2024-04-26 17:13:27, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007276 2330 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens chromobox homolog 3 (CBX3), transcript variant 1, mRNA. ACCESSION NM_007276 VERSION NM_007276.4 GI:325197149 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2330) AUTHORS Smallwood,A., Hon,G.C., Jin,F., Henry,R.E., Espinosa,J.M. and Ren,B. TITLE CBX3 regulates efficient RNA processing genome-wide JOURNAL Genome Res. 22 (8), 1426-1436 (2012) PUBMED 22684280 REMARK GeneRIF: Loss of CBX3 results in global RNA processing defect. REFERENCE 2 (bases 1 to 2330) AUTHORS Saini,V., Hose,C.D., Monks,A., Nagashima,K., Han,B., Newton,D.L., Millione,A., Shah,J., Hollingshead,M.G., Hite,K.M., Burkett,M.W., Delosh,R.M., Silvers,T.E., Scudiero,D.A. and Shoemaker,R.H. TITLE Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma JOURNAL PLoS ONE 7 (8), E41401 (2012) PUBMED 22870217 REMARK GeneRIF: Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. Erratum:[PLoS One. 2012;7(11). doi:10.1371/annotation/8c74aaee-897d-4682-b62d-d95a3506c210] REFERENCE 3 (bases 1 to 2330) AUTHORS Ruan,J., Ouyang,H., Amaya,M.F., Ravichandran,M., Loppnau,P., Min,J. and Zang,J. TITLE Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a JOURNAL PLoS ONE 7 (4), E35376 (2012) PUBMED 22514736 REMARK GeneRIF: The Cbx3 chromodomain binds with comparable affinities to all of the methylated H3K9, H1K26 and G9aK185 peptides. REFERENCE 4 (bases 1 to 2330) AUTHORS Shimura,M., Toyoda,Y., Iijima,K., Kinomoto,M., Tokunaga,K., Yoda,K., Yanagida,M., Sata,T. and Ishizaka,Y. TITLE Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation JOURNAL J. Cell Biol. 194 (5), 721-735 (2011) PUBMED 21875947 REMARK GeneRIF: HIV-1 Vpr displaces heterochromatin protein 1-alpha and heterochromatin protein 1-gamma from chromatin, resulting in premature chromatid separation. REFERENCE 5 (bases 1 to 2330) AUTHORS Canudas,S., Houghtaling,B.R., Bhanot,M., Sasa,G., Savage,S.A., Bertuch,A.A. and Smith,S. TITLE A role for heterochromatin protein 1gamma at human telomeres JOURNAL Genes Dev. 25 (17), 1807-1819 (2011) PUBMED 21865325 REMARK GeneRIF: HP1gamma localizes to telomeres in S phase, where it is required to establish/maintain cohesion REFERENCE 6 (bases 1 to 2330) AUTHORS Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M. TITLE Chromatin components as part of a putative transcriptional repressing complex JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (13), 7322-7326 (1998) PUBMED 9636147 REFERENCE 7 (bases 1 to 2330) AUTHORS Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A. TITLE Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (13), 7316-7321 (1998) PUBMED 9636146 REFERENCE 8 (bases 1 to 2330) AUTHORS Lessard,J., Baban,S. and Sauvageau,G. TITLE Stage-specific expression of polycomb group genes in human bone marrow cells JOURNAL Blood 91 (4), 1216-1224 (1998) PUBMED 9454751 REFERENCE 9 (bases 1 to 2330) AUTHORS Ye,Q., Callebaut,I., Pezhman,A., Courvalin,J.C. and Worman,H.J. TITLE Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR JOURNAL J. Biol. Chem. 272 (23), 14983-14989 (1997) PUBMED 9169472 REFERENCE 10 (bases 1 to 2330) AUTHORS Ye,Q. and Worman,H.J. TITLE Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 JOURNAL J. Biol. Chem. 271 (25), 14653-14656 (1996) PUBMED 8663349 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CV575477.1, BC000954.1, BX648807.1 and DB565723.1. On Mar 4, 2011 this sequence version replaced gi:20544152. Summary: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]. Transcript Variant: This variant (1) contains an alternate 5' exon but encodes the same protein as transcript variant 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000954.1, BM470921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-268 CV575477.1 27-294 269-1304 BC000954.1 1-1036 1305-2074 BX648807.1 1033-1802 2075-2330 DB565723.1 209-464 FEATURES Location/Qualifiers source 1..2330 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7p15.2" gene 1..2330 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="chromobox homolog 3" /db_xref="GeneID:11335" /db_xref="HGNC:1553" /db_xref="MIM:604477" exon 1..351 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" variation 116 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:191109734" variation 132 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:370222376" variation 145 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="t" /db_xref="dbSNP:55780669" variation 257 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:139133255" exon 352..403 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" variation 354 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:369210080" variation 363 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="c" /db_xref="dbSNP:372876793" variation 371 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:370877360" misc_feature 374..376 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="upstream in-frame stop codon" variation 375 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:200166027" CDS 380..931 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="heterochromatin protein HP1 gamma; chromobox homolog 3 (HP1 gamma homolog, Drosophila); heterochromatin-like protein 1; modifier 2 protein; heterochromatin protein 1 homolog gamma" /codon_start=1 /product="chromobox protein homolog 3" /protein_id="NP_009207.2" /db_xref="GI:15082258" /db_xref="CCDS:CCDS5398.1" /db_xref="GeneID:11335" /db_xref="HGNC:1553" /db_xref="MIM:604477" /translation="
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
" misc_feature 407..409 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q13185.4); acetylation site" misc_feature 485..613 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; Region: CHROMO; cd00024" /db_xref="CDD:237991" misc_feature 509..511 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q13185.4); acetylation site" misc_feature order(524..526,530..532,539..541,551..553,563..565, 575..580) /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="histone binding site; other site" /db_xref="CDD:237991" misc_feature 527..529 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q13185.4); acetylation site" misc_feature 656..658 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13185.4); phosphorylation site" misc_feature 656..658 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 662..664 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13185.4); phosphorylation site" misc_feature 662..664 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 668..670 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13185.4); phosphorylation site" misc_feature 668..670 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 674..676 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13185.4); phosphorylation site" misc_feature 674..676 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 683..685 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 746..904 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g; Region: ChSh; cd00034" /db_xref="CDD:237998" misc_feature order(764..766,785..787,848..850,872..874,881..883, 893..895) /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:237998" misc_feature order(872..874,881..883) /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /note="potential binding pit; other site" /db_xref="CDD:237998" misc_feature 896..898 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 905..907 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13185.4); phosphorylation site" misc_feature 905..907 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 404..546 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" variation 443 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:371590498" variation 538 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:192881539" exon 547..709 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" variation 596 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:199646600" variation 632 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:11554895" variation 640 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:148438009" variation 673 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:142550836" variation 682 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:372035189" exon 710..804 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" STS 717..914 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /standard_name="CBX3" /db_xref="UniSTS:503620" variation 733 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:376630956" variation 766 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:200410047" variation 796 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:200791010" exon 805..2330 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /inference="alignment:Splign:1.39.8" variation 851 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:372760990" variation 853 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:372183110" variation 881 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="t" /db_xref="dbSNP:151101852" variation 914..915 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="a" /db_xref="dbSNP:34210465" variation 946 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:9768418" variation 963 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:191976883" variation 974 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="t" /db_xref="dbSNP:145395285" variation 1023 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="c" /db_xref="dbSNP:184267440" variation 1070 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:376832373" variation 1161 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:189467571" variation 1266 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:182369741" variation 1269 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:9768454" variation 1301..1302 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tt" /db_xref="dbSNP:368752748" variation 1302..1307 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tttgtgtg" /db_xref="dbSNP:150882395" variation 1302..1305 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tttgtg" /db_xref="dbSNP:150158222" variation 1303..1316 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="ttgtgtgtgtgtgtgt" /db_xref="dbSNP:56362406" variation 1304..1309 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:199895382" variation 1304..1305 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tgt" /db_xref="dbSNP:78265643" variation 1304..1305 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tgtg" /db_xref="dbSNP:202216295" variation 1304 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tg" /db_xref="dbSNP:200992022" variation 1305 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:9769357" variation 1306..1308 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="gtgt" /db_xref="dbSNP:70943279" variation 1307 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:12532361" variation 1309 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:200128779" variation 1315 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:201652043" variation 1317 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:201093455" variation 1368 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:111871239" variation 1426 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:184550155" variation 1485 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:10156063" variation 