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2020-10-24 07:22:28, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006989               5606 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens RAS p21 protein activator 4 (RASA4), transcript
            variant 1, mRNA.
ACCESSION   NM_006989 XM_936264
VERSION     NM_006989.5  GI:299829176
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5606)
  AUTHORS   Dai,Y., Walker,S.A., de Vet,E., Cook,S., Welch,H.C. and
            Lockyer,P.J.
  TITLE     Ca2+-dependent monomer and dimer formation switches CAPRI Protein
            between Ras GTPase-activating protein (GAP) and RapGAP activities
  JOURNAL   J. Biol. Chem. 286 (22), 19905-19916 (2011)
   PUBMED   21460216
  REMARK    GeneRIF: Ca2+-dependent monomer and dimer formation switches CAPRI
            Protein between Ras GTPase-activating protein (GAP) and RapGAP
            activities
REFERENCE   2  (bases 1 to 5606)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J. Cell Biol. 170 (2), 183-190 (2005)
   PUBMED   16009725
  REMARK    GeneRIF: CAPRI seems to low-pass filter the Ca2+ signal, converting
            different intensities of stimulation into different durations of
            Ras activity.
REFERENCE   3  (bases 1 to 5606)
  AUTHORS   Minagawa,T., Fukuda,M. and Mikoshiba,K.
  TITLE     Distinct phosphoinositide binding specificity of the GAP1 family
            proteins: characterization of the pleckstrin homology domains of
            MRASAL and KIAA0538
  JOURNAL   Biochem. Biophys. Res. Commun. 288 (1), 87-90 (2001)
   PUBMED   11594756
REFERENCE   4  (bases 1 to 5606)
  AUTHORS   Lockyer,P.J., Kupzig,S. and Cullen,P.J.
  TITLE     CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK
            pathway
  JOURNAL   Curr. Biol. 11 (12), 981-986 (2001)
   PUBMED   11448776
  REMARK    GeneRIF: CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras
            GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK
            pathway following G protein-coupled receptor stimulated
            intracellular Ca2+ elevation that recruits CAPRI to the plasma
            membrane.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105052.3 and AC093668.4.
            On Jun 30, 2010 this sequence version replaced gi:121114293.
            
            Summary: This gene encodes a member of the GAP1 family of
            GTPase-activating proteins that suppresses the
            Ras/mitogen-activated protein kinase pathway in response to Ca(2+).
            Stimuli that increase intracellular Ca(2+) levels result in the
            translocation of this protein to the plasma membrane, where it
            activates Ras GTPase activity. Consequently, Ras is converted from
            the active GTP-bound state to the inactive GDP-bound state and no
            longer activates downstream pathways that regulate gene expression,
            cell growth, and differentiation. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011110.2, BC110873.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC105052.3         30366-30499         c
            135-191             AC105052.3         24827-24883         c
            192-305             AC105052.3         23082-23195         c
            306-367             AC105052.3         22502-22563         c
            368-497             AC105052.3         19599-19728         c
            498-579             AC105052.3         16065-16146         c
            580-711             AC105052.3         13998-14129         c
            712-806             AC105052.3         13601-13695         c
            807-924             AC105052.3         9753-9870           c
            925-1075            AC105052.3         9375-9525           c
            1076-1140           AC105052.3         9046-9110           c
            1141-1253           AC105052.3         8188-8300           c
            1254-1446           AC105052.3         7791-7983           c
            1447-1584           AC105052.3         7448-7585           c
            1585-1729           AC105052.3         6735-6879           c
            1730-1899           AC105052.3         6026-6195           c
            1900-2037           AC105052.3         3900-4037           c
            2038-2173           AC105052.3         1376-1511           c
            2174-2294           AC093668.4         198168-198288       c
            2295-2359           AC093668.4         196954-197018       c
            2360-5606           AC093668.4         193596-196842       c
FEATURES             Location/Qualifiers
     source          1..5606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22"
     gene            1..5606
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="RAS p21 protein activator 4"
                     /db_xref="GeneID:10156"
                     /db_xref="HGNC:23181"
                     /db_xref="MIM:607943"
     exon            1..134
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(29)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376878121"
     variation       complement(35)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374409068"
     CDS             70..2481
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     GTPase-activating protein 4; Ca2+-promoted Ras
                     inactivator; calcium-promoted Ras inactivator;
                     rasGAP-activating-like protein 2"
                     /codon_start=1
                     /product="ras GTPase-activating protein 4 isoform 1"
                     /protein_id="NP_008920.5"
                     /db_xref="GI:299829177"
                     /db_xref="CCDS:CCDS5725.1"
                     /db_xref="GeneID:10156"
                     /db_xref="HGNC:23181"
                     /db_xref="MIM:607943"
                     /translation="
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
"
     misc_feature    85..447
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="C2 domain first repeat present in RasA1 and RasA4;
                     Region: C2A_Rasal1_RasA4; cd04054"
                     /db_xref="CDD:176018"
     misc_feature    order(130..132,148..150,289..291,295..297,313..315)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="Ca2+ binding pocket [ion binding]; other site"
                     /db_xref="CDD:176018"
     misc_feature    469..840
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="C2 domain second repeat present in RasA1 and RasA4;
                     Region: C2B_RasA1_RasA4; cd04025"
                     /db_xref="CDD:175991"
     misc_feature    order(514..516,532..534,673..675,679..681,697..699)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="Ca2+ binding pocket [ion binding]; other site"
                     /db_xref="CDD:175991"
     misc_feature    868..1860
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="Ras GTPase activating-like 4 protein (RASAL4), also
                     known as Ca2+ -promoted Ras inactivator (CAPRI), is a
                     member of the GAP1 family. Members of the GAP1 family are
                     characterized by a conserved domain structure comprising
                     N-terminal tandem C2 domains, a...; Region: RasGAP_RASA4;
                     cd05395"
                     /db_xref="CDD:88581"
     misc_feature    order(976..978,1084..1086,1096..1107,1126..1128,
                     1459..1461,1483..1488,1495..1500,1582..1584,1603..1605,
                     1609..1611,1630..1635)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="putative GAP/RAS interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:88581"
     misc_feature    1774..2082
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="RAS_GTPase activating protein (GAP)_CG9209
                     pleckstrin homology (PH) domain; Region: PH_RasGAP_CG9209;
                     cd01244"
                     /db_xref="CDD:176320"
     misc_feature    order(1792..1794,1798..1800,1837..1839,1843..1851)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:176320"
     misc_feature    2110..2199
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="BTK motif; Region: BTK; pfam00779"
                     /db_xref="CDD:144394"
     variation       complement(82)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146516658"
     variation       complement(90)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150204185"
     exon            135..191
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            192..305
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            306..367
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            368..497
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(375)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140941587"
     variation       complement(392)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151024405"
     variation       complement(400)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372956201"
     variation       complement(408)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142342278"
     variation       complement(417)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369222056"
     variation       complement(436)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139960113"
     variation       complement(491)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200132914"
     exon            498..579
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            580..711
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(697)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148994026"
     exon            712..806
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            807..924
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            925..1075
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            1076..1140
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1096)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144817729"
     variation       complement(1115)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141060382"
     variation       complement(1123)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144395384"
