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2024-04-19 23:06:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006788 4368 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens ralA binding protein 1 (RALBP1), mRNA.
ACCESSION NM_006788
VERSION NM_006788.3 GI:46358409
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4368)
AUTHORS Sehrawat,A., Yadav,S., Awasthi,Y.C., Basu,A., Warden,C. and
Awasthi,S.
TITLE P300 regulates the human RLIP76 promoter activity and gene
expression
JOURNAL Biochem. Pharmacol. 85 (8), 1203-1211 (2013)
PUBMED 23419874
REMARK GeneRIF: p300 associates with the RLIP76 promoter via an
overlapping cMYB and cETS binding site and regulates RLIP76
promoter activity and its expression.
REFERENCE 2 (bases 1 to 4368)
AUTHORS Wang,Q., Wang,J.Y., Zhang,X.P., Lv,Z.W., Fu,D., Lu,Y.C., Hu,G.H.,
Luo,C. and Chen,J.X.
TITLE RLIP76 is overexpressed in human glioblastomas and is required for
proliferation, tumorigenesis and suppression of apoptosis
JOURNAL Carcinogenesis 34 (4), 916-926 (2013)
PUBMED 23276796
REMARK GeneRIF: RLIP76 may suppress apoptosis and promote the
proliferation of glioma cells by direct adenosine
triphosphate-dependent xenobiotic transport and by activating the
Rac1-JNK signaling pathway.
REFERENCE 3 (bases 1 to 4368)
AUTHORS Neel,N.F., Rossman,K.L., Martin,T.D., Hayes,T.K., Yeh,J.J. and
Der,C.J.
TITLE The RalB small GTPase mediates formation of invadopodia through a
GTPase-activating protein-independent function of the RalBP1/RLIP76
effector
JOURNAL Mol. Cell. Biol. 32 (8), 1374-1386 (2012)
PUBMED 22331470
REMARK GeneRIF: RalB-mediated invadopodium formation was dependent on
RalBP1/RLIP76; disruption of the ATPase function of RalBP1 impaired
invadopodium formation.
REFERENCE 4 (bases 1 to 4368)
AUTHORS Matarrese,P., Colasanti,T., Ascione,B., Margutti,P., Franconi,F.,
Alessandri,C., Conti,F., Riccieri,V., Rosano,G., Ortona,E. and
Malorni,W.
TITLE Gender disparity in susceptibility to oxidative stress and
apoptosis induced by autoantibodies specific to RLIP76 in vascular
cells
JOURNAL Antioxid. Redox Signal. 15 (11), 2825-2836 (2011)
PUBMED 21671802
REMARK GeneRIF: The impairment of RLIP76 by aaRLIP76 can play a role in
the damage of vascular cells from females, contributing to the
gender-associated pathogenesis of immune-mediated vascular
diseases.
REFERENCE 5 (bases 1 to 4368)
AUTHORS Kashatus,D.F., Lim,K.H., Brady,D.C., Pershing,N.L., Cox,A.D. and
Counter,C.M.
TITLE RALA and RALBP1 regulate mitochondrial fission at mitosis
JOURNAL Nat. Cell Biol. 13 (9), 1108-1115 (2011)
PUBMED 21822277
REMARK GeneRIF: Data show that disrupting either RALA or RALBP1 leads to a
loss of mitochondrial fission at mitosis, improper segregation of
mitochondria during cytokinesis and a decrease in ATP levels and
cell number.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4368)
AUTHORS Iouzalen,N., Camonis,J. and Moreau,J.
TITLE Identification and characterization in Xenopus of XsmgGDS, a RalB
binding protein
JOURNAL Biochem. Biophys. Res. Commun. 250 (2), 359-363 (1998)
PUBMED 9753634
REFERENCE 7 (bases 1 to 4368)
AUTHORS Ikeda,M., Ishida,O., Hinoi,T., Kishida,S. and Kikuchi,A.
TITLE Identification and characterization of a novel protein interacting
with Ral-binding protein 1, a putative effector protein of Ral
JOURNAL J. Biol. Chem. 273 (2), 814-821 (1998)
PUBMED 9422736
REFERENCE 8 (bases 1 to 4368)
AUTHORS Yamaguchi,A., Urano,T., Goi,T. and Feig,L.A.
