 [positive regulation of histone H4-K20 methylation] evidence: IDA
GeneID:672 -> Biological process: GO:0071158 [positive regulation of cell cycle arrest] evidence: IDA
GeneID:672 -> Biological process: GO:0071681 [cellular response to indole-3-methanol] evidence: IDA
GeneID:672 -> Biological process: GO:0085020 [protein K6-linked ubiquitination] evidence: IDA
GeneID:672 -> Biological process: GO:2000145 [regulation of cell motility] evidence: IDA
GeneID:672 -> Biological process: GO:2000617 [positive regulation of histone H3-K9 acetylation] evidence: IDA
GeneID:672 -> Biological process: GO:2000620 [positive regulation of histone H4-K16 acetylation] evidence: IDA
GeneID:672 -> Cellular component: GO:0000151 [ubiquitin ligase complex] evidence: NAS
GeneID:672 -> Cellular component: GO:0001726 [ruffle] evidence: IDA
GeneID:672 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:672 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:672 -> Cellular component: GO:0005694 [chromosome] evidence: ISS
GeneID:672 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:672 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
GeneID:672 -> Cellular component: GO:0008274 [gamma-tubulin ring complex] evidence: NAS
GeneID:672 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0031436 [BRCA1-BARD1 complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0031941 [filamentous actin] evidence: IDA
GeneID:672 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
GeneID:672 -> Cellular component: GO:0070531 [BRCA1-A complex] evidence: IDA
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DBCLS
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