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2024-04-20 16:07:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007050 12644 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, receptor type, T
(PTPRT), transcript variant 2, mRNA.
ACCESSION NM_007050
VERSION NM_007050.5 GI:148539859
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 12644)
AUTHORS Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
TITLE Loci associated with N-glycosylation of human immunoglobulin G show
pleiotropy with autoimmune diseases and haematological cancers
JOURNAL PLoS Genet. 9 (1), E1003225 (2013)
PUBMED 23382691
REFERENCE 2 (bases 1 to 12644)
AUTHORS Pasquo,A., Consalvi,V., Knapp,S., Alfano,I., Ardini,M.,
Stefanini,S. and Chiaraluce,R.
TITLE Structural stability of human protein tyrosine phosphatase rho
catalytic domain: effect of point mutations
JOURNAL PLoS ONE 7 (2), E32555 (2012)
PUBMED 22389709
REMARK GeneRIF: The catalytic domain point mutants show a decreased
thermal and thermodynamic stability and decreased activation energy
relative to phosphatase activity, when compared to wild- type
REFERENCE 3 (bases 1 to 12644)
AUTHORS Scott,A. and Wang,Z.
TITLE Tumour suppressor function of protein tyrosine phosphatase
receptor-T
JOURNAL Biosci. Rep. 31 (5), 303-307 (2011)
PUBMED 21517784
REMARK GeneRIF: [review] High-throughput mutational analysis identifies
loss-of-function mutations in six PTPs in human colon cancers,
providing critical cancer genetics evidence that PTPs can act as
tumour suppressor genes.
Review article
REFERENCE 4 (bases 1 to 12644)
AUTHORS Zhao,Y., Zhang,X., Guda,K., Lawrence,E., Sun,Q., Watanabe,T.,
Iwakura,Y., Asano,M., Wei,L., Yang,Z., Zheng,W., Dawson,D.,
Willis,J., Markowitz,S.D., Satake,M. and Wang,Z.
TITLE Identification and functional characterization of paxillin as a
target of protein tyrosine phosphatase receptor T
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (6), 2592-2597 (2010)
PUBMED 20133777
REMARK GeneRIF: Data show that paxillin is a direct substrate of PTPRT and
that PTPRT specifically regulates paxillin phosphorylation at
tyrosine residue 88(Y88).
REFERENCE 5 (bases 1 to 12644)
AUTHORS Wang,Z., Shen,D., Parsons,D.W., Bardelli,A., Sager,J., Szabo,S.,
Ptak,J., Silliman,N., Peters,B.A., van der Heijden,M.S.,
Parmigiani,G., Yan,H., Wang,T.L., Riggins,G., Powell,S.M.,
Willson,J.K., Markowitz,S., Kinzler,K.W., Vogelstein,B. and
Velculescu,V.E.
TITLE Mutational analysis of the tyrosine phosphatome in colorectal
cancers
JOURNAL Science 304 (5674), 1164-1166 (2004)
PUBMED 15155950
REFERENCE 6 (bases 1 to 12644)
AUTHORS Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
TITLE Genomic organization and alternative splicing of the human and
mouse RPTPrho genes: Correction
JOURNAL BMC Genomics 2, 5 (2001)
PUBMED 11814386
REFERENCE 7 (bases 1 to 12644)
AUTHORS Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
TITLE Genomic organization and alternative splicing of the human and
mouse RPTPrho genes
JOURNAL BMC Genomics 2, 1 (2001)
PUBMED 11423001
REFERENCE 8 (bases 1 to 12644)
AUTHORS McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
TITLE Identification and characterization of RPTP rho, a novel RPTP
mu/kappa-like receptor protein tyrosine phosphatase whose
expression is restricted to the central nervous system
JOURNAL Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998)
PUBMED 9602027
REFERENCE 9 (bases 1 to 12644)
AUTHORS McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
Chiu,I.M., Burghes,A.H. and Rotter,A.
