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2024-04-18 20:49:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007198 2586 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proline synthetase co-transcribed homolog (bacterial)
(PROSC), mRNA.
ACCESSION NM_007198
VERSION NM_007198.3 GI:201862209
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2586)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
REFERENCE 2 (bases 1 to 2586)
AUTHORS Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
TITLE Cloning and characterization of human and mouse PROSC (proline
synthetase co-transcribed) genes
JOURNAL J. Hum. Genet. 44 (5), 337-342 (1999)
PUBMED 10496079
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA086552.1, BC012334.1, AL136616.1 and BM984988.1.
On Sep 16, 2008 this sequence version replaced gi:38788480.
##Evidence-Data-START##
Transcript exon combination :: BC012334.1, AL136616.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 DA086552.1 1-10
11-1569 BC012334.1 1-1559
1570-1606 AL136616.1 1550-1586
1607-2566 BC012334.1 1597-2556
2567-2586 BM984988.1 1-20 c
FEATURES Location/Qualifiers
source 1..2586
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11.2"
gene 1..2586
/gene="PROSC"
/note="proline synthetase co-transcribed homolog
(bacterial)"
/db_xref="GeneID:11212"
/db_xref="HGNC:9457"
/db_xref="HPRD:16060"
/db_xref="MIM:604436"
exon 1..176
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 54
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:367563760"
variation 69
/gene="PROSC"
/replace="a"
/replace="c"
/db_xref="dbSNP:371407450"
CDS 78..905
/gene="PROSC"
/note="proline synthetase co-transcribed (bacterial
homolog); proline synthetase co-transcribed bacterial
homolog protein"
/codon_start=1
/product="proline synthase co-transcribed bacterial
homolog protein"
/protein_id="NP_009129.1"
/db_xref="GI:6005842"
/db_xref="CCDS:CCDS6096.1"
/db_xref="GeneID:11212"
/db_xref="HGNC:9457"
/db_xref="HPRD:16060"
/db_xref="MIM:604436"
/translation="
MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH
"
misc_feature 126..821
/gene="PROSC"
/note="Pyridoxal 5-phosphate (PLP)-binding TIM barrel
domain of Type III PLP-Dependent Enzymes, Eukaryotic
YBL036c-like proteins; Region: PLPDE_III_YBL036c_euk;
cd06822"
/db_xref="CDD:143496"
misc_feature order(210..212,216..218,279..281,357..359,618..620,
624..626,750..755,798..809)
/gene="PROSC"
/note="pyridoxal 5'-phosphate (PLP) binding site [chemical
binding]; other site"
/db_xref="CDD:143496"
misc_feature 216..218
/gene="PROSC"
/note="catalytic residue [active]"
/db_xref="CDD:143496"
variation 121
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:151283151"
variation 123
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:139294873"
variation 131
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:201064928"
variation 133
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:149994926"
variation 141
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:11546424"
variation 147
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:35423325"
exon 177..284
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
STS 189..312
/gene="PROSC"
/standard_name="WI-15099"
/db_xref="UniSTS:18470"
variation 196
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:372260705"
variation 198
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:376835563"
variation 200
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:368217641"
variation 208..209
/gene="PROSC"
/replace=""
/replace="gggggg"
/db_xref="dbSNP:138293942"
variation 209
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:202002761"
variation 214
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:372469431"
variation 222
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:369269403"
variation 234
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:79148472"
variation 242
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:372146404"
variation 243
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:376512693"
variation 264
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:200513367"
variation 284
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:201043042"
exon 285..320
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
exon 321..396
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 358
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:201316839"
variation 365
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:113010140"
variation 368
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:147621253"
variation 395
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:142137105"
exon 397..531
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 406
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:370405023"
variation 439
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:143124940"
variation 455
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:148228365"
variation 470..471
/gene="PROSC"
/replace=""
/replace="c"
/db_xref="dbSNP:34593340"
variation 491
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:141202312"
variation 515
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:201540375"
variation 517
/gene="PROSC"
/replace="c"
/replace="g"
/db_xref="dbSNP:200888037"
variation 522
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:150307985"
exon 532..674
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 545
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:137861716"
variation 567
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:143064520"
variation 571
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:371828740"
variation 584
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:375765190"
variation 637
/gene="PROSC"
/replace="c"
/replace="g"
/db_xref="dbSNP:370158685"
exon 675..773
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 681
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:372681891"
variation 701
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:377188078"
variation 704
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:370091019"
variation 714
/gene="PROSC"
/replace="a"
/replace="c"
/db_xref="dbSNP:192760931"
variation 750
/gene="PROSC"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:146142368"
variation 753
