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2024-04-20 02:35:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007257 4846 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens paraneoplastic Ma antigen 2 (PNMA2), mRNA.
ACCESSION NM_007257 XM_376764
VERSION NM_007257.5 GI:156766040
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4846)
AUTHORS Han,H., Yang,Y., Lu,Z., He,Q. and Lin,Z.
TITLE Decreased D2-40 and increased p16INK4A immunoreactivities correlate
with higher grade of cervical intraepithelial neoplasia
JOURNAL Diagn Pathol 6, 59 (2011)
PUBMED 21729305
REMARK GeneRIF: Immunohistochemical analysis of MA2/D2-40 combined with
p16(INK4A) may have a significant implication in clinical practice
for better identifying the grade of cervical intraepithelial
neoplasia.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4846)
AUTHORS Cui,T., Hurtig,M., Elgue,G., Li,S.C., Veronesi,G., Essaghir,A.,
Demoulin,J.B., Pelosi,G., Alimohammadi,M., Oberg,K. and
Giandomenico,V.
TITLE Paraneoplastic antigen Ma2 autoantibodies as specific blood
biomarkers for detection of early recurrence of small intestine
neuroendocrine tumors
JOURNAL PLoS ONE 5 (12), E16010 (2010)
PUBMED 21209860
REMARK GeneRIF: Ma2 may have a role in early recurrence of small intestine
neuroendocrine tumors
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4846)
AUTHORS Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
Jurisica,I. and Li,S.S.
TITLE Systematic identification of SH3 domain-mediated human
protein-protein interactions by peptide array target screening
JOURNAL Proteomics 7 (11), 1775-1785 (2007)
PUBMED 17474147
REFERENCE 4 (bases 1 to 4846)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 5 (bases 1 to 4846)
AUTHORS Schuller,M., Jenne,D. and Voltz,R.
TITLE The human PNMA family: novel neuronal proteins implicated in
paraneoplastic neurological disease
JOURNAL J. Neuroimmunol. 169 (1-2), 172-176 (2005)
PUBMED 16214224
REFERENCE 6 (bases 1 to 4846)
AUTHORS Rosenfeld,M.R., Eichen,J.G., Wade,D.F., Posner,J.B. and Dalmau,J.
TITLE Molecular and clinical diversity in paraneoplastic immunity to Ma
proteins
JOURNAL Ann. Neurol. 50 (3), 339-348 (2001)
PUBMED 11558790
REFERENCE 7 (bases 1 to 4846)
AUTHORS Voltz,R., Gultekin,S.H., Rosenfeld,M.R., Gerstner,E., Eichen,J.,
Posner,J.B. and Dalmau,J.
TITLE A serologic marker of paraneoplastic limbic and brain-stem
encephalitis in patients with testicular cancer
JOURNAL N. Engl. J. Med. 340 (23), 1788-1795 (1999)
PUBMED 10362822
REFERENCE 8 (bases 1 to 4846)
AUTHORS Dalmau,J., Gultekin,S.H., Voltz,R., Hoard,R., DesChamps,T.,
Balmaceda,C., Batchelor,T., Gerstner,E., Eichen,J., Frennier,J.,
Posner,J.B. and Rosenfeld,M.R.
TITLE Ma1, a novel neuron- and testis-specific protein, is recognized by
the serum of patients with paraneoplastic neurological disorders
JOURNAL Brain 122 (PT 1), 27-39 (1999)
PUBMED 10050892
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA779744.1, BC047515.1, AB020690.1, BC036489.1 and AA025092.1.
On Sep 5, 2007 this sequence version replaced gi:61676176.
