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2024-04-20 07:12:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006570 1657 bp mRNA linear PRI 24-MAR-2012
DEFINITION Homo sapiens Ras-related GTP binding A (RRAGA), mRNA.
ACCESSION NM_006570
VERSION NM_006570.4 GI:57863286
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1657)
AUTHORS Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
Dunham,I.
TITLE DNA sequence and analysis of human chromosome 9
JOURNAL Nature 429 (6990), 369-374 (2004)
PUBMED 15164053
REFERENCE 2 (bases 1 to 1657)
AUTHORS Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
Nishimoto,T.
TITLE A novel human nucleolar protein, Nop132, binds to the G proteins,
RRAG A/C/D
JOURNAL J. Biol. Chem. 279 (9), 8343-8350 (2004)
PUBMED 14660641
REFERENCE 3 (bases 1 to 1657)
AUTHORS Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
TITLE Novel G proteins, Rag C and Rag D, interact with GTP-binding
proteins, Rag A and Rag B
JOURNAL J. Biol. Chem. 276 (10), 7246-7257 (2001)
PUBMED 11073942
REFERENCE 4 (bases 1 to 1657)
AUTHORS Hirose,E., Nakashima,N., Sekiguchi,T. and Nishimoto,T.
TITLE RagA is a functional homologue of S. cerevisiae Gtr1p involved in
the Ran/Gsp1-GTPase pathway
JOURNAL J. Cell. Sci. 111 (PT 1), 11-21 (1998)
PUBMED 9394008
REFERENCE 5 (bases 1 to 1657)
AUTHORS Li,Y., Kang,J. and Horwitz,M.S.
TITLE Interaction of an adenovirus 14.7-kilodalton protein inhibitor of
tumor necrosis factor alpha cytolysis with a new member of the
GTPase superfamily of signal transducers
JOURNAL J. Virol. 71 (2), 1576-1582 (1997)
PUBMED 8995684
REFERENCE 6 (bases 1 to 1657)
AUTHORS Schurmann,A., Brauers,A., Massmann,S., Becker,W. and Joost,H.G.
TITLE Cloning of a novel family of mammalian GTP-binding proteins (RagA,
RagBs, RagB1) with remote similarity to the Ras-related GTPases
JOURNAL J. Biol. Chem. 270 (48), 28982-28988 (1995)
PUBMED 7499430
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX442654.2, BC009990.2 and BX346838.2.
On Jan 15, 2005 this sequence version replaced gi:34147579.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-30 BX442654.2 85-114
31-1610 BC009990.2 1-1580
1611-1657 BX346838.2 80-126
FEATURES Location/Qualifiers
source 1..1657
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p22.1"
gene 1..1657
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="Ras-related GTP binding A"
/db_xref="GeneID:10670"
/db_xref="HGNC:16963"
/db_xref="HPRD:10205"
/db_xref="MIM:612194"
exon 1..1652
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/inference="alignment:Splign:1.39.8"
variation 141
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:3177673"
variation 225
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="c"
/db_xref="dbSNP:2233802"
variation 248
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369894748"
variation 251
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:193122559"
variation 278
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374326262"
variation 286
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199503026"
CDS 287..1228
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="adenovirus E3-14.7K interacting protein 1; rag A;
adenovirus E3 14.7 kDa-interacting protein 1"
/codon_start=1
/product="ras-related GTP-binding protein A"
/protein_id="NP_006561.1"
/db_xref="GI:5729999"
/db_xref="CCDS:CCDS6488.1"
/db_xref="GeneID:10670"
/db_xref="HGNC:16963"
/db_xref="HPRD:10205"
/db_xref="MIM:612194"
/translation="
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
"
misc_feature 311..1162
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="Rag GTPase, subfamily of Ras-related GTPases,
includes Ras-related GTP-binding proteins A and B; Region:
RagA_like; cd11384"
/db_xref="CDD:206744"
misc_feature 311..991
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="Gtr1/RagA G protein conserved region; Region:
Gtr1_RagA; pfam04670"
/db_xref="CDD:218203"
misc_feature 326..349
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="G1 box; other site"
/db_xref="CDD:206744"
misc_feature order(341..352,479..481,665..670,674..676,773..781)
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206744"
misc_feature 410..412
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="G2 box; other site"
/db_xref="CDD:206744"
misc_feature 422..430
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="Switch I region; other site"
/db_xref="CDD:206744"
misc_feature 470..481
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="G3 box; other site"
/db_xref="CDD:206744"
misc_feature order(476..481,542..547)
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="Switch II region; other site"
/db_xref="CDD:206744"
misc_feature 665..676
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="G4 box; other site"
/db_xref="CDD:206744"
misc_feature 773..781
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="G5 box; other site"
/db_xref="CDD:206744"
misc_feature order(890..892,896..898,965..967,974..979,986..991,
998..1000,1007..1012,1016..1018,1025..1048,1067..1069,
1103..1105)
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:206744"
variation 294
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:145113359"
variation 394
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:147598725"
variation 397
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:185703836"
variation 401
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace=""
/replace="c"
/db_xref="dbSNP:34801997"
variation 443
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369320390"
variation 445
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:374900153"
variation 454
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:202118774"
variation 463
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201417292"
variation 509
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="c"
/db_xref="dbSNP:200448994"
variation 523
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11537831"
variation 525
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:78420942"
variation 538
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:142163961"
variation 643
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="c"
/db_xref="dbSNP:190567188"
