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2024-03-28 22:21:58, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006814               3695 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) inhibitor subunit 1
            (PI31) (PSMF1), transcript variant 1, mRNA.
ACCESSION   NM_006814
VERSION     NM_006814.3  GI:145611425
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Kirk,R., Laman,H., Knowles,P.P., Murray-Rust,J., Lomonosov,M.,
            Meziane el,K. and McDonald,N.Q.
  TITLE     Structure of a conserved dimerization domain within the F-box
            protein Fbxo7 and the PI31 proteasome inhibitor
  JOURNAL   J. Biol. Chem. 283 (32), 22325-22335 (2008)
   PUBMED   18495667
  REMARK    GeneRIF: a model for FP domain-mediated dimerization of SCF(Fbxo7)
            and PI31
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
            Lebendiker,M. and Brandeis,M.
  TITLE     Mammalian Cdh1/Fzr mediates its own degradation
  JOURNAL   EMBO J. 23 (7), 1619-1626 (2004)
   PUBMED   15029244
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Conticello,S.G., Harris,R.S. and Neuberger,M.S.
  TITLE     The Vif protein of HIV triggers degradation of the human
            antiretroviral DNA deaminase APOBEC3G
  JOURNAL   Curr. Biol. 13 (22), 2009-2013 (2003)
   PUBMED   14614829
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Yu,X., Yu,Y., Liu,B., Luo,K., Kong,W., Mao,P. and Yu,X.F.
  TITLE     Induction of APOBEC3G ubiquitination and degradation by an HIV-1
            Vif-Cul5-SCF complex
  JOURNAL   Science 302 (5647), 1056-1060 (2003)
   PUBMED   14564014
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   McCutchen-Maloney,S.L., Matsuda,K., Shimbara,N., Binns,D.D.,
            Tanaka,K., Slaughter,C.A. and DeMartino,G.N.
  TITLE     cDNA cloning, expression, and functional characterization of PI31,
            a proline-rich inhibitor of the proteasome
  JOURNAL   J. Biol. Chem. 275 (24), 18557-18565 (2000)
   PUBMED   10764772
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Tanahashi,N., Kawahara,H., Murakami,Y. and Tanaka,K.
  TITLE     The proteasome-dependent proteolytic system
  JOURNAL   Mol. Biol. Rep. 26 (1-2), 3-9 (1999)
   PUBMED   10363639
  REMARK    Review article
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat. Med. 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J. Virol. 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031665.19, BC126127.1 and
            D88378.1.
            On Apr 23, 2007 this sequence version replaced gi:30581146.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            protein that inhibits the activation of the proteasome by the 11S
            and 19S regulators. Alternative transcript variants have been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Transcript variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88378.1, BM553198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AL031665.19        5906-6189
            285-513             BC126127.1         166-394
            514-1108            D88378.1           463-1057
            1109-3695           AL031665.19        52506-55092
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3695
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="proteasome (prosome, macropain) inhibitor subunit 1
                     (PI31)"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:9571"
     exon            1..306
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       24
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112970423"
     variation       25
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373800205"
     variation       55
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2072963"
     variation       61
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142307914"
     variation       90
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2072962"
     misc_feature    97..99
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="upstream in-frame stop codon"
     variation       100
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45556531"
     variation       103
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556998"
     variation       128
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:184941703"
     variation       131
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370516342"
     variation       137
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77671210"
     variation       141
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556999"
     CDS             178..993
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="proteasome inhibitor hP131 subunit; hPI31"
                     /codon_start=1
                     /product="proteasome inhibitor PI31 subunit"
                     /protein_id="NP_006805.2"
                     /db_xref="GI:145611426"
                     /db_xref="CCDS:CCDS13010.1"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:9571"
                     /translation="
MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPNPDHLPPPGYDDMYL
"
     misc_feature    190..627
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="PI31 proteasome regulator N-terminal; Region:
                     PI31_Prot_N; pfam11566"
                     /db_xref="CDD:192774"
     misc_feature    634..636
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    <733..921
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="PI31 proteasome regulator; Region: PI31_Prot_C;
                     pfam08577"
                     /db_xref="CDD:203989"
     misc_feature    931..933
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q92530.2); phosphorylation site"
     variation       190
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367616709"
     variation       197
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557004"
     variation       208
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11557000"
     variation       221
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367981594"
     variation       238
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11557002"
     variation       284
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1803415"
     variation       293
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140462835"
     exon            307..459
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       308
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372603862"
     variation       309
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35517343"
     variation       318
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377541588"
     variation       332
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370346644"
     variation       380
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35236223"
     variation       389
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374106093"
     variation       395
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187966028"
     variation       398
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376977314"
     variation       413
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138434060"
     variation       430
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371397613"
     variation       448
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199540229"
     variation       453
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374352660"
     exon            460..542
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       474
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143893706"
     variation       513
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6514113"
     variation       526
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138799263"
     exon            543..728
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       548
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371369250"
     variation       549
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149328389"
     variation       551
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377313597"
     variation       568
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369760576"
     variation       575
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144643969"
     variation       577
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148476395"
     variation       580
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201806021"
     variation       587
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141436228"
     variation       596
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142534580"
     variation       599
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145936617"
     variation       643
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146300768"
     variation       644
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200994349"
     variation       645
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139986096"
     variation       649
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146612629"
     variation       655
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141024057"
     variation       698
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2235587"
     variation       706
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145879723"
     variation       716
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369290324"
     variation       717
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149005058"
     exon            729..782
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       737
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375788504"
     variation       746
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147039294"
     variation       752
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79465651"
     variation       756
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200198078"
     variation       765
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142460244"
     variation       782
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200297814"
     exon            783..941
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     variation       787
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371970750"
     variation       788
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148816301"
     variation       813
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376298956"
     variation       821
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114332593"
     variation       838
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6074204"
     variation       864
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148321012"
     variation       883
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143820411"
     variation       901
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200259216"
     variation       902
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148156083"
     variation       931
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199817261"
     variation       939
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150771213"
     variation       940
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117357529"
     exon            942..3695
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:1.39.8"
     STS             993..1811
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="PSMF1_3511"
                     /db_xref="UniSTS:462471"
     variation       1006
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201939911"
     variation       1016
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367774059"
     variation       1034
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115433407"
     variation       1048
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374138693"
     STS             1050..1203
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="RH78439"
                     /db_xref="UniSTS:81955"
     variation       1118
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189360363"
     variation       1200
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372979271"
     variation       1266
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139171551"
     variation       1317..1318
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557001"
     variation       1317
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17716261"
     variation       1387
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3177815"
     variation       1400
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1049957"
     variation       1405
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2072965"
     variation       1462
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143095770"
     variation       1579
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370335266"
     variation       1666
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6108754"
     variation       1714
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78284852"
     variation       1764
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6032989"
     variation       1875
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182205930"
     variation       1894
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185585896"
     variation       1922..1923
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:147857520"
     variation       1969
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:6108755"
     variation       2011
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147475008"
     STS             2042..2275
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="RH75207"
                     /db_xref="UniSTS:88410"
     variation       2094
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368044805"
     variation       2109
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200269898"
     STS             2132..2257
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="WI-12610"
                     /db_xref="UniSTS:62334"
     variation       2156
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139266521"
     variation       2196
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374421076"
     variation       2222
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2404"
     variation       2227
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190099428"
     variation       2326
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45560131"
     variation       2350
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149551097"
     variation       2364
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61204479"
     variation       2507
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61435577"
     variation       2556
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181663182"
     variation       2598
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58388416"
     variation       2649
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144645038"
     variation       2669
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6104677"
     variation       2679
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3087751"
     variation       2785
