2024-03-29 01:24:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006257 3286 bp mRNA linear PRI 29-JUN-2013 DEFINITION Homo sapiens protein kinase C, theta (PRKCQ), transcript variant 1, mRNA. ACCESSION NM_006257 VERSION NM_006257.3 GI:334848124 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3286) AUTHORS Lopez-Sanchez,I., Garcia-Marcos,M., Mittal,Y., Aznar,N., Farquhar,M.G. and Ghosh,P. TITLE Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (14), 5510-5515 (2013) PUBMED 23509302 REMARK GeneRIF: Protein kinase C-theta (PKCtheta;) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. REFERENCE 2 (bases 1 to 3286) AUTHORS Duan,Q.L., Lasky-Su,J., Himes,B.E., Qiu,W., Litonjua,A.A., Damask,A., Lazarus,R., Klanderman,B., Irvin,C.G., Peters,S.P., Hanrahan,J.P., Lima,J.J., Martinez,F.D., Mauger,D., Chinchilli,V.M., Soto-Quiros,M., Avila,L., Celedon,J.C., Lange,C., Weiss,S.T. and Tantisira,K.G. TITLE A genome-wide association study of bronchodilator response in asthmatics JOURNAL Pharmacogenomics J. (2013) In press PUBMED 23508266 REMARK Publication Status: Available-Online prior to print REFERENCE 3 (bases 1 to 3286) AUTHORS Michalczyk,I., Sikorski,A.F., Kotula,L., Junghans,R.P. and Dubielecka,P.M. TITLE The emerging role of protein kinase Ctheta in cytoskeletal signaling JOURNAL J. Leukoc. Biol. 93 (3), 319-327 (2013) PUBMED 23192428 REMARK GeneRIF: The emerging role of protein kinase Ctheta; in cytoskeletal signaling. Review article REFERENCE 4 (bases 1 to 3286) AUTHORS Giambra,V., Jenkins,C.R., Wang,H., Lam,S.H., Shevchuk,O.O., Nemirovsky,O., Wai,C., Gusscott,S., Chiang,M.Y., Aster,J.C., Humphries,R.K., Eaves,C. and Weng,A.P. TITLE NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-theta and reactive oxygen species JOURNAL Nat. Med. 18 (11), 1693-1698 (2012) PUBMED 23086478 REMARK GeneRIF: These results reveal key functional roles for PKC-theta and ROS in T cell acute lymphoblastic leukemia and suggest that aggressive biological behavior in vivo could be limited by therapeutic strategies that promote PKC-theta expression or activity REFERENCE 5 (bases 1 to 3286) AUTHORS Kumar,D.V., Shanmugasundaram,J., Sundaram,C. and Anandaraj,M.P. TITLE Activity of novel protein kinase C and distribution of protein kinase C theta in subcellular fractions of normal and Duchenne muscular dystrophic muscle JOURNAL Indian J. Biochem. Biophys. 39 (6), 377-381 (2002) PUBMED 22905394 REMARK GeneRIF: alterations in nPKC location and increased expression of PKC theta observed is a result of modification of PKC-mediated signal transduction and cell function REFERENCE 6 (bases 1 to 3286) AUTHORS Conant,K., Ma,M., Nath,A. and Major,E.O. TITLE Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes JOURNAL J. Virol. 70 (3), 1384-1389 (1996) PUBMED 8627654 REFERENCE 7 (bases 1 to 3286) AUTHORS Erdel,M., Baier-Bitterlich,G., Duba,C., Isakov,N., Altman,A., Utermann,G. and Baier,G. TITLE Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH JOURNAL Genomics 25 (2), 595-597 (1995) PUBMED 7790001 REFERENCE 8 (bases 1 to 3286) AUTHORS Chang,J.D., Xu,Y., Raychowdhury,M.K. and Ware,J.A. TITLE Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets JOURNAL J. Biol. Chem. 268 (19), 14208-14214 (1993) PUBMED 7686153 REMARK Erratum:[J Biol Chem. 1994 Dec 9;269(49):31322. PMID: 16964635] REFERENCE 9 (bases 1 to 3286) AUTHORS Baier,G., Telford,D., Giampa,L., Coggeshall,K.M., Baier-Bitterlich,G., Isakov,N. and Altman,A. TITLE Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells JOURNAL J. Biol. Chem. 268 (7), 4997-5004 (1993) PUBMED 8444877 REFERENCE 10 (bases 1 to 3286) AUTHORS Jakobovits,A., Rosenthal,A. and Capon,D.J. TITLE Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C JOURNAL EMBO J. 9 (4), 1165-1170 (1990) PUBMED 2182321 REMARK Erratum:[EMBO J 1990 Oct;9(10):3413] COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL158043.14, BC101465.1, AL137145.13, AA234440.1 and R40214.1. On Jun 4, 2011 this sequence version replaced gi:48255887. Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L07032.1, BX647657.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-82 AL158043.14 94686-94767 c 83-2261 BC101465.1 11-2189 2262-2893 AL137145.13 131668-132299 c 2894-3226 AA234440.1 49-381 c 3227-3286 R40214.1 1-60 c FEATURES Location/Qualifiers source 1..3286 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10p15" gene 1..3286 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="protein kinase C, theta" /db_xref="GeneID:5588" /db_xref="HGNC:9410" /db_xref="HPRD:02710" /db_xref="MIM:600448" exon 1..82 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 83..209 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" CDS 92..2212 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /EC_number="2.7.11.13" /note="isoform 1 is encoded by transcript variant 1; protein kinase C theta type" /codon_start=1 /product="protein kinase C theta type isoform 1" /protein_id="NP_006248.1" /db_xref="GI:5453976" /db_xref="CCDS:CCDS7079.1" /db_xref="GeneID:5588" /db_xref="HGNC:9410" /db_xref="HPRD:02710" /db_xref="MIM:600448" /translation="
