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2024-03-29 01:24:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006257               3286 bp    mRNA    linear   PRI 29-JUN-2013
DEFINITION  Homo sapiens protein kinase C, theta (PRKCQ), transcript variant 1,
            mRNA.
ACCESSION   NM_006257
VERSION     NM_006257.3  GI:334848124
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Lopez-Sanchez,I., Garcia-Marcos,M., Mittal,Y., Aznar,N.,
            Farquhar,M.G. and Ghosh,P.
  TITLE     Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the
            guanine exchange factor, GIV/Girdin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (14), 5510-5515 (2013)
   PUBMED   23509302
  REMARK    GeneRIF: Protein kinase C-theta (PKCtheta;) phosphorylates and
            inhibits the guanine exchange factor, GIV/Girdin.
REFERENCE   2  (bases 1 to 3286)
  AUTHORS   Duan,Q.L., Lasky-Su,J., Himes,B.E., Qiu,W., Litonjua,A.A.,
            Damask,A., Lazarus,R., Klanderman,B., Irvin,C.G., Peters,S.P.,
            Hanrahan,J.P., Lima,J.J., Martinez,F.D., Mauger,D.,
            Chinchilli,V.M., Soto-Quiros,M., Avila,L., Celedon,J.C., Lange,C.,
            Weiss,S.T. and Tantisira,K.G.
  TITLE     A genome-wide association study of bronchodilator response in
            asthmatics
  JOURNAL   Pharmacogenomics J. (2013) In press
   PUBMED   23508266
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3286)
  AUTHORS   Michalczyk,I., Sikorski,A.F., Kotula,L., Junghans,R.P. and
            Dubielecka,P.M.
  TITLE     The emerging role of protein kinase Ctheta in cytoskeletal
            signaling
  JOURNAL   J. Leukoc. Biol. 93 (3), 319-327 (2013)
   PUBMED   23192428
  REMARK    GeneRIF: The emerging role of protein kinase Ctheta; in
            cytoskeletal signaling.
            Review article
REFERENCE   4  (bases 1 to 3286)
  AUTHORS   Giambra,V., Jenkins,C.R., Wang,H., Lam,S.H., Shevchuk,O.O.,
            Nemirovsky,O., Wai,C., Gusscott,S., Chiang,M.Y., Aster,J.C.,
            Humphries,R.K., Eaves,C. and Weng,A.P.
  TITLE     NOTCH1 promotes T cell leukemia-initiating activity by
            RUNX-mediated regulation of PKC-theta and reactive oxygen species
  JOURNAL   Nat. Med. 18 (11), 1693-1698 (2012)
   PUBMED   23086478
  REMARK    GeneRIF: These results reveal key functional roles for PKC-theta
            and ROS in T cell acute lymphoblastic leukemia and suggest that
            aggressive biological behavior in vivo could be limited by
            therapeutic strategies that promote PKC-theta expression or
            activity
REFERENCE   5  (bases 1 to 3286)
  AUTHORS   Kumar,D.V., Shanmugasundaram,J., Sundaram,C. and Anandaraj,M.P.
  TITLE     Activity of novel protein kinase C and distribution of protein
            kinase C theta in subcellular fractions of normal and Duchenne
            muscular dystrophic muscle
  JOURNAL   Indian J. Biochem. Biophys. 39 (6), 377-381 (2002)
   PUBMED   22905394
  REMARK    GeneRIF: alterations in nPKC location and increased expression of
            PKC theta observed is a result of modification of PKC-mediated
            signal transduction and cell function
REFERENCE   6  (bases 1 to 3286)
  AUTHORS   Conant,K., Ma,M., Nath,A. and Major,E.O.
  TITLE     Extracellular human immunodeficiency virus type 1 Tat protein is
            associated with an increase in both NF-kappa B binding and protein
            kinase C activity in primary human astrocytes
  JOURNAL   J. Virol. 70 (3), 1384-1389 (1996)
   PUBMED   8627654
REFERENCE   7  (bases 1 to 3286)
  AUTHORS   Erdel,M., Baier-Bitterlich,G., Duba,C., Isakov,N., Altman,A.,
            Utermann,G. and Baier,G.