TITLE An Eps homology (EH) domain protein that binds to the Ral-GTPase
target, RalBP1
JOURNAL J. Biol. Chem. 272 (50), 31230-31234 (1997)
PUBMED 9395447
REFERENCE 9 (bases 1 to 4368)
AUTHORS Park,S.H. and Weinberg,R.A.
TITLE A putative effector of Ral has homology to Rho/Rac GTPase
activating proteins
JOURNAL Oncogene 11 (11), 2349-2355 (1995)
PUBMED 8570186
REFERENCE 10 (bases 1 to 4368)
AUTHORS Jullien-Flores,V., Dorseuil,O., Romero,F., Letourneur,F.,
Saragosti,S., Berger,R., Tavitian,A., Gacon,G. and Camonis,J.H.
TITLE Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with
CDC42/Rac GTPase-activating protein activity
JOURNAL J. Biol. Chem. 270 (38), 22473-22477 (1995)
PUBMED 7673236
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BQ224100.1, BX352266.2, BQ674032.1, L42542.1, BF794440.1 and
BC013126.1.
On Apr 12, 2004 this sequence version replaced gi:21361362.
Summary: RALBP1 plays a role in receptor-mediated endocytosis and
is a downstream effector of the small GTP-binding protein RAL (see
RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound
inactive and GTP-bound active forms, which shift from the inactive
to the active state through the action of RALGDS (MIM 601619),
which in turn is activated by RAS (see HRAS; MIM 190020) (summary
by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC013126.1, L42542.1 [ECO:0000331]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-15 BQ224100.1 2-16
16-17 BX352266.2 687-688 c
18-54 BQ224100.1 19-55
55-459 BQ674032.1 7-411
460-2562 L42542.1 468-2570
2563-2564 BF794440.1 795-796
2565-4368 BC013126.1 2427-4230
FEATURES Location/Qualifiers
source 1..4368
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18p11.3"
gene 1..4368
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="ralA binding protein 1"
/db_xref="GeneID:10928"
/db_xref="HGNC:9841"
/db_xref="HPRD:09013"
/db_xref="MIM:605801"
exon 1..160
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 145
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:9963963"
exon 161..459
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
misc_feature 171..173
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="upstream in-frame stop codon"
variation 195
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804316"
CDS 216..2183
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="ral-interacting protein 1; DNP-SG ATPase; 76 kDa
Ral-interacting protein; dinitrophenyl S-glutathione
ATPase"
/codon_start=1
/product="ralA-binding protein 1"
/protein_id="NP_006779.1"
/db_xref="GI:5803145"
/db_xref="CCDS:CCDS11845.1"
/db_xref="GeneID:10928"
/db_xref="HGNC:9841"
/db_xref="HPRD:09013"
/db_xref="MIM:605801"
/translation="
MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI
"
misc_feature 399..401
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15311.3); phosphorylation site"
misc_feature 489..491
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15311.3); phosphorylation site"
misc_feature 489..491
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 492..494
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15311.3); phosphorylation site"
misc_feature 492..494
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 783..1328
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="RhoGap_RalBP1: RhoGAP (GTPase-activator protein
[GAP] for Rho-like small GTPases) domain present in RalBP1
proteins, also known as RLIP, RLIP76 or cytocentrin.