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
" misc_feature 155..439 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="C2 domain; Region: C2; cl14603" /db_xref="CDD:212363" misc_feature 359..361 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine, by LCK; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 359..361 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:01080" misc_feature 569..718 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; Region: C1; cd00029" /db_xref="CDD:28911" misc_feature order(569..571,608..610,617..619,659..661,668..670, 683..685,692..694,716..718) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="zinc binding sites [ion binding]; other site" /db_xref="CDD:28911" misc_feature order(590..592,599..604,629..649) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="putative DAG/PE binding site; other site" /db_xref="CDD:28911" misc_feature order(599..601,605..607) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="putative RAS interaction site [polypeptide binding]; other site" /db_xref="CDD:28911" misc_feature 746..748 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 746..748 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:02710" misc_feature 785..934 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; Region: C1; cd00029" /db_xref="CDD:28911" misc_feature order(785..787,824..826,833..835,875..877,884..886, 899..901,908..910,932..934) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="zinc binding sites [ion binding]; other site" /db_xref="CDD:28911" misc_feature order(806..808,815..820,845..865) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="putative DAG/PE binding site; other site" /db_xref="CDD:28911" misc_feature order(815..817,821..823) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="putative RAS interaction site [polypeptide binding]; other site" /db_xref="CDD:28911" misc_feature 1133..1135 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 1151..1153 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:02799" misc_feature 1229..1993 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 1241..2188 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta; Region: STKc_nPKC_theta; cd05619" /db_xref="CDD:173709" misc_feature order(1247..1261,1271..1273,1310..1312,1316..1318, 1415..1417,1463..1468,1472..1474,1484..1486,1490..1492, 1601..1603,1607..1609,1613..1618,1622..1624,1652..1657, 1664..1666,1706..1723,1802..1804,1820..1822,1829..1831) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="active site" /db_xref="CDD:173709" misc_feature order(1247..1258,1271..1273,1310..1312,1316..1318, 1373..1375,1463..1474,1481..1486,1613..1618,1622..1624, 1652..1657) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173709" misc_feature order(1259..1261,1484..1486,1490..1492,1601..1603, 1607..1609,1613..1615,1664..1666,1706..1723,1802..1804, 1820..1822,1829..1831) /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173709" misc_feature 1652..1723 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="activation loop (A-loop); other site" /db_xref="CDD:173709" misc_feature 1703..1705 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2117..2119 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="turn motif phosphorylation site [posttranslational modification]; other site" /db_xref="CDD:173709" misc_feature 2117..2119 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 2117..2119 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2144..2146 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 2144..2146 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2162..2179 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /note="hydrophobic motif (HM); other site" /db_xref="CDD:173709" misc_feature 2174..2176 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site" misc_feature 2174..2176 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 210..409 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 410..470 