Home |
Help |
Advanced search
2024-04-24 07:54:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006497 3174 bp mRNA linear PRI 09-JUN-2013
DEFINITION Homo sapiens hypermethylated in cancer 1 (HIC1), transcript variant
1, mRNA.
ACCESSION NM_006497
VERSION NM_006497.3 GI:148229915
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3174)
AUTHORS Dehennaut,V., Loison,I., Dubuissez,M., Nassour,J., Abbadie,C. and
Leprince,D.
TITLE DNA double-strand breaks lead to activation of hypermethylated in
cancer 1 (HIC1) by SUMOylation to regulate DNA repair
JOURNAL J. Biol. Chem. 288 (15), 10254-10264 (2013)
PUBMED 23417673
REMARK GeneRIF: epigenetic HIC1 inactivation, which is an early step in
tumorigenesis, could contribute to the accumulation of DNA
mutations through impaired DNA repair and thus favor tumorigenesis.
REFERENCE 2 (bases 1 to 3174)
AUTHORS Dehennaut,V., Loison,I., Boulay,G., Van Rechem,C. and Leprince,D.
TITLE Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1
(Hypermethylated In Cancer 1)
JOURNAL Biochem. Biophys. Res. Commun. 430 (1), 49-53 (2013)
PUBMED 23178572
REMARK GeneRIF: these results further demonstrate that HIC1 is a key
player in the regulation of the DNA damage response.
REFERENCE 3 (bases 1 to 3174)
AUTHORS Svedlund,J., Koskinen Edblom,S., Marquez,V.E., Akerstrom,G.,
Bjorklund,P. and Westin,G.
TITLE Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene
epigenetically deregulated in hyperparathyroid tumors by histone H3
lysine modification
JOURNAL J. Clin. Endocrinol. Metab. 97 (7), E1307-E1315 (2012)
PUBMED 22544915
REMARK GeneRIF: A growth-regulatory role of HIC1 in the parathyroid glands
and perturbed expression of HIC1 may represent an early event
during tumor development.
REFERENCE 4 (bases 1 to 3174)
AUTHORS Dehennaut,V., Loison,I., Pinte,S. and Leprince,D.
TITLE Molecular dissection of the interaction between HIC1 and SIRT1
JOURNAL Biochem. Biophys. Res. Commun. 421 (2), 384-388 (2012)
PUBMED 22510409
REMARK GeneRIF: these results demonstrate that the activating acetylation
to SUMOylation switch of HIC1 is favored by genotoxic stresses to
regulate the DNA damage response.
REFERENCE 5 (bases 1 to 3174)
AUTHORS Eggers,H., Steffens,S., Grosshennig,A., Becker,J.U.,
Hennenlotter,J., Stenzl,A., Merseburger,A.S., Kuczyk,M.A. and
Serth,J.
TITLE Prognostic and diagnostic relevance of hypermethylated in cancer 1
(HIC1) CpG island methylation in renal cell carcinoma
JOURNAL Int. J. Oncol. 40 (5), 1650-1658 (2012)
PUBMED 22327210
REMARK GeneRIF: Identify HIC1 hypermethylation in renal cell carcinoma as
an independent predictor of reduced recurrence-free survival.
REFERENCE 6 (bases 1 to 3174)
AUTHORS Guerardel,C., Deltour,S., Pinte,S., Monte,D., Begue,A., Godwin,A.K.
and Leprince,D.
TITLE Identification in the human candidate tumor suppressor gene HIC-1
of a new major alternative TATA-less promoter positively regulated
by p53
JOURNAL J. Biol. Chem. 276 (5), 3078-3089 (2001)
PUBMED 11073960
REMARK GeneRIF: A new major alternative promoter of HIC1 (HIC-1) is
conserved in the murine locus and positively regulated by TP53.
REFERENCE 7 (bases 1 to 3174)
AUTHORS Deltour,S., Guerardel,C. and Leprince,D.
TITLE Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a
general mechanism for BTB/POZ transcriptional repressors: the case
of HIC-1 and gammaFBP-B
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (26), 14831-14836 (1999)
PUBMED 10611298
REMARK GeneRIF: HIC-1 (HIC1) is a transcriptional repressor. However, in
contrast to other BTB/POZ transcriptional repressors ( such as BCL6
or PLZF) it fails to recruit SMRT/NCoR-mSin3A/HDAC complexes via
its BTB/POZ domain.
REFERENCE 8 (bases 1 to 3174)
AUTHORS Deltour,S., Guerardel,C., Stehelin,D. and Leprince,D.
TITLE The carboxy-terminal end of the candidate tumor suppressor gene
HIC-1 is phylogenetically conserved
JOURNAL Biochim. Biophys. Acta 1443 (1-2), 230-232 (1998)
PUBMED 9838134
REFERENCE 9 (bases 1 to 3174)
AUTHORS Fujii,H., Biel,M.A., Zhou,W., Weitzman,S.A., Baylin,S.B. and
Gabrielson,E.
TITLE Methylation of the HIC-1 candidate tumor suppressor gene in human
breast cancer
JOURNAL Oncogene 16 (16), 2159-2164 (1998)
PUBMED 9572497
REFERENCE 10 (bases 1 to 3174)
AUTHORS Wales,M.M., Biel,M.A., el Deiry,W., Nelkin,B.D., Issa,J.P.,
Cavenee,W.K., Kuerbitz,S.J. and Baylin,S.B.
TITLE p53 activates expression of HIC-1, a new candidate tumour
suppressor gene on 17p13.3
JOURNAL Nat. Med. 1 (6), 570-577 (1995)
PUBMED 7585125
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AJ583694.1, BC030208.1,
AC090617.16 and BQ004706.1.
This sequence is a reference standard in the RefSeqGene project.
On May 23, 2007 this sequence version replaced gi:61676185.
Summary: This gene functions as a growth regulatory and tumor
repressor gene. Hypermethylation or deletion of the region of this
gene have been associated with tumors and the contiguous-gene
syndrome, Miller-Dieker syndrome. Alternative splicing of this gene
results in multiple transcript variants. [provided by RefSeq, Sep
2010].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: HY013006.1, HY046720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-19 AJ583694.1 206-224
20-442 BC030208.1 1-423
443-2766 AC090617.16 167818-170141 c
2767-3174 BQ004706.1 1-408 c
FEATURES Location/Qualifiers
source 1..3174
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3"
gene 1..3174
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="hypermethylated in cancer 1"
/db_xref="GeneID:3090"
/db_xref="HGNC:4909"
/db_xref="HPRD:04826"
/db_xref="MIM:603825"
exon 1..140
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/inference="alignment:Splign:1.39.8"
exon 141..3157
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/inference="alignment:Splign:1.39.8"
variation 155
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:369608521"
STS 157..407
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="Hic1"
/db_xref="UniSTS:498503"
CDS 161..2305
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="isoform 1 is encoded by transcript variant 1; zinc
finger and BTB domain-containing protein 29"
/codon_start=1
/product="hypermethylated in cancer 1 protein isoform 1"
/protein_id="NP_006488.2"
/db_xref="GI:61676186"
/db_xref="CCDS:CCDS42230.1"
/db_xref="GeneID:3090"
/db_xref="HGNC:4909"
/db_xref="HPRD:04826"
/db_xref="MIM:603825"
/translation="
MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT
"
misc_feature 224..553
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="BTB/POZ domain; Region: BTB; pfam00651"
/db_xref="CDD:201372"
misc_feature 1706..1774
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1751..1825
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1784..>1930
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="FOG: Zn-finger [General function prediction only];
Region: COG5048"
/db_xref="CDD:34653"
misc_feature 1835..1909
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
variation 205
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:202126573"
STS 230..422
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54864"
/db_xref="UniSTS:164094"
variation 253
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201428525"
variation 270
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:200866682"
STS 337..672
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54865"
/db_xref="UniSTS:164095"
variation 368
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:375891653"
variation 448
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:143756173"
variation 499
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:372719892"
variation 553
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:147657937"
STS 601..853
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54866"
/db_xref="UniSTS:164096"
STS 804..1117
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54867"
/db_xref="UniSTS:164097"
variation 1040..1041
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="g"
/db_xref="dbSNP:150364074"
STS 1072..1313
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54868"
/db_xref="UniSTS:164098"
variation 1115
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:373870177"
variation 1150
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:77393586"
variation 1211
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:182733310"
STS 1239..1440
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54869"
/db_xref="UniSTS:164099"
variation 1283
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:373366887"
variation 1303
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:370995439"
variation 1312
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:375461568"
variation 1354
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:377067216"
STS 1378..1668
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54752"
/db_xref="UniSTS:164100"
variation 1390
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:115113418"
variation 1399
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:199689510"
variation 1459
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:373778061"
variation 1492
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="g"
/replace="t"
/db_xref="dbSNP:371242587"
variation 1505
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:202115526"
variation 1529
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:201599490"
variation 1534
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:371253281"
variation 1548
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="g"
/replace="t"
/db_xref="dbSNP:371934522"
variation 1557
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="c"
/db_xref="dbSNP:34263875"
variation 1569
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376477815"
variation 1571
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:370020453"
variation 1576
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201813917"
variation 1585
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:375775546"
STS 1592..1801
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54870"
/db_xref="UniSTS:164101"
variation 1642
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201380957"
variation 1651
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:373038310"
variation 1666
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376846488"
variation 1696
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:369179545"
variation 1711
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:75796056"
STS 1737..1920
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54871"
/db_xref="UniSTS:164089"
variation 1768
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:371173480"
variation 1814
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:373992938"
variation 1843
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376884773"
STS 1862..2109
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54872"
/db_xref="UniSTS:164090"
variation 1897
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:370184800"
variation 1961
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:199947545"
variation 2039
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:188260013"
variation 2064
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:200496232"
variation 2099
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:373603534"
variation 2128
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:202155372"
STS 2162..2419
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54874"
/db_xref="UniSTS:164092"
variation 2242
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:374377797"
variation 2276
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:1063317"
variation 2308
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201398249"
STS 2379..2571
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54875"
/db_xref="UniSTS:164093"
variation 2406
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:374245376"
variation 2470
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:377630513"
variation 2570
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:72634003"
variation 2758
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:111245437"
variation 2779
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:114468879"
variation 2859
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="t"
/db_xref="dbSNP:3215740"
STS 2918..3051
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="RH78924"
/db_xref="UniSTS:61512"
variation 2934
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="t"
/db_xref="dbSNP:34644105"
variation 2952
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:73976190"
variation 2987
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:369296924"
variation 3082
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:116213695"
variation 3125
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:146467608"
polyA_signal 3138..3143
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
polyA_site 3157
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
ORIGIN
ggctgagacgcgaccaggacgcggggaggacggaccagcaggacagaccgaccgggggcccggcgggcggagggcagcgcagccacgtcccccctggatccgccgtcagccgggcccggggctttcgacatgccccccaggagagtgtgctgggcagacgatgctggacacgatggaggcgcccggccactccaggcagctgctgctgcagctcaacaaccagcgcaccaagggcttcttgtgcgacgtgatcatcgtggtgcagaacgccctcttccgcgcgcacaagaacgtgctggcggccagcagcgcctacctcaagtccctggtggtgcatgacaacctgctcaacctggaccatgacatggtgagcccggccgtgttccgcctggtgctggacttcatctacaccggccgcctggctgacggcgcagaggcggctgcggccgcggccgtggccccgggggctgagccgagcctgggcgccgtgctggccgccgccagctacctgcagatccccgacctcgtggcgctgtgcaagaaacgcctcaagcgccacggcaagtactgccacctgcggggcggcggcggcggcggcggcggctacgcgccctatggtcggccgggccggggcctgcgggccgccacgccggtcatccaggcctgctacccgtccccagtcgggcctccgccgccgcctgccgcggagccgccctcgggcccagaggccgcggtcaacacgcactgcgccgagctgtacgcgtcgggacccggcccggccgccgcactctgtgcctcggagcgccgctgctcccctctttgtggcctggacctgtccaagaagagcccgccgggctccgcggcgccagagcggccgctggctgagcgcgagctgcccccgcgcccggacagccctcccagcgccggccccgccgcctacaaggagccgcctctcgccctgccgtcgctgccgccgctgcccttccagaagctggaggaggccgcaccgccttccgacccatttcgcggcggcagcggcagcccgggacccgagccccccggccgccccgacgggcctagtctcctctatcgctggatgaagcacgagccgggcctgggtagctatggcgacgagctgggccgggagcgcggctcccccagcgagcgctgcgaagagcgtggtggggacgcggccgtctcgcccggggggcccccgctcggcctggcgccgccgccgcgctaccctggcagcctggacgggcccggcgcgggcggcgacggcgacgactacaagagcagcagcgaggagaccggtagcagcgaggaccccagcccgcctggcggccacctcgagggctacccatgcccgcacctggcctatggcgagcccgagagcttcggtgacaacctgtacgtgtgcattccgtgcggcaagggcttccccagctctgagcagctgaacgcgcacgtggaggctcacgtggaggaggaggaagcgctgtacggcagggccgaggcggccgaagtggccgctggggccgccggcctagggcccccttttggaggcggcggggacaaggtcgccggggctccgggtggcctgggagagctgctgcggccctaccgctgcgcgtcgtgcgacaagagctacaaggacccggccacgctgcggcagcacgagaagacgcactggctgacccggccctacccatgcaccatctgcgggaagaagttcacgcagcgtgggaccatgacgcgccacatgcgcagccacctgggcctcaagcccttcgcgtgcgacgcgtgcggcatgcggttcacgcgccagtaccgcctcacggagcacatgcgcatccactcgggcgagaagccctacgagtgccaggtgtgcggcggcaagttcgcacagcaacgcaacctcatcagccacatgaagatgcacgccgtggggggcgcggccggcgcggccggggcgctggcgggcttgggggggctccccggcgtccccggccccgacggcaagggcaagctcgacttccccgagggcgtctttgctgtggctcgcctcacggccgagcagctgagcctgaagcagcaggacaaggcggccgcggccgagctgctggcgcagaccacgcacttcctgcacgaccccaaggtggcgctggagagcctctacccgctggccaagttcacggccgagctgggcctcagccccgacaaggcggccgaggtgctgagccagggcgctcacctggcggccgggcccgacggccggaccatcgaccgtttctctcccacctagagcgcccctcgccagcccgctctgtcgctgctgcgcggccctggcccgcaccccagggagcggcgggggcggcgcgcagggcccactgtgcccgggacaaccgcagcgtcgccacagtggcggctccacctctcggcggcctcacctggcctcactgcttcgtgccttagctcgggggtcgggggagaaccccgggacgggggtgggatggggtaagggaaatttatatttttgatatcagctttgaccaaaggagaccccaggcccctcccgcctcttcctgtggttcgtcggccccctcccccggctccgcgctgctcttagagggggaggggtgtcactgtcggggcactcctagccctacctccggcccttgcgaccacacccattctcactgtgaatctccccgctggggtcggagcgtcgggcagagttggggagtggggaggggactgagccggccggagggccccccgcacccccgctcccacccaccccgggactgataatgtgaagttcctcattttgcacaagtggcactagccccagggccaacccttccttcctcagtcaccaagggcggggagttctggagtcggaaggcgaagagcctaccaccaggtctcccactcccgcggtgccctcccttcccttccctgcggccccggaccatatttattgcatgcgccccggcggccccccatcccgagcccaggctgggctgggctggaacgcggtctctttagctccctcctcttcgtttgtatatttcctaccttgtacacaggctcttccagagccgcttccattttctatactcgaaccaaacagcaataaagcagtaaccaaggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3090 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:3090 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:3090 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:3090 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3090 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IDA
GeneID:3090 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:3090 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:3090 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:3090 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:3090 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:3090 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:3090 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
GeneID:3090 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:3090 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
GeneID:3090 -> Biological process: GO:0030178 [negative regulation of Wnt receptor signaling pathway] evidence: IDA
GeneID:3090 -> Biological process: GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] evidence: ISS
GeneID:3090 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:3090 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:3090 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
GeneID:3090 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:3090 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.