LOCUS       NM_006580               3290 bp    mRNA    linear   PRI 12-MAY-2013
DEFINITION  Homo sapiens claudin 16 (CLDN16), mRNA.
ACCESSION   NM_006580
VERSION     NM_006580.3  GI:297515474
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Godron,A., Harambat,J., Boccio,V., Mensire,A., May,A.,
            Rigothier,C., Couzi,L., Barrou,B., Godin,M., Chauveau,D.,
            Faguer,S., Vallet,M., Cochat,P., Eckart,P., Guest,G., Guigonis,V.,
            Houillier,P., Blanchard,A., Jeunemaitre,X. and Vargas-Poussou,R.
  TITLE     Familial hypomagnesemia with hypercalciuria and nephrocalcinosis:
            phenotype-genotype correlation and outcome in 32 patients with
            CLDN16 or CLDN19 mutations
  JOURNAL   Clin J Am Soc Nephrol 7 (5), 801-809 (2012)
   PUBMED   22422540
  REMARK    GeneRIF: Six different mutations of CLDN16 were detected (five
            missense and one nonsense); three of the missense mutations were
            previously unknown (p.Cys80Tyr, p.Lys183Glu, and p.Gly233Arg).
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Guran,T., Akcay,T., Bereket,A., Atay,Z., Turan,S., Haisch,L.,
            Konrad,M. and Schlingmann,K.P.
  TITLE     Clinical and molecular characterization of Turkish patients with
            familial hypomagnesaemia: novel mutations in TRPM6 and CLDN16 genes
  JOURNAL   Nephrol. Dial. Transplant. 27 (2), 667-673 (2012)
   PUBMED   21669885
  REMARK    GeneRIF: A novel mutation of CLDN16 gene is responsible for
            familial hypomagnesaemia in Turkish children.
REFERENCE   3  (bases 1 to 3290)
  AUTHORS   Haisch,L., Almeida,J.R., Abreu da Silva,P.R., Schlingmann,K.P. and
            Konrad,M.
  TITLE     The role of tight junctions in paracellular ion transport in the
            renal tubule: lessons learned from a rare inherited tubular
            disorder
  JOURNAL   Am. J. Kidney Dis. 57 (2), 320-330 (2011)
   PUBMED   21186073
  REMARK    GeneRIF: Multiple distinct mutations in the CLDN16 and CLDN19 genes
            have been found responsible for familial hypomagnesemia with
            hypercalciuria and nephrocalcinosis.
REFERENCE   4  (bases 1 to 3290)
  AUTHORS   Kasapkara,C.S., Tumer,L., Okur,I. and Hasanoglu,A.
  TITLE     A novel mutation of the claudin 16 gene in familial hypomagnesemia
            with hypercalciuria and nephrocalcinosis mimicking rickets
  JOURNAL   Genet. Couns. 22 (2), 187-192 (2011)
   PUBMED   21848011
  REMARK    GeneRIF: Claudin 16 gene revealed homozygosity for the
            p.K183E(AAA>GAA) C. 547A>G indicating the diagnosis of
            hypomagnesemia with hypercalciuria and nephrocalcinosis.
REFERENCE   5  (bases 1 to 3290)
  AUTHORS   Martin,T.A. and Jiang,W.G.
  TITLE     Claudin-16/paracellin-1, cloning, expression, and its role in tight
            junction functions in cancer and endothelial cells
  JOURNAL   Methods Mol. Biol. 762, 383-407 (2011)
   PUBMED   21717372
  REMARK    GeneRIF: Claudin-16 plays a role beyond that of an initial
            metastasis repressor in breast cancer.
REFERENCE   6  (bases 1 to 3290)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   7  (bases 1 to 3290)
  AUTHORS   Weber,S., Hoffmann,K., Jeck,N., Saar,K., Boeswald,M.,
            Kuwertz-Broeking,E., Meij,I.I., Knoers,N.V., Cochat,P.,
            Sulakova,T., Bonzel,K.E., Soergel,M., Manz,F., Schaerer,K.,
            Seyberth,H.W., Reis,A. and Konrad,M.
  TITLE     Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis
            maps to chromosome 3q27 and is associated with mutations in the
            PCLN-1 gene
  JOURNAL   Eur. J. Hum. Genet. 8 (6), 414-422 (2000)
   PUBMED   10878661
REFERENCE   8  (bases 1 to 3290)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   9  (bases 1 to 3290)
  AUTHORS   Simon,D.B., Lu,Y., Choate,K.A., Velazquez,H., Al-Sabban,E.,
            Praga,M., Casari,G., Bettinelli,A., Colussi,G.,
            Rodriguez-Soriano,J., McCredie,D., Milford,D., Sanjad,S. and
            Lifton,R.P.
  TITLE     Paracellin-1, a renal tight junction protein required for
            paracellular Mg2+ resorption
  JOURNAL   Science 285 (5424), 103-106 (1999)
   PUBMED   10390358
REFERENCE   10 (bases 1 to 3290)
  AUTHORS   Manz,F., Scharer,K., Janka,P. and Lombeck,J.
  TITLE     Renal magnesium wasting, incomplete tubular acidosis,
            hypercalciuria and nephrocalcinosis in siblings
  JOURNAL   Eur. J. Pediatr. 128 (2), 67-79 (1978)
   PUBMED   668721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314955.1, BC069662.1,
            AC009520.16 and CB241927.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jun 4, 2010 this sequence version replaced gi:21536296.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. The protein encoded by this gene, a
            member of the claudin family, is an integral membrane protein and a
            component of tight junction strands. It is found primarily in the
            kidneys, specifically in the thick ascending limb of Henle, where
            it acts as either an intercellular pore or ion concentration sensor
            to regulate the paracellular resorption of magnesium ions. Defects
            in this gene are a cause of primary hypomagnesemia, which is
            characterized by massive renal magnesium wasting with
            hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis
            and renal failure. This gene and the CLDN1 gene are clustered on
            chromosome 3q28. [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314955.1, BC069662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025092 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AK314955.1         1-180
            181-1589            BC069662.1         1-1409
            1590-3165           AC009520.16        115449-117024
            3166-3290           CB241927.1         1-125               c
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..3290
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /note="claudin 16"
                     /db_xref="GeneID:10686"
                     /db_xref="HGNC:2037"
                     /db_xref="HPRD:04906"
                     /db_xref="MIM:603959"
     exon            1..572
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="alignment:Splign:1.39.8"
     variation       8
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149691624"
     variation       103
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187663828"
     misc_feature    138..140
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /note="upstream in-frame stop codon"
     STS             182..1371
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /db_xref="UniSTS:483932"
     STS             199..1216
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /db_xref="UniSTS:481728"
     variation       208
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192579160"
     variation       214
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376639837"
     variation       223
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113105686"
     variation       246
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200322099"
     CDS             249..1166
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /note="paracellin-1; hypomagnesemia 3, with hypercalciuria
                     and nephrocalcinosis; PCLN-1"
                     /codon_start=1
                     /product="claudin-16"
                     /protein_id="NP_006571.1"
                     /db_xref="GI:5729970"
                     /db_xref="CCDS:CCDS3296.1"
                     /db_xref="GeneID:10686"
                     /db_xref="HGNC:2037"
                     /db_xref="HPRD:04906"
                     /db_xref="MIM:603959"
                     /translation="

MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCPCCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYAVDTRV

"
     misc_feature    468..530
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5I7.1);
                     transmembrane region"
     misc_feature    489..1007
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    699..761
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5I7.1);
                     transmembrane region"
     misc_feature    804..866
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5I7.1);
                     transmembrane region"
     misc_feature    966..1028
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y5I7.1);
                     transmembrane region"
     variation       277
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140781331"
     variation       310
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144731880"
     variation       325
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145475632"
     variation       358
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139923283"
     variation       393
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200400125"
     variation       412
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201380153"
     variation       412
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:56086318"
     variation       414
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3214506"
     variation       414
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:368234054"
     variation       418
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149955797"
     variation       460
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:104893724"
     variation       462
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372525072"
     variation       471
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199839143"
     variation       477
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375640819"
     variation       478
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368215264"
     variation       480
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145118503"
     variation       482
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372129081"
     variation       503