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:6104679"
     variation       2797..2799
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace=""
                     /replace="gat"
                     /db_xref="dbSNP:375033452"
     variation       2929
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148480285"
     variation       2988
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14581"
     variation       2993
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144111121"
     variation       3018
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1803414"
     variation       3041
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6040254"
     variation       3044
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1049901"
     STS             3058..3191
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="A002B36"
                     /db_xref="UniSTS:59173"
     STS             3058..3191
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="G19899"
                     /db_xref="UniSTS:59172"
     STS             3075..3224
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /standard_name="WI-14248"
                     /db_xref="UniSTS:38191"
     variation       3136
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190171892"
     variation       3178
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115030515"
     polyA_signal    3213..3218
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     variation       3219
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:58247375"
     variation       3238
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181436301"
     polyA_site      3241
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     variation       3250
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139899685"
     variation       3444
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185907709"
     variation       3453
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183686460"
     variation       3476
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:202042518"
     variation       3488
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76368168"
     variation       3490
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79497799"
     variation       3535
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78032784"
     variation       3656
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190826471"
     polyA_site      3695
                     /gene="PSMF1"
                     /gene_synonym="PI31"
ORIGIN      
cttccggcttccccgccccgccccgtccccgggcgtctccattttggtctcaggtgtggactcggcaagaaccagcgcaagagggaagcagagttatagctaccccggccgcggagccggctcactgcactacccccgcccccttctttcctccagacgccgaagtcgcgggcgctcatggcgggcctggaggtactgttcgcatcggcagcgccggccatcacctgcaggcaggacgcgctcgtctgcttcttgcattgggaagtggtgacacacggttacttcggcttgggtgtcggtgaccagccgggtcccaatgataagaagtcagaactgctgccagctgggtggaacaacaataaagacctgtatgtcctccggtatgagtataaggatgggtccagaaagctccttgtgaaagccatcaccgtggagagcagcatgatcctcaatgtgctggaatatggctcacagcaagtggcagacttgaccctgaacttggatgattatatcgatgcagaacacctgggtgacttccacaggacctacaagaacagtgaggagcttcggtctcgtattgtgtctggaatcatcacacctatccatgagcagtgggaaaaggctaatgtaagcagtccccaccgggagttcccccctgctaccgccagagaggtggacccactccggattcctccacaccacccacacaccagtcggcagcctccctggtgtgatcccctgggcccgtttgttgtcgggggagaagacttagacccttttgggcctcggagaggtggcatgattgtggatcccctgagatctggcttcccaagagcacttattgacccttcctcaggcctcccgaaccgacttcctccaggcgctgtgcccccaggagctcgctttgacccctttggacccattgggaccagcccacccggacctaacccagaccatctccccccgccgggctacgatgacatgtacctgtgaaggcctcaagaatgtaacatcccaggcttccctccattctcctggagctgccaccgctgtccccatcagcaaccatgttcttgcaggctgggggcaagggattctgctcatgtgtttgcagaccggctgggatagcctccccaccccttatcagagccaagacacctgctgcagctctccacctagctgcagatagctcccaaagagaaatcagtgtgtctctttcaccatcagctcctcccctttcaccaccagctcctctccacttcccaagggagactccggcaaccttcagcaacatatatcctcgaccagatgcagtgctataagaacagaacgcattttggatgttattattaagaaccaaatgtcaatacagaattcatgttgccggtttcccacttttctttttacattaatgcatagctgcttccatttatgagactttagagtttgagtttctgtagggctgaatgactctttttcctgcccagggcccattcttgcttctcaggcaccttccgtttattaattgccattgctcctgacatcactaagatgggtccccttctggctgcatgaatggaaatgagtgactggaaatcccataggccacaagaatgactttcacaagggcaggaacattgtggaaagactgcatcattctgatgaggcaaaatcctccagctattcctgtctgggccagttttgtaggtccatctgtgcatgggcagcagtagtcaaaaagccaaggaaaaaacagagcagacctgaaggctaatcttatttttgccactaacttagtgaatgaccctaagcaagttccttctcctcttagggccttgtgccaagcctatgaaattggaggtggctttcctgctctaaagcattttgatgtctcattctgtgtttggtaacccctataaactggggcagaggaaaagaatgatggttcaaggccatacttcccttgaaccttgtgtggttcttgcctaactctgtggtttttggaccccatggggcccagacagagcacaggagcatgggctgcctctgagtgtggtgttgaacttcgggaggagcagggagccctgcaccttgtgtcctggcccacctgacctttggtgttctccggatccttttcagcccgaggcctgacagacgcgggcagtgatgagccctgttctggagtggaaagagcacgatagagcaccaggctaagaggcacgagatcaaggcggtagtcacttccgctctgcagctagcatttcaaccatatgtggatcctttcatttctcagctccctggattccttcccctaaattaggacctattatttacctgtaggtaagcaagctactgtagctcttctgaggtatctgccaggctgttttctgtagcctcagattgcctatctgcttagcctgagaacaggtagatgaaaactaaactgatgcctaggcccagggtcagtctcagatggaagctgggcctgggtggggaggctagcatgcgtggctccctgggtatttctgtcagtccccatggcaagcagtgatttagtaaaacaccccagagtcagggaagccaaccaccttgaaacctttagaacatctctgctttggagaaagacccagagatcaggcagaggtgcagattcaatcattactcataacctttgagagatggcaaatgggaggagtgttagtctttgttttggaattggaccattcttgcaaccaaaaggacttagagcagtttgctcataaagacatcctttattataaaaggaagtatttaaaggatgatagagaccatcagatagaagcagggaaggtagataacttttaggaccttgatgtgaggaaaagataaaatttaaacaataaatttgccacttagattttctagcagcaaagtccgaaaagatagttatatacaaaattctgttttctgaaaacaaaattgtgattcaccttcagaattggccattttttttgtgagtttccttgcatcaaggacactgagaaacacagtcattgtcttaggtgttctatgggaggaagtgaatagagcctttaggaacttcctggtcaagcttatggtgcttattttgatctgggccacttccctccttccagtcatgagtaatcatcaaggagcaagttggagtgtttcaggtgtatattttgtagaacccaaaagattggagccttaacaataaacatcagcactaagtgacctgttcctccttttttaaatagcagctttattgagatataatttacatacccataatttacatacctgtttaaagtatacaattcagtggatttagtatgttcacagtgttgcacatccaccaccatttctaattcctgaacattttcaccacctcaaaaagaaaccacacacccattggcatgactccccattcccttgctcccagccccaggcaaccactaacatctgtctctaaagattttttttttttttctggacagttctcataagtggaatcactcagtattatggccttttgtgtctggcttctttcatttcatgtgatgttttcaagattcattcatgctgtagcatgtatccatggtatggatatatcacattttgcttatccttttatcagttgatggacagttgggttgtttctacaaaaaggctattatgagtaatgcagccaagaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9491 -> Molecular function: GO:0004866 [endopeptidase inhibitor activity] evidence: NAS
            GeneID:9491 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9491 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:9491 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:9491 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:9491 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:9491 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:9491 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: NAS
            GeneID:9491 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:9491 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:9491 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: NAS
            GeneID:9491 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:9491 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:9491 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:9491 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:9491 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:9491 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:9491 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:9491 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:9491 -> Cellular component: GO:0005839 [proteasome core complex] evidence: NAS

by @meso_cacase at DBCLS
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