variation 653
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:143131452"
variation 662
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:200648187"
variation 694
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:373170644"
variation 712
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376143602"
variation 730
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:60279941"
variation 748
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:140401379"
variation 778
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:11790968"
variation 874
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:150185537"
variation 886
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:371093338"
variation 952
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:41268997"
variation 985
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201954758"
variation 1006
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:141987080"
variation 1046
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:374494840"
variation 1059
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:145687014"
variation 1072
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375786255"
variation 1087
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:374965789"
variation 1131
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1048309"
variation 1143
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:371960968"
variation 1195
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:144684784"
variation 1212
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:375711548"
variation 1238
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:371357648"
variation 1261..1262
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace=""
/replace="t"
/db_xref="dbSNP:144345924"
variation 1306
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:148208253"
variation 1352
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="t"
/db_xref="dbSNP:180937233"
STS 1353..1482
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/standard_name="D9S1030E"
/db_xref="UniSTS:41812"
variation 1445
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:375818269"
variation 1450
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:35200919"
variation 1452
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="g"
/replace="t"
/db_xref="dbSNP:34665041"
STS 1484..1589
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/standard_name="A001X42"
/db_xref="UniSTS:61655"
STS 1484..1589
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/standard_name="G19763"
/db_xref="UniSTS:61654"
variation 1534
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="c"
/replace="g"
/db_xref="dbSNP:141162845"
polyA_signal 1589..1594
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
polyA_site 1610
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/experiment="experimental evidence, no additional details
recorded"
polyA_signal 1629..1634
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
variation 1645
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
/replace="a"
/replace="g"
/db_xref="dbSNP:115117739"
polyA_site 1652
/gene="RRAGA"
/gene_synonym="FIP-1; FIP1; RAGA"
ORIGIN
cgccggaagtgggtggtggcggggacgcagcggctccctcccggaaagcgagcgtatctcccgagccgttgccactgacagccgcgggcgctcccatctgagtaagagccagcccgtccgcggcctctccagccccgggttcgcgctctcgactctcctgcctgcccagctgcgcggcggagcggagcgaggcgcggcctgcgagtccccggcagcccccgacccctccctcggcgctgcgtgtaggccgcgccctcaggcccagtccgcggtgccccggcgggtgatgccaaatacagccatgaagaaaaaggtgctgctgatggggaagagcgggtcggggaagaccagcatgaggtcgataatcttcgccaattacattgctcgcgacacccggcgcctgggggccaccattgacgtggaacactcccacgtccgattcctagggaacctggtgctgaacctgtgggactgtggcggtcaggacaccttcatggaaaattacttcaccagccagcgagacaatatcttccgtaacgtggaagttttgatttacgtgtttgacgtggagagccgcgaactggaaaaggacatgcattattaccagtcgtgtctggaggccatcctccagaactctcctgacgccaaaatcttctgcctggtgcacaaaatggatctggttcaggaggatcagcgtgacctgatttttaaagagcgagaggaagacctgaggcgtctgtctcgcccgctggagtgtgcttgttttcgaacgtccatctgggatgagacgctctacaaagcctggtccagcatcgtctaccagctgattcccaacgttcagcagctggagatgaacctcaggaattttgcccaaatcattgaggccgatgaagttctgctgttcgaaagagctacattcttggttatttcccactaccagtgcaaagagcagcgcgacgtccaccggtttgagaagatcagcaacatcatcaaacagttcaagctgagctgcagtaaattggccgcttccttccagagcatggaagttaggaattccaacttcgctgctttcatcgacatcttcacctcaaatacgtacgtgatggtggtcatgtcagatccgtcgatcccttctgcggccactctgatcaacattcgcaatgcccggaaacactttgagaagctggagagagtggatggccccaagcacagtctccttatgcgttgaatattgccaaatgctctttctgaaaatgctgaattgccttttttgtttgcatcctttatttttaatattcataatgtcgtgtgcttaaaagtgggctttgaagtgtgtgctgcttactcctttcatctttctccccgcttccccagtctttaaacattggacgctatttactcagctacccagtagagcttgaagctgacctttctgagaagttggtatggtgtaacactaaagtaggtggttcgtgtgtgttctcattacctggttatgatagatatgcacatcaaagcctttaccagtatcttcctgtattccgtatcagattgcaaagacggaatgttactattttatcagcaaggtattaaaatgcatttataaattcttcttggcttcattcatgaataaacgtgttagcaatttaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10670 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10670 -> Molecular function: GO:0005525 [GTP binding] evidence: IDA
GeneID:10670 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:10670 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
GeneID:10670 -> Molecular function: GO:0051219 [phosphoprotein binding] evidence: IDA
GeneID:10670 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10670 -> Biological process: GO:0008219 [cell death] evidence: IDA
GeneID:10670 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IDA
GeneID:10670 -> Biological process: GO:0032008 [positive regulation of TOR signaling cascade] evidence: NAS
GeneID:10670 -> Biological process: GO:0034613 [cellular protein localization] evidence: IMP
GeneID:10670 -> Biological process: GO:0045919 [positive regulation of cytolysis] evidence: IDA
GeneID:10670 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: IMP
GeneID:10670 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10670 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:10670 -> Cellular component: GO:0005764 [lysosome] evidence: IDA
GeneID:10670 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:10670 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
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