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2024-04-18 10:35:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006388 2248 bp mRNA linear PRI 08-JUL-2013
DEFINITION Homo sapiens K(lysine) acetyltransferase 5 (KAT5), transcript
variant 2, mRNA.
ACCESSION NM_006388
VERSION NM_006388.3 GI:332205925
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2248)
AUTHORS Kaidi,A. and Jackson,S.P.
TITLE KAT5 tyrosine phosphorylation couples chromatin sensing to ATM
signalling
JOURNAL Nature 498 (7452), 70-74 (2013)
PUBMED 23708966
REMARK GeneRIF: tyrosine phosphorylation of KAT5 increases after DNA
damage in a manner that promotes KAT5 binding to the histone mark
H3K9me3; this triggers KAT5-mediated acetylation of the ATM kinase,
promoting DNA-damage-checkpoint activation and cell survival
REFERENCE 2 (bases 1 to 2248)
AUTHORS Jha,S., Gupta,A., Dar,A. and Dutta,A.
TITLE RVBs are required for assembling a functional TIP60 complex
JOURNAL Mol. Cell. Biol. 33 (6), 1164-1174 (2013)
PUBMED 23297341
REMARK GeneRIF: RVBs are also required for heat stability of TIP60.com by
a p400-independent pathway.
REFERENCE 3 (bases 1 to 2248)
AUTHORS Muller,T., Schrotter,A., Loosse,C., Pfeiffer,K., Theiss,C.,
Kauth,M., Meyer,H.E. and Marcus,K.
TITLE A ternary complex consisting of AICD, FE65, and TIP60
down-regulates Stathmin1
JOURNAL Biochim. Biophys. Acta 1834 (1), 387-394 (2013)
PUBMED 22902274
REMARK GeneRIF: A ternary complex consisting of AICD, FE65, and TIP60
down-regulates Stathmin1.
REFERENCE 4 (bases 1 to 2248)
AUTHORS Laurberg,J.R., Brems-Eskildsen,A.S., Nordentoft,I., Fristrup,N.,
Schepeler,T., Ulhoi,B.P., Agerbaek,M., Hartmann,A., Bertz,S.,
Wittlinger,M., Fietkau,R., Rodel,C., Borre,M., Jensen,J.B.,
Orntoft,T. and Dyrskjot,L.
TITLE Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic
recombination 11 homolog) predict treatment-specific outcome of
localised invasive bladder cancer
JOURNAL BJU Int. 110 (11 PT C), E1228-E1236 (2012)
PUBMED 23046361
REMARK GeneRIF: TIP60 protein expression was a predictive marker for DSS
after cystectomy in two independent cohorts. This novel marker was
the strongest predictive factor in multivariate analysis in
patients receiving cystectomy.
REFERENCE 5 (bases 1 to 2248)
AUTHORS Coffey,K., Blackburn,T.J., Cook,S., Golding,B.T., Griffin,R.J.,
Hardcastle,I.R., Hewitt,L., Huberman,K., McNeill,H.V., Newell,D.R.,
Roche,C., Ryan-Munden,C.A., Watson,A. and Robson,C.N.
TITLE Characterisation of a Tip60 specific inhibitor, NU9056, in prostate
cancer
JOURNAL PLoS ONE 7 (10), E45539 (2012)
PUBMED 23056207
REMARK GeneRIF: Studies indicate histone acetyltransferase Tip60 as a
potential therapeutic target for the treatment of prostate cancer.
REFERENCE 6 (bases 1 to 2248)
AUTHORS Brady,M.E., Ozanne,D.M., Gaughan,L., Waite,I., Cook,S., Neal,D.E.
and Robson,C.N.
TITLE Tip60 is a nuclear hormone receptor coactivator
JOURNAL J. Biol. Chem. 274 (25), 17599-17604 (1999)
PUBMED 10364196
REFERENCE 7 (bases 1 to 2248)
AUTHORS Dechend,R., Hirano,F., Lehmann,K., Heissmeyer,V., Ansieau,S.,
Wulczyn,F.G., Scheidereit,C. and Leutz,A.
TITLE The Bcl-3 oncoprotein acts as a bridging factor between
NF-kappaB/Rel and nuclear co-regulators
JOURNAL Oncogene 18 (22), 3316-3323 (1999)
PUBMED 10362352
REFERENCE 8 (bases 1 to 2248)
AUTHORS Kimura,A. and Horikoshi,M.
TITLE Tip60 acetylates six lysines of a specific class in core histones
in vitro
JOURNAL Genes Cells 3 (12), 789-800 (1998)
PUBMED 10096020
REFERENCE 9 (bases 1 to 2248)
AUTHORS Yamamoto,T. and Horikoshi,M.
TITLE Novel substrate specificity of the histone acetyltransferase
activity of HIV-1-Tat interactive protein Tip60
JOURNAL J. Biol. Chem. 272 (49), 30595-30598 (1997)
PUBMED 9388189
REFERENCE 10 (bases 1 to 2248)
AUTHORS Kamine,J., Elangovan,B., Subramanian,T., Coleman,D. and
Chinnadurai,G.
TITLE Identification of a cellular protein that specifically interacts
with the essential cysteine region of the HIV-1 Tat transactivator
JOURNAL Virology 216 (2), 357-366 (1996)
PUBMED 8607265
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB003934.1, DA043042.1,
BC064912.1 and BU737532.1.
On May 6, 2011 this sequence version replaced gi:36287048.
Summary: The protein encoded by this gene belongs to the MYST
family of histone acetyl transferases (HATs) and was originally
isolated as an HIV-1 TAT-interactive protein. HATs play important
roles in regulating chromatin remodeling, transcription and other
nuclear processes by acetylating histone and nonhistone proteins.
This protein is a histone acetylase that has a role in DNA repair
and apoptosis and is thought to play an important role in signal
transduction. Alternative splicing of this gene results in multiple
transcript variants. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2), also known as alpha, lacks an
alternate in-frame segment, compared to variant 1, resulting in a
shorter protein (isoform 2), that has a shorter N-terminus,
compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U74667.1, BC064912.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-16 DB003934.1 1-16
17-593 DA043042.1 6-582
594-2215 BC064912.1 334-1955
2216-2248 BU737532.1 1-33 c
FEATURES Location/Qualifiers
source 1..2248
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
gene 1..2248
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="K(lysine) acetyltransferase 5"
/db_xref="GeneID:10524"
/db_xref="HGNC:5275"
/db_xref="MIM:601409"
exon 1..278
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 35..36
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace=""
/replace="cc"
/db_xref="dbSNP:139060964"
variation 35
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:4645910"
variation 106
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace=""
/replace="c"
/db_xref="dbSNP:373551156"
variation 118
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="t"
/db_xref="dbSNP:4645911"
variation 156
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112313136"
variation 185
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375270159"
STS 214..1845
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/db_xref="UniSTS:483047"
misc_feature 222..224
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="upstream in-frame stop codon"
variation 234
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:71455780"
variation 251
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201205470"
variation 255
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:186911544"
variation 259
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:375275397"
variation 262
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367676300"
CDS 267..1808
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/EC_number="2.3.1.48"
/note="isoform 2 is encoded by transcript variant 2; cPLA2
interacting protein; HIV-1 Tat interactive protein, 60kDa;
K-acetyltransferase 5; Tat interacting protein, 60kDa;
histone acetyltransferase KAT5; cPLA(2)-interacting
protein; 60 kDa Tat-interactive protein; histone
acetyltransferase HTATIP"
/codon_start=1
/product="histone acetyltransferase KAT5 isoform 2"
/protein_id="NP_006379.2"
/db_xref="GI:36287049"
/db_xref="CCDS:CCDS31610.1"
/db_xref="GeneID:10524"
/db_xref="HGNC:5275"
/db_xref="MIM:601409"
/translation="
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
"
misc_feature 336..494
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="Chromatin organization modifier (chromo) domain is
a conserved region of around 50 amino acids found in a
variety of chromosomal proteins, which appear to play a
role in the functional organization of the eukaryotic
nucleus. Experimental evidence...; Region: CHROMO;
cd00024"
/db_xref="CDD:28908"
misc_feature order(342..344,399..401,405..407,414..416,426..428,
438..440,450..455)
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="histone binding site; other site"
/db_xref="CDD:28908"
misc_feature 420..422
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q92993.2); acetylation site"
misc_feature 522..524
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92993.2); phosphorylation site"
misc_feature 522..524
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 522..524
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00454"
misc_feature 534..536
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK1; propagated from
UniProtKB/Swiss-Prot (Q92993.2); phosphorylation site"
misc_feature 534..536
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 534..536
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00454"
misc_feature 921..1784
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="probable histone acetyltransferase MYST;
Provisional; Region: PLN03238"
/db_xref="CDD:178776"
misc_feature 1068..1070
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:02534"
misc_feature 1068..1070
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:04078"
misc_feature 1110..1112
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:04078"
misc_feature 1110..1112
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:02534"
misc_feature 1119..1697
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="MOZ/SAS family; Region: MOZ_SAS; pfam01853"
/db_xref="CDD:202012"
misc_feature 1395..1415
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q92993.2);
Region: Acetyl-CoA binding"
variation 273
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:71455781"
exon 279..345
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 284
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140468859"
variation 296
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145735863"
variation 314
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138317008"
exon 346..414
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 359
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149093594"
variation 365
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:4645914"
exon 415..551
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 492
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:369527314"
variation 498
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541271"
variation 500
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541269"
variation 509
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372595844"
variation 516
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:115896676"
variation 517
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:11541270"
variation 533
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:116830965"
variation 542
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201415653"
exon 552..707
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 556
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201831239"
variation 562
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369250083"
variation 588
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201410482"
variation 609
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148238235"
variation 623
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:141373536"
variation 624
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:78447196"
variation 626
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377518842"
variation 658
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200103121"
exon 708..782
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 752
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147419775"
variation 761
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:137945879"
exon 783..857
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 790
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143413716"
variation 805
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:386834229"
variation 811
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369137034"
variation 823
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372880133"
variation 836
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201879725"
exon 858..1106
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 875
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368421147"
variation 880
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200974760"
variation 924
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:4645921"
variation 932
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371854405"
variation 963
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:139506891"
variation 982
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200620312"
variation 987
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149683297"
variation 998
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144349144"
variation 1035
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:114058675"
variation 1040
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368796194"
variation 1073
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:111345240"
variation 1076
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148757761"
exon 1107..1196
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1111
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:111512947"
variation 1149
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143910658"
exon 1197..1337
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1211
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376820640"
variation 1231
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368959604"
variation 1250
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146875234"
variation 1277
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:140561633"
variation 1284
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199667540"
variation 1290
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377274648"
variation 1307
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144191296"
exon 1338..1431
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1364
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200248772"
variation 1409
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146588319"
variation 1427
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201020447"
exon 1432..1591
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1463
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11227272"
variation 1533
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370970433"
variation 1553
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150212692"
variation 1564
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:375524599"
variation 1565
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:114460328"
variation 1583
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:368492530"
exon 1592..1673
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1654
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200625753"
exon 1674..2233
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1729
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145568166"
variation 1752
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199674306"
variation 1754
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:11385"
variation 1837
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199779470"
variation 1838
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200332583"
variation 1840
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201309659"
variation 1858
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370375120"
variation 1868
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:186106053"
STS 1987..2202
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="IB3011"
/db_xref="UniSTS:46906"
STS 1988..2218
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="STS-U40989"
/db_xref="UniSTS:64845"
STS 2030..2229
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="HSC0AE062"
/db_xref="UniSTS:47861"
variation 2039
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375782368"
STS 2060..2193
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="RH18259"
/db_xref="UniSTS:56059"
variation 2100
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190723966"
variation 2152
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:554051"
variation 2155
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:199982885"
polyA_signal 2210..2215
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
variation 2222
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:3177082"
polyA_site 2231
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
variation 2232
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180585"
polyA_site 2233
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
ORIGIN
gcacccggtgggcgtcacgtgacggactcagtagaccgccactggctgtgcacgttatggggtttccacctagggctcggcctgaggcttgtaacactccgttttcccccgagtcacaggggcagtcttgcccctcgcagctgggtcgcggtgtctctcaaaggtccccctctacaggggcttcgtgaggcccgggcccacagggcgctcggtcccggaagtgacgtctcccagaggggccggaagtggcagtggagggagggaagatggcggaggtgggggagataatcgagggctgccgcctacccgtgctgcggcggaaccaggacaacgaagatgagtggcccctggccgagatcctgagcgtgaaggacatcagtggccggaagcttttctacgtccattacattgacttcaacaaacgtctggatgaatgggtgacgcatgagcggctggacctaaagaagatccagttccccaagaaagaggccaagacccccactaagaacggacttcctgggtcccgtcctggctctccagagagagaggtgccggcctcggcgcaggccagcgggaagaccttgccaatcccggtccagatcacactccgcttcaacctgcccaaggagcgggaggccattcccggtggcgagcctgaccagccgctctcctccagctcctgcctgcagcccaaccaccgctcaacgaaacggaaggtggaggtggtttcaccagcaactccagtgcccagcgagacagccccggcctcggtttttccccagaatggagccgcccgtagggcagtggcagcccagccaggacggaagcgaaaatcgaattgtttgggcactgatgaggactcccaggacagctctgatggaataccgtcagcaccacgcatgactggcagcctggtgtctgatcgaagccacgacgacatcgtcacccggatgaagaacattgagtgcattgagctgggccggcaccgcctcaagccgtggtacttctccccgtacccacaggaactcaccacattgcctgtcctctacctgtgcgagttctgcctcaagtacggccgtagtctcaagtgtcttcagcgtcatttgaccaagtgtgacctacgacatcctccaggcaatgagatttaccgcaagggcaccatctccttctttgagattgatggacgtaagaacaagagttattcccagaacctgtgtcttttggccaagtgtttccttgaccataagacactgtactatgacacagaccctttcctcttctacgtcatgacagagtatgactgtaagggcttccacatcgtgggctacttctccaaggagaaagaatcaacggaagactacaatgtggcctgcatcctaaccctgcctccctaccagcgccggggctacggcaagctgctgatcgagttcagctatgaactctccaaagtggaagggaaaacagggacccctgagaagcccctctcagaccttggcctcctatcctatcgaagctactggtcccagaccatcctggagatcctgatggggctgaagtcggagagcggggagaggccacagatcaccatcaatgagattagtgaaatcaccagcatcaagaaggaggatgtcatctccactctgcagtacctcaatctcatcaactactacaagggccagtacatcctcacactgtcagaggacatcgtggatggccatgagcgggccatgctcaagcggctcctgcggatcgactccaagtgtctgcacttcactcccaaggactggagcaagagggggaagtggtgaccagacactgcccactgcagtgccaagacggcagcaggactggggctgatagcccaccccgcccccactgcagctcccacaaagcactctaagggagatggggctgaggacagctcaaaaaggagaggacaggcctggcaggggcccactggtgcccagcaccaaggcgagctccgggctcagaccaactccaaggtcagctggccacaggcccaggcctcctctgaagcagggaccagagggagccaggcagctgtgtacagtgagaagggatccggatgggggagctctgtacagagggctggtgattgtaaaaatttcttttgtaaagtagaagttgggggtggggtgggtgctggctgcaaaaatttctggcttctcttacccctattgcccccggcaataaattgtttctatatgccagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: IDA
GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS
GeneID:10524 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:10524 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10524 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:10524 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:10524 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS
GeneID:10524 -> Molecular function: GO:0070491 [repressing transcription factor binding] evidence: IPI
GeneID:10524 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:10524 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:10524 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:10524 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IDA
GeneID:10524 -> Biological process: GO:0016573 [histone acetylation] evidence: IDA
GeneID:10524 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:10524 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS
GeneID:10524 -> Biological process: GO:0032703 [negative regulation of interleukin-2 production] evidence: IDA
GeneID:10524 -> Biological process: GO:0040008 [regulation of growth] evidence: IEA
GeneID:10524 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
GeneID:10524 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:10524 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
GeneID:10524 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10524 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:10524 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:10524 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:10524 -> Cellular component: GO:0032777 [Piccolo NuA4 histone acetyltransferase complex] evidence: IDA
GeneID:10524 -> Cellular component: GO:0035267 [NuA4 histone acetyltransferase complex] evidence: IDA
GeneID:10524 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_006379 -> EC 2.3.1.48
by
@meso_cacase at
DBCLS
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