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 471..633 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 634..665 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 666..751 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 752..881 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 882..991 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" variation 976 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="a" /replace="t" /db_xref="dbSNP:34193902" exon 992..1109 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" variation 1080 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="c" /replace="t" /db_xref="dbSNP:2236379" exon 1110..1270 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 1271..1444 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" variation 1435 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="c" /replace="t" /db_xref="dbSNP:35751269" exon 1445..1536 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 1537..1599 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 1600..1738 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 1739..1927 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" variation 1786 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="c" /replace="t" /db_xref="dbSNP:34060945" exon 1928..2056 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" exon 2057..3276 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /inference="alignment:Splign:1.39.8" STS 2127..2761 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /standard_name="PRKCQ_2384" /db_xref="UniSTS:471728" variation 2276 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="a" /replace="t" /db_xref="dbSNP:1065081" STS 2329..2583 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /standard_name="RH68983" /db_xref="UniSTS:10356" STS 2346..2613 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /standard_name="D10S2139" /db_xref="UniSTS:31654" variation 2564 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="c" /replace="t" /db_xref="dbSNP:2236380" STS 2649..2748 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /standard_name="SHGC-36302" /db_xref="UniSTS:31422" variation 2708 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /replace="a" /replace="g" /db_xref="dbSNP:2453" STS 3028..3249 /gene="PRKCQ" /gene_synonym="nPKC-theta; PRKCT" /standard_name="STS-W72149" /db_xref="UniSTS:76607" ORIGIN
ccgccagtccccgcgcagtccccgcgcagtccccgcgcagtcccagcgccaccgggcagcagcggcgccgtgctcgctccagggcgcaaccatgtcgccatttcttcggattggcttgtccaactttgactgcgggtcctgccagtcttgtcagggcgaggctgttaacccttactgtgctgtgctcgtcaaagagtatgtcgaatcagagaacgggcagatgtatatccagaaaaagcctaccatgtacccaccctgggacagcacttttgatgcccatatcaacaagggaagagtcatgcagatcattgtgaaaggcaaaaacgtggacctcatctctgaaaccaccgtggagctctactcgctggctgagaggtgcaggaagaacaacgggaagacagaaatatggttagagctgaaacctcaaggccgaatgctaatgaatgcaagatactttctggaaatgagtgacacaaaggacatgaatgaatttgagacggaaggcttctttgctttgcatcagcgccggggtgccatcaagcaggcaaaggtccaccacgtcaagtgccacgagttcactgccaccttcttcccacagcccacattttgctctgtctgccacgagtttgtctggggcctgaacaaacagggctaccagtgccgacaatgcaatgcagcaattcacaagaagtgtattgataaagttatagcaaagtgcacaggatcagctatcaatagccgagaaaccatgttccacaaggagagattcaaaattgacatgccacacagatttaaagtctacaattacaagagcccgaccttctgtgaacactgtgggaccctgctgtggggactggcacggcaaggactcaagtgtgatgcatgtggcatgaatgtgcatcatagatgccagacaaaggtggccaacctttgtggcataaaccagaagctaatggctgaagcgctggccatgattgagagcactcaacaggctcgctgcttaagagatactgaacagatcttcagagaaggtccggttgaaattggtctcccatgctccatcaaaaatgaagcaaggccgccatgtttaccgacaccgggaaaaagagagcctcagggcatttcctgggagtctccgttggatgaggtggataaaatgtgccatcttccagaacctgaactgaacaaagaaagaccatctctgcagattaaactaaaaattgaggattttatcttgcacaaaatgttggggaaaggaagttttggcaaggtcttcctggcagaattcaagaaaaccaatcaatttttcgcaataaaggccttaaagaaagatgtggtcttgatggacgatgatgttgagtgcacgatggtagagaagagagttctttccttggcctgggagcatccgtttctgacgcacatgttttgtacattccagaccaaggaaaacctcttttttgtgatggagtacctcaacggaggggacttaatgtaccacatccaaagctgccacaagttcgacctttccagagcgacgttttatgctgctgaaatcattcttggtctgcagttccttcattccaaaggaatagtctacagggacctgaagctagataacatcctgttagacaaagatggacatatcaagatcgcggattttggaatgtgcaaggagaacatgttaggagatgccaagacgaataccttctgtgggacacctgactacatcgccccagagatcttgctgggtcagaaatacaaccactctgtggactggtggtccttcggggttctcctttatgaaatgctgattggtcagtcgcctttccacgggcaggatgaggaggagctcttccactccatccgcatggacaatcccttttacccacggtggctggagaaggaagcaaaggaccttctggtgaagctcttcgtgcgagaacctgagaagaggctgggcgtgaggggagacatccgccagcaccctttgtttcgggagatcaactgggaggaacttgaacggaaggagattgacccaccgttccggccgaaagtgaaatcaccatttgactgcagcaatttcgacaaagaattcttaaacgagaagccccggctgtcatttgccgacagagcactgatcaacagcatggaccagaatatgttcaggaacttttccttcatgaaccccgggatggagcggctgatatcctgaatcttgcccctccagagacaggaaagaatttgccttctccctgggaactggttcaagagacactgcttgggttcctttttcaacttggaaaaagaaagaaacactcaacaataaagactgagacccgttcgcccccatgtgacttttatctgtagcagaaaccaagtctacttcactaatgacgatgccgtgtgtctcgtctcctgacatgtctcacagacgctcctgaagttaggtcattactaaccatagttatttacttgaaagatgggtctccgcacttggaaaggtttcaagacttgatactgcaataaattatggctcttcacctgggcgccaactgctgatcaatgaaatgcttgttgaatcaggggcaaacggagtacagacgtctcaagactgaaacggccccattgcctggtctagtagcggatctcactcagccgcagacaagtaatcactaacccgttttattctattcctatctgtggatgtgtaaatggctggggggccagccctggataggtttttatgggaattctttacaataaacatagcttgtaacttgagatctacaaatccattcatcctgattgggcatgaaatccatggtcaagaggacaagtggaaagtgagagggaaggtttgctagacaccttcgcttgttatcttgtcaagatagaaaagatagtatcatttcacccttgccagtaaaaacctttccatccacccattctcagcagactccagtattggcacagtcactcactgccattctcacactataacaagaaaagaaatgaagtgcataagtctcctgggaaaagaaccttaaccccttctcgtgccatgactggtgatttcatgactcataagcccctccgtaggcatcattcaagatcaatggcccatgcatgctgtttgcagcagtcaattgagttgaattagaattccaaccatacattttaaaggtatttgtgctgtgtgtatattttgataaaatgttgtgacttcatggcaaacaggtggatgtgtaaaaatggaataaaaaaaaaaaaagagtcaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5588 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: NAS GeneID:5588 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS GeneID:5588 -> Molecular function: GO:0004697 [protein kinase C activity] evidence: IEA GeneID:5588 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS GeneID:5588 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5588 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS GeneID:5588 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:5588 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:5588 -> Biological process: GO:0001558 [regulation of cell growth] evidence: NAS GeneID:5588 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: ISS GeneID:5588 -> Biological process: GO:0006468 [protein phosphorylation] evidence: NAS GeneID:5588 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: ISS GeneID:5588 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5588 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:5588 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA GeneID:5588 -> Biological process: GO:0007411 [axon guidance] evidence: TAS GeneID:5588 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:5588 -> Biological process: GO:0007603 [phototransduction, visible light] evidence: TAS GeneID:5588 -> Biological process: GO:0016056 [rhodopsin mediated signaling pathway] evidence: TAS GeneID:5588 -> Biological process: GO:0016567 [protein ubiquitination] evidence: TAS GeneID:5588 -> Biological process: GO:0022400 [regulation of rhodopsin mediated signaling pathway] evidence: TAS GeneID:5588 -> Biological process: GO:0030168 [platelet activation] evidence: TAS GeneID:5588 -> Biological process: GO:0032740 [positive regulation of interleukin-17 production] evidence: ISS GeneID:5588 -> Biological process: GO:0032753 [positive regulation of interleukin-4 production] evidence: ISS GeneID:5588 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: NAS GeneID:5588 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS GeneID:5588 -> Biological process: GO:0042102 [positive regulation of T cell proliferation] evidence: IEA GeneID:5588 -> Biological process: GO:0045086 [positive regulation of interleukin-2 biosynthetic process] evidence: IEA GeneID:5588 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:5588 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: IMP GeneID:5588 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS GeneID:5588 -> Biological process: GO:0050870 [positive regulation of T cell activation] evidence: ISS GeneID:5588 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IDA GeneID:5588 -> Biological process: GO:0070233 [negative regulation of T cell apoptotic process] evidence: IMP GeneID:5588 -> Biological process: GO:0090330 [regulation of platelet aggregation] evidence: ISS GeneID:5588 -> Biological process: GO:2000318 [positive regulation of T-helper 17 type immune response] evidence: ISS GeneID:5588 -> Biological process: GO:2000570 [positive regulation of T-helper 2 cell activation] evidence: ISS GeneID:5588 -> Cellular component: GO:0001772 [immunological synapse] evidence: IEA GeneID:5588 -> Cellular component: GO:0005622 [intracellular] evidence: NAS GeneID:5588 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5588 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_006248 -> EC 2.7.11.13
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