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2024-04-25 09:44:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007280 1249 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens Opa interacting protein 5 (OIP5), mRNA.
ACCESSION NM_007280
VERSION NM_007280.1 GI:24307928
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1249)
AUTHORS Koinuma,J., Akiyama,H., Fujita,M., Hosokawa,M., Tsuchiya,E.,
Kondo,S., Nakamura,Y. and Daigo,Y.
TITLE Characterization of an Opa interacting protein 5 involved in lung
and esophageal carcinogenesis
JOURNAL Cancer Sci. 103 (3), 577-586 (2012)
PUBMED 22129094
REMARK GeneRIF: OIP5 expression was significantly associated with poor
prognosis of lung and esophageal cancer patients
REFERENCE 2 (bases 1 to 1249)
AUTHORS Chun,H.K., Chung,K.S., Kim,H.C., Kang,J.E., Kang,M.A., Kim,J.T.,
Choi,E.H., Jung,K.E., Kim,M.H., Song,E.Y., Kim,S.Y., Won,M. and
Lee,H.G.
TITLE OIP5 is a highly expressed potential therapeutic target for
colorectal and gastric cancers
JOURNAL BMB Rep 43 (5), 349-354 (2010)
PUBMED 20510019
REMARK GeneRIF: These results indicate that knockdown of OIP5 may induce
apoptosis in cancer cells.
REFERENCE 3 (bases 1 to 1249)
AUTHORS Naetar,N., Hutter,S., Dorner,D., Dechat,T., Korbei,B., Gotzmann,J.,
Beug,H. and Foisner,R.
TITLE LAP2alpha-binding protein LINT-25 is a novel chromatin-associated
protein involved in cell cycle exit
JOURNAL J. Cell. Sci. 120 (PT 5), 737-747 (2007)
PUBMED 17284516
REFERENCE 4 (bases 1 to 1249)
AUTHORS Fujita,Y., Hayashi,T., Kiyomitsu,T., Toyoda,Y., Kokubu,A., Obuse,C.
and Yanagida,M.
TITLE Priming of centromere for CENP-A recruitment by human hMis18alpha,
hMis18beta, and M18BP1
JOURNAL Dev. Cell 12 (1), 17-30 (2007)
PUBMED 17199038
REMARK GeneRIF: Three human proteins essential for centromere/kinetochore
structure and function, hMis18alpha, hMis18beta, and M18BP1, the
complex of which is accumulated specifically at the telophase-G1
centromere, are identified.[Mis18alpha, Mis18beta, M18BP1]
REFERENCE 5 (bases 1 to 1249)
AUTHORS Yuryev,A. and Wennogle,L.P.
TITLE Novel raf kinase protein-protein interactions found by an
exhaustive yeast two-hybrid analysis
JOURNAL Genomics 81 (2), 112-125 (2003)
PUBMED 12620389
REFERENCE 6 (bases 1 to 1249)
AUTHORS Williams,J.M., Chen,G.C., Zhu,L. and Rest,R.F.
TITLE Using the yeast two-hybrid system to identify human epithelial cell
proteins that bind gonococcal Opa proteins: intracellular gonococci
bind pyruvate kinase via their Opa proteins and require host
pyruvate for growth
JOURNAL Mol. Microbiol. 27 (1), 171-186 (1998)
PUBMED 9466265
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC015050.1.
##Evidence-Data-START##
Transcript exon combination :: BC015050.1, AF025441.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1249
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15.1"
gene 1..1249
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/note="Opa interacting protein 5"
/db_xref="GeneID:11339"
/db_xref="HGNC:20300"
/db_xref="HPRD:09352"
/db_xref="MIM:606020"
exon 1..382
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/inference="alignment:Splign:1.39.8"
variation complement(6)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:184813481"
variation complement(18)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:367777796"
variation complement(35)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:374695010"
variation complement(49)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:371761092"
variation complement(54)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:192801570"
variation complement(56)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:374158292"
CDS 61..750
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/note="cancer/testis antigen 86; MIS18 kinetochore protein
homolog B; LAP2alpha interactor-25; OIP-5; opa-interacting
protein 5"
/codon_start=1
/product="protein Mis18-beta"
/protein_id="NP_009211.1"
/db_xref="GI:24307929"
/db_xref="CCDS:CCDS10074.1"
/db_xref="GeneID:11339"
/db_xref="HGNC:20300"
/db_xref="HPRD:09352"
/db_xref="MIM:606020"
/translation="
MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN
"
misc_feature 202..204
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43482.2); phosphorylation site"
misc_feature 721..723
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O43482.2); phosphorylation site"
misc_feature 733..735
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43482.2); phosphorylation site"
variation complement(61)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:145740305"
variation complement(66)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:370751576"
variation complement(71)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:202135766"
variation complement(73)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:112727289"
variation complement(74)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:201356433"
variation complement(87)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:149802500"
variation complement(89)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:201962885"
variation complement(91)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:374036062"
variation complement(92)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:370713618"
variation complement(95)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:368459286"
variation complement(99)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:371613700"
variation complement(118)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="t"
/db_xref="dbSNP:147610892"
variation complement(131)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:369380332"
variation complement(135)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:200037270"
variation complement(143)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:377001694"
variation complement(156)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:145267416"
variation complement(164)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:139765740"
variation complement(169)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="c"
/db_xref="dbSNP:200477785"
variation complement(197)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:373000681"
variation complement(198)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:74012264"
variation complement(216)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:112502662"
variation complement(229)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:142040983"
variation complement(234)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:369135858"
variation complement(241)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="g"
/db_xref="dbSNP:35123814"
variation complement(243)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="c"
/db_xref="dbSNP:371343522"
variation complement(252)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:367869608"
variation complement(273)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:201818984"
variation complement(346)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:374055137"
exon 383..449
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/inference="alignment:Splign:1.39.8"
variation complement(434)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:143931676"
exon 450..572
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/inference="alignment:Splign:1.39.8"
variation complement(456)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="c"
/db_xref="dbSNP:371045360"
variation complement(489)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:368534686"
variation complement(515)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="c"
/db_xref="dbSNP:367621399"
variation complement(548)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:199569545"
variation complement(554)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:75983701"
variation complement(570)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:111625807"
exon 573..654
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/inference="alignment:Splign:1.39.8"
variation complement(596)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="t"
/db_xref="dbSNP:143003728"
variation complement(604)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:202041575"
variation complement(617)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="t"
/db_xref="dbSNP:199882050"
variation complement(646)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:114645506"
exon 655..1236
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/inference="alignment:Splign:1.39.8"
variation complement(664)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:377350927"
variation complement(683)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:200589092"
variation complement(685)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:150485331"
variation complement(688)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:139348470"
variation complement(689)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="g"
/replace="t"
/db_xref="dbSNP:374289568"
variation complement(713)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:143255947"
variation complement(771)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="g"
/db_xref="dbSNP:369999957"
variation complement(959)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:74012259"
variation complement(987)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="t"
/db_xref="dbSNP:74012258"
variation complement(1001)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="a"
/replace="c"
/db_xref="dbSNP:115325774"
variation complement(1110)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:146239241"
variation complement(1151)
/gene="OIP5"
/gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
MIS18B; MIS18beta"
/replace="c"
/replace="t"
/db_xref="dbSNP:183523074"
ORIGIN
gagctgtgcttggggcggggcctggcgtgtattcgaaaggaaggcgccggctgcgggaagatggcggctcagccgctgcggcatcgctcacgttgtgcaacgccgccccggggggacttttgtggtggcactgagagggcgattgaccaagcttcttttacgacctccatggagtgggatacgcaggtggtgaaggggtcctcgccgctcggccccgcagggctgggggctgaggagccagccgccggcccgcagctgccgtcttggctgcagcctgagaggtgcgctgtgttccagtgcgcacagtgtcacgcagtgctcgccgactcggtgcacctcgcctgggacctgtcgcggtccctcggggccgtggtcttctccagagttacaaataacgtcgttttggaagcgcccttcctagttggcattgaaggttcactcaaaggcagtacttacaaccttttattctgtggttcttgtgggattcccgttggtttccatctgtattctacccatgctgccctggctgccttgagaggtcacttctgcctttccagtgacaaaatggtgtgctatctcttaaaaacaaaagccatagtaaatgcatcagagatggatattcaaaatgttcctctatcagaaaagattgcagagctgaaagagaagatagtgctaacgcacaatcgcttaaaatcactaatgaagattctgagtgaagtgactcctgaccagtccaagccagaaaactgatcctgtaccaaagcttgagtgtcaggttcaggctttattgctgtcttcaacaacaggtgctgcttagtcatttcttgaaaaagattggcttcaagaatggaggggaaatgcagtttctatttacctttaggctgattttccaaattatttgtgaagctgtttttagaagatgagagactaaggattcttctcttttatagctatttgccttaagaacttactttagattcttattgaattcataatacttatctctgaaaatgtctttgactgtaaatttaggaattaagatgcagagtcccatgtgtcctctgatctaaagttgcatggttggtctgaaaatagagttgggcttaatgttgacttctattactcctgcatggagcagttgttatgaatactaatacatcactttttaacttctgtaaaatacagatcataatattctataggtaatgtttaataaattgcctgaataatatacaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11339 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:11339 -> Biological process: GO:0006334 [nucleosome assembly] evidence: TAS
GeneID:11339 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:11339 -> Biological process: GO:0007154 [cell communication] evidence: NAS
GeneID:11339 -> Biological process: GO:0034080 [CENP-A containing nucleosome assembly at centromere] evidence: TAS
GeneID:11339 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:11339 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IEA
GeneID:11339 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:11339 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:11339 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:11339 -> Cellular component: GO:0010369 [chromocenter] evidence: IEA
GeneID:11339 -> Cellular component: GO:0015030 [Cajal body] evidence: IDA
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