  TITLE     Mapping of the human protein kinase C-theta (PRKCQ) gene locus to
            the short arm of chromosome 10 (10p15) by FISH
  JOURNAL   Genomics 25 (2), 595-597 (1995)
   PUBMED   7790001
REFERENCE   8  (bases 1 to 3286)
  AUTHORS   Chang,J.D., Xu,Y., Raychowdhury,M.K. and Ware,J.A.
  TITLE     Molecular cloning and expression of a cDNA encoding a novel
            isoenzyme of protein kinase C (nPKC). A new member of the nPKC
            family expressed in skeletal muscle, megakaryoblastic cells, and
            platelets
  JOURNAL   J. Biol. Chem. 268 (19), 14208-14214 (1993)
   PUBMED   7686153
  REMARK    Erratum:[J Biol Chem. 1994 Dec 9;269(49):31322. PMID: 16964635]
REFERENCE   9  (bases 1 to 3286)
  AUTHORS   Baier,G., Telford,D., Giampa,L., Coggeshall,K.M.,
            Baier-Bitterlich,G., Isakov,N. and Altman,A.
  TITLE     Molecular cloning and characterization of PKC theta, a novel member
            of the protein kinase C (PKC) gene family expressed predominantly
            in hematopoietic cells
  JOURNAL   J. Biol. Chem. 268 (7), 4997-5004 (1993)
   PUBMED   8444877
REFERENCE   10 (bases 1 to 3286)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J. 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158043.14, BC101465.1, AL137145.13, AA234440.1 and R40214.1.
            On Jun 4, 2011 this sequence version replaced gi:48255887.
            
            Summary: Protein kinase C (PKC) is a family of serine- and
            threonine-specific protein kinases that can be activated by calcium
            and the second messenger diacylglycerol. PKC family members
            phosphorylate a wide variety of protein targets and are known to be
            involved in diverse cellular signaling pathways. PKC family members
            also serve as major receptors for phorbol esters, a class of tumor
            promoters. Each member of the PKC family has a specific expression
            profile and is believed to play a distinct role. The protein
            encoded by this gene is one of the PKC family members. It is a
            calcium-independent and phospholipid-dependent protein kinase. This
            kinase is important for T-cell activation. It is required for the
            activation of the transcription factors NF-kappaB and AP-1, and may
            link the T cell receptor (TCR) signaling complex to the activation
            of the transcription factors. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L07032.1, BX647657.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL158043.14        94686-94767         c
            83-2261             BC101465.1         11-2189
            2262-2893           AL137145.13        131668-132299       c
            2894-3226           AA234440.1         49-381              c
            3227-3286           R40214.1           1-60                c
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15"
     gene            1..3286
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="protein kinase C, theta"
                     /db_xref="GeneID:5588"
                     /db_xref="HGNC:9410"
                     /db_xref="HPRD:02710"
                     /db_xref="MIM:600448"
     exon            1..82
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            83..209
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     CDS             92..2212
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /EC_number="2.7.11.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase C theta type"
                     /codon_start=1
                     /product="protein kinase C theta type isoform 1"
                     /protein_id="NP_006248.1"
                     /db_xref="GI:5453976"
                     /db_xref="CCDS:CCDS7079.1"
                     /db_xref="GeneID:5588"
                     /db_xref="HGNC:9410"
                     /db_xref="HPRD:02710"
                     /db_xref="MIM:600448"
                     /translation="
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
"
     misc_feature    155..439
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:212363"
     misc_feature    359..361
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by LCK; propagated from
                     UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site"
     misc_feature    359..361
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01080"
     misc_feature    569..718
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="Protein kinase C conserved region 1 (C1) .
                     Cysteine-rich zinc binding domain. Some members of this
                     domain family bind phorbol esters and diacylglycerol, some
                     are reported to bind RasGTP. May occur in tandem
                     arrangement. Diacylglycerol (DAG) is a second...; Region:
                     C1; cd00029"
                     /db_xref="CDD:28911"
     misc_feature    order(569..571,608..610,617..619,659..661,668..670,
                     683..685,692..694,716..718)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="zinc binding sites [ion binding]; other site"
                     /db_xref="CDD:28911"
     misc_feature    order(590..592,599..604,629..649)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="putative DAG/PE binding site; other site"
                     /db_xref="CDD:28911"
     misc_feature    order(599..601,605..607)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="putative RAS interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:28911"
     misc_feature    746..748
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q04759.3); phosphorylation site"
     misc_feature    746..748
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02710"
     misc_feature    785..934
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="Protein kinase C conserved region 1 (C1) .
                     Cysteine-rich zinc binding domain. Some members of this
                     domain family bind phorbol esters and diacylglycerol, some
                     are reported to bind RasGTP. May occur in tandem
                     arrangement. Diacylglycerol (DAG) is a second...; Region:
                     C1; cd00029"
                     /db_xref="CDD:28911"
     misc_feature    order(785..787,824..826,833..835,875..877,884..886,
                     899..901,908..910,932..934)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="zinc binding sites [ion binding]; other site"
                     /db_xref="CDD:28911"
     misc_feature    order(806..808,815..820,845..865)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="putative DAG/PE binding site; other site"
                     /db_xref="CDD:28911"
     misc_feature    order(815..817,821..823)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="putative RAS interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:28911"
     misc_feature    1133..1135
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q04759.3); phosphorylation site"
     misc_feature    1151..1153
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:02799"
     misc_feature    1229..1993
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    1241..2188
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Novel Protein Kinase C theta; Region:
                     STKc_nPKC_theta; cd05619"
                     /db_xref="CDD:173709"
     misc_feature    order(1247..1261,1271..1273,1310..1312,1316..1318,
                     1415..1417,1463..1468,1472..1474,1484..1486,1490..1492,
                     1601..1603,1607..1609,1613..1618,1622..1624,1652..1657,
                     1664..1666,1706..1723,1802..1804,1820..1822,1829..1831)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="active site"
                     /db_xref="CDD:173709"
     misc_feature    order(1247..1258,1271..1273,1310..1312,1316..1318,
                     1373..1375,1463..1474,1481..1486,1613..1618,1622..1624,
                     1652..1657)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173709"
     misc_feature    order(1259..1261,1484..1486,1490..1492,1601..1603,
                     1607..1609,1613..1615,1664..1666,1706..1723,1802..1804,
                     1820..1822,1829..1831)
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173709"
     misc_feature    1652..1723
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173709"
     misc_feature    1703..1705
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2117..2119
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:173709"
     misc_feature    2117..2119
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q04759.3); phosphorylation site"
     misc_feature    2117..2119
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2144..2146
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q04759.3); phosphorylation site"
     misc_feature    2144..2146
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2162..2179
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:173709"
     misc_feature    2174..2176
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q04759.3); phosphorylation site"
     misc_feature    2174..2176
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            210..409
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            410..470
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            471..633
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            634..665
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            666..751
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            752..881
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            882..991
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     variation       976
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:34193902"
     exon            992..1109
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     variation       1080
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2236379"
     exon            1110..1270
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            1271..1444
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     variation       1435
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35751269"
     exon            1445..1536
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            1537..1599
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            1600..1738
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            1739..1927
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     variation       1786
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34060945"
     exon            1928..2056
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     exon            2057..3276
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /inference="alignment:Splign:1.39.8"
     STS             2127..2761
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /standard_name="PRKCQ_2384"
                     /db_xref="UniSTS:471728"
     variation       2276
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1065081"
     STS             2329..2583
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /standard_name="RH68983"
                     /db_xref="UniSTS:10356"
     STS             2346..2613
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /standard_name="D10S2139"
                     /db_xref="UniSTS:31654"
     variation       2564
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2236380"
     STS             2649..2748
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /standard_name="SHGC-36302"
                     /db_xref="UniSTS:31422"
     variation       2708
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2453"
     STS             3028..3249
                     /gene="PRKCQ"
                     /gene_synonym="nPKC-theta; PRKCT"
                     /standard_name="STS-W72149"
                     /db_xref="UniSTS:76607"
ORIGIN      
ccgccagtccccgcgcagtccccgcgcagtccccgcgcagtcccagcgccaccgggcagcagcggcgccgtgctcgctccagggcgcaaccatgtcgccatttcttcggattggcttgtccaactttgactgcgggtcctgccagtcttgtcagggcgaggctgttaacccttactgtgctgtgctcgtcaaagagtatgtcgaatcagagaacgggcagatgtatatccagaaaaagcctaccatgtacccaccctgggacagcacttttgatgcccatatcaacaagggaagagtcatgcagatcattgtgaaaggcaaaaacgtggacctcatctctgaaaccaccgtggagctctactcgctggctgagaggtgcaggaagaacaacgggaagacagaaatatggttagagctgaaacctcaaggccgaatgctaatgaatgcaagatactttctggaaatgagtgacacaaaggacatgaatgaatttgagacggaaggcttctttgctttgcatcagcgccggggtgccatcaagcaggcaaaggtccaccacgtcaagtgccacgagttcactgccaccttcttcccacagcccacattttgctctgtctgccacgagtttgtctggggcctgaacaaacagggctaccagtgccgacaatgcaatgcagcaattcacaagaagtgtattgataaagttatagcaaagtgcacaggatcagctatcaatagccgagaaaccatgttccacaaggagagattcaaaattgacatgccacacagatttaaagtctacaattacaagagcccgaccttctgtgaacactgtgggaccctgctgtggggactggcacggcaaggactcaagtgtgatgcatgtggcatgaatgtgcatcatagatgccagacaaaggtggccaacctttgtggcataaaccagaagctaatggctgaagcgctggccatgattgagagcactcaacaggctcgctgcttaagagatactgaacagatcttcagagaaggtccggttgaaattggtctcccatgctccatcaaaaatgaagcaaggccgccatgtttaccgacaccgggaaaaagagagcctcagggcatttcctgggagtctccgttggatgaggtggataaaatgtgccatcttccagaacctgaactgaacaaagaaagaccatctctgcagattaaactaaaaattgaggattttatcttgcacaaaatgttggggaaaggaagttttggcaaggtcttcctggcagaattcaagaaaaccaatcaatttttcgcaataaaggccttaaagaaagatgtggtcttgatggacgatgatgttgagtgcacgatggtagagaagagagttctttccttggcctgggagcatccgtttctgacgcacatgttttgtacattccagaccaaggaaaacctcttttttgtgatggagtacctcaacggaggggacttaatgtaccacatccaaagctgccacaagttcgacctttccagagcgacgttttatgctgctgaaatcattcttggtctgcagttccttcattccaaaggaatagtctacagggacctgaagctagataacatcctgttagacaaagatggacatatcaagatcgcggattttggaatgtgcaaggagaacatgttaggagatgccaagacgaataccttctgtgggacacctgactacatcgccccagagatcttgctgggtcagaaatacaaccactctgtggactggtggtccttcggggttctcctttatgaaatgctgattggtcagtcgcctttccacgggcaggatgaggaggagctcttccactccatccgcatggacaatcccttttacccacggtggctggagaaggaagcaaaggaccttctggtgaagctcttcgtgcgagaacctgagaagaggctgggcgtgaggggagacatccgccagcaccctttgtttcgggagatcaactgggaggaacttgaacggaaggagattgacccaccgttccggccgaaagtgaaatcaccatttgactgcagcaatttcgacaaagaattcttaaacgagaagccccggctgtcatttgccgacagagcactgatcaacagcatggaccagaatatgttcaggaacttttccttcatgaaccccgggatggagcggctgatatcctgaatcttgcccctccagagacaggaaagaatttgccttctccctgggaactggttcaagagacactgcttgggttcctttttcaacttggaaaaagaaagaaacactcaacaataaagactgagacccgttcgcccccatgtgacttttatctgtagcagaaaccaagtctacttcactaatgacgatgccgtgtgtctcgtctcctgacatgtctcacagacgctcctgaagttaggtcattactaaccatagttatttacttgaaagatgggtctccgcacttggaaaggtttcaagacttgatactgcaataaattatggctcttcacctgggcgccaactgctgatcaatgaaatgcttgttgaatcaggggcaaacggagtacagacgtctcaagactgaaacggccccattgcctggtctagtagcggatctcactcagccgcagacaagtaatcactaacccgttttattctattcctatctgtggatgtgtaaatggctggggggccagccctggataggtttttatgggaattctttacaataaacatagcttgtaacttgagatctacaaatccattcatcctgattgggcatgaaatccatggtcaagaggacaagtggaaagtgagagggaaggtttgctagacaccttcgcttgttatcttgtcaagatagaaaagatagtatcatttcacccttgccagtaaaaacctttccatccacccattctcagcagactccagtattggcacagtcactcactgccattctcacactataacaagaaaagaaatgaagtgcataagtctcctgggaaaagaaccttaaccccttctcgtgccatgactggtgatttcatgactcataagcccctccgtaggcatcattcaagatcaatggcccatgcatgctgtttgcagcagtcaattgagttgaattagaattccaaccatacattttaaaggtatttgtgctgtgtgtatattttgataaaatgttgtgacttcatggcaaacaggtggatgtgtaaaaatggaataaaaaaaaaaaaagagtcaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5588 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: NAS
            GeneID:5588 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
            GeneID:5588 -> Molecular function: GO:0004697 [protein kinase C activity] evidence: IEA
            GeneID:5588 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS
            GeneID:5588 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5588 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS
            GeneID:5588 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:5588 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:5588 -> Biological process: GO:0001558 [regulation of cell growth] evidence: NAS
            GeneID:5588 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:5588 -> Biological process: GO:0006468 [protein phosphorylation] evidence: NAS
            GeneID:5588 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: ISS
            GeneID:5588 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5588 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
            GeneID:5588 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
            GeneID:5588 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:5588 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5588 -> Biological process: GO:0007603 [phototransduction, visible light] evidence: TAS
            GeneID:5588 -> Biological process: GO:0016056 [rhodopsin mediated signaling pathway] evidence: TAS
            GeneID:5588 -> Biological process: GO:0016567 [protein ubiquitination] evidence: TAS
            GeneID:5588 -> Biological process: GO:0022400 [regulation of rhodopsin mediated signaling pathway] evidence: TAS
            GeneID:5588 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:5588 -> Biological process: GO:0032740 [positive regulation of interleukin-17 production] evidence: ISS
            GeneID:5588 -> Biological process: GO:0032753 [positive regulation of interleukin-4 production] evidence: ISS
            GeneID:5588 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: NAS
            GeneID:5588 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:5588 -> Biological process: GO:0042102 [positive regulation of T cell proliferation] evidence: IEA
            GeneID:5588 -> Biological process: GO:0045086 [positive regulation of interleukin-2 biosynthetic process] evidence: IEA
            GeneID:5588 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5588 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: IMP
            GeneID:5588 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
            GeneID:5588 -> Biological process: GO:0050870 [positive regulation of T cell activation] evidence: ISS
            GeneID:5588 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IDA
            GeneID:5588 -> Biological process: GO:0070233 [negative regulation of T cell apoptotic process] evidence: IMP
            GeneID:5588 -> Biological process: GO:0090330 [regulation of platelet aggregation] evidence: ISS
            GeneID:5588 -> Biological process: GO:2000318 [positive regulation of T-helper 17 type immune response] evidence: ISS
            GeneID:5588 -> Biological process: GO:2000570 [positive regulation of T-helper 2 cell activation] evidence: ISS
            GeneID:5588 -> Cellular component: GO:0001772 [immunological synapse] evidence: IEA
            GeneID:5588 -> Cellular component: GO:0005622 [intracellular] evidence: NAS
            GeneID:5588 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5588 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_006248 -> EC 2.7.11.13

by @meso_cacase at DBCLS
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