TITLE Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
fibroblast growth factor (FGF-1) transcripts delineate a
rostrocaudal boundary in the granule cell layer of the murine
cerebellar cortex
JOURNAL J. Comp. Neurol. 391 (4), 444-455 (1998)
PUBMED 9486824
REFERENCE 10 (bases 1 to 12644)
AUTHORS Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
and Nomura,N.
TITLE Construction and characterization of human brain cDNA libraries
suitable for analysis of cDNA clones encoding relatively large
proteins
JOURNAL DNA Res. 4 (1), 53-59 (1997)
PUBMED 9179496
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF043644.4, AL021395.16,
AB006621.2, AL707728.1, DA791336.1 and R50970.1.
On Jun 2, 2007 this sequence version replaced gi:48762923.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP possesses an extracellular
region, a single transmembrane region, and two tandem intracellular
catalytic domains, and thus represents a receptor-type PTP. The
extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
Ig-like and fibronectin type III-like repeats. The protein domain
structure and the expression pattern of the mouse counterpart of
this PTP suggest its roles in both signal transduction and cellular
adhesion in the central nervous system. Two alternatively spliced
transcript variants of this gene, which encode distinct proteins,
have been reported. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) lacks a fragment within the
coding region when compared to variant 1. The translation remains
in-frame, and thus encodes a protein that lacks an internal
segment, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC153300.1, AB006621.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-268 AF043644.4 1-268
269-272 AL021395.16 19423-19426 c
273-1242 AB006621.2 181-1150
1243-1347 AL707728.1 48-152
1348-4044 AB006621.2 1256-3952
4045-4528 AF043644.4 4111-4594
4529-9906 AB006621.2 4437-9814
9907-10249 DA791336.1 232-574
10250-12615 AB006621.2 10158-12523
12616-12644 R50970.1 1-29 c
FEATURES Location/Qualifiers
source 1..12644
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q12-q13"
gene 1..12644
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="protein tyrosine phosphatase, receptor type, T"
/db_xref="GeneID:11122"
/db_xref="HGNC:9682"
/db_xref="MIM:608712"
exon 1..272
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
CDS 185..4510
/gene="PTPRT"
/gene_synonym="RPTPrho"
/EC_number="3.1.3.48"
/note="isoform 2 precursor is encoded by transcript
variant 2; receptor protein tyrosine phosphatase;
receptor-type tyrosine-protein phosphatase T; R-PTP-T;
RPTP-rho; receptor-type tyrosine-protein phosphatase rho"
/codon_start=1
/product="receptor-type tyrosine-protein phosphatase T
isoform 2 precursor"
/protein_id="NP_008981.4"
/db_xref="GI:148539860"
/db_xref="CCDS:CCDS42874.1"
/db_xref="GeneID:11122"
/db_xref="HGNC:9682"
/db_xref="MIM:608712"
/translation="
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
"
sig_peptide 185..259
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 260..4507
/gene="PTPRT"
/gene_synonym="RPTPrho"
/product="receptor-type tyrosine-protein phosphatase T
isoform 2"
misc_feature 278..751
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Meprin, A5 protein, and protein tyrosine
phosphatase Mu (MAM) domain. MAM is an extracellular
domain which mediates protein-protein interactions and is
