2024-03-29 07:34:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006325 1087 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens RAN, member RAS oncogene family (RAN), mRNA. ACCESSION NM_006325 VERSION NM_006325.3 GI:219879807 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1087) AUTHORS Yuen,H.F., Gunasekharan,V.K., Chan,K.K., Zhang,S.D., Platt-Higgins,A., Gately,K., O'Byrne,K., Fennell,D.A., Johnston,P.G., Rudland,P.S. and El-Tanani,M. TITLE RanGTPase: a candidate for Myc-mediated cancer progression JOURNAL J. Natl. Cancer Inst. 105 (7), 475-488 (2013) PUBMED 23468463 REMARK GeneRIF: Results suggest that Ran is required for and is a potential therapeutic target of Myc-driven cancer progression in both breast and lung cancers. REFERENCE 2 (bases 1 to 1087) AUTHORS Nagai,M. and Yoneda,Y. TITLE Downregulation of the small GTPase ras-related nuclear protein accelerates cellular ageing JOURNAL Biochim. Biophys. Acta 1830 (3), 2813-2819 (2013) PUBMED 23160023 REMARK GeneRIF: Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells. REFERENCE 3 (bases 1 to 1087) AUTHORS Mastroeni,D., Chouliaras,L., Grover,A., Liang,W.S., Hauns,K., Rogers,J. and Coleman,P.D. TITLE Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology JOURNAL PLoS ONE 8 (1), E53349 (2013) PUBMED 23308199 REMARK GeneRIF: Reduced RAN expression and disrupted transport between cytoplasm and nucleus are the key events in Alzheimer's disease pathophysiology. REFERENCE 4 (bases 1 to 1087) AUTHORS Milano,S.K., Kwon,W., Pereira,R., Antonyak,M.A. and Cerione,R.A. TITLE Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation JOURNAL J. Biol. Chem. 287 (30), 24955-24966 (2012) PUBMED 22679017 REMARK GeneRIF: a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important consequences for oncogenic transformation. REFERENCE 5 (bases 1 to 1087) AUTHORS Atabakhsh,E. and Schild-Poulter,C. TITLE RanBPM is an inhibitor of ERK signaling JOURNAL PLoS ONE 7 (10), E47803 (2012) PUBMED 23118896 REMARK GeneRIF: RanBPM loss of expression results in constitutive activation of the ERK pathway and promotes cellular events leading to cellular transformation and tumorigenesis. REFERENCE 6 (bases 1 to 1087) AUTHORS Yokoyama,N., Hayashi,N., Seki,T., Pante,N., Ohba,T., Nishii,K., Kuma,K., Hayashida,T., Miyata,T., Aebi,U. et al. TITLE A giant nucleopore protein that binds Ran/TC4 JOURNAL Nature 376 (6536), 184-188 (1995) PUBMED 7603572 REFERENCE 7 (bases 1 to 1087) AUTHORS Dawson,S.J. and White,L.A. TITLE Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin JOURNAL J. Infect. 24 (3), 317-320 (1992) PUBMED 1602151 REFERENCE 8 (bases 1 to 1087) AUTHORS Bischoff,F.R. and Ponstingl,H. TITLE Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (23), 10830-10834 (1991) PUBMED 1961752 REFERENCE 9 (bases 1 to 1087) AUTHORS Matsumoto,T. and Beach,D. TITLE Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase JOURNAL Cell 66 (2), 347-360 (1991) PUBMED 1855255 REFERENCE 10 (bases 1 to 1087) AUTHORS Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P. TITLE Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line JOURNAL Mol. Cell. Biol. 10 (4), 1793-1798 (1990) PUBMED 2108320 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000852.1 and BC004272.1. On Jan 9, 2009 this sequence version replaced gi:6042206. Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051908.2, AF054183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1068 BC000852.1 1-1068 1069-1087 BC004272.1 1032-1050 FEATURES Location/Qualifiers source 1..1087 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q24.3" gene 1..1087 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="RAN, member RAS oncogene family" /db_xref="GeneID:5901" /db_xref="HGNC:9846" /db_xref="HPRD:03109" /db_xref="MIM:601179" exon 1..55 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" variation 22 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:147215193" variation 29 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:11546491" variation 46 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:1127636" exon 56..101 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" CDS 66..716 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="guanosine triphosphatase Ran; RanGTPase; OK/SW-cl.81; member RAS oncogene family; GTPase Ran; ras-like protein TC4; ras-related nuclear protein; androgen receptor-associated protein 24" /codon_start=1 /product="GTP-binding nuclear protein Ran" /protein_id="NP_006316.1" /db_xref="GI:5453555" /db_xref="CCDS:CCDS9271.1" /db_xref="GeneID:5901" /db_xref="HGNC:9846" /db_xref="HPRD:03109" /db_xref="MIM:601179" /translation="
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
" misc_feature 66..713 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="GTP-binding nuclear protein Ran; Provisional; Region: PTZ00132" /db_xref="CDD:240284" misc_feature 69..71 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="N-acetylalanine; propagated from UniProtKB/Swiss-Prot (P62826.3); acetylation site" misc_feature 96..593 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Ras-related nuclear proteins (Ran)/TC4 family of small GTPases; Region: Ran; cd00877" /db_xref="CDD:206643" misc_feature 114..137 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="G1 box; other site" /db_xref="CDD:206643" misc_feature order(117..119,180..182,186..188,192..197,270..275, 288..290,300..302,345..353,447..449,453..455) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="GAP interaction site [polypeptide binding]; other site" /db_xref="CDD:206643" misc_feature order(120..122,264..266,276..284,291..293,345..365, 369..374,381..386,393..395,465..467,474..476,483..485) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="GEF interaction site [polypeptide binding]; other site" /db_xref="CDD:206643" misc_feature order(123..125,129..140,429..431,438..440,516..521) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:206643" misc_feature order(150..152,159..167,216..221,228..233,405..407, 480..485,492..494,537..539,564..572) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Co-activator interaction site; other site" /db_xref="CDD:206643" misc_feature order(156..170,183..209) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Switch I region; other site" /db_xref="CDD:206643" misc_feature order(174..176,255..257,285..296,300..302,306..311, 342..344,393..398,432..434,438..443,447..449,459..461, 465..467,492..494,519..524) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Exportin interaction site in Cse1p/Kap60p/RanGTP complex [polypeptide binding]; other site" /db_xref="CDD:206643" misc_feature 189..191 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="G2 box; other site" /db_xref="CDD:206643" misc_feature order(204..206,255..257,285..287,294..299,306..311, 393..395,465..467,483..488,522..533,537..539) /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Importin (transport factor) interaction site [polypeptide binding]; other site" /db_xref="CDD:206643" misc_feature 243..245 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P62826.3); acetylation site" misc_feature 258..269 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="G3 box; other site" /db_xref="CDD:206643" misc_feature 264..320 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="Switch II region; other site" /db_xref="CDD:206643" misc_feature 276..278 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P62826.3); acetylation site" misc_feature 360..362 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P62826.3); acetylation site" misc_feature 429..440 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="G4 box; other site" /db_xref="CDD:206643" misc_feature 468..470 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P62826.3); phosphorylation site" misc_feature 504..506 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 504..506 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 513..521 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /note="G5 box; other site" /db_xref="CDD:206643" misc_feature 528..530 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 540..542 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P62826.3); acetylation site" variation 69 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:11546489" exon 102..186 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" STS 106..248 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /standard_name="GDB:451538" /db_xref="UniSTS:157307" variation 108 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:142740158" variation 117 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="g" /replace="t" /db_xref="dbSNP:200416921" variation 140 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:199512241" variation 143 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:116832702" variation 160 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:11546492" variation 185 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:116685516" exon 187..312 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" variation 191 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:199644788" variation 230 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:145207608" variation 233 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:114011062" variation 245 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:150576123" variation 254 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:2293512" variation 263 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="t" /db_xref="dbSNP:201353570" variation 296 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:200748775" exon 313..500 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" variation 314 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="g" /db_xref="dbSNP:139618829" variation 326 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:149783374" variation 335 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:146783236" variation 347 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="g" /replace="t" /db_xref="dbSNP:1802283" variation 377 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:11546493" variation 408 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:200176335" STS 459..673 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /standard_name="STS-M31469" /db_xref="UniSTS:4649" exon 501..671 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" variation 506 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:373832485" variation 627 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:201928609" variation 629 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:199809948" variation 662 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:371816272" exon 672..1071 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /inference="alignment:Splign:1.39.8" variation 866 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:15220" variation 868 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:145363958" variation 882..883 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="" /replace="g" /db_xref="dbSNP:373935763" variation 887 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="t" /db_xref="dbSNP:113688889" STS 923..1018 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /standard_name="WI-16177" /db_xref="UniSTS:69938" variation 960 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:3803012" variation 969 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="c" /replace="t" /db_xref="dbSNP:1802299" variation 982 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="c" /db_xref="dbSNP:1045515" variation 985 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" /replace="a" /replace="g" /db_xref="dbSNP:149187550" polyA_signal 1046..1051 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" polyA_site 1071 /gene="RAN" /gene_synonym="ARA24; Gsp1; TC4" ORIGIN
cgcttccgccatctttccagcctcagtcggacgggcgcggagacgcttctggaaggaacgccgcgatggctgcgcagggagagccccaggtccagttcaaacttgtattggttggtgatggtggtactggaaaaacgaccttcgtgaaacgtcatttgactggtgaatttgagaagaagtatgtagccaccttgggtgttgaggttcatcccctagtgttccacaccaacagaggacctattaagttcaatgtatgggacacagccggccaggagaaattcggtggactgagagatggctattatatccaagcccagtgtgccatcataatgtttgatgtaacatcgagagttacttacaagaatgtgcctaactggcatagagatctggtacgagtgtgtgaaaacatccccattgtgttgtgtggcaacaaagtggatattaaggacaggaaagtgaaggcgaaatccattgtcttccaccgaaagaagaatcttcagtactacgacatttctgccaaaagtaactacaactttgaaaagcccttcctctggcttgctaggaagctcattggagaccctaacttggaatttgttgccatgcctgctctcgccccaccagaagttgtcatggacccagctttggcagcacagtatgagcacgacttagaggttgctcagacaactgctctcccggatgaggatgatgacctgtgagaatgaagctggagcccagcgtcagaagtctagttttataggcagctgtcctgtgatgtcagcggtgcagcgtgtgtgccacctcattattatctagctaagcggaacatgtgcttcatctgtgggatgctgaaggagatgagtgggcttcggagtgaatgtggcagtttaaaaaataacttcattgtttggacctgcatatttagctgttttggaacgcagttgattccttgagtttcatatataagactgctgcagtcacatcacaatattcagtggtgaaatcttgtttgttactgtcattcccattccttttcgtttagaatcagaataaagttgtatttcaaatatctaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5901 -> Molecular function: GO:0003682 [chromatin binding] evidence: TAS GeneID:5901 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: NAS GeneID:5901 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS GeneID:5901 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5901 -> Molecular function: GO:0005525 [GTP binding] evidence: IDA GeneID:5901 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS GeneID:5901 -> Biological process: GO:0006259 [DNA metabolic process] evidence: TAS GeneID:5901 -> Biological process: GO:0006405 [RNA export from nucleus] evidence: NAS GeneID:5901 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IEA GeneID:5901 -> Biological process: GO:0006611 [protein export from nucleus] evidence: IDA GeneID:5901 -> Biological process: GO:0006611 [protein export from nucleus] evidence: NAS GeneID:5901 -> Biological process: GO:0007052 [mitotic spindle organization] evidence: TAS GeneID:5901 -> Biological process: GO:0007067 [mitosis] evidence: TAS GeneID:5901 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:5901 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: IEA GeneID:5901 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5901 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5901 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS GeneID:5901 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: IEA GeneID:5901 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS GeneID:5901 -> Biological process: GO:0032092 [positive regulation of protein binding] evidence: IDA GeneID:5901 -> Biological process: GO:0034629 [cellular protein complex localization] evidence: IEA GeneID:5901 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:5901 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS GeneID:5901 -> Biological process: GO:0051301 [cell division] evidence: IEA GeneID:5901 -> Biological process: GO:0075733 [intracellular transport of viral material] evidence: TAS GeneID:5901 -> Cellular component: GO:0000785 [chromatin] evidence: IDA GeneID:5901 -> Cellular component: GO:0005643 [nuclear pore] evidence: NAS GeneID:5901 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5901 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5901 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5901 -> Cellular component: GO:0042470 [melanosome] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_006316 -> EC 3.6.5.1 NP_006316 -> EC 3.6.5.2 NP_006316 -> EC 3.6.5.3 NP_006316 -> EC 3.6.5.4
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