RalBP1 plays an important role in endocytosis during
interphase. During mitosis, RalBP1...; Region:
RhoGap_RalBP1; cd04381"
/db_xref="CDD:63850"
misc_feature 834..1355
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="GTPase-activator protein for Rho-like GTPases;
Region: RhoGAP; smart00324"
/db_xref="CDD:197653"
misc_feature order(909..911,1017..1019,1029..1031,1236..1238,
1245..1250,1296..1298)
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="putative GTPase interaction site [polypeptide
binding]; other site"
/db_xref="CDD:63850"
misc_feature 909..911
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/note="catalytic residue [active]"
/db_xref="CDD:63850"
misc_feature 1104..1106
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01498"
misc_feature 1422..1712
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15311.3);
Region: Interacts with RalA"
misc_feature 1602..1604
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15311.3); phosphorylation site"
variation 230
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:142745932"
variation 253
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="g"
/replace="t"
/db_xref="dbSNP:200050154"
variation 261
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:147413500"
variation 326
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:139639775"
variation 343
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:371220710"
variation 399
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:201602095"
variation 410
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:201145450"
exon 460..918
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
STS 482..707
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/standard_name="RH80877"
/db_xref="UniSTS:88024"
variation 486
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:375010086"
variation 530
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:367547483"
variation 532
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:372081924"
variation 554
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:112195345"
variation 622
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:74838839"
variation 660
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:11559053"
variation 678
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:139161232"
variation 732
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:117752793"
variation 741
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:149502553"
variation 751
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:375158770"
variation 824
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:368559132"
variation 838
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:28552921"
variation 864
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:114518459"
variation 873
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:372077609"
variation 914
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:148679903"
exon 919..1268
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 956
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:112113600"
variation 959
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:374765771"
variation 975
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:368700058"
variation 988
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:368845774"
variation 1044
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:373416081"
variation 1056
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:375926697"
variation 1065
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:142799309"
variation 1079
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:201106324"
variation 1178
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:146546064"
variation 1179
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:140099378"
variation 1180
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:143680866"
variation 1181
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="g"
/replace="t"
/db_xref="dbSNP:146856822"
variation 1196
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:367736049"
exon 1269..1430
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1271
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:185003945"
variation 1310
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:370113769"
variation 1342
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:201125287"
variation 1367
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:140677227"
variation 1376
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:150447479"
variation 1384
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:374235427"
variation 1385
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:147257149"
exon 1431..1562
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1450
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:200197423"
variation 1529
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:145413955"
exon 1563..1670
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1668
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:372277773"
exon 1671..1792
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1771
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:149216756"
variation 1772
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:143047560"
exon 1793..1916
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1847
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:368804758"
variation 1881
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:138642497"
exon 1917..4354
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/inference="alignment:Splign:1.39.8"
variation 1942
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:144964228"
variation 1943
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:142766266"
variation 1956
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:374024426"
variation 1970
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:367939064"
variation 1979
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:372882231"
variation 1985
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:61739335"
variation 2007
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:376577692"
variation 2019
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:369532344"
variation 2029
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:372929952"
variation 2039
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:377226893"
variation 2065
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:35867116"
variation 2074
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:137976679"
variation 2084
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:201580280"
variation 2085
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:141739854"
variation 2088
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:200994399"
variation 2115
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:150549954"
variation 2137
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:368834573"
variation 2146
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:373024496"
variation 2150
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:377586790"
variation 2173
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:201564046"
variation 2192
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:372797994"
variation 2201
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:112115013"
variation 2210
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:370765981"
variation 2216
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:375549274"
variation 2227
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:374894294"
variation 2246
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:142029067"
variation 2247
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:150889840"
variation 2250
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="g"
/replace="t"
/db_xref="dbSNP:186267703"
variation 2252
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:367836645"
variation 2253
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:139358761"
variation 2471
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:371560204"
variation 2497
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:10898"
variation 2499
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:149604798"
variation 2524
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:190448771"
variation 2563
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:14336"
variation 2579
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:181298333"
variation 2605
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:185559392"
variation 2712
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:374205484"
STS 2772..3051
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/standard_name="G43251"
/db_xref="UniSTS:94906"
variation 2832
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="g"
/replace="t"
/db_xref="dbSNP:377125415"
variation 2898
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:3321"
variation 2939
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:3322"
variation 2979
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:144400646"
variation 3135
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:190876967"
variation 3216
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:182972888"
variation 3233
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:185899016"
variation 3258
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:140996592"
variation 3337
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:369861791"
variation 3345
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:16955192"
variation 3472
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:374053155"
variation 3772
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:376166475"
variation 3853
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="c"
/db_xref="dbSNP:192480820"
variation 4039
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:73939867"
variation 4083
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:12680"
variation 4084
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="g"
/db_xref="dbSNP:183230250"
variation 4093
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:372750210"
STS 4113..4258
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/standard_name="D18S910E"
/db_xref="UniSTS:72417"
variation 4144
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="c"
/replace="t"
/db_xref="dbSNP:368477271"
variation 4145
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:16955201"
variation 4178
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="t"
/db_xref="dbSNP:147558631"
STS 4201..4329
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/standard_name="SHGC-32001"
/db_xref="UniSTS:21308"
variation 4215..4216
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace=""
/replace="t"
/db_xref="dbSNP:34412957"
variation 4266
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:376012476"
variation 4292
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="g"
/db_xref="dbSNP:202115989"
variation 4307
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="g"
/replace="t"
/db_xref="dbSNP:73395762"
variation 4337
/gene="RALBP1"
/gene_synonym="RIP1; RLIP1; RLIP76"
/replace="a"
/replace="t"
/db_xref="dbSNP:187394285"
ORIGIN