found in a diverse set of proteins, many of which are
known to function in cell adhesion. Members...; Region:
MAM; cd06263"
/db_xref="CDD:99706"
misc_feature 287..292
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="putative adhesion site; other site"
/db_xref="CDD:99706"
misc_feature 767..1039
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:213125"
misc_feature 1049..1264
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Fibronectin type 3 domain; Region: FN3; smart00060"
/db_xref="CDD:197496"
misc_feature 1352..1624
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1544..1546,1589..1591)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1592..1597,1601..1603)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1688..1936
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1856..1858,1901..1903)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1904..1909,1913..1918)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2426..2488
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14522.6);
transmembrane region"
misc_feature 2846..3610
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 2927..3610
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(3338..3340,3431..3436,3443..3445,3452..3457)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="active site"
/db_xref="CDD:28929"
misc_feature 3434..3454
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14522.6);
Region: Substrate binding (By similarity)"
misc_feature 3704..4492
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 3794..4492
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(4208..4210,4313..4318,4325..4327,4334..4339)
/gene="PTPRT"
/gene_synonym="RPTPrho"
/note="active site"
/db_xref="CDD:28929"
exon 273..398
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 399..670
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 671..752
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 753..868
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 869..1043
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 910
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:34099024"
exon 1044..1337
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 1338..1634
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 1635..1744
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 1745..1946
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 1897
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:35858700"
exon 1947..2049
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2050..2323
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2324..2360
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2361..2496
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2497..2526
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2527..2675
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2676..2866
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 2698
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:35071062"
exon 2867..2954
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 2955..3031
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 3032..3068
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 3034
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:36105887"
exon 3069..3166
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 3124
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:34284587"
exon 3167..3283
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 3284..3438
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 3439..3574
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 3575..3724
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 3725..3898
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 3814
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:35010609"
exon 3899..4030
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 4031..4156
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 4045
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:2016647"
variation 4093
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:34623060"
exon 4157..4320
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 4321..4456
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
exon 4457..12637
/gene="PTPRT"
/gene_synonym="RPTPrho"
/inference="alignment:Splign:1.39.8"
variation 4474
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:35393708"
variation 4496
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:35066008"
variation 7563
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="c"
/db_xref="dbSNP:201337579"
variation 7673
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:1065155"
variation 7734
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:877431"
STS 8188..8367
/gene="PTPRT"
/gene_synonym="RPTPrho"
/standard_name="RH66086"
/db_xref="UniSTS:51297"
STS 8451..8591
/gene="PTPRT"
/gene_synonym="RPTPrho"
/standard_name="G31023"
/db_xref="UniSTS:46687"
variation 9181
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:3746538"
variation 9907
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:3787281"
variation 9926
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:3827068"
variation 10122
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="a"
/replace="g"
/db_xref="dbSNP:3787282"
variation 10353..10354
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace=""
/replace="g"
/replace="tg"
/db_xref="dbSNP:3838029"
STS 11414..11545
/gene="PTPRT"
/gene_synonym="RPTPrho"
/standard_name="D20S591E"
/db_xref="UniSTS:60724"
variation 11764..11765
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace=""
/replace="tttgc"
/db_xref="dbSNP:3833311"
variation 11958
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace="c"
/replace="t"
/db_xref="dbSNP:3746539"
STS 12305..12445
/gene="PTPRT"
/gene_synonym="RPTPrho"
/standard_name="RH104430"
/db_xref="UniSTS:98755"
variation 12414
/gene="PTPRT"
/gene_synonym="RPTPrho"
/replace=""
/replace="t"
/db_xref="dbSNP:3838030"
STS 12500..12624
/gene="PTPRT"
/gene_synonym="RPTPrho"
/standard_name="G42933"
/db_xref="UniSTS:94828"
polyA_signal 12598..12603
/gene="PTPRT"
/gene_synonym="RPTPrho"
polyA_site 12637
/gene="PTPRT"
/gene_synonym="RPTPrho"
ORIGIN
cctcccgcctcagttcgcgccgcgcctcggcttggaacgcaggagcgccggctccgggagcccgagcggagccagccgcgcgcacagccagcggccgcgccggcgatgcggggccaccccgcgcccgccccagtcccggccccggcccccgcgggaaggggctgagctgcccgccgccgcccggatggcgagcctcgccgcgctcgccctcagcctgctcctgaggctgcagctgccgccactgcccggcgcccgggctcagagcgccgcaggtggctgttcctttgatgagcactacagcaactgtggttatagtgtggctctagggaccaatgggttcacctgggagcagattaacacatgggagaaaccaatgctggaccaggcagtgcccacaggatctttcatgatggtgaacagctctgggagagcctctggccagaaggcccaccttctcctgccaaccctgaaggagaatgacacccactgcatcgacttccattactacttctccagccgtgacaggtccagcccaggggccttgaacgtctacgtgaaggtgaatggtggcccccaagggaaccctgtgtggaatgtgtccggggtcgtcactgagggctgggtgaaggcagagctcgccatcagcactttctggccacatttctatcaggtgatatttgaatccgtctcattgaagggtcatcctggctacatcgccgtggacgaggtccgggtccttgctcatccatgcagaaaagcacctcattttctgcgactccaaaacgtggaggtgaatgtggggcagaatgccacatttcagtgcattgctggtgggaagtggtctcagcatgacaagctttggctccagcaatggaatggcagggacacggccctgatggtcacccgtgtggtcaaccacaggcgcttctcagccacagtcagtgtggcagacactgcccagcggagcgtcagcaagtaccgctgtgtgatccgctctgatggtgggtctggtgtgtccaactacgcggagctgatcgtgaaagagcctcccacgcccattgctcccccagagctgctggctgtgggggccacatacctgtggatcaagccaaatgccaactccatcatcggggatggccccatcatcctgaaggaagtggaatatcgcaccaccacaggcacgtgggcagagacccacatagtcgactctcccaactataagctgtggcatctggaccccgatgttgagtatgagatccgagtgctcctcacacgaccaggtgaggggggtacgggaccgccagggcctcccctcaccaccaggaccaagtgtgcagatccggtacatggcccacagaacgtggaaatcgtagacatcagagcccggcagctgaccctgcagtgggagcccttcggctacgcggtgacccgctgccatagctacaacctcaccgtgcagtaccagtatgtgttcaaccagcagcagtacgaggccgaggaggtcatccagacctcctcccactacaccctgcgaggcctgcgccccttcatgaccatccggctgcgactcttgctgtctaaccccgagggccgaatggagagcgaggagctggtggtgcagactgaggaagacgttccaggagctgttcctctagaatccatccaaggggggccctttgaggagaagatctacatccagtggaaacctcccaatgagaccaatggggtcatcacgctctacgagatcaactacaaggctgtcggctcgctggacccaagtgctgacctctcgagccagagggggaaagtgttcaagctccggaatgaaacccaccacctctttgtgggtctgtacccagggaccacctattccttcaccatcaaggccagcacagcaaagggctttgggccccctgtcaccactcggattgccaccaaaatttcagctccatccatgcctgagtacgacacagacaccccattgaatgagacagacacgaccatcacagtgatgctgaaacccgctcagtcccggggagctcctgtcagtgtttatcagctggttgtcaaggaggagcgacttcagaagtcacggagggcagctgacattattgagtgcttttcggtgcccgtgagctatcggaatgcctccagcctcgattctctacactactttgctgctgagttgaagcctgccaacctgcctgtcacccagccatttacagtgggtgacaataagacatacaatggctactggaaccctcctctctctcccctgaaaagctacagcatctacttccaggcactcagcaaagccaatggagagaccaaaatcaactgtgttcgtctggctacaaaaggtgcctccacccagaattctaacactgtggagccagagaagcaggtggacaacaccgtgaagatggctggcgtgatcgctggcctcctcatgttcatcatcattctcctgggcgtgatgctcaccatcaaaaggagaagaaatgcttattcctactcctattacttgaagctggccaagaagcagaaggagacccagagtggagcccagagggagatggggcctgtggcctctgccgacaaacccaccaccaagctcagcgccagccgcaatgatgaaggcttctcttctagttctcaggacgtcaacggattcacagatggcagccgcggggagctttcccagcccaccctcacgatccagactcatccctaccgcacctgtgaccctgtggagatgagctacccccgggaccagttccaacccgccatccgggtggctgacttgctgcagcacatcacgcagatgaagagaggccagggctacgggttcaaggaggaatacgaggccttaccagaggggcagacagcttcgtgggacacagccaaggaggatgaaaaccgcaataagaatcgatatgggaacatcatatcctacgaccattcccgggtgaggctgctggtgctggatggagacccgcactctgactacatcaatgccaactacattgacggataccatcgacctcggcactacattgcgactcaaggtccgatgcaggagactgtaaaggacttttggagaatgatctggcaggagaactccgccagcatcgtcatggtcacaaacctggtggaagtgggcagggtgaaatgtgtgcgatactggccagatgacacggaggtctacggagacattaaagtcaccctgattgaaacagagcccctggcagaatacgtcatacgcaccttcacagtccagaagaaaggctaccatgagatccgggagctccgcctcttccacttcaccagctggcctgaccacggcgttccctgctatgccactggccttctgggcttcgtccgccaggtcaagttcctcaaccccccggaagctgggcccatagtggtccactgcagtgctggggctgggcggactggctgcttcattgccattgacaccatgcttgacatggccgagaatgaaggggtggtggacatcttcaactgcgtgcgtgagctccgggcccaaagggtcaacctggtacagacagaggagcaatatgtgtttgtgcacgatgccatcctggaagcgtgcctctgtggcaacactgccatccctgtgtgtgagttccgttctctctactacaatatcagcaggctggacccccagacaaactccagccaaatcaaagatgaatttcagaccctcaacattgtgacaccccgtgtgcggcccgaggactgcagcattgggctcctgccccggaaccatgataagaatcgaagtatggacgtgctgcctctggaccgctgcctgcccttccttatctcagtggacggagaatccagcaattacatcaacgcagcactgatggatagccacaagcagcctgccgccttcgtggtcacccagcaccctctacccaacaccgtggcagacttctggaggctggtgttcgattacaactgctcctctgtggtgatgctgaatgagatggacactgcccagttctgtatgcagtactggcctgagaagacctccgggtgctatgggcccatccaggtggagttcgtctccgcagacatcgacgaggacatcatccacagaatattccgcatctgtaacatggcccggccacaggatggttatcgtatagtccagcacctccagtacattggctggcctgcctaccgggacacgcccccctccaagcgctctctgctcaaagtggtccgacgactggagaagtggcaggagcagtatgacgggagggagggacgtactgtggtccactgcctaaatgggggaggccgtagtggaaccttctgtgccatctgcagtgtgtgtgagatgatccagcagcaaaacatcattgacgtgttccacatcgtgaaaacactgcgtaacaacaaatccaacatggtggagaccctggaacagtataaatttgtatacgaggtggcactggaatatttaagctccttttagctcaatgggatggggaacctgccggagtccagaggctgctgtgaccaagcccccttttgtgtgaatggcagtaactgggctcaggagctctgaggtggcaccctgcctgactccaaggagaagactggtggccctgtgttccacggggggctctgcaccttctgaggggtctcctgttgccgtgggagatgctgctccaaaaggcccaggcttccttttcaacctaaccagccacagccaagggcccaagcagaagtacacccacaagcaaggccttggatttctggctcccagaccacctgcttttgttctgagtttgtggatctcttggcaagccaactgtgcaggtgctggggagtgggaggctcccctgccctccttctccttaggagtggaggagatgtgtgttctgctcctctacgtcatggaaaagattgaggctcttgggggtcactgctctgctgccccctgcaacctccttcaggggcctctggcaccagacatttgcagtctggaccagtgtgaccttacgatgttccctaggccacaagagaggccccccatcctcacacctaacctgcatggggcttcgcccacaaccattctgtaccccttccccagcctgggccttgaccgtccagcattcactggccggccagctgtgtccacagcagtttttgataaaggtgttctttgcttttttgtgtggtcagtgggagggggtggaactgcagggaacttctctgctcctccttgtctttgtaaaaagggaccacctccctggggcagggcttgggctgacctgtaggatgtaacccctgtgtttctttggtggtagctttctttggaagagacaaacaagataagatttgattattttccaaagtgtatgtgaaaagaaactttcttttggagggtgtaaaatcttagtctcttatgtcaaaaagaagggggcgggggagtttgagtatgtacctctaagacaaatctctcgggccttttattttttcctggcaatgtccttaaaagctcccaccctgggacagcatgccactgagcaaggagagatgggtgagcctgaagatggtccctttggtttctggggcaaatagagcaccagctttgtgcataatttggatgtccaaatttgaactccttcctaaagaaacccagcagccaccttgaaaaaggccattgtggagcccattatactttgatttaaaataggccaagagaatcaggcctggagatctagggtcttgtccaaagtgtgagtgagtcaatgagagggaaccaacatttgctaagtctctactgtatgccagggatcatgcttggcactttccataggacatttcacacagtccttagaacccccaggagagagctactgacttgttatcatctccatttgatcatctcctccaatgaggaaacccacgcaccttccttagtaatgaaatcctgggttccaaaggggcaggtaatggcaatgagacttctccgtgctgttttcttcatcttctctaagccaagcaattattttatggagggaaaataaggccagaaacttctgagcagataactccacaaatggaaatttagtactttcttcctgatgccagttcttctgggaagcgcagaatttcagatatattttagtaacacattcccagctccccaggaaagccagtctcatctaatttcttagtcagtaaaaacaattccctgttccttcaggctatgaatggaccagccagggaaactctcgaccttgatctctagccagtgcttaggcccaatatctgacagcctcaggtgggctgggacctaggaagctccatcttgaaggctggtctagccccagacagggcatgaggggcagagaattcaagaaggtacagctttggccctcaagagcccactgtatgctggggaaatggaaccatggtgcagtagtgtggagtggatgagtgttccatgagcctaggagcaagaaagtctcttcggcctcgggcttcctggagaaggggacgtccattcctgctgggtcttaacaagcataaaaaggaaaaaaaggaaactcaggcaaagggatccatatgtgcaatggcaaagaaatgtgaaaaggcattgggagaagcagtctgggggaggccagcccagtgcgggcacagcacaacacggggagcagcaagagatgagccagggtccaggagacagatgcccatcgcgagtacagactttgtcctattggcaacaaggagtccatggagctttagagagatgcactcagcttcgtgttggccaagactccttctgggccaatggggctgcctcttttcctttcatcagacactgtgaaaacattcccttaagcgtgcactttttaatatcacatctatttgtctgtctgctcattgttttgttgctggaactaaatatgcaatggatcatgagactcagattctatgagaaacccagggtctctgctttaccacggagcagggtcaccaacccagatctccaggcccatgaggatggaacatgaaaggagccgacaaaagttgcttccattggcatgggctctggagctgtccagaagtccagggacaccagacttgatcaaggaagggctgtcactttagaggttcaaaaggaagtgcctcaaagcaaaggcaagcaaaggaaccccacgatgaacttgctcttttcctttgatgagcctctccccaggtgtatttcagcagaccccggggacccacccccactgggcctgctggcctccctcggctccagcccaatgccccagctggccttccccagcctgcaaggagcctgtagcatggcaaatctgcctgctgtatgctattttcttagatcttggtacatccagacaggatgagggtggagggagagctatttaacacaaatcctaagatttttttctgctcaggaaggggtgaaatagctggcagatacaaaagacagtggcttttatcattttaaatggtaggaatttaaggtgtgacttcagggagaaacaaacttgcaaaaaaaaaaaatctcaggccatgttggggtaacccagcaagggccagtgatgatttcccccagctcatccccttattttcccacaacccaaccattctctaaagcaggacagtgaataggtcttaggccagtgcacacaggaagaaattgaggcttatggatggggatgacttccctaagatcccatgggacaaggatgtggcaaggcttggatgagatggggcaccagtgcccaggaatttgaacattttcctttacccaggaaatctccggagccaacaccaccacccccagggggtctccccaccccaccccatttacagggtgagctcagcctgtcatgagcagaggaaaatattattaatgctctctgagtctttacaacaggagctcttacctcatagatgtgggctctgtttggggaagatgcaaggaagtaatgagaagcccaggaaatttctccacctgtgtttatggcctaaatagcttcaggatgtatcttagctgcactccaacattgcatcctttctggggtgaagaatctgggccaaccaggggtccttgggcctctagaaggccacagtaggcctctctttgtgggaatggaaggggacagtttgcttttagtgctggccctctctgtgggtgtggcctgcaaaggaaccaacagaccctatgctggggactctaacatgtgagctcattaaattcttccagcattctaaaggagggtttgtgattgtcaccatttactgatgaggaaactaaggctcctaggggagaaatcacttgcccacagttccacagctagtgagtgaatgaaccaggatttaaaccggttttttctcactacagagacaatatttttccaccattgtatctcacatttttcccaggaggttacccataacagaagagactagagtggaacagatacgtcagtggataaagctcaaagcaaacaacagtaagcttaaaattccttcatagtctcatgttttacgttcacaattcatgcaaaatttgcattccactttctgatttagccttgttggttttaatatgactctatgaatatttcaaaaaaaaatgtgctctgttcctcatgttgttctgttctgttcaccccgctatgacggaccctaggtcagctggtcttcagcttgaccctagaattgactctaggagcagtgaccctgctgcctcccagagccagttataggctcaagatcaagaccaactgaccttctcctaggcagctcctttggtgtgtgggtgctctgacctcactgttcatgaggggacctcaactaaggcatcttccagttgggtgctggaaggaacccattaactcacactagaatgatgaggatttgctcatctggcgtggagaaggatgagcccacaaaaccctaaagggaaaagagaagctggacacagctgtactcagcagattcctgaatgctaggctggaaagtggtgcctgttgtccaagtggagtcacatggttgctaatgtgggcaagtctgaggacacacttcatgagcagctggggtctggaaggctcctcactttaccctagccacacataattactgggtgcctacagcacctagcaccttggagggggcactattaggaaatcgagattactatggcacaattaattcctgggtaaggcatggggttgtggtggacagagctcagtctttagtttgaacgaaaacatacatacatgaaaaacatacatgaaaaaaggaccctcatcaacattagaaggggtagatttggagcactttaggcaggaaaacaggaacgcaaggccaggaaactggaacccagtgaatactcagaaccgaggatgcagatgacttatttagcaaaatggtcacttctgtgacatagctggagaaaggatgggtaacagcttgccagagccacttggaacaagggcaaatctcagtgtctggggcaaaagatgatgcatttccctctgacccatcatgtttattcatcctccactccccattgccacactagctcttgctgtaagtcctcaccaggatctacatttcctcgtcgctggtgggaaccccttagagtacatagaggtatcagtccagtaagactgctctacacaacagaagtgaggcccagggagtagcagccaggcccttatcctgttacctctgcaggagtgactgcccaacccagatccagagacattgaaggaaatgataattccttggtacctcactgccttgggacaaaatgaagaaagccacccttccttaggctgcagcttgccactcctgggctgggtaaacaggtcatcagcaccaagctcaaccaggagtaacactctggaagacatgggtgagcccaagaggaagcatgaacaggacgctgttcctaagtcatgtcaacaggttgtgctgggccaggatccccagggaaaaaaatggtcaacccaactggagggtaggttagaagaaaaaaaacataaacgtggatagtcatgtcatctcaaatccctgacttggcttccccattacttaacagtctgagctccttcttagcctgtgaccagcttcaaatcacagccaagtaaaacaaggaaataggaaaagtaaatccaactagaagagacaagctgagattcagatttgtttactcctcccatgcaaagtttccctgttggaggttttccatgtatacatgtctagaagtgatagaatgcaaggccttggctttgtcttgcagggatctgcctttgaggtcatagactgaacagcagggagagaggttagtggtggagtgtggggggagctgttctagctccagtttcttctgacacatttttcaggatcatggatctgatcctccgaagcacagcagagatatctaagccatatttgtgcacatgagcagactcttctagttttttagtaaccagggatgggcttttgcatggcactgactatagagatgtcttgtagagatcaagccagtcttttgcatcccacctgcccacctccagaagagatgggaaaaggtcatcaaagggcattcaccaactgaaatccactcatgaatgttaggtctctaaaaggaggcatcaacactcacaatggtagcctccaaacctagcatcccacctatctaagagctcaggggtggtccactggggcagatacaagggaagtgcaagggctcaggatgaaagaaaatctattgggaagagttttaggggcttgatcattatggggcttccttctatatctgagaactgctctgggtggtgagatgtggactctgatccttaattggaatgttcggagaatgagtgtctggtggccttgaagtgttggacagaaaagtatcagtataaaagcctggagctcagggtaattaatgtagttcatggttccttagtgagcaggactcttggatgtggaggagaaagggtcataggaagtaaaccaccaaaattacaaaattgagtctctgtacaattacttcagtgcctttgggcttatgaatacaaatcagtgggccttctctatgatggtccaacaaactctcagtgtccaccctgtccctgtatctcccatggaagatgaataatgtcaggtgttctttgggtcaaaggccccagggcagtctggaggcttagagggcagagtggtgtcattccatgtaaagttaggcttctgaggggtcaggcagaatatggtgtccatatcttccatagctctgcagattcttggatgaagtcaagcacagtttgctagacccaggtcactcctctgagtataactaggacccatgagtgaaacttaatagctgtaaggaagaacctgctgtctgccagagaggataagctgcccatctcagcagctgtctaaaagaaggcaggtgtctctttaaagggaagagaagcattggtgaaatggatttcaggtcacttccattccagatgggtgagatcttgtggagctgggatcatgtttgaactcattcatacctgtagagcacgaatccaagtagattgtgtttggtctgtacaggctgaagccccctgctctcccacccaagtgcccccactgagcaggccaacatgctgttgtggccacatatactgggctgatccaggctggttatcaccaaacagcaaaccatagggaacagctgctttgccatagacccaatacccatgtagatctctcatgagagcagccataactcagacccactgaccaacagggccatgagtgacagccagaaccagtgaaggtccaagtaggacacagagcagggcttttcttaccatacacattatctccagaggttatttctaccccactccctattcaaggcctgttggagcacactgcaaaagcaaaagcacagtaactcaatttacacatgattataatcatttccagtgcacacatttcatcaccaggtggatcctgagctagcccatgtaaatccgggttaacccatattggtaatcatactcaaaagcacttttcaccctacattctactagccaatcaaagacaaagagttgtggcctctaccattgccttggcttctggacaccctcacaagctatcccaaggttcccgctcaactccagggaggctgacatcttcacatccactgggcatataatattgcatgagaccaaagtctccacactctttgcagcctcctccatgaatcccaatggcctgcacttgtacagtttgggtgtttgatagataaagcacgtatgagaagagaaaacaaaataaatcaactttttaaaaaagccagcactgtgctgtcaatgttttttttttcttttcaattctagctcagaaaagcagaaggtaaataatgtcaggtcaatgaatatcagatatattttttgactgtacattacagtgaagtgtaatctttttacacctgcaagtccatcttatttattcttgtaaatgttccctgacaatgtttgtaatatggctgtgttaaaaaatctatacaataaagctgtgaccctgagattcatgttttcctaagataaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11122 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IMP
GeneID:11122 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:11122 -> Molecular function: GO:0008013 [beta-catenin binding] evidence: IPI
GeneID:11122 -> Molecular function: GO:0016790 [thiolester hydrolase activity] evidence: IEA
GeneID:11122 -> Molecular function: GO:0045294 [alpha-catenin binding] evidence: IDA
GeneID:11122 -> Molecular function: GO:0045295 [gamma-catenin binding] evidence: IDA
GeneID:11122 -> Molecular function: GO:0045296 [cadherin binding] evidence: IPI
GeneID:11122 -> Molecular function: GO:0051393 [alpha-actinin binding] evidence: IEA
GeneID:11122 -> Molecular function: GO:0070097 [delta-catenin binding] evidence: IPI
GeneID:11122 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA
GeneID:11122 -> Biological process: GO:0007155 [cell adhesion] evidence: NAS
GeneID:11122 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IDA
GeneID:11122 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:11122 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IMP
GeneID:11122 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:11122 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:11122 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_008981 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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