2024-03-28 22:21:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006814 3695 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens proteasome (prosome, macropain) inhibitor subunit 1 (PI31) (PSMF1), transcript variant 1, mRNA. ACCESSION NM_006814 VERSION NM_006814.3 GI:145611425 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3695) AUTHORS Kirk,R., Laman,H., Knowles,P.P., Murray-Rust,J., Lomonosov,M., Meziane el,K. and McDonald,N.Q. TITLE Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor JOURNAL J. Biol. Chem. 283 (32), 22325-22335 (2008) PUBMED 18495667 REMARK GeneRIF: a model for FP domain-mediated dimerization of SCF(Fbxo7) and PI31 REFERENCE 2 (bases 1 to 3695) AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F., Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M. and Zoghbi,H.Y. TITLE A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration JOURNAL Cell 125 (4), 801-814 (2006) PUBMED 16713569 REFERENCE 3 (bases 1 to 3695) AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M., Lebendiker,M. and Brandeis,M. TITLE Mammalian Cdh1/Fzr mediates its own degradation JOURNAL EMBO J. 23 (7), 1619-1626 (2004) PUBMED 15029244 REFERENCE 4 (bases 1 to 3695) AUTHORS Conticello,S.G., Harris,R.S. and Neuberger,M.S. TITLE The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G JOURNAL Curr. Biol. 13 (22), 2009-2013 (2003) PUBMED 14614829 REFERENCE 5 (bases 1 to 3695) AUTHORS Yu,X., Yu,Y., Liu,B., Luo,K., Kong,W., Mao,P. and Yu,X.F. TITLE Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex JOURNAL Science 302 (5647), 1056-1060 (2003) PUBMED 14564014 REFERENCE 6 (bases 1 to 3695) AUTHORS McCutchen-Maloney,S.L., Matsuda,K., Shimbara,N., Binns,D.D., Tanaka,K., Slaughter,C.A. and DeMartino,G.N. TITLE cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome JOURNAL J. Biol. Chem. 275 (24), 18557-18565 (2000) PUBMED 10764772 REFERENCE 7 (bases 1 to 3695) AUTHORS Tanahashi,N., Kawahara,H., Murakami,Y. and Tanaka,K. TITLE The proteasome-dependent proteolytic system JOURNAL Mol. Biol. Rep. 26 (1-2), 3-9 (1999) PUBMED 10363639 REMARK Review article REFERENCE 8 (bases 1 to 3695) AUTHORS Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H. TITLE Evidence for a newly discovered cellular anti-HIV-1 phenotype JOURNAL Nat. Med. 4 (12), 1397-1400 (1998) PUBMED 9846577 REFERENCE 9 (bases 1 to 3695) AUTHORS Madani,N. and Kabat,D. TITLE An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein JOURNAL J. Virol. 72 (12), 10251-10255 (1998) PUBMED 9811770 REFERENCE 10 (bases 1 to 3695) AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W. TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997) PUBMED 9079628 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031665.19, BC126127.1 and D88378.1. On Apr 23, 2007 this sequence version replaced gi:30581146. Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) is the predominant transcript. Transcript variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D88378.1, BM553198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-284 AL031665.19 5906-6189 285-513 BC126127.1 166-394 514-1108 D88378.1 463-1057 1109-3695 AL031665.19 52506-55092 FEATURES Location/Qualifiers source 1..3695 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20p13" gene 1..3695 /gene="PSMF1" /gene_synonym="PI31" /note="proteasome (prosome, macropain) inhibitor subunit 1 (PI31)" /db_xref="GeneID:9491" /db_xref="HGNC:9571" exon 1..306 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 24 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="c" /db_xref="dbSNP:112970423" variation 25 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:373800205" variation 55 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:2072963" variation 61 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:142307914" variation 90 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:2072962" misc_feature 97..99 /gene="PSMF1" /gene_synonym="PI31" /note="upstream in-frame stop codon" variation 100 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:45556531" variation 103 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:11556998" variation 128 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:184941703" variation 131 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:370516342" variation 137 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:77671210" variation 141 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:11556999" CDS 178..993 /gene="PSMF1" /gene_synonym="PI31" /note="proteasome inhibitor hP131 subunit; hPI31" /codon_start=1 /product="proteasome inhibitor PI31 subunit" /protein_id="NP_006805.2" /db_xref="GI:145611426" /db_xref="CCDS:CCDS13010.1" /db_xref="GeneID:9491" /db_xref="HGNC:9571" /translation="
MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPNPDHLPPPGYDDMYL
" misc_feature 190..627 /gene="PSMF1" /gene_synonym="PI31" /note="PI31 proteasome regulator N-terminal; Region: PI31_Prot_N; pfam11566" /db_xref="CDD:192774" misc_feature 634..636 /gene="PSMF1" /gene_synonym="PI31" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature <733..921 /gene="PSMF1" /gene_synonym="PI31" /note="PI31 proteasome regulator; Region: PI31_Prot_C; pfam08577" /db_xref="CDD:203989" misc_feature 931..933 /gene="PSMF1" /gene_synonym="PI31" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q92530.2); phosphorylation site" variation 190 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:367616709" variation 197 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:11557004" variation 208 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:11557000" variation 221 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:367981594" variation 238 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:11557002" variation 284 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:1803415" variation 293 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:140462835" exon 307..459 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 308 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:372603862" variation 309 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:35517343" variation 318 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:377541588" variation 332 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="c" /db_xref="dbSNP:370346644" variation 380 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:35236223" variation 389 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:374106093" variation 395 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:187966028" variation 398 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:376977314" variation 413 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:138434060" variation 430 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:371397613" variation 448 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:199540229" variation 453 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:374352660" exon 460..542 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 474 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:143893706" variation 513 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:6514113" variation 526 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:138799263" exon 543..728 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 548 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:371369250" variation 549 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:149328389" variation 551 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:377313597" variation 568 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:369760576" variation 575 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:144643969" variation 577 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:148476395" variation 580 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:201806021" variation 587 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:141436228" variation 596 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:142534580" variation 599 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:145936617" variation 643 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:146300768" variation 644 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:200994349" variation 645 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:139986096" variation 649 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:146612629" variation 655 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:141024057" variation 698 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:2235587" variation 706 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="c" /db_xref="dbSNP:145879723" variation 716 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:369290324" variation 717 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:149005058" exon 729..782 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 737 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:375788504" variation 746 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:147039294" variation 752 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:79465651" variation 756 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:200198078" variation 765 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:142460244" variation 782 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:200297814" exon 783..941 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" variation 787 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:371970750" variation 788 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:148816301" variation 813 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:376298956" variation 821 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:114332593" variation 838 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:6074204" variation 864 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:148321012" variation 883 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:143820411" variation 901 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:200259216" variation 902 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:148156083" variation 931 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:199817261" variation 939 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:150771213" variation 940 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:117357529" exon 942..3695 /gene="PSMF1" /gene_synonym="PI31" /inference="alignment:Splign:1.39.8" STS 993..1811 /gene="PSMF1" /gene_synonym="PI31" /standard_name="PSMF1_3511" /db_xref="UniSTS:462471" variation 1006 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:201939911" variation 1016 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:367774059" variation 1034 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:115433407" variation 1048 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:374138693" STS 1050..1203 /gene="PSMF1" /gene_synonym="PI31" /standard_name="RH78439" /db_xref="UniSTS:81955" variation 1118 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:189360363" variation 1200 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:372979271" variation 1266 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:139171551" variation 1317..1318 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:11557001" variation 1317 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:17716261" variation 1387 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:3177815" variation 1400 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:1049957" variation 1405 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:2072965" variation 1462 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:143095770" variation 1579 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:370335266" variation 1666 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:6108754" variation 1714 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:78284852" variation 1764 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:6032989" variation 1875 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:182205930" variation 1894 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:185585896" variation 1922..1923 /gene="PSMF1" /gene_synonym="PI31" /replace="" /replace="tg" /db_xref="dbSNP:147857520" variation 1969 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="c" /db_xref="dbSNP:6108755" variation 2011 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:147475008" STS 2042..2275 /gene="PSMF1" /gene_synonym="PI31" /standard_name="RH75207" /db_xref="UniSTS:88410" variation 2094 /gene="PSMF1" /gene_synonym="PI31" /replace="g" /replace="t" /db_xref="dbSNP:368044805" variation 2109 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:200269898" STS 2132..2257 /gene="PSMF1" /gene_synonym="PI31" /standard_name="WI-12610" /db_xref="UniSTS:62334" variation 2156 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:139266521" variation 2196 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:374421076" variation 2222 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:2404" variation 2227 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:190099428" variation 2326 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:45560131" variation 2350 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:149551097" variation 2364 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:61204479" variation 2507 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:61435577" variation 2556 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:181663182" variation 2598 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:58388416" variation 2649 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:144645038" variation 2669 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:6104677" variation 2679 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="c" /db_xref="dbSNP:3087751" variation 2785 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:6104679" variation 2797..2799 /gene="PSMF1" /gene_synonym="PI31" /replace="" /replace="gat" /db_xref="dbSNP:375033452" variation 2929 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:148480285" variation 2988 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:14581" variation 2993 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:144111121" variation 3018 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="t" /db_xref="dbSNP:1803414" variation 3041 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:6040254" variation 3044 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:1049901" STS 3058..3191 /gene="PSMF1" /gene_synonym="PI31" /standard_name="A002B36" /db_xref="UniSTS:59173" STS 3058..3191 /gene="PSMF1" /gene_synonym="PI31" /standard_name="G19899" /db_xref="UniSTS:59172" STS 3075..3224 /gene="PSMF1" /gene_synonym="PI31" /standard_name="WI-14248" /db_xref="UniSTS:38191" variation 3136 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:190171892" variation 3178 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:115030515" polyA_signal 3213..3218 /gene="PSMF1" /gene_synonym="PI31" variation 3219 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:58247375" variation 3238 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:181436301" polyA_site 3241 /gene="PSMF1" /gene_synonym="PI31" variation 3250 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:139899685" variation 3444 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:185907709" variation 3453 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:183686460" variation 3476 /gene="PSMF1" /gene_synonym="PI31" /replace="" /replace="t" /db_xref="dbSNP:202042518" variation 3488 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:76368168" variation 3490 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="t" /db_xref="dbSNP:79497799" variation 3535 /gene="PSMF1" /gene_synonym="PI31" /replace="c" /replace="g" /db_xref="dbSNP:78032784" variation 3656 /gene="PSMF1" /gene_synonym="PI31" /replace="a" /replace="g" /db_xref="dbSNP:190826471" polyA_site 3695 /gene="PSMF1" /gene_synonym="PI31" ORIGIN
cttccggcttccccgccccgccccgtccccgggcgtctccattttggtctcaggtgtggactcggcaagaaccagcgcaagagggaagcagagttatagctaccccggccgcggagccggctcactgcactacccccgcccccttctttcctccagacgccgaagtcgcgggcgctcatggcgggcctggaggtactgttcgcatcggcagcgccggccatcacctgcaggcaggacgcgctcgtctgcttcttgcattgggaagtggtgacacacggttacttcggcttgggtgtcggtgaccagccgggtcccaatgataagaagtcagaactgctgccagctgggtggaacaacaataaagacctgtatgtcctccggtatgagtataaggatgggtccagaaagctccttgtgaaagccatcaccgtggagagcagcatgatcctcaatgtgctggaatatggctcacagcaagtggcagacttgaccctgaacttggatgattatatcgatgcagaacacctgggtgacttccacaggacctacaagaacagtgaggagcttcggtctcgtattgtgtctggaatcatcacacctatccatgagcagtgggaaaaggctaatgtaagcagtccccaccgggagttcccccctgctaccgccagagaggtggacccactccggattcctccacaccacccacacaccagtcggcagcctccctggtgtgatcccctgggcccgtttgttgtcgggggagaagacttagacccttttgggcctcggagaggtggcatgattgtggatcccctgagatctggcttcccaagagcacttattgacccttcctcaggcctcccgaaccgacttcctccaggcgctgtgcccccaggagctcgctttgacccctttggacccattgggaccagcccacccggacctaacccagaccatctccccccgccgggctacgatgacatgtacctgtgaaggcctcaagaatgtaacatcccaggcttccctccattctcctggagctgccaccgctgtccccatcagcaaccatgttcttgcaggctgggggcaagggattctgctcatgtgtttgcagaccggctgggatagcctccccaccccttatcagagccaagacacctgctgcagctctccacctagctgcagatagctcccaaagagaaatcagtgtgtctctttcaccatcagctcctcccctttcaccaccagctcctctccacttcccaagggagactccggcaaccttcagcaacatatatcctcgaccagatgcagtgctataagaacagaacgcattttggatgttattattaagaaccaaatgtcaatacagaattcatgttgccggtttcccacttttctttttacattaatgcatagctgcttccatttatgagactttagagtttgagtttctgtagggctgaatgactctttttcctgcccagggcccattcttgcttctcaggcaccttccgtttattaattgccattgctcctgacatcactaagatgggtccccttctggctgcatgaatggaaatgagtgactggaaatcccataggccacaagaatgactttcacaagggcaggaacattgtggaaagactgcatcattctgatgaggcaaaatcctccagctattcctgtctgggccagttttgtaggtccatctgtgcatgggcagcagtagtcaaaaagccaaggaaaaaacagagcagacctgaaggctaatcttatttttgccactaacttagtgaatgaccctaagcaagttccttctcctcttagggccttgtgccaagcctatgaaattggaggtggctttcctgctctaaagcattttgatgtctcattctgtgtttggtaacccctataaactggggcagaggaaaagaatgatggttcaaggccatacttcccttgaaccttgtgtggttcttgcctaactctgtggtttttggaccccatggggcccagacagagcacaggagcatgggctgcctctgagtgtggtgttgaacttcgggaggagcagggagccctgcaccttgtgtcctggcccacctgacctttggtgttctccggatccttttcagcccgaggcctgacagacgcgggcagtgatgagccctgttctggagtggaaagagcacgatagagcaccaggctaagaggcacgagatcaaggcggtagtcacttccgctctgcagctagcatttcaaccatatgtggatcctttcatttctcagctccctggattccttcccctaaattaggacctattatttacctgtaggtaagcaagctactgtagctcttctgaggtatctgccaggctgttttctgtagcctcagattgcctatctgcttagcctgagaacaggtagatgaaaactaaactgatgcctaggcccagggtcagtctcagatggaagctgggcctgggtggggaggctagcatgcgtggctccctgggtatttctgtcagtccccatggcaagcagtgatttagtaaaacaccccagagtcagggaagccaaccaccttgaaacctttagaacatctctgctttggagaaagacccagagatcaggcagaggtgcagattcaatcattactcataacctttgagagatggcaaatgggaggagtgttagtctttgttttggaattggaccattcttgcaaccaaaaggacttagagcagtttgctcataaagacatcctttattataaaaggaagtatttaaaggatgatagagaccatcagatagaagcagggaaggtagataacttttaggaccttgatgtgaggaaaagataaaatttaaacaataaatttgccacttagattttctagcagcaaagtccgaaaagatagttatatacaaaattctgttttctgaaaacaaaattgtgattcaccttcagaattggccattttttttgtgagtttccttgcatcaaggacactgagaaacacagtcattgtcttaggtgttctatgggaggaagtgaatagagcctttaggaacttcctggtcaagcttatggtgcttattttgatctgggccacttccctccttccagtcatgagtaatcatcaaggagcaagttggagtgtttcaggtgtatattttgtagaacccaaaagattggagccttaacaataaacatcagcactaagtgacctgttcctccttttttaaatagcagctttattgagatataatttacatacccataatttacatacctgtttaaagtatacaattcagtggatttagtatgttcacagtgttgcacatccaccaccatttctaattcctgaacattttcaccacctcaaaaagaaaccacacacccattggcatgactccccattcccttgctcccagccccaggcaaccactaacatctgtctctaaagattttttttttttttctggacagttctcataagtggaatcactcagtattatggccttttgtgtctggcttctttcatttcatgtgatgttttcaagattcattcatgctgtagcatgtatccatggtatggatatatcacattttgcttatccttttatcagttgatggacagttgggttgtttctacaaaaaggctattatgagtaatgcagccaagaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9491 -> Molecular function: GO:0004866 [endopeptidase inhibitor activity] evidence: NAS GeneID:9491 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9491 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:9491 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS GeneID:9491 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:9491 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS GeneID:9491 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS GeneID:9491 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: NAS GeneID:9491 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:9491 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS GeneID:9491 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:9491 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: NAS GeneID:9491 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:9491 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS GeneID:9491 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:9491 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:9491 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:9491 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:9491 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:9491 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:9491 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:9491 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:9491 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:9491 -> Cellular component: GO:0005839 [proteasome core complex] evidence: NAS
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