atcattgtaaacaggcagaggctgggcggggtgggaatggggcgcccgaggccggcctggggcgcagcgcaggaggcggctccggtggctgcggcggcagcgtgagcgcgaggaggcggaggctgcggcggggcggacggtcgcgcggcggcaggcacaggtgtaatggataggtaacagagaagacctcgtcccttcctagtcagggcatcagcatgactgagtgcttcctgccccccaccagcagccccagtgaacaccgcagggtggagcatggcagcgggcttacccggacccccagctctgaagagatcagccctactaagtttcctggattgtaccgcactggcgagccctcacctccccatgacatcctccatgagcctcctgatgtagtgtctgatgatgagaaagatcatgggaagaaaaaagggaaatttaagaaaaaggaaaagaggactgaaggctatgcagcctttcaggaagatagctctggagatgaggcagaaagtccttctaaaatgaagaggtccaagggaatccatgttttcaagaagcccagcttttctaaaaagaaggaaaaggattttaaaataaaagagaaacccaaagaagaaaagcataaagaagaaaagcacaaagaagaaaaacataaagagaagaagtcaaaagacttgacagcagctgatgttgttaaacagtggaaggaaaagaagaaaaagaaaaagccaattcaggagccagaggtgcctcagattgatgttccaaatctcaaacccatttttggaattcctttggctgatgcagtagagaggaccatgatgtatgatggcattcggctgccagccgttttccgtgaatgtatagattacgtagagaagtatggcatgaagtgtgaaggcatctacagagtatcaggaattaaatcaaaggtggatgagctaaaagcagcctatgaccgggaggagtctacaaacttggaagactatgagcctaacactgtagccagtttgctgaagcagtatttgcgagaccttccagagaatttgcttaccaaagagcttatgcccagatttgaagaggcttgtgggaggaccacggagactgagaaagtgcaggaattccagcgtttactcaaagaactgccagaatgtaactatcttctgatttcttggctcattgtgcacatggaccatgtcattgcaaaggaactggaaacaaaaatgaatatacagaacatttctatagtgctcagcccaactgtgcagatcagcaatcgagtcctgtatgtgtttttcacacatgtgcaagaactctttggaaatgtggtactaaagcaagtgatgaaacctctgcgatggtctaacatggccacgatgcccacgctgccagagacccaggcgggcatcaaggaggagatcaggagacaggagtttcttttgaattgtttacatcgagatctgcagggtgggataaaggatttgtctaaagaagaaagattatgggaagtacaaagaattttgacagccctcaaaagaaaactgagagaagctaaaagacaggagtgtgaaaccaagattgcacaagagatagccagtctttcaaaagaggatgtttccaaagaagagatgaatgaaaatgaagaagttataaatattctccttgctcaggagaatgagatcctgactgaacaggaggagctcctggccatggagcagtttctgcgccggcagattgcctcagaaaaagaagagattgaacgcctcagagctgagattgctgaaattcagagtcgccagcagcacggccgaagtgagactgaggagtactcctccgagagcgagagcgagagtgaggatgaggaggagctgcagatcattctggaagacttacagagacagaacgaagagctggaaataaagaacaatcatttgaatcaagcaattcatgaggagcgcgaggccatcatcgagctgcgcgtgcagctgcggctgctccagatgcagcgagccaaggccgagcagcaggcgcaggaggacgaggagcctgagtggcgcgggggtgccgtccagccgcccagagacggcgtccttgagccaaaagcagctaaagagcagccaaaggcaggcaaggagccggcaaagccatcgcccagcagggataggaaggagacgtccatctgagcagcctgcgtggccgtctggagtccgtgagactgaaaggacccgtgcatcttactgtaacccgggggccaggccggctctctcgctgtacattctgtaaaggtgtcttctcttctcagactcttcctctgtcacacgtctgactccttcacgtcaggctcaggttccatgggaggacgaagcagtggacgcattgtgggctttagggacagatgagttttccagatagtgtcagcttatttgaagattaattttctttgttaacttaaaataactattttaacccttgagtggcttctttttaaaccaaaaaccgtctttctttgcttttttatcacagcagaatcaggatctctttctcattcaaggggggaaccaccccaggtcagcgctgcgcctgctgtggccgccgcgagccacgccctctgggatctctggtaccgtcactcttgcttgtgccttccacaccttctcggtgcagatccctatgggggagctgcctcacgttctctgactggtcagagcagcgcctggtgggtgttccctggcccactctcctctctccttctgcagttctaaaccacagtctataagcccgagtcaccaggacggcctgtctggccacagacaggggctgcctgtggagcctgcccaccggcccccggcagtgcagtccagcggggaggaggctgcccgttcctgccagttcctcactgcggggaccagcaaaggccttctcactgggttggtcaaaggtagtcaccttggcctggtgcatccacagaggatgttgttcaaaccagaaatcttttaaacgactgaccttccttaaaaacagaatgactccgattgcttgcttgggctagaatgtacacgtctccttgcctgaataagccatatatatgctcttaaacaaaagtttgaaattatccatatcatctcagtgaacctactggtggactcccaattgacaagattgagcaatagaaaaaaattcctttcctttgaatgatagctgtgattcaccccaccccattttcttgtttctggtccatccgatgagacggatgctctgatgctctgaggcttctgggaggctgggccctggaggcaacgtgctgcaggcgcactctgtcagagtgaacagcaccgcgagacaggccaggctcgtggctcggaagacaaaccccacacacactcaaggggtcgaaaacaaaccccacacgagggctctcacctccttctcctaggtagtatttattttcagcacctgtttgatgcagtttttaatcctctacctattgcactgttgtgactcgttggccattatttgatttttgtacgaaaaaaagctttgttatagaaatcagcatactatttttttaaatctggagagaagatattctggtgactgaaagtatggtcgggtgtcagatataaatgtgcaaatgccttcttgctgtcctgtcggtctcagtacgttcactttatagctgctggcaatatcgaaggttccttttttgtttgtgtaaactctaatttctatcaaggtgtcatggatttttaaaattagtatttcattacaaatgtctcagcattggttaactaatttttgccaggaccattattgatcaagcaaataaattcaacagccatttgggaaaaagaaaagcttctagtttttttgtacacattctttctgtgaggagattgagtactctgcagctggcgaggagttggttgaggcacttcttcaaggccaagggggaacacagtgttttgtttccagctcactttgtacccctcacctctgcagacacggggagaaccccggacccctggcatgcatgctggcggcggcatgcctcccttccacaagcccatgctgctgcagagggagcctgtgtttgcaaaacccagtggactgggctgggtctgctgtctgagcagctcctggctccggtgggaactgcacacaagtccactggcctggcttggccccaggcattgcaattgacagacatttgcatttcatacggtaaatgaggactcagcacagccaaccataatcagcatgtctgggatagactggtctagaataaaaatgaagtttccattgctttgtttgctttaaaaattccacaattaaaatatctgtcattgaaagcttaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10928 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IDA
GeneID:10928 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10928 -> Molecular function: GO:0016887 [ATPase activity] evidence: IDA
GeneID:10928 -> Molecular function: GO:0017160 [Ral GTPase binding] evidence: IPI
GeneID:10928 -> Molecular function: GO:0030675 [Rac GTPase activator activity] evidence: IDA
GeneID:10928 -> Molecular function: GO:0043492 [ATPase activity, coupled to movement of substances] evidence: IDA
GeneID:10928 -> Molecular function: GO:0048365 [Rac GTPase binding] evidence: IPI
GeneID:10928 -> Biological process: GO:0006200 [ATP catabolic process] evidence: IDA
GeneID:10928 -> Biological process: GO:0006810 [transport] evidence: IDA
GeneID:10928 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:10928 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:10928 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: IPI
GeneID:10928 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:10928 -> Biological process: GO:0043087 [regulation of GTPase activity] evidence: IDA
GeneID:10928 -> Biological process: GO:0043089 [positive regulation of Cdc42 GTPase activity] evidence: IDA
GeneID:10928 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: TAS
GeneID:10928 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:10928 -> Cellular component: GO:0016020 [membrane] evidence: IDA
by
@meso_cacase at
DBCLS
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