GGRNA | NM_006620.3

LOCUS       NM_006620               7163 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens HBS1-like (S. cerevisiae) (HBS1L), transcript variant
            1, mRNA.
ACCESSION   NM_006620
VERSION     NM_006620.3  GI:194578914
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7163)
  AUTHORS   Li,J., Glessner,J.T., Zhang,H., Hou,C., Wei,Z., Bradfield,J.P.,
            Mentch,F.D., Guo,Y., Kim,C., Xia,Q., Chiavacci,R.M., Thomas,K.A.,
            Qiu,H., Grant,S.F., Furth,S.L., Hakonarson,H. and Sleiman,P.M.
  TITLE     GWAS of blood cell traits identifies novel associated loci and
            epistatic interactions in Caucasian and African-American children
  JOURNAL   Hum. Mol. Genet. 22 (7), 1457-1464 (2013)
   PUBMED   23263863
REFERENCE   2  (bases 1 to 7163)
  AUTHORS   Menzel,S., Garner,C., Rooks,H., Spector,T.D. and Thein,S.L.
  TITLE     HbA2 levels in normal adults are influenced by two distinct genetic
            mechanisms
  JOURNAL   Br. J. Haematol. 160 (1), 101-105 (2013)
   PUBMED   23043469
REFERENCE   3  (bases 1 to 7163)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   4  (bases 1 to 7163)
  AUTHORS   Bae,H.T., Baldwin,C.T., Sebastiani,P., Telen,M.J., Ashley-Koch,A.,
            Garrett,M., Hooper,W.C., Bean,C.J., Debaun,M.R., Arking,D.E.,
            Bhatnagar,P., Casella,J.F., Keefer,J.R., Barron-Casella,E.,
            Gordeuk,V., Kato,G.J., Minniti,C., Taylor,J., Campbell,A.,
            Luchtman-Jones,L., Hoppe,C., Gladwin,M.T., Zhang,Y. and
            Steinberg,M.H.
  TITLE     Meta-analysis of 2040 sickle cell anemia patients: BCL11A and
            HBS1L-MYB are the major modifiers of HbF in African Americans
  JOURNAL   Blood 120 (9), 1961-1962 (2012)
   PUBMED   22936743
  REMARK    GeneRIF: Studies indicate that single nucleotide polymorphisms
            (SNPs) in regions of BCL11A and HBS1L-MYB intergenic polymorphism
            are the major modifiers of HbF in African Americans.
REFERENCE   5  (bases 1 to 7163)
  AUTHORS   Qayyum,R., Snively,B.M., Ziv,E., Nalls,M.A., Liu,Y., Tang,W.,
            Yanek,L.R., Lange,L., Evans,M.K., Ganesh,S., Austin,M.A.,
            Lettre,G., Becker,D.M., Zonderman,A.B., Singleton,A.B.,
            Harris,T.B., Mohler,E.R., Logsdon,B.A., Kooperberg,C., Folsom,A.R.,
            Wilson,J.G., Becker,L.C. and Reiner,A.P.
  TITLE     A meta-analysis and genome-wide association study of platelet count
            and mean platelet volume in african americans
  JOURNAL   PLoS Genet. 8 (3), E1002491 (2012)
   PUBMED   22423221
REFERENCE   6  (bases 1 to 7163)
  AUTHORS   Lettre,G., Sankaran,V.G., Bezerra,M.A., Araujo,A.S., Uda,M.,
            Sanna,S., Cao,A., Schlessinger,D., Costa,F.F., Hirschhorn,J.N. and
            Orkin,S.H.
  TITLE     DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci
            associate with fetal hemoglobin levels and pain crises in sickle
            cell disease
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 105 (33), 11869-11874 (2008)
   PUBMED   18667698
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7163)
  AUTHORS   Menzel,S., Jiang,J., Silver,N., Gallagher,J., Cunningham,J.,
            Surdulescu,G., Lathrop,M., Farrall,M., Spector,T.D. and Thein,S.L.
  TITLE     The HBS1L-MYB intergenic region on chromosome 6q23.3 influences
            erythrocyte, platelet, and monocyte counts in humans
  JOURNAL   Blood 110 (10), 3624-3626 (2007)
   PUBMED   17712044
  REMARK    GeneRIF: The HBS1L-MYB intergenic region on chromosome 6q23.3
            influences erythrocyte, platelet, and monocyte counts.
REFERENCE   8  (bases 1 to 7163)
  AUTHORS   Thein,S.L., Menzel,S., Peng,X., Best,S., Jiang,J., Close,J.,
            Silver,N., Gerovasilli,A., Ping,C., Yamaguchi,M., Wahlberg,K.,
            Ulug,P., Spector,T.D., Garner,C., Matsuda,F., Farrall,M. and
            Lathrop,M.
  TITLE     Intergenic variants of HBS1L-MYB are responsible for a major
            quantitative trait locus on chromosome 6q23 influencing fetal
            hemoglobin levels in adults
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 104 (27), 11346-11351 (2007)
   PUBMED   17592125
  REMARK    GeneRIF: HBS1L-related genetic variants play a key role in control
            of fetal hemoglobin levels.
REFERENCE   9  (bases 1 to 7163)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 7163)
  AUTHORS   Wallrapp,C., Verrier,S.B., Zhouravleva,G., Philippe,H.,
            Philippe,M., Gress,T.M. and Jean-Jean,O.
  TITLE     The product of the mammalian orthologue of the Saccharomyces
            cerevisiae HBS1 gene is phylogenetically related to eukaryotic
            release factor 3 (eRF3) but does not carry eRF3-like activity
  JOURNAL   FEBS Lett. 440 (3), 387-392 (1998)
   PUBMED   9872408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB051030.1, BC001465.2 and
            AL445190.9.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 29, 2008 this sequence version replaced gi:24431963.
            
            Summary: This gene encodes a member of the GTP-binding elongation
            factor family. It is expressed in multiple tissues with the highest
            expression in heart and skeletal muscle. The intergenic region of
            this gene and the MYB gene has been identified to be a quantitative
            trait locus (QTL) controlling fetal hemoglobin level, and this
            region influnces erythrocyte, platelet, and monocyte counts as well
            as erythrocyte volume and hemoglobin content. DNA polymorphisms at
            this region associate with fetal hemoglobin levels and pain crises
            in sickle cell disease. A single nucleotide polymorphism in exon 1
            of this gene is significantly associated with severity in
            beta-thalassemia/Hemoglobin E. Multiple alternatively spliced
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ459826.1, AK024258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DB051030.1         1-91
            92-2407             BC001465.2         1-2316
            2408-7163           AL445190.9         21070-25825         c
FEATURES             Location/Qualifiers
     source          1..7163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..7163
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="HBS1-like (S. cerevisiae)"
                     /db_xref="GeneID:10767"
                     /db_xref="HGNC:4834"
                     /db_xref="HPRD:06582"
                     /db_xref="MIM:612450"
     exon            1..250
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    175..177
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="upstream in-frame stop codon"
     variation       177
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112374595"
     variation       188
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113123443"
     CDS             208..2262
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="isoform 1 is encoded by transcript variant 1; Hsp70
                     subfamily B suppressor 1-like protein; HBS1-like protein;
                     ERF3-similar protein"
                     /codon_start=1
                     /product="HBS1-like protein isoform 1"
                     /protein_id="NP_006611.1"
                     /db_xref="GI:5729864"
                     /db_xref="CCDS:CCDS5173.1"