     variation       complement(1125)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370139033"
     exon            1141..1253
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1172)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372070045"
     exon            1254..1446
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            1447..1584
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            1585..1729
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            1730..1899
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            1900..2037
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            2038..2173
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            2174..2294
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(2261)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201206752"
     exon            2295..2359
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     exon            2360..5606
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:1.39.8"
     polyA_site      2934
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
     variation       complement(3907)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143668034"
     variation       complement(4113)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368246765"
     variation       complement(4162)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376488381"
     STS             4201..4267
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="GDB:4585406"
                     /db_xref="UniSTS:40002"
     variation       complement(4293)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148998561"
     variation       complement(4394)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200553107"
     variation       complement(4406..4409)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace=""
                     /replace="tttt"
                     /db_xref="dbSNP:143912199"
     STS             4455..4565
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="D10S275"
                     /db_xref="UniSTS:147992"
     STS             4465..4534
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="D1S1423"
                     /db_xref="UniSTS:149619"
     STS             4496..4584
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       complement(4613)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145870823"
     STS             4769..4925
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="RH47924"
                     /db_xref="UniSTS:86874"
     variation       complement(4862)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368684154"
     variation       complement(4863..4864)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:147078079"
     variation       complement(4869)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371475242"
     variation       complement(4880)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373687264"
     STS             5328..5501
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="STS-AA025752"
                     /db_xref="UniSTS:65020"
     STS             5336..5423
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /standard_name="GDB:4585437"
                     /db_xref="UniSTS:65729"
     variation       complement(5412)
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199610101"
     polyA_signal    5584..5589
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
     polyA_site      5606
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
ORIGIN      
ccagtccagcgcccgccgcccgccaccccggaccccggtgtctggcttcccccgagccgggaccccgcgatggccaagcgcagctcgctgtacatccgcatcgtggaggggaagaaccttcccgccaaggacatcactggcagcagcgacccctactgcatcgtgaaggtggacaatgagcccatcatcaggacagccacagtgtggaagaccctgtgccccttctggggtgaggagtaccaagtgcacctgccgcccaccttccacgctgtggctttctatgtcatggatgaggatgccctcagccgggacgacgttatcggaaaggtctgccttacaagggacaccatagcctctcaccctaagggtttcagcgggtgggcccacctgacggaggtcgaccccgatgaggaggtgcagggcgagatccacctgcggctggaagtgtggccaggggcccgggcctgccggctacgctgctctgtgctggaggccagggatctggccccaaaggaccgcaatggcacatctgaccccttcgtccgagtgcgctacaagggccggacacgggagacctcgatcgtgaagaagtcatgctacccacgctggaatgagacgtttgaatttgagctgcaggagggggccatggaggcgctgtgcgtggaggcctgggactgggaccttgtcagccgaaacgacttcctgggcaaagtggtgattgatgtccagagactgcgggtggtgcagcaggaggagggctggttccggctgcagcccgaccagtccaagagccggcggcatgacgagggcaacctgggctccttgcagctggaggtgcggctgcgggacgagacggtgctgccctccagctactaccagccactggtgcacctgctgtgccacgaggtcaagctgggcatgcagggcccagggcagctgatcccactcatcgaggagacaaccagcaccgagtgtcgccaggacgtggccacgaacctgctcaagctcttcctggggcaggggctggccaaggacttcctggacctgctcttccagctggagctgagtcgcaccagtgagaccaacaccctgttccggagcaactctctggcctcaaagtccatggagtcttttctgaaggtggccgggatgcagtacctgcacggcgtcctgggccccatcatcaacaaggtgtttgaggagaagaagtacgtggagctggaccccagcaaagtggaagttaaggatgtagggtgctccgggctgcaccgcccgcagaccgaggccgaggtgctggagcagagcgcgcagacgctgcgcgcccacctgggggccctgctgagcgcgctcagccgctcggttcgcgcgtgccccgccgtggtgcgcgccaccttccgccagctcttccggcgcgtgcgcgagcgcttccccggcgcccagcacgagaatgtaccgttcatcgccgtcaccagcttcctgtgcctgcgcttcttctctcccgccatcatgtcgcccaagctcttccacctgcgggagcgccacgcggacgcccgcaccagccgcaccctgctcctgttggccaaggcagtccagaacgtgggcaacatggacacgccggcttccagggccaaggaggcttggatggagccgctgcagcccaccgtgcgccagggcgtggcgcagctgaaggacttcatcaccaagctcgtggacatcgaggagaaggacgagctggacctgcagcggacgctgagtttgcaggcgccacctgtgaaggaggggccactcttcatccacaggaccaagggcaagggccccctcatgtcctcctccttcaagaagctctacttctccctcactaccgaggccctcagcttcgcgaagacgcccagctccaagaaaagcgccctcatcaagttagccaacatccgggcagcggaaaaggttgaggaaaagagctttggcggctcgcacgtcatgcaggtcatctacacggacgacgccggcaggccccagactgcctacctgcagtgcaagtgtgtgaatgagcttaaccagtggctgtctgcgctgcggaaggtgagcatcaacaacaccggactgctgggctcctaccaccctggcgtcttccgtggggacaagtggagctgctgccaccaaaaagagaagacaggtcagggctgcgataagacccggtcacgggtgaccctgcaggagtggaatgaccctcttgaccatgaccttgaggcccagctcatctaccggcacctgctgggcgtggaggccatgctgtgggagaggcaccgggagctgagcgggggcgcagaggcaggcacggtgcccacgagccctggcaaagtccccgaggactcattggcccggctgctccgggtgctgcaggacctccgcgaggcccatagctccagcccggccggctccccaccctcagagcccaactgcctcctggagctgcagacgtgaggcccgccctacgctccccttgctgagtcccctgccaagcgctcggagcccccccaggacactctgcaccccctcaccccggtcctcctcattagggtgcagggcctaggtctcttccaggtgggggaggggggagagtcaggaataaggggatccccagaagtgcagagctgagcaggcttgggcctgtcatggctggccggaagtgtccccagctccctacagacgctgtagccatcactgcctctccagggaccctcctctcctgcccaggacagacccagccagaaccactgctaggatgggccgcacccaggggtctggcctccagggacctagagaatgggagggagaacggggccccaggagacccggccgccaccccacccgctacccttgggtgccacagggctgtgctgttgccaacagtaaacctgctcttactgtccaggctctggggtcttgtgatgagggtctggggagaaagtgggcccggggggaccccggaggctgtcggtggatgtgccgatgatggggctgacagtatgggctctgggcatccctgttcccccctctttcttccccccactcttctggggtcgggggttcctttcccttcccagttgctgtccctgggtcccctctttcatgtcccacaggccacagagcccagtgtgtccaaccagctgttctctcctcaaagcagcccccaagcaagtcccttctctagggtgtccctgaggacagcacagaggcgggactcagagaccccattcctcttcacgcagcccttaccccaagccctctagctgtgtggctggcagtgttggccacgtaggggctcccatccccccaccattgtgtcacatgggctgccaggctcagctcccagctgcgtccacagtgacctggatcagggtggggacaaggactggaccctccttctccagaaggccttcagctcttgccttgccatgcagtcacctccttccccctctgaccccagatcccaaaggtgcaccgttgccccagcccctttctggccccatggggtttctctgatgccttcatcatagaggcccggggctggtccgatggttggcaaaacttgactccggcccagtccccactcttggggacttagaacccctgctgtcctgggatctggcctgcctttctttggtcagtccctgtggtcccccaccagctccccctcccatagggctgcccaccaagccctgcccccagcccaagaggagcccccactgcctgcggggcagtgatgtctggccaccggctcacaccaatgacttggtcctggggtggcagaagcagcaggtgacaggagcagggcccctgtccctctcttctggccctgtggtacccaggccacacgttgtgcccgctcttggggctgaccggctgtagggaccaccagccgctgctactgtgggccgccccggggcagggtgggcagggcttttgtgggttatgaggacacagaagtccctgaggcccccagacctggctcagccaacctccttcctcccccggttgccccccactctaaagcctcctccctcccagcgtccactggctccaggctcctcacaacagcagctcatagacacggggcgtctccaggtggtcccagccctccagatgtttctagctctccaggtgggcgctgttttcacgtctgcctgcatccattcattccttcattcctcacctttatcctgttatctctatttttttaagctaccaggaaggaaagggaagaagagatcacgaaactgggacccccagaaaggaggagtgggctttgaacttagacatctacctcagagctcaaataggttgtttaaaatcacattcaattttcagatgaaggggaactttatagttttttttttttttttttttttgagacagagtctcactgtgttgcccaggctggagtgcaaatggcttgatcttggttcactgcaacctctgcctcccaggttcaagcaattctcttgcctcagcctcccgagtagctgggactaaaggcgtgtgccaccatgcccagctaattcttgtatttttagtagagacggagtttctccatgttggccagactggtctcgaactcctgacctcaggtgatctgaccgccttggcctccgaaagtgctgagattacagttgcgagccactgtgcgtggccagaactttataataagagacttgaagctgggtgtgacggtgcacacctctagtcccagctactcgggaggccaagacagaaggatcaccttgaggccaggagtttaaggccagcctgggcaacatagcaaaacctagtccctaaaattaaaaaaaaaaaaaaaaaaaaaaggaaaataaaggagacttgaaatttttgaactaaatagtggtgatggctacacattgtgaatgtaattaacaccactgagttaaacacttaaaatggttaaaatggcaaattgtatgttatacctattttactacaataaaaagtataaaaaagagaagatatttaggtgacttacagcaaccaattgcaacaaaacaaaatgttaagaaatgatctttttatgaggcaattggaaatttgaacactgatcaactataggatgattggaattattaatttttaaaggtgtgataagatactgcacttggctgggcacagtggcacatgcctgtaatcccagctacttggcaggctgaggtgggagaatcgcttgagctcaggagttcgagaccagcctgggcaacgtggcgaaatccccgtctttacaaaaacaaacaaacaaacaaaaaagatattgcagttgtgttgtaagcgtccttatctttcagagctacatagtggaatgtttatggaatatttaggataaatgatataggcatttgggatttgctgcaaaatgacccagaggcaggggtcagggggagaggtagagatgagacaagaggtagaggggagaggtagaggtagccacgagctgataattacagacaagagatgcggagtatgtgggggctcattatcctgcatagtctatctttgtatatctttgaacttttcaagaataaaaaagcttaaaaagtata
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10156 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IDA
            GeneID:10156 -> Molecular function: GO:0005099 [Ras GTPase activator activity] evidence: ISS
            GeneID:10156 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
            GeneID:10156 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:10156 -> Biological process: GO:0032320 [positive regulation of Ras GTPase activity] evidence: ISS
            GeneID:10156 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
            GeneID:10156 -> Biological process: GO:0046580 [negative regulation of Ras protein signal transduction] evidence: ISS
            GeneID:10156 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
            GeneID:10156 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:10156 -> Cellular component: GO:0031235 [intrinsic to internal side of plasma membrane] evidence: ISS

by @meso_cacase at DBCLS
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