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2024-04-27 11:56:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006282 6344 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens serine/threonine kinase 4 (STK4), mRNA.
ACCESSION NM_006282
VERSION NM_006282.2 GI:38327560
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6344)
AUTHORS Collak,F.K., Yagiz,K., Luthringer,D.J., Erkaya,B. and Cinar,B.
TITLE Threonine-120 phosphorylation regulated by
phosphoinositide-3-kinase/Akt and mammalian target of rapamycin
pathway signaling limits the antitumor activity of mammalian
sterile 20-like kinase 1
JOURNAL J. Biol. Chem. 287 (28), 23698-23709 (2012)
PUBMED 22619175
REMARK GeneRIF: Data suggest that phosphoinositide-3-kinase/Akt and
mammalian target of rapamycin (mTOR) pathway signaling
differentially regulate phospho-Mst1-Thr-120/Thr-183.
REFERENCE 2 (bases 1 to 6344)
AUTHORS Xie,S.L., Shen,J.Z., Fu,H.Y., Wu,D.S., Wang,X.T. and Cao,D.M.
TITLE [Expression of Hippo signaling pathway core element MST1 in acute
leukemia patients and its significance]
JOURNAL Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (3), 527-530 (2012)
PUBMED 22739148
REMARK GeneRIF: Low expression of MST1 may be related with the
pathogenesis and prognosis of acute leukemia.
REFERENCE 3 (bases 1 to 6344)
AUTHORS Abdollahpour,H., Appaswamy,G., Kotlarz,D., Diestelhorst,J.,
Beier,R., Schaffer,A.A., Gertz,E.M., Schambach,A., Kreipe,H.H.,
Pfeifer,D., Engelhardt,K.R., Rezaei,N., Grimbacher,B., Lohrmann,S.,
Sherkat,R. and Klein,C.
TITLE The phenotype of human STK4 deficiency
JOURNAL Blood 119 (15), 3450-3457 (2012)
PUBMED 22294732
REMARK GeneRIF: STK4 deficiency is a novel human primary immunodeficiency
syndrome.
REFERENCE 4 (bases 1 to 6344)
AUTHORS Nehme,N.T., Pachlopnik Schmid,J., Debeurme,F., Andre-Schmutz,I.,
Lim,A., Nitschke,P., Rieux-Laucat,F., Lutz,P., Picard,C.,
Mahlaoui,N., Fischer,A. and de Saint Basile,G.
TITLE MST1 mutations in autosomal recessive primary immunodeficiency
characterized by defective naive T-cell survival
JOURNAL Blood 119 (15), 3458-3468 (2012)
PUBMED 22174160
REMARK GeneRIF: MST1 mutations in autosomal recessive primary
immunodeficiency characterized by defective naive T-cell survival.
REFERENCE 5 (bases 1 to 6344)
AUTHORS Constantinescu Aruxandei,D., Makbul,C., Koturenkiene,A.,
Ludemann,M.B. and Herrmann,C.
TITLE Dimerization-induced folding of MST1 SARAH and the influence of the
intrinsically unstructured inhibitory domain: low thermodynamic
stability of monomer
JOURNAL Biochemistry 50 (51), 10990-11000 (2011)
PUBMED 22112013
REMARK GeneRIF: Data indicate that dimerization domain of MST1 is
unstructured as monomer and undergoes dimerization-induced folding.
Data indicate that inhibitory domain of MST1 is disordered region
both as single domain and as construct with dimerization domain.
REFERENCE 6 (bases 1 to 6344)
AUTHORS Creasy,C.L. and Chernoff,J.
TITLE Cloning and characterization of a member of the MST subfamily of
Ste20-like kinases
JOURNAL Gene 167 (1-2), 303-306 (1995)
PUBMED 8566796
REFERENCE 7 (bases 1 to 6344)
AUTHORS Creasy,C.L. and Chernoff,J.
TITLE Cloning and characterization of a human protein kinase with
homology to Ste20
JOURNAL J. Biol. Chem. 270 (37), 21695-21700 (1995)
PUBMED 7665586
REFERENCE 8 (bases 1 to 6344)
AUTHORS Schultz,S.J. and Nigg,E.A.
TITLE Identification of 21 novel human protein kinases, including 3
members of a family related to the cell cycle regulator nimA of
Aspergillus nidulans
JOURNAL Cell Growth Differ. 4 (10), 821-830 (1993)
PUBMED 8274451
REFERENCE 9 (bases 1 to 6344)
AUTHORS Han,S., Stuart,L.A. and Degen,S.J.
TITLE Characterization of the DNF15S2 locus on human chromosome 3:
identification of a gene coding for four kringle domains with
homology to hepatocyte growth factor
JOURNAL Biochemistry 30 (40), 9768-9780 (1991)
PUBMED 1655021
REFERENCE 10 (bases 1 to 6344)
AUTHORS Gerber,M.J., Drabkin,H.A., Firnhaber,C., Miller,Y.E., Scoggin,C.H.
and Smith,D.I.
TITLE Regional localization of chromosome 3-specific DNA fragments by
using a hybrid cell deletion mapping panel
JOURNAL Am. J. Hum. Genet. 43 (4), 442-451 (1988)
PUBMED 2902784
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL597960.1, BC038850.1,
U60207.1, BU153393.1, BU429479.1, T18610.1, BM455776.1, BU902081.1,
BQ216721.1, BC042861.1, AK027088.1, BM459914.1, BM450795.1,
BQ434275.1, BU633556.1 and BU689980.1.
This sequence is a reference standard in the RefSeqGene project.
On Nov 14, 2003 this sequence version replaced gi:5454095.
Summary: The protein encoded by this gene is a cytoplasmic kinase
that is structurally similar to the yeast Ste20p kinase, which acts
upstream of the stress-induced mitogen-activated protein kinase
cascade. The encoded protein can phosphorylate myelin basic protein
and undergoes autophosphorylation. A caspase-cleaved fragment of
the encoded protein has been shown to be capable of phosphorylating
histone H2B. The particular phosphorylation catalyzed by this
protein has been correlated with apoptosis, and it's possible that
this protein induces the chromatin condensation observed in this
process. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U60207.1, U18297.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-48 AL597960.1 6-53
49-1238 BC038850.1 15-1204
1239-1962 U60207.1 1191-1914
1963-1980 BC038850.1 2024-2041
1981-2611 BU153393.1 95-725
2612-2644 BU429479.1 201-233
2645-2708 BU153393.1 759-822
2709-2717 T18610.1 190-198
2718-2770 BU153393.1 833-885
2771-2789 BU153393.1 887-905
2790-3171 BM455776.1 7-388
3172-3867 BU902081.1 156-851
3868-4441 BQ216721.1 99-672
4442-4600 BC042861.1 14-172
4601-4838 AK027088.1 386-623
4839-4959 BC042861.1 413-533
4960-5428 BM459914.1 70-538
5429-5526 BM450795.1 345-442
5527-5666 BQ434275.1 520-659
5667-6011 BC042861.1 1240-1584
6012-6331 BU633556.1 24-343 c
6332-6344 BU689980.1 1-13 c
FEATURES Location/Qualifiers
source 1..6344
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q11.2-q13.2"
gene 1..6344
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="serine/threonine kinase 4"
/db_xref="GeneID:6789"
/db_xref="HGNC:11408"
/db_xref="HPRD:05395"
/db_xref="MIM:604965"
exon 1..125
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 35
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139822097"
variation 45
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:372584607"
STS 54..1595
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/db_xref="UniSTS:483393"
variation 63
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199641028"
variation 89
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:190920315"
CDS 91..1554
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/EC_number="2.7.11.1"
/note="kinase responsive to stress 2; mammalian sterile
20-like 1; dJ211D12.2 (serine/threonine kinase 4 (MST1,
KRS2)); MST-1; STE20-like kinase MST1; mammalian
STE20-like protein kinase 1; serine/threonine-protein
kinase Krs-2"
/codon_start=1
/product="serine/threonine-protein kinase 4"
/protein_id="NP_006273.1"
/db_xref="GI:5454096"
/db_xref="CCDS:CCDS13341.1"
/db_xref="GeneID:6789"
/db_xref="HGNC:11408"
/db_xref="HPRD:05395"
/db_xref="MIM:604965"
/translation="
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
"
misc_feature 91..93
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (Q13043.2); acetylation site"
misc_feature 97..99
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature 166..933
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="Catalytic domain of the Protein Serine/Threonine
Kinases, Mammalian Ste20-like protein kinase 1 and 2;
Region: STKc_MST1_2; cd06612"
/db_xref="CDD:132943"
misc_feature 178..933
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(196..210,220..222,259..261,265..267,346..348,
394..405,412..417,424..426,535..537,541..552,556..558,
589..591,598..600,640..651,655..657,736..738,763..765)
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="active site"
/db_xref="CDD:132943"
misc_feature order(196..210,220..222,259..261,265..267,346..348,
394..405,412..417,424..426,547..552,556..558,589..591)
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132943"
misc_feature order(205..210,535..537,541..549,598..600,640..651,
655..657,736..738,763..765)
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132943"
misc_feature 448..450
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKB/AKT1; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature order(586..624,628..657)
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132943"
misc_feature 619..621
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05395"
misc_feature 637..639
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature 637..639
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05395"
misc_feature 649..651
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05395"
misc_feature 883..885
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13043.2); phosphorylation site"
misc_feature 1048..1050
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13043.2); phosphorylation site"
misc_feature 1048..1050
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1066..1071
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q13043.2); cleavage site"
misc_feature 1066..1068
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1069..1071
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05395"
misc_feature 1108..1110
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature 1135..1140
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q13043.2); cleavage site"
misc_feature 1135..1137
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1189..1191
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature 1249..1251
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKB/AKT1; propagated from
UniProtKB/Swiss-Prot (Q13043.2); phosphorylation site"
misc_feature 1318..1320
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13043.2); phosphorylation site"
misc_feature 1330..1332
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13043.2); phosphorylation site"
misc_feature 1384..1530
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/note="C terminal SARAH domain of Mst1; Region:
Mst1_SARAH; pfam11629"
/db_xref="CDD:152065"
variation 93
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369482504"
exon 126..206
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 137
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142594802"
variation 158
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150984577"
variation 168
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373205117"
exon 207..335
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 212
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:140854695"
variation 216
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370431590"
variation 219
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150111569"
variation 220
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147806598"
variation 257
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374689115"
exon 336..450
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 336
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368631495"
variation 363
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:75329306"
variation 377
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:141098686"
variation 382
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146109137"
variation 384
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146936124"
variation 387
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371926152"
variation 390
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138052948"
variation 391
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375543946"
variation 439
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:387907316"
variation 440
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202040819"
variation 449
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368513990"
exon 451..615
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 477
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371332575"
variation 486
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369130861"
variation 533
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374685235"
variation 574
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:55850759"
exon 616..783
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 632
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202070040"
variation 642
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:79020002"
variation 709
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377733474"
variation 710
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201578965"
variation 722
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:76539764"
variation 756
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:139310380"
exon 784..921
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 794
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370157810"
variation 811
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371236375"
variation 829
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368707737"
variation 848
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149432644"
variation 862
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372125666"
variation 886
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:143845252"
variation 898..899
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="c"
/db_xref="dbSNP:375042437"
variation 901
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:80013229"
variation 908
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374505931"
variation 913
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:373362307"
exon 922..1050
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 935
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6103955"
variation 949
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372387562"
variation 961
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:148138374"
variation 969
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:377009560"
variation 1000
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201208315"
variation 1001
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200716827"
variation 1004
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:371733260"
variation 1019
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35447878"
variation 1024
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:17420378"
variation 1035
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201769432"
variation 1036
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374601797"
exon 1051..1237
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 1085
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:146085540"
variation 1115
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201970002"
variation 1129
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374331006"
variation 1147
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:140089638"
variation 1152
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376301299"
variation 1154
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35944046"
variation 1161
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375700226"
variation 1176
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201046502"
variation 1191
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:112013913"
variation 1224
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201696028"
variation 1232
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201224293"
exon 1238..1395
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 1262
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371924549"
variation 1291
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376797397"
variation 1337
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:33963346"
variation 1361
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:146304786"
exon 1396..6331
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/inference="alignment:Splign:1.39.8"
variation 1410
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369760175"
STS 1418..1562
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="RH66078"
/db_xref="UniSTS:9534"
variation 1434
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142232604"
variation 1459
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:376065907"
variation 1499
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200190272"
variation 1520
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201001614"
variation 1525
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:368897909"
STS 1537..1730
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="RH18007"
/db_xref="UniSTS:34846"
variation 1537
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201951179"
variation 1569
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:11700156"
variation 1583
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201468440"
variation 1605
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375069525"
variation 1658
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:189966758"
variation 1688
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:116979029"
variation 1719
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146404453"
variation 1740
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:111342768"
variation 1781
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139088556"
variation 1805
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:182706923"
variation 1900
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:373433745"
variation 1912
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:117066251"
variation 1924..1925
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="at"
/db_xref="dbSNP:11471509"
variation 1925..1926
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="at"
/db_xref="dbSNP:34259011"
variation 1928..1929
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="at"
/db_xref="dbSNP:10680887"
variation 1932..1933
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="at"
/db_xref="dbSNP:11471759"
variation 1937..1938
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="ta"
/db_xref="dbSNP:59732297"
STS 2079..2203
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="Z94383"
/db_xref="UniSTS:80135"
variation 2104
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:376629519"
variation 2148
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:188014392"
variation 2324
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143954059"
variation 2397
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144896941"
variation 2522
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:191233826"
variation 2674
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6017482"
variation 2680
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:6031972"
variation 2690
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:182985493"
variation 2700
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:6031973"
variation 2751
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35255459"
variation 2883
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:373746200"
variation 2885
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187510225"
variation 2926
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:142124819"
variation 2934
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:45525238"
variation 2957
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:192017433"
variation 2961
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:184790516"
variation 3098
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:187632343"
variation 3152
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372801471"
variation 3188
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:45443293"
variation 3205
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:2425689"
variation 3238
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:192375312"
variation 3288
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:6073627"
variation 3299
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:151189831"
variation 3391
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6031974"
variation 3407
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6031975"
variation 3464
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:140339858"
variation 3497
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:184289591"
variation 3500
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6031976"
variation 3546
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377701608"
variation 3549
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142462940"
variation 3557
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145295742"
variation 3650
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6031977"
variation 3740
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370253682"
variation 3763..3764
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="tc"
/db_xref="dbSNP:140133525"
variation 3764..3765
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="ct"
/replace="tc"
/db_xref="dbSNP:148852249"
variation 3773..3774
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="ct"
/db_xref="dbSNP:72290679"
variation 3774..3775
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="c"
/replace="ct"
/replace="tc"
/db_xref="dbSNP:34809968"
variation 3776..3777
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="tt"
/db_xref="dbSNP:375113959"
variation 3790
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:116483852"
variation 3811
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:6031978"
STS 3845..4864
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="L18426"
/db_xref="UniSTS:34648"
STS 3849..3998
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="G35510"
/db_xref="UniSTS:44150"
variation 3875
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:73611744"
variation 3929..3930
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="t"
/db_xref="dbSNP:374258641"
variation 3984
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:73611745"
variation 4003
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:75094244"
variation 4012
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:189590052"
STS 4029..4668
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="GDB:314949"
/db_xref="UniSTS:156503"
variation 4054
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142285124"
variation 4165
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:181602684"
variation 4241
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:45487095"
STS 4242..4449
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="RH68914"
/db_xref="UniSTS:31144"
variation 4278
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:6073628"
variation 4296
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6073629"
variation 4335
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:114298760"
variation 4345
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377446019"
variation 4551..4552
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:11086950"
variation 4551
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="a"
/db_xref="dbSNP:11475684"
variation 4561
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="aaa"
/db_xref="dbSNP:79165819"
variation 4586
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="g"
/db_xref="dbSNP:200462544"
variation 4586
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:6073630"
variation 4601..4602
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="t"
/db_xref="dbSNP:34849318"
STS 4648..4820
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
variation 4657
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370873307"
STS 4687..4776
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 4835
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:73611746"
STS 4837..4877
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="D17S1239"
/db_xref="UniSTS:149852"
variation 4847
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:12481124"
variation 4857
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147027697"
variation 4945..4946
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="t"
/db_xref="dbSNP:112810108"
variation 4954..4955
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="t"
/db_xref="dbSNP:71668856"
variation 4960
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="t"
/db_xref="dbSNP:34932056"
variation 4961
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373620386"
variation 4965
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376745205"
variation 4970
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:370907699"
variation 5135
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375774094"
variation 5182
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:75732429"
variation 5208
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:181531153"
variation 5221
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:74409718"
variation 5247
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="g"
/db_xref="dbSNP:186509849"
variation 5278
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:80141431"
variation 5393
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:192152414"
variation 5407
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1135685"
variation 5429..5430
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="a"
/db_xref="dbSNP:377623751"
variation 5429
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:76694369"
variation 5440..5441
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="a"
/db_xref="dbSNP:11483582"
variation 5443
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:74878530"
variation 5445
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:62206409"
variation 5527
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180210"
variation 5528
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180211"
variation 5567
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139756753"
variation 5576
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1128131"
variation 5579
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1128132"
variation 5609
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1044934"
variation 5630
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374552591"
variation 5644
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="t"
/db_xref="dbSNP:138162812"
variation 5679
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:78588317"
variation 5707
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:180866223"
variation 5728
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:6094092"
STS 5790..6012
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/standard_name="D20S1069"
/db_xref="UniSTS:29490"
variation 5861
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:368246934"
variation 5890
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="g"
/replace="t"
/db_xref="dbSNP:6130747"
variation 6015..6016
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace=""
/replace="a"
/db_xref="dbSNP:71776709"
variation 6022
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:74810864"
variation 6034
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
/replace="a"
/replace="c"
/db_xref="dbSNP:8000"
polyA_signal 6307..6312
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
polyA_site 6331
/gene="STK4"
/gene_synonym="KRS2; MST1; TIIAC; YSK3"
ORIGIN
gcggaagtgtgggagggtctgcggggcgggctcaggaggtccgcgggaggatggagcagtgagcgggtctgggcggctgctggcagcgccatggagacggtacagctgaggaacccgccgcgccggcagctgaaaaagttggatgaagatagtttaaccaaacaaccagaagaagtatttgatgtcttagagaaacttggagaagggtcctatggcagcgtatacaaagctattcataaagagaccggccagattgttgctattaagcaagttcctgtggaatcagacctccaggagataatcaaagaaatctctataatgcagcaatgtgacagccctcatgtagtcaaatattatggcagttattttaagaacacagacttatggatcgttatggagtactgtggggctggttctgtatctgatatcattcgattacgaaataaaacgttaacagaagatgaaatagctacaatattacaatcaactcttaagggacttgaataccttcattttatgagaaaaatacaccgagatatcaaggcaggaaatattttgctaaatacagaaggacatgcaaaacttgcagattttggggtagcaggtcaacttacagataccatggccaagcggaatacagtgataggaacaccattttggatggctccagaagtgattcaggaaattggatacaactgtgtagcagacatctggtccctgggaataactgccatagaaatggctgaaggaaagcccccttatgctgatatccatccaatgagggcaatcttcatgattcctacaaatcctcctcccacattccgaaaaccagagctatggtcagataactttacagattttgtgaaacagtgtcttgtaaagagccctgagcagagggccacagccactcagctcctgcagcacccatttgtcaggagtgccaaaggagtgtcaatactgcgagacttaattaatgaagccatggatgtgaaactgaaacgccaggaatcccagcagcgggaagtggaccaggacgatgaagaaaactcagaagaggatgaaatggattctggcacgatggttcgagcagtgggtgatgagatgggcactgtccgagtagccagcaccatgactgatggagccaatactatgattgagcacgatgacacgttgccatcacaactgggcaccatggtgatcaatgcagaggatgaggaagaggaaggaactatgaaaagaagggatgagaccatgcagcctgcgaaaccatcctttcttgaatattttgaacaaaaagaaaaggaaaaccagatcaacagctttggcaagagtgtacctggtccactgaaaaattcttcagattggaaaataccacaggatggagactacgagtttcttaagagttggacagtggaggaccttcagaagaggctcttggccctggaccccatgatggagcaggagattgaagagatccggcagaagtaccagtccaagcggcagcccatcctggatgccatagaggctaagaagagacggcaacaaaacttctgagcaaggccaggctgtgagggccccagctccacccaggctttgggtgaattctggatggcttgcctcatgtttgttagccagcacttctgctctgtcgtctctccacagcacctttgtgaactcaggaatgtgcgccagtgggaagggctctcttgacagtcagcgtgccatcttgatgtgtgtatgtacattggtcaggtatattatctcaaaggatttatattggcgcttttaactcagagttttaaaccccaggaacagagactcctagttgagtgatagctgggaaagttttacattgtctgtttttcttctcccaatagctttcaattgttctttctggaagacttttaaaaaaatataaatatgcatatatatatataaattataaatagattccccacgcagtgtggtggcatctctgtacaggtacagttttaaacggtttgcctcttttctgtaagattatggtactgtggaacatgagggcagaggacaccgggaggctgttagggggtcactgaatcccaggagccaacctccccctttgcagggctgcatttaaaaattaggtttgggacagttcttgtaccgtggtttcagccttgtgtggtcatcactggcttctggagctattggtgatgtccaagggaaagctttgagagtttatgtttactctttgagtcccaggagaagcctggcaccctctttgcaaattggcctttgctctttcaatgcctttcatccatctccactctctcaactgcctaaagtcacagcacagatactgcccagtgccttaagaggagacatgatctctaccagggactctcagcaaacacgggactgtgttcagtccacaaaggaaaagcgtttttgaagctctcattgttcatgtaaaaatcatacacgtggcatgttgctccacattccttacacacaggggtagaggggattgcttttgtgacccacgttcaaatatgtgactgttttcttttctcttttactgctaagcagcctggaaaggataaatgaatattagactaagatttgttttccaggaggctcaatctgaacacacagaatgtcagagctggaagggactatagagatcatctgatctgatcctcttgtacggatgatcgcaaaactgaggtgtagagaggggaatggccaaaatcacaaagcaagttagcgttaagagctgagactagaattcagggtcctcactcccaggccaccgaaccatgcagccccttctttgggggaagagacctgtgtcagtcttggttaattgttccagggaaccttgctaacagaaacttgctcttgccttggctcttcagtagatgacctggctgtaaagagattccctggacgagccagatcattcagtttcagcgagtccttgagctccacaacatctaccagatatagcagacaagcacccatggaggcaggtttcgggcctgaagcagatcagagggctttgcaaaagacagcatagagccatcttcctgcaactttacctctttccctcagatggggagccatgactgggttgcacctcaggatactgtaatttgactccataattgcttttgctcctgaaacctgggaatcaatggaaaggcagggaatgtgcctcttctgtggccagattctgttatttgcaattaaagcaagtttttaaaaaatgcaagaggcagttgttagtcttcagggcttggcaactgaaatagctatgtggcggatacggaaaacagaggacaatttgaggatcttgctggaataataaatgacagctaccatttgttgagcacctattatatatcaggcactgagctgggtaggctctaaacttcacaataaccctgtgacttaactactttatctccattttgtagttgaagaaataagttcagagagaaagattccttcccaaggtcatgcagctagtaaatgatagaatcaggattcatagcatcactatagggggtcaatatttacacaaaaaaggaaagtcacaagcctgtttaaaatgaagtgaccaccttttcttgcatagactaaataactcgaactggcatttttaggttggaaagacagctgaattagtagttaagtctgatagccaagtaagttttaaaaaccaaagcatccaggatgcacacccctgcaccatttgctgtgcgaattaatagttctgtctctctctctctttcttttttctttttattctttgagatggattttcgctcttgtcgcccaggctggagtacaatggcacgatcttggctcactgcaacctccgcctcccgggttcaagcgattcttctgctgggattacagcatatgccaccatgcccagattatttttttgtatttgtagtagagacggggtttcaccatgtcagtcaggctggtcttgaactcctgacctcaggtgatccacccgcctcagcctcccacactgctgggattacaggcatgagccaccgctcctggcctctctttcttttttaaacaaagaactttgcacttggccagagaggaggagaaagcccattttctcccttcctaagctagatccaaataaaagaaagttcagttttcccccataactattcttgggtcatgaactttgatctggagtttgttttgtttcaggaatgtgtgcacccagcttgctgatccaacaaagtctattgcttaccagtctagcttgatgaagccttttggccagaagtcaatttgttttggatcagagaaatttcctgacaaggtatatttgttttctagtgacagaaaggcaaaggaacaagtcctagttgttgttgttgttgttgaatactaaatttaagatatgtcagcttgctttcaatgagccttgggcttctgttattgcttgagcatttggaactcgagcttccagagaaatttgaggtcctcgcttgttctctgccttcaagaaacaatgacctgattctgtctttaaaaaaaaaaatctcagaattctttttttgtttgtgtttttttttttttttgagacagagtctcactctgttgcccaggctggagtgcagtggcgccatctcggctcactgcaacctccgcctcccaggttcaagcaattctcctgcctcagcctcccaggtagctgccactacaggtgctgcaccaccacgcccggctaatttttgtatttttagtagagacagggtttcaccatattagccaggtgggtcttgaactcctgaccttgtgatccacccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccttgcctggccaaaaatctcagaattctttaagactgttttaattgctccatcagtaattttgaagcactttcctttttttttttttttcccctttttgtccctttccccaagccaccaattggatggatgaatgtttgacggggaagaggaagggtaggaggatgcatggatgagtggatgagtggatcgatggatgtattgataaatagatagaaccagtcatctgaagcaacttaagaattgtagccttgactccttgagactgtagatttcgatccaggaaacatttatttagcacctgccagatgccagaaatttataccatttaaaactcagtaagtcttttaaatatcaggaaggagagaagcgacatcatgatacatcctatgggtattaaaaagccaatagaatattatgaataattttatgctaataaatttaacaacttcaacatcataaacaaattccttgaaaaataaaaagtaccaaaattcattcaagaagaaatagataccagcctgagcaacatggcaaaatcccatctctacaaaacatcaaaaaaaaaaaaaattagtcgggcatggtggtgcacacctgtaatcccagcttgtcaggaggctgaagtgggaggatcacctgagcccagggaggtcaaggatgcagtgagccatggtctcaccactgcactctagcctgggtgacagaatgagaccccgtctcaaaaaaaaagaagaagtagataatctgaatagccctatatctatagaaacttaatagtgctgggagatataggtattattatcctcattttacagatgtgaaaattgaggctcagagaagtaaagtctattgctcaaggtcatgtggctagaatatggcagagccatgattcagatccaggtcttctgattcttattccagtgtcctttctagcataccatgttgcctctaaagattgcagctccttatttactagaaaattgttcctgcccaatctacatctccacctcaccccatcttttcttaagcactatgtttgtgtttttatcagtattatattcattgtctttggaatacatgttcttgtttgtgtttggaaaaaaaatctcttttaccagcttgcactcggaccaacttggaaaaaaaaaagcttaaatgtttttgctatgtacagtttaaaaatgtgaagtttgtagctttaactttttgtaagaaaatctaataacactggcttaagtgctgacttgaaatgctattttgtaaggtttggatgtaagtaatcaattgaggtcagcagtttgtatgagacatagcttcctccattgcccccactccttttttcttttttaagtttgagatgcttcctgtgtttttatgttagaattgttgttctccttcttttcttcttcctatacctcatcacgtttgttttaaataaactgtcctttggaccacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6789 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
GeneID:6789 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: EXP
GeneID:6789 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:6789 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6789 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:6789 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:6789 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:6789 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:6789 -> Molecular function: GO:0043539 [protein serine/threonine kinase activator activity] evidence: IDA
GeneID:6789 -> Molecular function: GO:0046983 [protein dimerization activity] evidence: IDA
GeneID:6789 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IDA
GeneID:6789 -> Biological process: GO:0001569 [patterning of blood vessels] evidence: IEA
GeneID:6789 -> Biological process: GO:0001841 [neural tube formation] evidence: IEA
GeneID:6789 -> Biological process: GO:0003157 [endocardium development] evidence: IEA
GeneID:6789 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6789 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6789 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IDA
GeneID:6789 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6789 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:6789 -> Biological process: GO:0007417 [central nervous system development] evidence: IEA
GeneID:6789 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:6789 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:6789 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:6789 -> Biological process: GO:0035329 [hippo signaling cascade] evidence: IDA
GeneID:6789 -> Biological process: GO:0035329 [hippo signaling cascade] evidence: TAS
GeneID:6789 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
GeneID:6789 -> Biological process: GO:0046621 [negative regulation of organ growth] evidence: IEA
GeneID:6789 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:6789 -> Biological process: GO:0060215 [primitive hemopoiesis] evidence: IEA
GeneID:6789 -> Biological process: GO:0060706 [cell differentiation involved in embryonic placenta development] evidence: IEA
GeneID:6789 -> Biological process: GO:0071902 [positive regulation of protein serine/threonine kinase activity] evidence: IDA
GeneID:6789 -> Biological process: GO:0090090 [negative regulation of canonical Wnt receptor signaling pathway] evidence: IMP
GeneID:6789 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6789 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6789 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_006273 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.