                     /db_xref="GeneID:10767"
                     /db_xref="HGNC:4834"
                     /db_xref="HPRD:06582"
                     /db_xref="MIM:612450"
                     /translation="

MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKGPPIEDAIASSDVLETASKSANPPHTIQASEEQSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE

"
     misc_feature    208..621
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="Domain of unknown function (DUF1916); Region:
                     DUF1916; pfam08938"
                     /db_xref="CDD:149872"
     misc_feature    373..375
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    379..381
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    556..558
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9Y450.1); phosphorylation site"
     misc_feature    586..588
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9Y450.1); phosphorylation site"
     misc_feature    973..2259
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="Translation elongation factor EF-1alpha (GTPase)
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TEF1; COG5256"
                     /db_xref="CDD:34853"
     misc_feature    991..1650
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="Elongation Factor 1-alpha (EF1-alpha) protein
                     family; Region: EF1_alpha; cd01883"
                     /db_xref="CDD:206670"
     misc_feature    1006..1029
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="G1 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    order(1009..1011,1015..1017,1027..1032,1039..1041,
                     1048..1053,1192..1197,1249..1254,1321..1326,1465..1467,
                     1477..1479)
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:206670"
     misc_feature    order(1015..1017,1021..1032,1423..1428,1432..1434,
                     1540..1548)
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206670"
     misc_feature    order(1027..1029,1156..1158,1165..1170,1174..1176,
                     1180..1182,1186..1194,1198..1200,1231..1233,1237..1239,
                     1243..1251,1255..1257,1264..1266)
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="EF1Balpha binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206670"
     misc_feature    1162..1194
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206670"
     misc_feature    1180..1182
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="G2 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    1237..1248
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="G3 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    1243..1299
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206670"
     misc_feature    1423..1434
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="G4 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    1540..1548
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="G5 box; other site"
                     /db_xref="CDD:206670"
     misc_feature    1666..1914
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="eRF3_II_like: domain similar to domain II of the
                     eukaryotic class II release factor (eRF3). In eukaryotes,
                     translation termination is mediated by two interacting
                     release factors, eRF1 and eRF3, which act as class I and
                     II factors, respectively. eRF1...; Region: eRF3_II_like;
                     cd03698"
                     /db_xref="CDD:58089"
     misc_feature    1933..2253
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /note="HBS1_C: this family represents the C-terminal
                     domain of Hsp70 subfamily B suppressor 1 (HBS1) which is
                     homologous to the domain III of EF-1alpha. This group
                     contains proteins similar to yeast Hbs1, a G protein known
                     to be important for efficient growth...; Region: HBS1_C;
                     cd04093"
                     /db_xref="CDD:58075"
     variation       246
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112424574"
     exon            251..316
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       309
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35916433"
     exon            317..442
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       337
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113665733"
     variation       370
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113532184"
     variation       401
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112702237"
     exon            443..637
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     STS             457..585
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /standard_name="PMC140821P3"
                     /db_xref="UniSTS:270977"
     variation       613
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113745241"
     exon            638..746
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       646
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111758776"
     variation       657
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35697718"
     variation       745
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34860737"
     exon            747..1006
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1007..1172
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1173..1290
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1291..1437
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       1388
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111422826"
     exon            1438..1512
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     STS             1463..1555
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /standard_name="HBS1L"
                     /db_xref="UniSTS:504542"
     exon            1513..1630
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1631..1699
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1700..1804
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1805..1895
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            1896..2004
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     exon            2005..2105
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       2038
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:36025561"
     exon            2106..2250
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       2112
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113089804"
     STS             2119..2250
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /standard_name="PMC140821P2"
                     /db_xref="UniSTS:270976"
     variation       2160
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1139174"
     variation       2222
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113801496"
     exon            2251..7163
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /inference="alignment:Splign:1.39.8"
     variation       2362
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112748112"
     variation       2498
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113902835"
     STS             2673..2856
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /standard_name="RH46724"
                     /db_xref="UniSTS:73570"
     STS             2708..2908
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /standard_name="HSC20G062"
                     /db_xref="UniSTS:19610"
     polyA_signal    2885..2890
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
     variation       2899
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:111504247"
     polyA_site      2916
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
     variation       3018
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112465963"
     variation       3473
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112290620"
     variation       3759
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111768274"
     variation       4207
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112529964"
     variation       4352
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112911622"
     variation       4593
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:111639058"
     variation       4665
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112518126"
     variation       5805
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112112993"
     variation       5873
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112795442"
     variation       6542
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111288345"
     variation       6687
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112150644"
     variation       6746
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111520283"
     variation       6884
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1135205"
     variation       6967
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113666687"
     variation       7005
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1135206"
     variation       7032
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113255530"
     variation       7074..7075
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:112383774"
     polyA_site      7163
                     /gene="HBS1L"
                     /gene_synonym="EF-1a; ERFS; HBS1; HSPC276"
ORIGIN

agggaggcggacagtgaccctgaggcattgccgtcgcgcggtgcacagctaagacgtcgcgcttgcgcaggcgctcggcgcagaggcctgcgggaagccaagatggcgcataggggttctccaggctgcagttggcgccttatcagtatctaagcggagtgttttggaaggagttaaggggctgtggcaaacgccctctccgccgtcatggcccggcatcggaatgttcgaggctataactacgatgaagattttgaagatgatgatctctacggccagtctgtagaggatgattattgtatttcgccgtcaacagctgctcagtttatttattcacggcgtgacaaaccttccgttgagcctgtggaagaatatgattatgaagatctgaaagaatcttccaattctgtttcaaaccatcagctcagtggatttgatcaagctcgtctttattcatgccttgatcacatgagagaggtacttggagatgctgtgccagatgaaatattaattgaagcagttctgaagaacaagtttgatgtgcagaaggctttgtcaggggttctggaacaagatagagtgcagagtttgaaggacaagaatgaggcaacagtatctacaggaaagatagcaaaaggaaaaccagtagattcccagacatcgcgaagtgaatctgaaattgtgccaaaagttgctaaaatgactgtatctggaaagaagcaaactatgggatttgaagtgcctggagtatcttctgaagaaaatggtcatagtttccacacacctcaaaaaggaccgcccattgaagatgccattgcttcttccgatgttcttgagactgcttctaaatctgctaatccaccccacacgattcaagcatcagaagagcagagttcaaccccagcaccggtgaaaaagtctggcaagctgaggcagcaaatagatgtgaaggcggaactggagaagcggcaaggagggaagcagctactcaacttagtggtcattggtcatgttgatgctgggaaaagtactctgatgggccatatgctttatcttctgggtaatataaacaaaagaactatgcataagtatgaacaggagtctaaaaaggctggcaaagcttcgtttgcatatgcatgggtcttggatgaaactggcgaagaaagggaaaggggagtaaccatggatgttggtatgacaaagtttgaaaccacaaccaaagttattacattaatggatgctccaggccataaggacttcattccaaatatgattacaggagcagcccaggcggatgtagctgttttagttgtagatgccagcaggggagagtttgaagctggatttgagactggaggacaaacacgagagcatggactcttggtccgttctctgggagtgacgcagcttgcagttgcagttaataaaatggatcaggttaattggcaacaagaaaggtttcaagagattactggaaaacttgggcactttcttaagcaagcaggttttaaggagagtgatgtaggttttattcctacaagtggtctcagtggtgaaaatctaatcacaagatctcagtcaagtgaactcacaaaatggtataaaggactatgtttattagaacaaattgattcctttaagcctccccagcgatctattgacaaaccttttagattatgtgtgtccgatgttttcaaagatcaaggatctggattttgcataactggtaaaatagaagctggttatatccaaactggtgaccgactactggcaatgcctcctaatgaaacttgtaccgtgaaaggaatcactctgcatgatgaacctgtcgactgggcggcagcaggcgatcatgttagtcttactttggttgggatggatatcatcaaaatcaatgttggctgcatattttgtggccccaaagtacccattaaagcttgcactcgtttcagagcccgaatcctcatctttaatattgaaattcctatcactaaaggatttcctgtgctgttacactaccaaactgtcagtgaacccgccgttattaaacgattgattagtgtcttaaacaaaagcacgggtgaagtcacaaagaaaaagcctaagtttttgactaaaggccagaatgcattggtagagctacagacacaaagaccaatagctcttgagctatataaagactttaaagagctggggaggttcatgctacgttacggtggttctacaatagctgctggtgttgtcactgagataaaagaatgatgggtcagaatttctaccacgtttctggatacagtgaaatagctaacctctgtttcaagaatgcagttattaagtcaaaggaacaatgtgcaattgatatgtttttagatgagagagaaaaattaaagctaaaattagctgcaaagaagtattaataatcacctctgcaaaaattctaagttgccaactggcaaagaaagtctaatgttaaaaacaactttgcctttgaaacgttaataaatggatttactttgctaagatttatggcaagtgtcaaaaatagtatctgaagatactgaatcatcatgaaatgaactctacttctggccaaagcacaatgtatttgcagttttctcttttgattcaattatactgcacatgttttaaggaaaagtaacttaattgggtttttcaggcagttgatatttgacctaagctttttttttttttttttttccagttaatgctaagaaaagatttggggaaggttataataaaagtattttgtggtgaccataagaatgtccctccccaaacaagtaaacttgtgaaagtttaatttggaattagtggaagctgttcctttgaaagccaagatattatttaagttgtaaagccagctaataaaatgccttagtttgagcataatacaaactgtgttttgttctttagacatttatgagattctctgccactaacagtaaatatgatttaggggttttgtgggatctttttcacctaagagtttcctagctctgtcacatgaattcttttttatcctaatggcagatccaatttcatctcattcatttttttaaccataacttgcttttcccattctcacttttagaattatacctatgatggccctttctttatcttgcttaccttatagattataagtcccctgtgagtaagtaagagtcatgtttttctttaaagtttcaacaacaaaccccaaggtttatttatttaacaacaggtattcgttgaggtgccttctgggtgcaaggagctttagagtagattttgacctcagctgaacctggaactctgatctgatagactgtttatgataagcttttttttttattagcagcgtgatttgtatatcgatggcttaacatatacaacagcatttcttctccctgcaccttttcgtgaacctgacattttgaacataagcaataacatctgtatggtaaagtaggcagattatacatgtgttgcttagtgaatgattaccaagtgaacacacttggtatattgctttaccaaaatacatgtgtagttgtcacttcagattcactgagttaagaaagttttatttaaatattaatattaatcaagaatttaacagatatatgtgacagaaatctaacttcaagtgactgaagcagaaagaaaaatttttgaatgacataactgagaaaattagaggtagctctagctttgattccatttagatcgagcagctcacacaatgttagcaaggactcatctccactctgccttccctggtgctggttttgctctcaaactctatatagaactctcggccgggcgcggtggctcacacctgtaatcaaaacactttgggaggctgagtcgggaggatagcgtgagcccaggagtttgagaccagctaaggcaatatagtgagaccatgtctctacagaaaaaatttaaaaacagatcagctgggtgtggtgccacatgcctgtagtcccagcttctcaggaggctggggtgggaagatcacttgagcccaggaggtcgaggctgcagtgagccatgatcacatcactgcagtccagcctgggtgacagagcaagacctgtcaccctgccacccataaaaaacctcttctgtaatgccaggttcttgacaagatgtgataattccacacttacatcctcagatctcccatccagggcaaggacagactaaaagagcatatcttctccagaagtcctagaaacatctcatcattgactatgattgaattttatttattaatacttccctaggatatcctgtgtttgagtgtgaagttaatatcacacaaagcatgtagctaacagttgtgtgagggttggaaattcagggtgctgttaggaaggggaaatggattggggtttaaggtagggggagtaaaaacaagaaaccatccactctgtatattatataagactgtgatcgaattaagaattttagtttacagtttagcataaacaaatagtagtagaaatgaatgcatttattcattccttccttctccaatagtgtttaagtacaatctttttatttgcattttattgatgattgattgtggttgaaaggagtggtgatattatttcgaggatccactgtgtaagaagactgttggcagtggaaggctcgagttgattaagtgacaaagaggtaaagcagacatgcccaagcttggttatgctctgatttcctaccctgttactttcatccataatttatagtacatccattttgtgtcattttgcttcaggtatttcttgtcctgactgtcttcttttttatgattttactgtttcttcacactaatggctttgtcctctgactttgactctttgtgagattcttctgagcagttaacctctaggataatgtggcttgaacacattacagaactatgttttgacttgttagtattattcacacattcatgacaattgagcctctctactgtgagaaatgttttagaggccagtttctaggcatagctgtttttctcccatgagtatgcaaatcaatagttttaaccattgttaaaatgcaatcatagtgacttcagaaaatttggaaaatacagaaaatatagggaagaataaaattaacccacagttctgtcacctaaaggtaactgctgccaatgttttcatgtatttcttttctgtctctccaatgcatttttttacatagttgtgagcgttagccaagttattttcatgttgttatgtaatcaatatttttcaatagaagtattagaggttttttttattgatataaaaataacaattacagatcctgatatatagaagttattcaaaattatacagttttcaaaaaatcaagacaagtaggcccaatacaaactactgaatcatcttctaatttccctctaaaatatttatagaaatatgtaagtagaaaaacattcatcctttcctcgtctaattatgatcctgccatattccaggcacaagagaaagctctggggcttgagtcttaatagggctgatagtccaaccaggggacagggtatcataaagagataattcaaaactttaagattggagggtaggtgatggtagaaaattctgcggcaaacatttgttgatgctcatcatttgttgatgtcatcaaagatcaccagggcataattataatcaaaattagttttattgatgcttgctgcagcaagagagactgcacaccactggggtctatgggtgcttctcagtgggaaggtgtaaggaggggcttgctaagaatttgagcacatgtagctaattttaaggagggctcaagtgagcaagggtttcttctggattgagtgctgtcagaaagtggattgagtgctgtcagaaagtgggagtgattttgcaactgggtatcttaatttttatgttgtgggtgggaggaaaggaaagaagcaacagtcacccatgttagccacaagaagaggttggctgtttatggtttgcacagtgactttgtttttatctgtgctcaggcatgattacagtatctcattttatccggattacagtgacctcatctgatgttagagatttgagaattgttaaatgttcagcaggagaacgccaccgcctagtgtgaatgctaggtcagaagctgctttttcacactgaaaccatttaagtatgtacaaataagttaatagtgtaaatgtaggtgtaaaatacaatgcaaaacaaaataatgaagtaagtgaattaaattattgcaccaaatatggggatatgaaatagggaaagaaaagcattaagttacttatagtccataaagggactacattattttgttactctgataatcccataaaacaaagttttaagaatgtttacagtaaccatgaatggaattagtgaaactattcatatcaatgcaaaaaaaaaaaaaaaaaaagcaaagaaactaagtctgtacagcaaaagatggaaaggaaacaagaaaattaaatgaagacaaaggttgtgattattacagtaaatgaaaataggtttttatctttaaaatgtagactcaaactgcaaagctaatgatatgctatctgcaaaatattcctattttgtaaataaataaaaccatagatttaaagaagaaagggcacagatgtactggggagacaaaaataactgatccgttgggtgtataccatgtgccaagcaattttcatatactcatttaacatgacatatctataattatatgaggcagatattattaacctcagtctatagatgagaagactaaagctcagagggattgctaaaaactagtaaataaattatggaaccatgatttgaatttagatttaagtctgactgaggcatgttcagagacactacactgcctctccagaaatcaggagtagcaatattaacactggacaaagaatttaaagcaagtaaaaaaaaattaagagaatttcatattaataacaagtataatgcacaataaaactgtaccaaatgacataaaaatgcataatgaaatttattagaaattaaaaattaaagggcatagttacaattattgaggaattctcatagctctgccttatagatcatgtaaacaaacaaggtcatagaggacttaaatagcaaagcagaaaaaaa

//

Annotations: