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2024-04-26 01:59:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006277 6112 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens intersectin 2 (ITSN2), transcript variant 1, mRNA.
ACCESSION NM_006277
VERSION NM_006277.2 GI:194294520
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6112)
AUTHORS McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
TITLE Genome-wide pharmacogenomic study of neurocognition as an indicator
of antipsychotic treatment response in schizophrenia
JOURNAL Neuropsychopharmacology 36 (3), 616-626 (2011)
PUBMED 21107309
REFERENCE 2 (bases 1 to 6112)
AUTHORS Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T.,
Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A.,
Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M.
and Kaibuchi,K.
TITLE Mutation of ARHGAP9 in patients with coronary spastic angina
JOURNAL J. Hum. Genet. 55 (1), 42-49 (2010)
PUBMED 19911011
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 6112)
AUTHORS Klein,I.K., Predescu,D.N., Sharma,T., Knezevic,I., Malik,A.B. and
Predescu,S.
TITLE Intersectin-2L regulates caveola endocytosis secondary to
Cdc42-mediated actin polymerization
JOURNAL J. Biol. Chem. 284 (38), 25953-25961 (2009)
PUBMED 19622753
REMARK GeneRIF: ITSN-2L, a guanine nucleotide exchange factor for Cdc42,
regulates different steps of caveola endocytosis in ECs by
controlling the temporal and spatial actin polymerization and
remodeling sub-adjacent to the plasma membrane.
REFERENCE 4 (bases 1 to 6112)
AUTHORS Voss,M., Lettau,M. and Janssen,O.
TITLE Identification of SH3 domain interaction partners of human FasL
(CD178) by phage display screening
JOURNAL BMC Immunol. 10, 53 (2009)
PUBMED 19807924
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 6112)
AUTHORS Lim,C.S., Seet,B.T., Ingham,R.J., Gish,G., Matskova,L., Winberg,G.,
Ernberg,I. and Pawson,T.
TITLE The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits
the endocytic regulator intersectin 2 through a selective SH3
domain interaction
JOURNAL Biochemistry 46 (35), 9874-9885 (2007)
PUBMED 17696407
REMARK GeneRIF: We show that the PPLP motif of K15 protein selectively
binds the SH3-C domain of an endocytic adaptor protein, Intersectin
2 (ITSN2).
REFERENCE 6 (bases 1 to 6112)
AUTHORS Nakayama,M., Kikuno,R. and Ohara,O.
TITLE Protein-protein interactions between large proteins: two-hybrid
screening using a functionally classified library composed of long
cDNAs
JOURNAL Genome Res. 12 (11), 1773-1784 (2002)
PUBMED 12421765
REFERENCE 7 (bases 1 to 6112)
AUTHORS McGavin,M.K., Badour,K., Hardy,L.A., Kubiseski,T.J., Zhang,J. and
Siminovitch,K.A.
TITLE The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein
(WASp)-mediated actin polymerization to T cell antigen receptor
endocytosis
JOURNAL J. Exp. Med. 194 (12), 1777-1787 (2001)
PUBMED 11748279
REFERENCE 8 (bases 1 to 6112)
AUTHORS Pucharcos,C., Casas,C., Nadal,M., Estivill,X. and de la Luna,S.
TITLE The human intersectin genes and their spliced variants are
differentially expressed
JOURNAL Biochim. Biophys. Acta 1521 (1-3), 1-11 (2001)
PUBMED 11690630
REFERENCE 9 (bases 1 to 6112)
AUTHORS Pucharcos,C., Estivill,X. and de la Luna,S.
TITLE Intersectin 2, a new multimodular protein involved in
clathrin-mediated endocytosis
JOURNAL FEBS Lett. 478 (1-2), 43-51 (2000)
PUBMED 10922467
REFERENCE 10 (bases 1 to 6112)
AUTHORS Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
Kay,B.K.
TITLE Cloning of ligand targets: systematic isolation of SH3
domain-containing proteins
JOURNAL Nat. Biotechnol. 14 (6), 741-744 (1996)
PUBMED 9630982
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA382952.1, AF182198.1 and
BC146779.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 17, 2008 this sequence version replaced gi:22325384.
