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2024-04-24 07:00:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006353 1980 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens high mobility group nucleosomal binding domain 4
(HMGN4), mRNA.
ACCESSION NM_006353
VERSION NM_006353.2 GI:23238232
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1980)
AUTHORS Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
Dunham,I., Rogers,J. and Beck,S.
TITLE The DNA sequence and analysis of human chromosome 6
JOURNAL Nature 425 (6960), 805-811 (2003)
PUBMED 14574404
REFERENCE 2 (bases 1 to 1980)
AUTHORS Birger,Y., Ito,Y., West,K.L., Landsman,D. and Bustin,M.
TITLE HMGN4, a newly discovered nucleosome-binding protein encoded by an
intronless gene
JOURNAL DNA Cell Biol. 20 (5), 257-264 (2001)
PUBMED 11410162
REFERENCE 3 (bases 1 to 1980)
AUTHORS Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
TITLE A 1.1-Mb transcript map of the hereditary hemochromatosis locus
JOURNAL Genome Res. 7 (5), 441-456 (1997)
PUBMED 9149941
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC001282.1 and AU143224.1.
On Sep 20, 2002 this sequence version replaced gi:10835239.
Summary: The protein encoded by this gene, a member of the HMGN
protein family, is thought to reduce the compactness of the
chromatin fiber in nucleosomes, thereby enhancing transcription
from chromatin templates. [provided by RefSeq, Mar 2013].
##Evidence-Data-START##
Transcript exon combination :: AU143224.1, BC001282.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..1980
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
gene 1..1980
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/note="high mobility group nucleosomal binding domain 4"
/db_xref="GeneID:10473"
/db_xref="HGNC:4989"
/db_xref="HPRD:17111"
exon 1..158
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/inference="alignment:Splign:1.39.8"
variation 43
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="c"
/db_xref="dbSNP:192987217"
variation 101
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552934"
variation 151
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:374275261"
exon 159..1969
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/inference="alignment:Splign:1.39.8"
misc_feature 179..181
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/note="upstream in-frame stop codon"
variation 196
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:200214002"
variation 222
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:16891790"
variation 223
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:369767548"
variation 236
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:372836264"
CDS 239..511
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/note="high-mobility group (nonhistone chromosomal)
protein 17-like 3; high mobility group protein N4;
high-mobility group protein 17-like 3; non-histone
chromosomal protein HMG-17-like 3"
/codon_start=1
/product="high mobility group nucleosome-binding
domain-containing protein 4"
/protein_id="NP_006344.1"
/db_xref="GI:10835240"
/db_xref="CCDS:CCDS4615.1"
/db_xref="GeneID:10473"
/db_xref="HGNC:4989"
/db_xref="HPRD:17111"
/translation="
MPKRKAKGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPRPKKASAKKGEKLPKGRKGKADAGKDGNNPAKNRDASTLQSQKAEGTGDAK
"
misc_feature 476..478
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O00479.3); phosphorylation site"
misc_feature 482..484
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O00479.3); acetylation site"
variation 277
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:146279544"
variation 290
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:139269061"
variation 298
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:375463401"
variation 336
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:34905463"
variation 341
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:146576097"
variation 347
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:377540622"
variation 351
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="t"
/db_xref="dbSNP:148754831"
variation 360
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="g"
/db_xref="dbSNP:200609248"
variation 365
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:369400733"
variation 368
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="g"
/db_xref="dbSNP:142356497"
variation 403
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="g"
/db_xref="dbSNP:142895565"
variation 408
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:373005223"
variation 415
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:151236366"
variation 425
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:115040324"
variation 429
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="c"
/db_xref="dbSNP:147106046"
variation 436
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:4871"
STS 447..669
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="D6S2358"
/db_xref="UniSTS:21901"
variation 449
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:142518878"
variation 500
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:34511704"
variation 510
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:369265989"
variation 522
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:186927421"
variation 576
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:140941850"
variation 616
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="g"
/replace="t"
/db_xref="dbSNP:149760275"
variation 617
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:377502372"
variation 709
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:370014904"
STS 813..976
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="RH46615"
/db_xref="UniSTS:42229"
variation 813
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:9348722"
variation 852
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:15580"
variation 895
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:140377460"
variation 960
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:145535311"
variation 1068
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="c"
/replace="t"
/db_xref="dbSNP:11966754"
variation 1070
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:138074103"
variation 1298
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="c"
/db_xref="dbSNP:1804835"
STS 1319..1455
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="RH68775"
/db_xref="UniSTS:71426"
STS 1367..1516
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="SHGC-35158"
/db_xref="UniSTS:6740"
variation 1381
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:193042267"
variation 1446
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="t"
/db_xref="dbSNP:185258550"
variation 1458
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:189677486"
variation 1464..1465
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace=""
/replace="g"
/db_xref="dbSNP:35770667"
polyA_signal 1514..1519
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
polyA_site 1529
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/experiment="experimental evidence, no additional details
recorded"
STS 1532..1661
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="G54070"
/db_xref="UniSTS:109452"
polyA_site 1541
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/experiment="experimental evidence, no additional details
recorded"
variation 1551
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:11552935"
variation 1612
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:4573"
variation 1665
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:181240711"
STS 1805..1931
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/standard_name="WI-13558"
/db_xref="UniSTS:22323"
variation 1894
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/replace="a"
/replace="g"
/db_xref="dbSNP:149082500"
polyA_signal 1943..1948
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
polyA_site 1969
/gene="HMGN4"
/gene_synonym="HMG17L3; NHC"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
atcctcaccttccctcgccttcctgttcctggcggagccgggctccgctcgtcttctctgtcttagggctggtgctggccctgcccacgcctagggctccggcgcgtcacgggcctcagctgggattcccgcgcccctcggacggccacgagactcggacatctttccaggaacagcgtgaggaggacagaagcacccaacaggactgctcaagccacctgcgaacactgctgctaccatgcccaagagaaaggcaaaaggagatgctaaaggtgataaagcaaaggtgaaggatgagccacagaggagatcagctcggttgtctgctaaaccagctcctccaaaaccagagcccaggcctaaaaaggcctctgcaaagaagggagagaagcttcccaaagggagaaaggggaaagcagatgctggaaaggatgggaacaaccctgcaaaaaaccgagatgcctctacactccagtcccagaaagcggaaggcactggggatgccaagtgaaatgtacatttttgagagctctgtacttatagtgactctactgtttgaaatactatttttttaaatcaagttttataaaagtgtagaattttggcttttttaagttatgttgttagcacacaggacacttccttgttgtcttttgtggaaagggcaagtaccactaatagggtgtatctcagaaactgaattgaaataagggaaaataggattttctgtcctggtttttgaagattgttcttgattcccttgattcccaggagagattctctgacattcacgtgtcagccactttggcacggaagccttacagtgtggggaaccaaaacttcgtgtctcccctttccccgatgccatcagcatagacttgacttccttaaaccgagagttttgatgtggccttggcaaccctaaaatcagctgtgttaggtaacaaaactcaggctttctgttgatgacatcgagatggtgtcacttaaaagagccaagattcctgttttcagtttgtggattcatcctgctggttttactttagtccctccatgtcaaagtgggcctgagaaaagctcatacatgcctcatgtgaagtgtccaccctctctgaaaatctttcttgttcaaaacagcaacgacatatcttgttaacttttacggtgacttttggaggaggggagtttggaaattgtaaaatgttatagattgttgcctatttcctgctgaaagtaaatgtttttaaaaagtatcatataaagctgaatacaaattggtttggggggagatcctttcctacccaaagtcataaatatattctttactgccttgtggaaattttatagttttgcctttcacatttgtctttagtctgtcctgaactgatttttgtgaaaattatgagttagaaattcaacttaacatttttcatattcgaagtggttgtctctgcactatttactgaaaagttcatcctttccccagtgatttgtaacactgcctctttcataaattaaatttttgtgtatgtgtgtgggtcttttgatggtttctattctgactgacatcaatttgtctaatcttgtagcagtacagtacagtcctgattattgcaactttaggaaaaggtctgataaaaaccaagatgcctccacattttgtcataattgtaaccaatttcacctctgtctccagtatcaccacaaaattgttcttccttggagtgtcttggctattcttagccaactgttcctccatattacttctagaattagaccaacaatttataaatcaaacaaacccaagagcattgaaattttgattggatttgtattgaatttatagattaatctggtaaaccatgtcatctttacaatgttgtcttccaatacatgaatatggtacagctcttcatttacttaggcctttgaaatatctttcaataaagtttataattttctccataaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10473 -> Molecular function: GO:0031492 [nucleosomal DNA binding] evidence: IEA
GeneID:10473 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
GeneID:10473 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
by
@meso_cacase at
DBCLS
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