##Evidence-Data-START##
Transcript exon combination :: DA779744.1, BC036489.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-578 DA779744.1 1-578
579-2389 BC047515.1 484-2294
2390-3603 AB020690.1 1797-3010
3604-4014 BC036489.1 3534-3944
4015-4840 AB020690.1 3422-4247
4841-4846 AA025092.1 1-6 c
FEATURES Location/Qualifiers
source 1..4846
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p21.2"
gene 1..4846
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/note="paraneoplastic Ma antigen 2"
/db_xref="GeneID:10687"
/db_xref="HGNC:9159"
/db_xref="MIM:603970"
exon 1..152
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/inference="alignment:Splign:1.39.8"
exon 153..282
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/inference="alignment:Splign:1.39.8"
variation 231
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11558461"
exon 283..4846
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/inference="alignment:Splign:1.39.8"
variation 289
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/replace="a"
/replace="c"
/db_xref="dbSNP:2233699"
variation 522
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2233700"
misc_feature 741..743
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/note="upstream in-frame stop codon"
CDS 771..1865
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/note="onconeuronal antigen MA2; retrotransposon gag
domain containing 2; 40 kDa neuronal protein;
paraneoplastic neuronal antigen MM2"
/codon_start=1
/product="paraneoplastic antigen Ma2"
/protein_id="NP_009188.1"
/db_xref="GI:11464969"
/db_xref="CCDS:CCDS34868.1"
/db_xref="GeneID:10687"
/db_xref="HGNC:9159"
/db_xref="MIM:603970"
/translation="
MALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHEGDD
"
misc_feature 774..776
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q9UL42.2); acetylation site"
misc_feature 783..>911
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/note="Zinc peptidases M18, M20, M28, and M42; Region:
Zinc_peptidase_like; cl14876"
/db_xref="CDD:213133"
misc_feature 1389..>1607
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/note="Retrotransposon gag protein; Region:
Retrotrans_gag; pfam03732"
/db_xref="CDD:146393"
variation 1326
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2233701"
STS 2344..3603
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/standard_name="GDB:314949"
/db_xref="UniSTS:156503"
STS 3591..3659
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
variation 4015
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2197181"
STS 4617..4766
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/standard_name="SHGC-24390"
/db_xref="UniSTS:48292"
STS 4671..4846
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/standard_name="RH80943"
/db_xref="UniSTS:85234"
STS 4681..4787
/gene="PNMA2"
/gene_synonym="MA2; MM2; RGAG2"
/standard_name="SHGC-36722"
/db_xref="UniSTS:60476"
ORIGIN
gagcggtgctcaggggagggctggaggggagggaaggagagagagaggggagggcggcaccgcccctagccccgcgctccggaagtgaagcggccagaccaccagctaatggatgcggagcggagggcccgctgaccgctctccgcgcctggagcagcttggcttggctggagctaagagccagacacaccactgtgtggaggtgggtgatgtcttcctgtgctaaaaggtgaataaataagctcctcacctctcgcggaacactcgggaacacatcaacaggggtccaagccgccctgctgggaggcttctcttcaagagttctgggtcccagagtggaaggcattttcccatcaactggagagagacgaaacatcagagaccaggaggctgtggagaaagcagctgtcccaggtgcctcaactatcagagaagggtcagcgtcacgtggctgccagcatctttgagaaaatcactggcaatcggacttcagagctgcgggcacaggtgtggttagaactgagatacgacctgcccacctgggtcaggcctaaagacaagaagtcctgagttcttgccactgagtaggccagggtcatttgtccagaaaactttgtgactgtctttgagtgacctagtctgggacccattcattggtgggttctaaggttagaagctcatccaggatattttcaatattaagtcagtgcatagctgcaccactaacaaattggtgcctgtagagtcagagtgggtcaattcttaggacaatggcgctggcactgttagaggactggtgcaggataatgagtgtggatgagcagaagtcactgatggttacggggataccggcggactttgaggaggctgagattcaggaggtccttcaggagactttaaagtctctgggcaggtatagactgcttggcaagatattccggaagcaggagaatgccaatgctgtcttactagagcttctggaagatactgatgtctcggccattcccagtgaggtccagggaaaggggggtgtctggaaggtgatctttaagacccctaatcaggacactgagtttcttgaaagattgaacctgtttctagaaaaagaggggcagacggtctcgggtatgtttcgagccctggggcaggagggcgtgtctccagccacagtgccctgcatctcaccagaattactggcccatttgttgggacaggcaatggcacatgcgcctcagcccctgctacccatgagataccggaaactgcgagtattctcagggagtgctgtcccagccccagaggaagagtcctttgaggtctggttggaacaggccacggagatagtcaaagagtggccagtaacagaggcagaaaagaaaaggtggctggcggaaagcctgcggggccctgccctggacctcatgcacatagtgcaggcagacaacccgtccatcagtgtagaagagtgtttggaggcctttaagcaagtgtttgggagcctagagagccgcaggacagcccaggtgaggtatctgaagacctatcaggaggaaggagagaaggtctcagcctatgtgttacggctagaaaccctgctccggagagcggtggagaaacgcgccatccctcggcgtattgcggaccaggtccgcctggagcaggtcatggctggggccactcttaaccagatgctgtggtgccggcttagggagctgaaggatcagggcccgccccccagcttccttgagctaatgaaggtaatacgggaagaagaggaggaagaggcctcctttgagaatgagagtatcgaagagccagaggaacgagatggctatggccgctggaatcatgagggagacgactgaaaaccacctgggggcaggacccacagccagtgggctaagacctttaaaaaatttttttctttaatgtatgggactgaaatcaaaccatgaaagccaattattgaccttccttccttccttccttccctcccttcctccttctctccttctctcctcctctctcctctcctctcctctctttccttccttccttccttttttctttttctctttcttctttatttcttgggtctcactctcatcacccaggctagagtgcagtggcacaaaaatctcggctcactgcagccttgacttcccaggctcaggctcaggtgatcctcacaccttagcctcccaagtacctgggactacaggcacgcaccaccatgcctagctattcttttgtatttttggtagagacagggttttgctgtgttgctcaggctggtctggaacccctaggctcaaatgatgtgcccaactcggcctcccaaagtgctgggattacaggcatgaaccgccatgcctggcccttgatttttctttttaagaaaaaaatatctaggagtttcttagaccctatgtagattattaatgaacaaaagattaaactccaaatattaaatagtaagcctgaaggaatctgaaacacttgtacttccaattttctttaaataatcccaaatagaccagaattggcccataccatagaagaaagaattggcagtcaaaaaaaaaaataccttttgtaatgtttgaaaaataaagctgtttgacttgtcaggtgttttcctttctcaaatcagcaaattctctctgagtgcctggctttgtgagacactgtacaaggagttacaagactacagctataacctgcagttgagcagttataaacctacaaaatgggccctgccctcagagaggttccagtctagatgaggagctgatctagacaggtaaaaggctaactaaccctttgtgtaaataagttcatcaccccagtaaaagtgtcatcacccagtgaataggaccacctctgcctgcagatttttgttgttgttgttgtcattgttgttgttgttttaacctgggaagtgttcttcctgcctttctgctaggtgtcagatagatggtcccagagctaggtgctgtgtcaggccctgaagacacagatgactcaacctaagctttactttccagaggtccacagcctgagaggtgtccccaaagaaagggggacatgaggggactgcatgcttgagagcagggttgtttagggcaggtttggatttagtgagcaggctggtttgcttagagaaggcttttagtggcaacaaaggatgaagaggagagaaaaggaactcacatttattgagggcctactgtgtgcaaagtgtttcatgtatatctcattgaatgtatacagccaccctgttgtggtataattttgctctttataaagagaaagaccgaagctcagatgagttaagtggtctcctcaacaccaaaatgccaagaagtgatggagcctagacagaagcccagaactttctgactcacactagtccatcctctaccatcacgatgactttcaaattgtgctctgcagttctgcagattttctagcagtgccatctccaaaatgtgttttaaactctttatttttttaattattattagtattattttgagactgagtcttgctctatcacccaggctggagtgcagtggtgcaatctcagctcactgcaacctccgcctcccaggttcaagcgatttcgtgcctcagcctcccgagtagctgggattacaggcacccaccaccacgcccagctaatttttgtatttttagtagaaatggggtttcaccatgttggccaggctggtctcgaactcctgacctcaagtgatccactcacctcggcctcccaaagtgctgggattacaggtgtgagccaccatgcctgggctaaactctttaagtctctagtaaatgcagctagattcaaatgggctgataaccaaattttaacacatcagcattcaccaccaggtttacttttattttcagattggctcattttgtgcagaccttagagcaaagtttcctttatggtatctgtgtacgtatccaaacttcttttaattgttcacagattttaaaagcggtagcaccacatggttgtgtagatcagacctgtgtatttagatcagacctgtgtatcacgtaagtgtgtgagtgcagtgcagatgagcaccatttagttatatgtgctaggcaaatctccaacacagttgatgtgtagtcttgtggtagatttgtgcatactgtaagcaaattgcttagcttctctagacatcagtttccacatctgaaaaataagaagatgagagtacacggttgttatgaacaaatgacttaatgctttttaagcacgttgcatgacatctggaacacagaaagccctcaatacattgaagctcttaggattttcacgatgttcctgtctgctcaatgcatgctttctttattgttctgacagttgtgtggtaacaagctaatatgcttccagttgacttccagtctaccctggtgttagaaaccgtttcatctcttattgtaaatttgagtgcttgttgttttttatatttgtgatgactcttccagcagttgttgacaattgttagaggtttgacttttaaataattacttattttttctgattgtggttcagtttaactgaagaatatcctgagattgtaagaaaagcattttttaaaaggtatcacttgtgatcatttatctttctaaattctatttttaatactgttccaccaaagtgatgcagtggttaccatgacaccctaatttcatgtgtttttgtatttatgaaaatagtttcattgtcatttattggcggtatacaaagtaaaatgttataaatgtgaagttataaaataaatatatgctaataaaatcctgagtttttctgtttcct
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10687 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10687 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:10687 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
by
@meso_cacase at
DBCLS
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