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:201046156"
variation 757
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:374410929"
variation 758
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:149411400"
variation 773
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:200504564"
exon 774..2569
/gene="PROSC"
/inference="alignment:Splign:1.39.8"
variation 777
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:201663835"
variation 781
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:367850837"
variation 811
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:144784344"
variation 820
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:201217697"
variation 850
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:200291280"
variation 860
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:202115195"
variation 869
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:372209680"
variation 878
/gene="PROSC"
/replace="c"
/replace="g"
/db_xref="dbSNP:375421178"
variation 881
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:377626500"
variation 904
/gene="PROSC"
/replace="c"
/replace="g"
/db_xref="dbSNP:142848609"
variation 932
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:7463174"
variation 1091
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:192078875"
variation 1327
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:182297861"
variation 1369
/gene="PROSC"
/replace="a"
/replace="t"
/db_xref="dbSNP:145716070"
STS 1438..1660
/gene="PROSC"
/standard_name="RH44321"
/db_xref="UniSTS:16407"
variation 1467
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:186970213"
variation 1568
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:368690770"
variation 1645..1646
/gene="PROSC"
/replace=""
/replace="c"
/db_xref="dbSNP:34258343"
variation 1699
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:372833357"
variation 1838
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:112013908"
variation 1854
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:377083762"
variation 1860
/gene="PROSC"
/replace=""
/replace="a"
/db_xref="dbSNP:199594861"
variation 1879
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:191811786"
variation 1897
/gene="PROSC"
/replace="a"
/replace="c"
/db_xref="dbSNP:182752090"
variation 1905
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:372986893"
variation 1986
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:187033342"
variation 2005
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:370199109"
variation 2039
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:190005963"
variation 2121
/gene="PROSC"
/replace="a"
/replace="t"
/db_xref="dbSNP:79416495"
STS 2299..2545
/gene="PROSC"
/standard_name="RH76760"
/db_xref="UniSTS:89270"
STS 2308..2547
/gene="PROSC"
/standard_name="RH68230"
/db_xref="UniSTS:19870"
variation 2326
/gene="PROSC"
/replace="g"
/replace="t"
/db_xref="dbSNP:199658841"
variation 2402
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:368669428"
variation 2446
/gene="PROSC"
/replace="a"
/replace="g"
/db_xref="dbSNP:182305951"
variation 2454
/gene="PROSC"
/replace="c"
/replace="t"
/db_xref="dbSNP:117350570"
variation 2476
/gene="PROSC"
/replace="c"
/replace="g"
/db_xref="dbSNP:79077193"
ORIGIN
gcaagctgggcggaaccggaagatggtgtgagccacgggctgccgggggcctggggctcggcgtcggtccccgggggatgtggagagctggcagcatgtcggccgagctgggagtcgggtgcgcattgcgggcggtgaacgagcgcgtgcagcaggctgtggcgcggcggccgcgggatctcccagccatccagccccggctagtggcggtcagcaaaaccaaacctgcagacatggtgatcgaggcctatggacatgggcagcgcacttttggcgagaactacgttcaggaactgctagaaaaagcatcaaatcccaaaattctgtctttgtgtcctgagatcaaatggcacttcattggccacctacagaaacaaaatgtcaacaaattgatggctgtccccaatctcttcatgctggaaacagtggattctgtgaagttggcagacaaagtgaacagttcctggcagagaaaaggttctcctgaaaggttaaaggttatggtccagattaacaccagcggagaagagagtaaacatggccttccaccttcagagaccatagccatcgtggagcacataaacgccaagtgtcctaacctggagtttgtggggctgatgaccataggaagctttgggcatgatcttagtcaaggaccaaatccagacttccagctgttattgtccctccgggaggagctgtgtaaaaagctgaacatccctgctgaccaggttgagctgagcatgggcatgtccgcggatttccagcatgcggttgaagtaggatctacaaatgtccgaataggaagcacgatttttggagagcgggattactcaaagaaacccaccccggacaagtgcgcagcagacgtgaaggccccgctggaggtggcacaggagcactgagccagggaatactgagagcactaactatgcactaacctagattttcatttcgatattccctgtgtcccagcgcagtcctgctctcctgtgacctgtggagagcactaatgatcacgtgtgttgatggaaaccatctgtgcttagtctctgacataggaagcttgcttcaggcaatggctttggattgagtttgagaaattcaaacatttctgcagaacagataccaaatcaatagctaggaatcatgttcaatattgaattctgcccaggagcatgaactgatccatgaatgccttttccaggttaaaatttggtcactgatgcctataatcgtggaagtcagagggattcccctttttcatctcattttaataggaaaattccttatggttaacatctccctacaaactcctactacgtcgtctaaattgctgctctggaataaggtgatttctgcccccagattcttccctagccggtagatacgtgaagatattcccaactgtggaatggcagtgtaggtagcttcaggaaatggctcaggttaattctcaaaacacaaattgttgctggccaggcatggtgactcatgcctgtaatcccagcaatttgggagacagaggcggaaggatcacctgagcctaggagttcaagaccagcctcagcaacagcaggagccccaccccccgtctctacaaaaaaatttaaaaattaactgggcatggtggctgaggtggaagaatggaagaatcacttgagcccaggagtttgaggctgcagtgagctatgattgcaccactgtactcctgccttaaaaaaaaaaaaaaaatcccaatagtccatgaaggctttgatctcttgggaagttcttcatagatgctgtcacatttcttaaagcaaccttttaatatgcagataataccccccaacttttttagagacagcctgtctcttaaaaaaaaaattaatttggtagtgagagcttgtgtcactgccactctgttttatccctgaaattaaaggataacataaggaggacttgggcctttctgacatcatcctgaagagacaggactttgcgtttttcctctgggacctacagtgatgagaatttaatgattatctcctccactataatcctctttagggtgattttttaaatcaaaacccagtgaatctcattactcctaagaaacgaaagattccttcaaagccttttcaggcacatggtttcaacaaagcctggctttgacattccttgtcctgaggagcactttccaggcatagttacagcttccccactgtatttacaagccagaattgtgcaactcttctggatcattaataaagtagcaagatcctcaaaaaacccaaaaacaccattctctaatagtcatgacaaatggcttcagtatggcttgttttttattttccagatggctttttctcttattttttgaagccccagtctttgattttacaggtaactttcaaaacatcatgatgctgccaaatgtacttttgtaaacttaaacattatgattcctgtattatttcagtgagagctacagtgtgatatttcagagtctattaaataaaaatgtgagtttgaattacaccatctgtgccaattacaaagcaattaaaagatttattttttatgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11212 -> Molecular function: GO:0030170 [pyridoxal phosphate binding] evidence: IBA
GeneID:11212 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:11212 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
GeneID:11212 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
GeneID:11212 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
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