1560 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:3735554" variation 1619 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="g" /db_xref="dbSNP:189258793" variation 1715 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:374505442" variation 1772 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:11554894" STS 1800..2043 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /standard_name="RH24974" /db_xref="UniSTS:85612" STS 1871..2051 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /standard_name="HSC11F052" /db_xref="UniSTS:60487" STS 1877..1978 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /standard_name="D7S2103E" /db_xref="UniSTS:151124" variation 1892 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="g" /db_xref="dbSNP:375726042" variation 1905 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:7186" variation 1979 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="t" /db_xref="dbSNP:78619479" variation 2036..2038 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="tgg" /db_xref="dbSNP:144437057" variation 2038..2040 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="" /replace="gtg" /db_xref="dbSNP:377589440" variation 2062 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="t" /db_xref="dbSNP:13247806" variation 2069 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:28407029" variation 2074 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="c" /db_xref="dbSNP:142267744" variation 2080 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:373262978" variation 2088 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="c" /replace="t" /db_xref="dbSNP:181300726" variation 2108 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="g" /db_xref="dbSNP:369134863" variation 2171 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="a" /replace="t" /db_xref="dbSNP:111891412" variation 2172 /gene="CBX3" /gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma" /replace="g" /replace="t" /db_xref="dbSNP:115829318" ORIGIN
cccttccggaaacacccgaatcaacttctagtcaaattattgttcacgccgcaatgacccacccctggcccgcgtctgtggaactgacccctggtgtacaggagagttcgctgctgaaagtggtcccaaaggggtactagtttttaagctcccaactccccctcccccagcgtctggaggattccacaccctcgcaccgcaggggcgaggaagtgggcggagtccggttttggcgccagccgctgaggctgccaagcagaaaagccaccgctgaggagactccggtcactgtcctcgccccgcctcccccttccctccccttggggaccaccgggcgccacgccgcgaacgtaatagctcttcaagtctgcaataaaaaatggcctccaacaaaactacattgcaaaaaatgggaaaaaaacagaatggaaagagtaaaaaagttgaagaggcagagcctgaagaatttgtcgtggaaaaagtactagatcgacgtgtagtgaatgggaaagtggaatatttcctgaagtggaagggatttacagatgctgacaatacttgggaacctgaagaaaatttagattgtccagaattgattgaagcgtttcttaactctcagaaagctggcaaagaaaaagatggtacaaaaagaaaatctttatctgacagtgaatctgatgacagcaaatcaaagaagaaaagagatgctgctgacaaaccaagaggatttgccagaggtcttgatcctgaaagaataattggtgccacagacagcagtggagaattgatgtttctcatgaaatggaaagattcagatgaggcagacttggtgctggcgaaagaggcaaatatgaagtgtcctcaaattgtaattgctttttatgaagagagactaacttggcattcttgtccagaagatgaagctcaataattgttcacattgttcttttatatatatttatatatatatataaaaattgggtcttagattttgatttactagtgtgacaaaataactacatcctaatgaaaatcaagtttgatatgtttgttttgaaagtagcgttggaagagttgttgggggttttttgcatccatagcactggttactttgaacaaataaataaaagctttctgtagttgcttcctttatcagaaaagaacatttgataccatggtatatcatttcctcttcattaaagaacagcttttctaaatgttgggggaaatgtccatagtcattactcagtcaaaacttgtgttctcatgagcctaaggaccattctagatttattacgtgttttttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatccataaaatgcatatgtaaatttttttttgtttttaagcattcacccaaacaaaaaaatcacaggtaaacccatgtttctgagatgccattattccaagcaaaataagagataatcccttcaagttaaattgaaaattttcctgaaaccatacatttcaagtgaaataagtaattctagataggacaatttaaattggataattttaaagtgtctataattgcagtggtttatttgcaaaattcctaaaaggaaaaattttatcactgccatcacagcaggtttcctcatccagatgaggaaactagacaaatgctagtgtgttttaactagctaaacaaaactaagttaaatgaacatttaaaagtttccctagcgggccattccttagcaaaatgttggaatccctgttgctacattgactaaaaggtcatgatgaatggaatatgtaagacttggctcatagaaacctaatcagatggttagaggtgttggcagtttaggacctgctgtcataaatgtgtgaacaaccttttgtaacctaacctattgacctgcatgttttttctttaccccaattcattacatggaggctcaatcttgagtttgctttactggttcagcaaaagccaggaagaacaactttgtagtaatcaaaatgttatccaactgtatattgtttactttattgtaaatactggtgaacagtggttaataaatagttttatattcctttatgcaattattagacttttttctttatttgatatgcctttacagtagaaatagaaatgcccacactcattggattatctttgtttataagttagatgataccagtaaggcattacagtacatatcctagatcttttgagcttacgagttttaaacttgaatatgtatttccacaggaatgtttccacagttgggaaataaaagtttcatgtgatgcctagggtcaattgtctcattaaaatgaggttttaaattctg
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:11335 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:11335 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI GeneID:11335 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI GeneID:11335 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:11335 -> Biological process: GO:0006338 [chromatin remodeling] evidence: NAS GeneID:11335 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA GeneID:11335 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA GeneID:11335 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP GeneID:11335 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: ISS GeneID:11335 -> Cellular component: GO:0000785 [chromatin] evidence: IDA GeneID:11335 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:11335 -> Cellular component: GO:0005635 [nuclear envelope] evidence: ISS GeneID:11335 -> Cellular component: GO:0005637 [nuclear inner membrane] evidence: NAS GeneID:11335 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA GeneID:11335 -> Cellular component: GO:0005720 [nuclear heterochromatin] evidence: IDA GeneID:11335 -> Cellular component: GO:0005819 [spindle] evidence: IDA GeneID:11335 -> Cellular component: GO:0031618 [nuclear centromeric heterochromatin] evidence: ISS
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