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2024-04-26 16:20:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006263 1012 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) activator subunit 1
(PA28 alpha) (PSME1), transcript variant 1, mRNA.
ACCESSION NM_006263
VERSION NM_006263.2 GI:30581139
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1012)
AUTHORS Longuespee,R., Boyon,C., Castellier,C., Jacquet,A., Desmons,A.,
Kerdraon,O., Vinatier,D., Fournier,I., Day,R. and Salzet,M.
TITLE The C-terminal fragment of the immunoproteasome PA28S (Reg alpha)
as an early diagnosis and tumor-relapse biomarker: evidence from
mass spectrometry profiling
JOURNAL Histochem. Cell Biol. 138 (1), 141-154 (2012)
PUBMED 22532226
REMARK GeneRIF: the first evidence of a novel ovarian cancer-specific
marker
REFERENCE 2 (bases 1 to 1012)
AUTHORS Ruckrich,T., Kraus,M., Gogel,J., Beck,A., Ovaa,H., Verdoes,M.,
Overkleeft,H.S., Kalbacher,H. and Driessen,C.
TITLE Characterization of the ubiquitin-proteasome system in
bortezomib-adapted cells
JOURNAL Leukemia 23 (6), 1098-1105 (2009)
PUBMED 19225532
REMARK GeneRIF: bortezomib-adapted HL-60 cells showed increased expression
and proteasome association of the 11S proteasome activator
REFERENCE 3 (bases 1 to 1012)
AUTHORS Lemaire,R., Menguellet,S.A., Stauber,J., Marchaudon,V., Lucot,J.P.,
Collinet,P., Farine,M.O., Vinatier,D., Day,R., Ducoroy,P.,
Salzet,M. and Fournier,I.
TITLE Specific MALDI imaging and profiling for biomarker hunting and
validation: fragment of the 11S proteasome activator complex, Reg
alpha fragment, is a new potential ovary cancer biomarker
JOURNAL J. Proteome Res. 6 (11), 4127-4134 (2007)
PUBMED 17939699
REMARK GeneRIF: the 11S proteasome activator complex, Reg alpha fragment,
may have a role in ovarian cancer
REFERENCE 4 (bases 1 to 1012)
AUTHORS Kobayashi,K., Xin,Y., Ymer,S.I., Werther,G.A. and Russo,V.C.
TITLE Subtractive hybridisation screen identifies genes regulated by
glucose deprivation in human neuroblastoma cells
JOURNAL Brain Res. 1170, 129-139 (2007)
PUBMED 17719568
REFERENCE 5 (bases 1 to 1012)
AUTHORS Zhang,D., Lim,S.G. and Koay,E.S.
TITLE Proteomic identification of down-regulation of oncoprotein DJ-1 and
proteasome activator subunit 1 in hepatitis B virus-infected
well-differentiated hepatocellular carcinoma
JOURNAL Int. J. Oncol. 31 (3), 577-584 (2007)
PUBMED 17671684
REMARK GeneRIF: DJ-1 and PA28alpha may have roles in the onset of
hepatocarcinogenesis
REFERENCE 6 (bases 1 to 1012)
AUTHORS Ahn,K., Erlander,M., Leturcq,D., Peterson,P.A., Fruh,K. and Yang,Y.
TITLE In vivo characterization of the proteasome regulator PA28
JOURNAL J. Biol. Chem. 271 (30), 18237-18242 (1996)
PUBMED 8663520
REFERENCE 7 (bases 1 to 1012)
AUTHORS Ahn,J.Y., Tanahashi,N., Akiyama,K., Hisamatsu,H., Noda,C.,
Tanaka,K., Chung,C.H., Shibmara,N., Willy,P.J., Mott,J.D. et al.
