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2024-03-29 01:02:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006690               4344 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens matrix metallopeptidase 24 (membrane-inserted)
            (MMP24), mRNA.
ACCESSION   NM_006690
VERSION     NM_006690.3  GI:73620939
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4344)
  AUTHORS   Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B,
            Yusuf S, Gerstein HC, Engert JC and Anand S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 4344)
  AUTHORS   Nalpas,B., Lavialle-Meziani,R., Plancoulaine,S., Jouanguy,E.,
            Nalpas,A., Munteanu,M., Charlotte,F., Ranque,B., Patin,E.,
            Heath,S., Fontaine,H., Vallet-Pichard,A., Pontoire,D.,
            Bourliere,M., Casanova,J.L., Lathrop,M., Brechot,C., Poynard,T.,
            Matsuda,F., Pol,S. and Abel,L.
  TITLE     Interferon gamma receptor 2 gene variants are associated with liver
            fibrosis in patients with chronic hepatitis C infection
  JOURNAL   Gut 59 (8), 1120-1126 (2010)
   PUBMED   20587546
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4344)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med. Genet. 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4344)
  AUTHORS   Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
            TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
            Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
            Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
            Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
            Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
            and Hingorani AD.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4344)
  AUTHORS   Luo,Y.P., Zhong,M., Wang,L.P., Zhong,M., Sun,G.Q. and Li,J.
  TITLE     [Inhibitory effects of RNA interference on MMP-24 expression and
            invasiveness of ovarian cancer SKOV(3) cells]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 29 (4), 781-784 (2009)
   PUBMED   19403421
  REMARK    GeneRIF: MMP-24 gene silencing by RNAi can suppress the
            invasiveness of ovarian cancer SKOV(3) cells in vitro.
REFERENCE   6  (bases 1 to 4344)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 4344)
  AUTHORS   Romanic,A.M., Burns-Kurtis,C.L., Ao,Z., Arleth,A.J. and
            Ohlstein,E.H.
  TITLE     Upregulated expression of human membrane type-5 matrix
            metalloproteinase in kidneys from diabetic patients
  JOURNAL   Am. J. Physiol. Renal Physiol. 281 (2), F309-F317 (2001)
   PUBMED   11457723
REFERENCE   8  (bases 1 to 4344)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J. Biol. Chem. 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
REFERENCE   9  (bases 1 to 4344)
  AUTHORS   Llano,E., Pendas,A.M., Freije,J.P., Nakano,A., Knauper,V.,
            Murphy,G. and Lopez-Otin,C.
  TITLE     Identification and characterization of human MT5-MMP, a new
            membrane-bound activator of progelatinase a overexpressed in brain
            tumors
  JOURNAL   Cancer Res. 59 (11), 2570-2576 (1999)
   PUBMED   10363975
REFERENCE   10 (bases 1 to 4344)
  AUTHORS   Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.
  TITLE     Assignment of the genes for membrane-type-4 matrix
            metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human
            chromosome band 12q24.3 and membrane-type-5 matrix
            metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human
            chromosome band 20q11.2-->q12, respectively, by radiation hybrid
            and in situ hybridization
  JOURNAL   Cytogenet. Cell Genet. 87 (1-2), 97-98 (1999)
   PUBMED   10640822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB021227.1, BC047614.1 and
            R60687.1.
            On Aug 19, 2005 this sequence version replaced gi:13027806.
            
            Summary: Proteins of the matrix metalloproteinase (MMP) family are
            involved in the breakdown of extracellular matrix in normal
            physiological processes, such as embryonic development,
            reproduction, and tissue remodeling, as well as in disease
            processes, such as arthritis and metastasis. Most MMP's are
            secreted as inactive proproteins which are activated when cleaved
            by extracellular proteinases. However, the protein encoded by this
            gene is a member of the membrane-type MMP (MT-MMP) subfamily; each
            member of this subfamily contains a potential transmembrane domain
            suggesting that these proteins are expressed at the cell surface
            rather than secreted. This protein activates MMP2 by cleavage. The
            gene has previously been referred to as MMP25 but has been renamed
            MMP24. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB021227.1, BC047614.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-806               AB021227.1         1-806
            807-4328            BC047614.1         747-4268
            4329-4344           R60687.1           1-16                c
FEATURES             Location/Qualifiers
     source          1..4344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.2"
     gene            1..4344
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="matrix metallopeptidase 24 (membrane-inserted)"
                     /db_xref="GeneID:10893"
                     /db_xref="HGNC:7172"
                     /db_xref="HPRD:05338"
                     /db_xref="MIM:604871"
     exon            1..249
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       2
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192126321"
     CDS             4..1941
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="membrane-type 5 matrix metalloproteinase; matrix
                     metalloproteinase 24 (membrane-inserted); matrix
                     metalloproteinase-24; membrane-type matrix
                     metalloproteinase 5; membrane-type-5 matrix
                     metalloproteinase"
                     /codon_start=1
                     /product="matrix metalloproteinase-24 preproprotein"
                     /protein_id="NP_006681.1"
                     /db_xref="GI:5729929"
                     /db_xref="CCDS:CCDS46593.1"
                     /db_xref="GeneID:10893"
                     /db_xref="HGNC:7172"
                     /db_xref="HPRD:05338"
                     /db_xref="MIM:604871"
                     /translation="
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
"
     sig_peptide     4..159
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     proprotein      160..1938
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /product="matrix metalloproteinase-24 proprotein"
     misc_feature    247..405
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="Putative peptidoglycan binding domain; Region:
                     PG_binding_1; pfam01471"
                     /db_xref="CDD:201815"
     misc_feature    412..435
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     Region: Cysteine switch (By similarity)"
     mat_peptide     469..1938
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /product="matrix metalloproteinase-24"
     misc_feature    487..984
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="Zinc-dependent metalloprotease, matrix
                     metalloproteinase (MMP) sub-family. MMPs are responsible
                     for a great deal of pericellular proteolysis of
                     extracellular matrix and cell surface molecules, playing
                     crucial roles in morphogenesis, cell fate...; Region:
                     ZnMc_MMP; cd04278"
                     /db_xref="CDD:58578"
     misc_feature    order(664..666,700..702,721..741,766..768,847..852,
                     877..879,907..915)
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="TIMP-binding surface; other site"
                     /db_xref="CDD:58578"
     misc_feature    order(847..852,859..861,877..879)
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="active site"
                     /db_xref="CDD:58578"
     misc_feature    1132..1710
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     Region: HX; cd00094"
                     /db_xref="CDD:28978"
     misc_feature    1132..1278
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     Region: Hemopexin 1"
     misc_feature    order(1156..1158,1162..1164,1291..1293,1297..1299,
                     1432..1434,1438..1440,1576..1578,1582..1584)
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="Metal binding sites [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:28978"
     misc_feature    1279..1416
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     Region: Hemopexin 2"
     misc_feature    1420..1566
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     Region: Hemopexin 3"
     misc_feature    1567..1710
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     Region: Hemopexin 4"
     misc_feature    1720..1938
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /note="Domain of unknown function (DUF3377); Region:
                     DUF3377; pfam11857"
                     /db_xref="CDD:204762"
     misc_feature    1810..1872
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5R2.1);
                     transmembrane region"
     exon            250..398
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       279
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147213806"
     variation       292
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373597415"
     variation       293
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140648293"
     variation       315
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3764733"
     variation       320
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375444013"
     variation       321
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6060322"
     variation       330
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368263991"
     variation       357
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201429856"
     variation       372
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:71350371"
     variation       373
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372102289"
     variation       392
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199855518"
     exon            399..515
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       400
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7345423"
     variation       407
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369070775"
     variation       416
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371591987"
     variation       418
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375020027"
     variation       455
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369700691"
     exon            516..820
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       556
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373921690"
     variation       580
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377395014"
     variation       599
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372733664"
     variation       611
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370441023"
     variation       614
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375216222"
     variation       633
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200622455"
     variation       638
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370836557"
     variation       687
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199700844"
     variation       691
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375086359"
     variation       693
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373842436"
     variation       771
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190477122"
     variation       819
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201524805"
     exon            821..982
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       825
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201850633"
     variation       826
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376734021"
     variation       886
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370546087"
     variation       888
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375374343"
     exon            983..1197
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       1033
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:52833951"
     variation       1037
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61729978"
     variation       1056
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200666312"
     variation       1068
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143339096"
     variation       1109
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199892177"
     variation       1123
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368746640"
     variation       1126
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35703318"
     variation       1194
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373122960"
     exon            1198..1336
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       1214
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139576876"
     variation       1257
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371306332"
     variation       1281
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374488445"
     variation       1290
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111895945"
     variation       1311
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202140682"
     exon            1337..1603
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       1339
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371695850"
     variation       1359
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376273351"
     variation       1374
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41290910"
     variation       1384
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368325243"
     variation       1421
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372495279"
     STS             1428..1602
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="RH135475"
                     /db_xref="UniSTS:158743"
     variation       1503
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200255002"
     variation       1512
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:188090548"
     variation       1542
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61729977"
     variation       1549
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369406481"
     variation       1560
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61729975"
     exon            1604..4333
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /inference="alignment:Splign:1.39.8"
     variation       1628
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200102286"
     STS             1644..2873
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="stSG636496"
                     /db_xref="UniSTS:460918"
     variation       1680
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184666059"
     variation       1684
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114249756"
     variation       1694
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:751887"
     variation       1725
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370507414"
     variation       1730
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373027505"
     variation       1733
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75564013"
     variation       1742
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370896350"
     variation       1744..1745
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:372291830"
     variation       1745
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374634355"
     STS             1756..2660
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="ECD00469"
                     /db_xref="UniSTS:281580"
     variation       1758
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200497071"
     variation       1761
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370527619"
     variation       1782
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150234484"
     variation       1784
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367921884"
     variation       1788
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202095693"
     variation       1794
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182077926"
     variation       1816
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368386809"
     STS             1819..2066
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57075"
                     /db_xref="UniSTS:381875"
     variation       1830
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372706982"
     variation       1834
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376807772"
     variation       1836
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368924948"
     variation       1863
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138945034"
     STS             1897..2693
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="MMP24_v514"
                     /db_xref="UniSTS:277492"
     variation       1919
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149443021"
     variation       1952
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374988435"
     variation       1961
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369104690"
     variation       1962
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374090086"
     variation       1970
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199987897"
     variation       2049
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145887658"
     STS             2065..2331
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57076"
                     /db_xref="UniSTS:381876"
     variation       2073
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73107210"
     variation       2098
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187193883"
     variation       2213
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202235161"
     variation       2251
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116554407"
     variation       2258..2259
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:375791322"
     STS             2319..2567
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57077"
                     /db_xref="UniSTS:381877"
     variation       2385
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190810178"
     variation       2404
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180724951"
     variation       2492
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186447228"
     variation       2532
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142738836"
     STS             2538..2795
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57078"
                     /db_xref="UniSTS:381878"
     variation       2668
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111428816"
     STS             2678..2894
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="A003A31"
                     /db_xref="UniSTS:69556"
     STS             2737..3617
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="ECD01027"
                     /db_xref="UniSTS:282135"
     STS             2787..3034
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57079"
                     /db_xref="UniSTS:381879"
     STS             2854..3967
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="stSG636497"
                     /db_xref="UniSTS:460919"
     variation       2863
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73107212"
     variation       2864
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77577148"
     variation       2867
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146097442"
     variation       2940
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6058221"
     variation       3008
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11697982"
     STS             3013..3258
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57080"
                     /db_xref="UniSTS:381880"
     variation       3039
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148733689"
     variation       3072
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182483533"
     variation       3075
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187518151"
     variation       3086
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141737831"
     variation       3123
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116117360"
     variation       3137
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190495884"
     variation       3138
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116326534"
     variation       3162
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6060341"
     variation       3210
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150575439"
     STS             3244..3505
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57081"
                     /db_xref="UniSTS:381881"
     variation       3339
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042971"
     variation       3395
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139565116"
     variation       3482
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6060342"
     STS             3489..3745
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57082"
                     /db_xref="UniSTS:381882"
     variation       3650
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183248069"
     STS             3725..3979
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57083"
                     /db_xref="UniSTS:381883"
     variation       3728
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73903036"
     variation       3760
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188898089"
     variation       3762
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11555916"
     variation       3776
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34569456"
     variation       3870
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34682766"
     STS             3951..4200
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /standard_name="REN57084"