Summary: This gene encodes a cytoplasmic protein which contains SH3
domains. This protein is a member of a family of proteins involved
in clathrin-mediated endocytosis. Intersectin 2 is thought to
regulate the formation of clathrin-coated vesicles and also may
function in the induction of T cell antigen receptor (TCR)
endocytosis. Alternatively spliced transcript variants have been
found for this gene that encode three distinct isoforms. Additional
variants have been found but their full length nature has not been
determined. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1), also known as ITSN2-L,
encodes the longest isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF182198.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-199 DA382952.1 251-449
200-4597 AF182198.1 179-4576
4598-4598 BC146779.1 4424-4424
4599-6112 AF182198.1 4578-6091
FEATURES Location/Qualifiers
source 1..6112
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2pter-p25.1"
gene 1..6112
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="intersectin 2"
/db_xref="GeneID:50618"
/db_xref="HGNC:6184"
/db_xref="MIM:604464"
exon 1..225
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 226..289
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
misc_feature 238..240
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="upstream in-frame stop codon"
CDS 259..5352
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="isoform 1 is encoded by transcript variant 1; SH3
domain-containing protein 1B; SH3P18-like WASP-associated
protein"
/codon_start=1
/product="intersectin-2 isoform 1"
/protein_id="NP_006268.2"
/db_xref="GI:194294521"
/db_xref="CCDS:CCDS1710.2"
/db_xref="GeneID:50618"
/db_xref="HGNC:6184"
/db_xref="MIM:604464"
/translation="
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
"
misc_feature 301..579
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Eps15 homology domain; Region: EH; smart00027"
/db_xref="CDD:197477"
misc_feature 334..507
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Eps15 homology domain; found in proteins implicated
in endocytosis, vesicle transport, and signal
transduction. The alignment contains a pair of EF-hand
motifs, typically one of them is canonical and binds to
Ca2+, while the other may not bind to Ca2+. A...; Region:
EH; cd00052"
/db_xref="CDD:28934"
misc_feature order(352..360,376..390)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="pseudo EF-hand loop; other site"
/db_xref="CDD:28934"
misc_feature order(403..405,433..435,445..447)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide binding pocket; other site"
/db_xref="CDD:28934"
misc_feature order(457..459,463..465,469..471,490..492)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28934"
misc_feature 886..888
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NZM3.3); phosphorylation site"
misc_feature 946..948
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NZM3.3); phosphorylation site"
misc_feature 967..1206
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Eps15 homology domain; Region: EH; smart00027"
/db_xref="CDD:197477"
misc_feature 1000..1200
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Eps15 homology domain; found in proteins implicated
in endocytosis, vesicle transport, and signal
transduction. The alignment contains a pair of EF-hand
motifs, typically one of them is canonical and binds to
Ca2+, while the other may not bind to Ca2+. A...; Region:
EH; cd00052"
/db_xref="CDD:28934"
misc_feature order(1018..1026,1045..1059)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="pseudo EF-hand loop; other site"
/db_xref="CDD:28934"
misc_feature order(1072..1074,1102..1104,1114..1116)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide binding pocket; other site"
/db_xref="CDD:28934"
misc_feature order(1126..1128,1132..1134,1138..1140,1159..1161)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28934"
misc_feature 1975..1977
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9NZM3.3); phosphorylation site"
misc_feature 2533..2703
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="First Src homology 3 domain (or SH3A) of
Intersectin-2; Region: SH3_Intersectin2_1; cd11988"
/db_xref="CDD:212921"
misc_feature order(2554..2556,2560..2562,2569..2571,2581..2583,
2641..2646,2683..2685,2689..2694)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212921"
misc_feature 2923..2925
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NZM3.3); phosphorylation site"
misc_feature 2962..3117
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Second Src homology 3 domain (or SH3B) of
Intersectin-2; Region: SH3_Intersectin2_2; cd11990"
/db_xref="CDD:212923"
misc_feature order(2977..2979,2983..2985,2992..2994,3004..3006,
3055..3060,3097..3099,3103..3108)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212923"
misc_feature 3160..3162
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q9NZM3.3); phosphorylation site"
misc_feature 3211..3366
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Third Src homology 3 domain (or SH3C) of
Intersectin-2; Region: SH3_Intersectin2_3; cd11992"
/db_xref="CDD:212925"
misc_feature order(3226..3228,3232..3234,3241..3243,3253..3255,
3304..3309,3346..3348,3352..3357)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212925"
misc_feature 3427..3603
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Fourth Src homology 3 domain (or SH3D) of
Intersectin-2; Region: SH3_Intersectin2_4; cd11994"
/db_xref="CDD:212927"
misc_feature order(3442..3444,3448..3450,3457..3459,3469..3471,
3523..3528,3580..3582,3586..3591)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212927"
misc_feature 3646..3807
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Fifth Src homology 3 domain (or SH3E) of
Intersectin-2; Region: SH3_Intersectin2_5; cd11996"
/db_xref="CDD:212929"
misc_feature order(3664..3666,3670..3672,3679..3681,3691..3693,
3745..3750,3787..3789,3793..3798)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212929"
misc_feature 3886..4437
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Guanine nucleotide exchange factor for
Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
(DH) domain. It appears that PH domains invariably occur
C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
/db_xref="CDD:29100"
misc_feature order(3904..3906,3916..3918,4204..4206,4288..4293,
4300..4305,4309..4314,4321..4326,4333..4338,4345..4347,
4423..4425,4435..4437)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:29100"
misc_feature 4567..4884
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="Pleckstrin homology (PH) domain; Region: PH;
cd00821"
/db_xref="CDD:176270"
misc_feature order(4567..4587,4600..4620,4627..4647,4729..4743,
4753..4767,4792..4812,4819..4836,4849..4884)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="core domain; other site"
/db_xref="CDD:176270"
misc_feature order(4585..4587,4600..4602,4606..4614)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="putative lipid binding motif; other site"
/db_xref="CDD:176270"
misc_feature 4921..5325
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="C2 domain present in Intersectin; Region:
C2_Intersectin; cd08375"
/db_xref="CDD:176021"
misc_feature order(5029..5031,5170..5172,5176..5178,5194..5196)
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/note="putative Ca2+ binding site [ion binding]; other
site"
/db_xref="CDD:176021"
exon 290..382
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 383..446
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 447..610
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 611..814
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 815..911
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 912..1051
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1052..1115
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1116..1253
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1254..1339
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1340..1602
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1603..1752
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1753..1893
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1894..1981
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 1982..2121
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2122..2202
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2203..2339
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2340..2515
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2516..2613
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2614..2795
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2796..2940
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 2941..3146
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3147..3211
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3212..3378
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3379..3424
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3425..3546
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3547..3643
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3644..3835
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3836..3957
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 3958..4064
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 4065..4248
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
variation 4118
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/replace="c"
/replace="t"
/db_xref="dbSNP:3731625"
exon 4249..4347
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 4348..4515
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 4516..4731
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 4732..4853
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
STS 4735..4853
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/standard_name="A004Q30"
/db_xref="UniSTS:21780"
exon 4854..4936
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
variation 4915
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/replace="a"
/replace="c"
/db_xref="dbSNP:3208747"
exon 4937..5020
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 5021..5194
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
exon 5195..6112
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/inference="alignment:Splign:1.39.8"
STS 5769..5840
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/standard_name="STS-Z40060"
/db_xref="UniSTS:47191"
STS 5913..6049
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
/standard_name="RH12863"
/db_xref="UniSTS:71667"
polyA_signal 6088..6093
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
polyA_site 6111
/gene="ITSN2"
/gene_synonym="PRO2015; SH3D1B; SH3P18; SWA; SWAP"
ORIGIN
cggccgccatgttgttgtggggctgaggcggcgccggcggagccctgagcggctgtgacaggctacgcaacaggttcgcgggcggcggcctgacgaccaagccagctgcagtggcggcgacggcggcagagcagggtctccccgcgcctgcccgcgcccaggctgccggtgctgagggacgcggagtcgcgctgtgacgagcgggaggcgcggcgagggcgccagatggctgagagctagcaaggaaaactcaggaccatgatggctcagtttcccacagctatgaatggagggccaaacatgtgggctattacctctgaagaacgtactaagcatgacaggcagtttgataacctcaaaccttcaggaggttacataacaggtgatcaagcacgtaattttttcctacaatcaggtctgccggcccctgttttagctgaaatatgggctttatcagacctaaacaaggatgggaagatggatcagcaagagttctccatagctatgaaactcatcaaactgaagcttcaaggccaacagttgcctgtggttctccctcctattatgaagcaaccccctatgttttctccattaatttctgctcgttttggaatgggaagcatgcccaatctgtccattcctcagccattgcctccagctgcacctataacatcattgtcttctgcgacttcagggaccaaccttcctcccttaatgatgcccactcccctagtgccttctgttagcacatcatcattaccaaatggaaccgccagtctcattcagcctttacccattccttattcttcttcaacattgcctcatgggtcatcttatagtctgatgatgggaggatttggaggtgctagtatacagaaagcgcagtctctgattgatttaggatctagtagctcaacttcctcgactgcttcactctcagggaactcacccaagactgggacctcagagtgggcagttcctcagcctacaagattaaaatatcggcaaaaatttaatactcttgacaaaagtatgagtggatatctctcaggttttcaagctagaaatgcccttcttcagtcaaatctttctcaaactcagctggctactatttggactctggctgacgttgatggtgatggacagctaaaagcagaagagtttattcttgcaatgcaccttactgacatggccaaagctggacagccattaccactgactttacctcctgagcttgttcctccatctttcagaggaggaaagcaaattgattccattaatggaactctgccttcatatcagaaaatgcaagaagaggagcctcagaagaaattaccagttacttttgaggacaaacggaaagccaactatgagcgagggaacatggagctggaaaagcgacgccaagccttgatggagcagcaacaaagggaggcagaacgtaaagcccagaaagaaaaggaagagtgggaacgaaaacagagagaattacaagaacaagaatggaagaaacaacttgaattagaaaaacgcttagagaagcaacgggaattggagagacaacgagaggaagaaaggagaaaagacatagaaagacgagaggcagcaaaacaggaacttgaacgacaacgtcgcttagaatgggagagaattcggcgacaggagcttctcaatcaaaagaatagagaacaagaagaaattgtcaggttaaactctaaaaagaagaatcttcatcttgagttggaagcactgaatggcaaacatcagcagatctcaggcagacttcaggatgtccgactcaaaaagcaaactcaaaagactgagctggaagttctggataagcagtgtgacttggaaattatggaaatcaagcaacttcaacaggaacttcaggaatatcagaataagcttatctatctggtacctgagaagcaattattaaatgaaagaattaaaaacatgcagttcagtaacacacctgattcaggggtcagtttacttcataaaaaatcattagaaaaggaagaattatgccaaagacttaaagaacagttagatgctcttgaaaaagaaactgcatctaagctgtcagaaatggattcttttaacaatcaactaaagtgtgggaatatggatgactctgttcttcagtgccttttgtctctgctaagctgtctcaacaacctcttcctcttacttaaggaactgagagaaacctacaacacacagcagttagcccttgaacagctttataagatcaaacgtgacaagttgaaggaaattgaaaggaaaagattagaactaatgcagaaaaagaaactagaagatgaggctgcaaggaaagcaaagcaaggaaaagaaaacttatggaaagaaaatcttagaaaggaggaagaagaaaaacaaaagcgactccaggaagaaaaaacacaagaaaaaattcaagaagaggaacggaaagctgaggagaaacaacgtaaggataaggatactttgaaagctgaggagaaaaaacgtgagacagctagtgttttggtgaattatagagcattatacccctttgaagcaaggaaccatgatgagatgagttttaattctggagatataattcaggttgatgaaaaaaccgtaggagaacctggttggctttatggtagttttcaaggaaattttggctggtttccatgcaattatgtagaaaaaatgccatcaagtgaaaatgaaaaagctgtatctccaaagaaggccttacttcctcctacagtttctttatctgctacctcaacttcctctgaaccactttcttcaaatcaaccagcatcagtgactgattatcaaaatgtatctttttcaaacctaactgtaaatacatcatggcagaaaaaatcagccttcactcgaactgtgtcccctggatctgtatcacctattcatggacagggacaagtggtagaaaacttaaaagcacaggccctttgttcctggactgcaaagaaagataaccacttgaacttctcaaaacatgacattattactgtcttggagcagcaagaaaattggtggtttggggaggtgcatggaggaagaggatggtttcccaaatcttatgtcaagatcattcctgggagtgaagtaaaacgggaagaaccagaagctttgtatgcagctgtaaataagaaacctacctcggcagcctattcagttggagaagaatatattgcactttatccatattcaagtgtggaacctggagatttgactttcacagaaggtgaagaaatattggtgacccagaaagatggagagtggtggacaggaagtattggagatagaagtggaatttttccatcaaactatgtcaaaccaaaggatcaagagagttttgggagtgctagcaagtctggagcatcaaataaaaaacctgagattgctcaggtaacttcagcatatgttgcttctggttctgaacaacttagccttgcaccaggacagttaatattaattctaaagaaaaatacaagtgggtggtggcaaggagagttacaggccagaggaaaaaagcgacagaaaggatggtttcctgccagtcatgttaaacttttgggtccaagtagtgaaagagccacacctgcctttcatcctgtatgtcaggtgattgctatgtatgactatgcagcaaataatgaagatgagctcagtttctccaagggacaactcattaatgttatgaacaaagatgatcctgattggtggcaaggagagatcaacggggtgactggtctctttccttcaaactacgttaagatgacgacagactcagatccaagtcaacagtggtgtgctgatctgcaaaccctggacacaatgcagccaattgagaggaaaagacagggctatattcatgagctgattcagaccgaagagcggtacatggctgaccttcagctcgtcgtcgaggtttttcagaaacgcatggcagagtcaggctttctcactgaaggggagatggccctgatttttgttaactggaaggagctcatcatgtccaacacaaagctgctgaaggctttgcgggtgcggaagaagaccgggggcgagaagatgccggtgcagatgattggggacatcctggccgctgagctgtcccacatgcaggcttacatcaggttctgcagctgccagcttaatggagcagctctgttacagcagaagacagatgaagacacagatttcaaagaatttttaaagaagctggcatctgacccgcggtgtaaaggaatgcccctctccagcttcctgctgaaacccatgcagaggatcacccgctacccactgctcatcagaagtattctggagaacaccccggagagccatgcagaccattcctccctaaagctggccctcgagcgggcagaggagctgtgctctcaagtgaatgagggagttcgggagaaggaaaactcggaccgactggagtggatccaggcgcacgtgcagtgtgaaggcctcgcggagcaacttattttcaactctctcaccaactgcctggggccccggaagctcttacacagtgggaaattatacaagaccaagagcaacaaggaactgcacggattcctcttcaatgacttcctgcttcttacctacatggtcaagcagtttgctgtttcctctggctctgagaaacttttcagctcgaagtccaatgctcaattcaaaatgtataaaacgcccattttcctgaatgaagtcttggtgaaactgcccacagacccttccagcgatgagcctgtcttccacatttcccacattgatcgggtctacaccctccgaacagacaacattaatgagaggaccgcctgggtgcagaagatcaaggcggcgtctgagcagtacatcgacaccgagaagaagaagcgtgagaaagcttaccaagcccgctcccaaaagacttcaggcattgggcgcctgatggtgcatgtcattgaagctacagaattaaaagcctgcaaaccaaatggaaagagcaacccatactgtgaaatcagcatgggctcccagagctacaccaccaggaccatccaggacacactcaatcccaagtggaattttaactgccagttctttattaaggatctctaccaagacgtgctgtgtctcaccctgtttgacagagaccagttttcaccagatgatttcctgggtcgtactgaaattccagtggcaaaaattcgaacagaacaggaaagcaaaggccctatgacccgccgactgctgctgcatgaggtccccaccggggaggtctgggtccgttttgacctgcagctttttgagcaaaaaactctcctgtaggggttctaaaggacagcaccagcgggacagcccacaaggctggggctggagaatgagagactgcgctctcttggggctgagggagcaccatgcagcttcacccctcacaaagccatgcacgctgggggctctgttttcctgcacactaaatagctagcaatctatgcaaacacctttcccataaagaaaccaaaccccatagtacagtgccttgtcctagtgttcacatgttcagctctgtttgtttagatgccaaggtttccattttcagggctataaaaagtattacttggaaatgaggcatcagaccaccagatgttaccgctcggttgaatgtgtccaccgtggagtggtttggtgacgctgtaaccattccacgccagtgacctctgctgggtcacagccactcaggaggggaagggtcaggatgagaggctgcagcctcgacacttggcgcggcctgatactgaaatagcgtctactcgtgcactgaataaaaacagaaacttgatcattttattcctgattagattttatcactctctgctaagacaatatagtctggagtataagtgggaaagcttgatttaaatactgtgaactctaataatgtggaaaatatttttcaactttaattttctgaagtataaattatttatgtaaattcattgtttttgcatatttcttaggacatgcatctttaagctttatcattgcccatatgtacagaaagagaataaagacatatgtttatggatgg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:50618 -> Molecular function: GO:0005070 [SH3/SH2 adaptor activity] evidence: TAS
GeneID:50618 -> Molecular function: GO:0005089 [Rho guanyl-nucleotide exchange factor activity] evidence: IEA
GeneID:50618 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:50618 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:50618 -> Biological process: GO:0006897 [endocytosis] evidence: IEA
GeneID:50618 -> Biological process: GO:0035023 [regulation of Rho protein signal transduction] evidence: IEA
GeneID:50618 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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