TITLE Primary structures of two homologous subunits of PA28, a
gamma-interferon-inducible protein activator of the 20S proteasome
JOURNAL FEBS Lett. 366 (1), 37-42 (1995)
PUBMED 7789512
REFERENCE 8 (bases 1 to 1012)
AUTHORS Realini,C., Dubiel,W., Pratt,G., Ferrell,K. and Rechsteiner,M.
TITLE Molecular cloning and expression of a gamma-interferon-inducible
activator of the multicatalytic protease
JOURNAL J. Biol. Chem. 269 (32), 20727-20732 (1994)
PUBMED 8051173
REFERENCE 9 (bases 1 to 1012)
AUTHORS Honore,B., Leffers,H., Madsen,P. and Celis,J.E.
TITLE Interferon-gamma up-regulates a unique set of proteins in human
keratinocytes. Molecular cloning and expression of the cDNA
encoding the RGD-sequence-containing protein IGUP I-5111
JOURNAL Eur. J. Biochem. 218 (2), 421-430 (1993)
PUBMED 8269930
REFERENCE 10 (bases 1 to 1012)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from L07633.1, BC000352.2 and
BU731923.1.
On May 13, 2003 this sequence version replaced gi:5453989.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. The immunoproteasome
contains an alternate regulator, referred to as the 11S regulator
or PA28, that replaces the 19S regulator. Three subunits (alpha,
beta and gamma) of the 11S regulator have been identified. This
gene encodes the alpha subunit of the 11S regulator, one of the two
11S subunits that is induced by gamma-interferon. Three alpha and
three beta subunits combine to form a heterohexameric ring. Two
transcripts encoding different isoforms have been identified.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes the predominant
isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC000352.2, BM923141.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..1012
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q11.2"
gene 1..1012
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/note="proteasome (prosome, macropain) activator subunit 1
(PA28 alpha)"
/db_xref="GeneID:5720"
/db_xref="HGNC:9568"
/db_xref="HPRD:02803"
/db_xref="MIM:600654"
exon 1..133
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="g"
/replace="t"
/db_xref="dbSNP:371895884"
variation 79..80
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace=""
/replace="c"
/db_xref="dbSNP:11432961"
CDS 95..844
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/note="isoform 1 is encoded by transcript variant 1; 29-kD
MCP activator subunit; interferon-gamma-inducible protein
5111; activator of multicatalytic protease subunit 1; 11S
regulator complex alpha subunit; interferon-gamma IEF SSP
5111; interferon gamma up-regulated I-5111 protein;
proteasome activator subunit-1; proteasome activator
complex subunit 1; REG-alpha; IGUP I-5111; 11S regulator
complex subunit alpha; proteasome activator 28 subunit
alpha"
/codon_start=1
/product="proteasome activator complex subunit 1 isoform
1"
/protein_id="NP_006254.1"
/db_xref="GI:5453990"
/db_xref="CCDS:CCDS9612.1"
/db_xref="GeneID:5720"
/db_xref="HGNC:9568"
/db_xref="HPRD:02803"
/db_xref="MIM:600654"
/translation="
MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
"
misc_feature 110..301
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/note="Proteasome activator pa28 alpha subunit; Region:
PA28_alpha; pfam02251"
/db_xref="CDD:145415"
misc_feature 392..841
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/note="Proteasome activator pa28 beta subunit; Region:
PA28_beta; pfam02252"
/db_xref="CDD:145416"
exon 134..166
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
exon 167..229
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 172
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:372194608"
variation 181
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:138856039"
variation 184
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="g"
/replace="t"
/db_xref="dbSNP:11548693"
variation 201
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:375851656"
exon 230..340
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 242
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:148923410"
variation 243
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:117249501"
variation 245
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:375715840"
variation 258
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:1803830"
variation 263
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:138520310"
variation 310
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:373078201"
variation 319
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:56198867"
variation 322
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:55747210"
variation 324
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:144096780"
exon 341..386
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 349
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="g"
/db_xref="dbSNP:147287924"
variation 359..361
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace=""
/replace="aag"
/db_xref="dbSNP:376506250"
variation 373
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:148348414"
exon 387..484
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 394..395
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace=""
/replace="c"
/db_xref="dbSNP:35315039"
variation 406
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:11548692"
variation 407
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:375628264"
variation 409
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="g"
/db_xref="dbSNP:201795415"
variation 427
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="g"
/replace="t"
/db_xref="dbSNP:150529650"
variation 466
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:11548694"
variation 469
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:368398253"
variation 480
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:372406157"
variation 481
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:139533252"
variation 482
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="g"
/db_xref="dbSNP:375148778"
exon 485..553
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 520
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:141492772"
variation 549..552
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace=""
/replace="tcca"
/db_xref="dbSNP:372750711"
exon 554..621
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 600
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="g"
/db_xref="dbSNP:201856614"
exon 622..676
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 636
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:146188494"
variation 670
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803828"
variation 671
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:372754747"
exon 677..763
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 686
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:144591736"
variation 687
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:374696333"
variation 700
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:372568481"
variation 712
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:200480712"
variation 728
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:139362285"
variation 734
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:199513402"
variation 743
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:144155948"
variation 753
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:368560988"
exon 764..995
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/inference="alignment:Splign:1.39.8"
variation 773
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:148664314"
variation 785
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:14929"
variation 825
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:14930"
STS 837..969
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/standard_name="RH75843"
/db_xref="UniSTS:91113"
variation 849
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803829"
variation 862
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049655"
variation 868
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:369270267"
variation 870
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:112188388"
variation 881
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="c"
/replace="g"
/db_xref="dbSNP:373484066"
variation 907
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:1803827"
variation 925
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:762089"
variation 965
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="c"
/db_xref="dbSNP:1140403"
polyA_signal 967..972
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
variation 974
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="g"
/db_xref="dbSNP:188982890"
variation 993
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:368816709"
polyA_site 995
/gene="PSME1"
/gene_synonym="IFI5111; PA28A; PA28alpha; REGalpha"
ORIGIN
aggcggagctgggtgcgagcgccctaccgctttcgctttcccttcgcggtgcccactccactccttgtgcggcgctaggccccccgtcccggtcatggccatgctcagggtccagcccgaggcccaagccaaggtggatgtgtttcgtgaagacctctgtaccaagacagagaacctgctcgggagctatttccccaagaagatttctgagctggatgcatttttaaaggagccagctctcaatgaagccaacttgagcaatctgaaggccccattggacatcccagtgcctgatccagtcaaggagaaagagaaagaggagcggaagaaacagcaggagaaggaagacaaggatgaaaagaagaagggggaggatgaagacaaaggtcctccctgtggcccagtgaactgcaatgaaaagatcgtggtccttctgcagcgcttgaagcctgagatcaaggatgtcattgagcagctcaacctggtcaccacctggttgcagctgcagatacctcggattgaggatggtaacaattttggagtggctgtccaggagaaggtgtttgagctgatgaccagcctccacaccaagctagaaggcttccacactcaaatctctaagtatttctctgagcgtggtgatgcagtgactaaagcagccaagcagccccatgtgggtgattatcggcagctggtgcacgagctggatgaggcagagtaccgggacatccggctgatggtcatggagatccgcaatgcttatgctgtgttatatgacatcatcctgaagaacttcgagaagctcaagaagcccaggggagaaacaaagggaatgatctattgagagccctctctcccattctgtgatgagtacagcagagaccttcctgctttttactggggactccagattttccccaaacttgcttctgttgagatttttccctcaccttgcctctcaggcacaataaatatagttataccactgcccatcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5720 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5720 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5720 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5720 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5720 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5720 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5720 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5720 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5720 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5720 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5720 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5720 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5720 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5720 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5720 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5720 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:5720 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5720 -> Cellular component: GO:0008537 [proteasome activator complex] evidence: IEA
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DBCLS
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