                     /db_xref="UniSTS:381884"
     variation       4013
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7280"
     variation       4046
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12293"
     variation       4094
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371449009"
     variation       4118
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144554200"
     variation       4201
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112372493"
     variation       4206
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:376479633"
     variation       4270
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3205397"
     polyA_signal    4312..4317
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
     polyA_site      4328
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
     polyA_site      4330
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
     polyA_site      4333
                     /gene="MMP24"
                     /gene_synonym="MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP;
                     MT5MMP; MTMMP5"
ORIGIN      
gggatgccgaggagccggggcggccgcgccgcgccggggccgccgccgccgccgccgccgccgggccaggccccgcgctggagccgctggcgggtccctgggcggctgctgctgctgctgctgcccgcgctctgctgcctcccgggcgccgcgcgggcggcggcggcggcggcgggggcagggaaccgggcagcggtggcggtggcggtggcgcgggcggacgaggcggaggcgcccttcgccgggcagaactggttaaagtcctatggctatctgcttccctatgactcacgggcatctgcgctgcactcagcgaaggccttgcagtcggcagtctccactatgcagcagttttacgggatcccggtcaccggtgtgttggatcagacaacgatcgagtggatgaagaaaccccgatgtggtgtccctgatcacccccacttaagccgtaggcggagaaacaagcgctatgccctgactggacagaagtggaggcaaaaacacatcacctacagcattcacaactataccccaaaagtgggtgagctagacacgcggaaagctattcgccaggctttcgatgtgtggcagaaggtgaccccactgacctttgaagaggtgccataccatgagatcaaaagtgaccggaaggaggcagacatcatgatcttttttgcttctggtttccatggcgacagctccccatttgatggagaagggggattcctggcccatgcctacttccctggcccagggattggaggagacacccactttgactccgatgagccatggacgctaggaaatgccaaccatgacgggaacgacctcttcctggtggctgtgcatgagctgggccacgcgctgggactggagcactccagcgaccccagcgccatcatggcgcccttctaccagtacatggagacgcacaacttcaagctgccccaggacgatctccagggcatccagaagatctatggacccccagccgagcctctggagcccacaaggccactccctacactccccgtccgcaggatccactcaccatcggagaggaaacacgagcgccagcccaggccccctcggccgcccctcggggaccggccatccacaccaggcaccaaacccaacatctgtgacggcaacttcaacacagtggccctcttccggggcgagatgtttgtctttaaggatcgctggttctggcgtctgcgcaataaccgagtgcaggagggctaccccatgcagatcgagcagttctggaagggcctgcctgcccgcatcgacgcagcctatgaaagggccgatgggagatttgtcttcttcaaaggtgacaagtattgggtgtttaaggaggtgacggtggagcctgggtacccccacagcctgggggagctgggcagctgtttgccccgtgaaggcattgacacagctctgcgctgggaacctgtgggcaagacctactttttcaaaggcgagcggtactggcgctacagcgaggagcggcgggccacggaccctggctaccctaagcccatcaccgtgtggaagggcatcccacaggctccccaaggagccttcatcagcaaggaaggatattacacctatttctacaagggccgggactactggaagtttgacaaccagaaactgagcgtggagccaggctacccgcgcaacatcctgcgtgactggatgggctgcaaccagaaggaggtggagcggcggaaggagcggcggctgccccaggacgacgtggacatcatggtgaccatcaacgatgtgccgggctccgtgaacgccgtggccgtggtcatcccctgcatcctgtccctctgcatcctggtgctggtctacaccatcttccagttcaagaacaagacaggccctcagcctgtcacctactataagcggccagtccaggaatgggtgtgagcagcccagagccctctctatccacttggtctggccagccaggcccttcctcaccagggtctgaggggcagctctggccagtgctcaccagggccagcagggccctaggctggggtcgtacagctgaagtggtgggtgcattggcctaggctgagcgtggggcagggaattatgggggctgtgccccagggtgggtgtctggcacccagctgccagccttctgtcctgggcaaactactccctacttaagggaataggccaggctccatccggaggcagggaccatgccaggaggagcccctgtggtcacggcatcctgtggtgtccatgaggtaccacagctccactcctggctggaacccagcaccctctgtgggaagccagcactagctctcatcccccatccgggagataccaccagtcctggtccccttttgccaacacctgctggtcagatgtccccctacccccaccccactgtcctccaaggctacaggacccctgcttctgacacagtgagcaacaagcctgggtttccctgctggcagacggcagatccctcaggaaacctgctccacttgtcagggtctcttcggagacccaggatttagggtcacatgctgcaggcagggctgtggcccagctgggtctgacaaggacccagctgtcacatcgtgaatatttaaatgtcctgtcactactgtcccattttgcaaaggctgcttgaggctttaggtgaactagaggtgactgtcttggtgatgaggccagcatagcggccctcccccaggcgacaaggaccaaggtgctgctaaggccactctagcgcccagacaccccagtagctgagctctgctcctatggctacagagctggggcagaagctgaccccatttctggaggaagatccgagtttgtgaccgtcctccactcccctctattgtcactgtccccagctttgctccagtctgtcacttgcagcctggagctcagcctcaccagttaggtgaggcagagatggctgcagggccaacactggcagagcctgggagtccttcggaaggggaccagggcgtctgaagtgctcagtgcccccactactctgaggccgactccagctactctgaggccgactcaatctctcggctggaagcagtgttttcccagagcttggcccttgctgacctcgctcactgggcccatcttcccacactgctcttagaaggacacccctaccggtagcagccccaagctgagggggctccctttttgaccttcactggcccgcccttcactgtctccagcaggagttcctagggcttggcctgccttgctccacagtacggcggaggcagccctgcttgtcactgaggagccctagacaaggccaatgggttcatcaatgcccactggctctctgccaaagccaaaaaggtgtcaggcagtctccagcgtgctggccgggtctcggatgccacccctgctcactgagcctgcatgggccttgcccccgaccctgtggtctctgggattggggtcggcttaccctgtagcacagacagggactcctgctgccctgggagctgtctcaagcaaaatctcttgtcccagaggtgcccatgtgggtccgctgtgtcccctgtcatcatccttgttttttctcattttggccaagggcaggctccctgggacaggcagggaacaactgcggagatattagtgattcataggtttgtacagtgttttatactttgcaaagcactttattagctcacacctgtccactcacatgaaactcgtgttaggccctgggaggccgacggtaactctcaccgtgccctcagatgaagcacagagaggttgttacttgcccgggccatccagtgggctggctgggtcttgtgtccccatctgtggacccctctagggtctgagatgagatgagaagtgtctcctgtatccacctcttcctggcctcccttcccccacttcctggtccctgtccactcctcaggttggtgctctcacttcttgaaagctctaggcacccccgcctcccgccaggctccccattggctcctggcaggccagctgagaatgaacaggagatggaggcaggcagcccaggctgcagaggtgagggatgtggggccaggcccagagggctcagcctagaggcttccaatctcagattctcctgcctgtggtcatctgtttgtccatcaccccaggacagggcagacagaggggcaaagcactgggggccccagagcctagcttcccctcagcctgggggacatcacagcatttcagtgtcagtcacattttaaactgatcagcctttgtataatgttttttaaatcatttctaaataaaacagaaatacagagtgaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10893 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IEA
            GeneID:10893 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
            GeneID:10893 -> Molecular function: GO:0008047 [enzyme activator activity] evidence: TAS
            GeneID:10893 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:10893 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:10893 -> Biological process: GO:0043085 [positive regulation of catalytic activity] evidence: TAS
            GeneID:10893 -> Cellular component: GO:0005578 [proteinaceous extracellular matrix] evidence: IEA
            GeneID:10893 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS

by @meso_cacase at DBCLS
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