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149116671"
     variation       557
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201545856"
     exon            573..675
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="alignment:Splign:1.39.8"
     variation       577
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142152395"
     variation       597
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146727044"
     variation       598
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893732"
     variation       607
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149965853"
     variation       608
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370592530"
     variation       619
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61752083"
     variation       623
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144105475"
     variation       629
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56147287"
     variation       650
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199651054"
     variation       665
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137882210"
     exon            676..840
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="alignment:Splign:1.39.8"
     variation       682
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104893731"
     variation       693
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104893720"
     variation       698
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373411163"
     variation       700
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:104893730"
     variation       701
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:104893729"
     variation       748
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104893725"
     variation       787
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140829596"
     variation       795
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376431300"
     variation       796
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370413403"
     variation       819
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893722"
     variation       824
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150478692"
     variation       836
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373189371"
     exon            841..1032
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="alignment:Splign:1.39.8"
     variation       841
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893723"
     variation       850
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138308105"
     variation       866
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149645885"
     variation       891
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371258878"
     variation       916
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201367228"
     variation       943
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:104893726"
     variation       946
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893727"
     variation       952
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:104893728"
     variation       963
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893721"
     variation       977
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368589513"
     variation       990
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143316426"
     variation       997
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139251569"
     variation       1002
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201641346"
     variation       1020
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143097871"
     exon            1033..3273
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /inference="alignment:Splign:1.39.8"
     STS             1048..1684
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /standard_name="CLDN16_1935"
                     /db_xref="UniSTS:280504"
     variation       1071
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:387906880"
     variation       1078
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35041121"
     variation       1079
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121908543"
     variation       1084
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139846352"
     variation       1117
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371465699"
     variation       1120
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141823638"
     variation       1122
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200023201"
     variation       1132
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374751726"
     variation       1146
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150621351"
     variation       1156
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:121908542"
     variation       1182
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368827991"
     variation       1217
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372140161"
     variation       1347
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145675747"
     variation       1370
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73053979"
     variation       1371
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149191729"
     variation       1403
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:191200989"
     variation       1409
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142380851"
     variation       1465
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181803078"
     STS             1548..1679
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /standard_name="SHGC-33716"
                     /db_xref="UniSTS:25753"
     variation       1636
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199716341"
     variation       1706..1708
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace=""
                     /replace="aac"
                     /db_xref="dbSNP:377623880"
     variation       1707
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186108585"
     variation       1756
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115611104"
     variation       1761
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:371139119"
     variation       1836
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112253194"
     variation       1960
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2293532"
     variation       2002
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377075907"
     variation       2008
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77656241"
     variation       2073
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116488781"
     STS             2217..2304
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       2233
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201642794"
     STS             2241..2388
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /standard_name="PMC156606P4"
                     /db_xref="UniSTS:271411"
     variation       2273
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375704078"
     variation       2283
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10470534"
     variation       2367
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190527986"
     variation       2375
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140801126"
     variation       2400
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144651280"
     variation       2414
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183599112"
     variation       2441
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188089990"
     variation       2451
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372146584"
     variation       2593
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191406701"
     variation       2619
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:13076274"
     variation       2634..2650
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace=""
                     /replace="ctgaaaagaatatcaac"
                     /db_xref="dbSNP:372414927"
     variation       2657
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113286536"
     variation       2887
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114902531"
     variation       2929
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:9844654"
     variation       2945
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115514339"
     variation       2978
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138543261"
     variation       2999
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116119310"
     variation       3080
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182724933"
     variation       3124
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202000030"
     variation       3183
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374777475"
     polyA_signal    3248..3253
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
     variation       3264
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187708101"
     polyA_site      3273
                     /gene="CLDN16"
                     /gene_synonym="HOMG3; PCLN1"
ORIGIN      

cttcttccgagtggggaggagaatagctcactctccctagagggcctaagaaagatcagtttacaggttccagcatggggtgggacccttcctccttcccccgtcttggcactggcacttggtctggtgaccaccactagcccacagttgggtcagaaaacgttacagaactcctctctcccccacccgaaacacactcagcccttgcactgacctgccttctgattggaggctggttgcttcggataatgacctccaggaccccactgttggttacagcctgtttgtattattcttactgcaactcaagacacctgcagcagggcgtgagaaaaagtaaaagaccagtattttcacattgccaggtaccagaaacacagaagactgacacccgccacttaagtggggccagggctggtgtctgcccatgttgccatcctgatgggctgcttgccacaatgagggatcttcttcaatacatcgcttgcttctttgcctttttctctgctgggtttttgattgtggccacctggactgactgttggatggtgaatgctgatgactctctggaggtgagcacaaaatgccgaggcctctggtgggaatgcgtcacaaatgcttttgatgggattcgcacctgtgatgagtacgattccatacttgcggagcatcccttgaagctggtggtaactcgagcgttgatgattactgcagatattctagctgggtttggatttctcaccctgctccttggtcttgactgcgtgaaattcctccctgatgagccgtacattaaagtccgcatctgctttgttgctggagccacgttactaatagcaggtaccccaggaatcattggctctgtgtggtatgctgttgatgtgtatgtggaacgttctactttggttttgcacaatatatttcttggtatccaatataaatttggttggtcctgttggctcggaatggctgggtctctgggttgctttttggctggagctgttctcacctgctgcttatatctttttaaagatgttggacctgagagaaactatccttattccttgaggaaagcctattcagccgcgggtgtttccatggccaagtcatactcagcccctcgcacagagacggccaaaatgtatgctgtagacacaagggtgtaaaatgcacgtttcagggtgtgtttgcatatgatttaatcaatcagtatggttacattgataaaatagtaagtcaatccaggaacagttatttagaattcatattgaattaaattaattgctagcttaatcaaaatgtttgattctcctatactttttctttctattactcttatattttcccgtcattctctctgctaaccttccaccttatgcacacactttccctatattttaagataagtctgctaggatgtagaaatatttgtttgtgatttctatatagctattagagattatgacatagtaatattaaaatgaaatgatacttaaacagaaagcaatttccaaagaggccagggaccctaatctttgaagagatgaagaaacttacttttctccctggcttttggttcactttttgtacttttaacaagtgggtgaattatttgataattttgaggaagattattcttttaaattcaaactagtatgtcaatgcctaccattactctgattatattaaaacagaaaaaggaaataacaacttcgtataccagccactggtgagagttaaagacaagagctgcccccccacccccaaatgtcaaaggcaaatgctaaattgatactggagctcgtggtgactttctacctcactaacaacataagggatctccatattatttcaccactattctagctttgctgatatattgccaaatgattagactacagaatagttcaaccagagaatttactcatttattgattaaacatccaaatactattgtaatatactatgttaaaattcatcaattcaagtgcccacacaccactgaatcatcagcaccaagcaatatattagacatatggcaaaattcaacaaatatattttgatataaataaataaacgttcacgactttacttaaaaaatcaatgttgcggctgggcacggtagctcgcgtctgtaatccccgcactttgggaggccaaggcgggtggatcacgaggtcaagagacggagaccatcctggctaacatggtgaaaccctgtctctactaaaaatacaaaaattagccgggcgtggtggcggtgcctgtagtcccagctactcgggaggctgaggcaggagaatcgtttgaacccaggaggtggaggttgcagtgagcggagatcgcaccattgcactccagtctggcaacagagcgagactccatctcaaaaaacaaaaataaataaataaataaatattcttcataaaatgtgggttttggggaaaatatagaattacatatacatttaacgaagtcgctaatgacatttcattcatattcataatgtaaccatcttgaatttttttaattgtagcgattttaaaaatgtttgtaaaatttaatttccagttttctaattacttgtcagtcacattaataacattagtacctttatggtacccttgcagtacctgaaaagaatatcaacctgaaaagaatatcaactcacccagaaattagttctttgaaaaaaaagaaattaagttgtgaatttctaaagaccttgaaataagtgtttcaaatttaaagaacaaagaatgatgtgaaaatgagattatgattcctactacatgaattaacgtttcgagattgctgtttattacttcccagagtatctttaacagtattctctgaagcagttccaatctagttggagaattaacagcaattgatttaactatctcatttttattaactgtaatttactttaaaaatatttgcaaatcatactcattagttatttgatcattgttctatgcattttaaaattaattttgtgttgttcctctcaatatttgtttttaacatttattcccatttttattttatactattgtctgtcatgctttatgtattccaataagtgtcttgaaatccttgtggggaaaggcaggacaaaaataattagttaattagatttgaaaaatgtaatttttccattttaaatatttcatttgtataagaaaatatttcagagaaccatgatgataatggatatgtgtgactgttttgaatttttttctcaattaaaacattttgtatgtaatgggaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10686 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:10686 -> Molecular function: GO:0015095 [magnesium ion transmembrane transporter activity] evidence: TAS
            GeneID:10686 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:10686 -> Biological process: GO:0006875 [cellular metal ion homeostasis] evidence: TAS
            GeneID:10686 -> Biological process: GO:0007588 [excretion] evidence: TAS
            GeneID:10686 -> Biological process: GO:0015693 [magnesium ion transport] evidence: TAS
            GeneID:10686 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:10686 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:10686 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:10686 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA