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2024-03-29 21:00:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006256               6104 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens protein kinase N2 (PKN2), mRNA.
ACCESSION   NM_006256
VERSION     NM_006256.2  GI:106507281
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6104)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J. Dent. Res. 91 (7 SUPPL), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   2  (bases 1 to 6104)
  AUTHORS   Bauer,A.F., Sonzogni,S., Meyer,L., Zeuzem,S., Piiper,A.,
            Biondi,R.M. and Neimanis,S.
  TITLE     Regulation of protein kinase C-related protein kinase 2 (PRK2) by
            an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal
            domain
  JOURNAL   J. Biol. Chem. 287 (24), 20590-20602 (2012)
   PUBMED   22511787
  REMARK    GeneRIF: Regulation of protein kinase C-related protein kinase 2
            (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its
            N-terminal domain.
REFERENCE   3  (bases 1 to 6104)
  AUTHORS   Kim,M.G., Moon,J.S., Kim,E.J., Lee,S.H. and Oh,J.W.
  TITLE     Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis
            C virus replication through inhibition of PRK2-mediated viral RNA
            polymerase phosphorylation
  JOURNAL   Biochem. Biophys. Res. Commun. 421 (1), 112-118 (2012)
   PUBMED   22490666
  REMARK    GeneRIF: these findings suggest that Hsp90 plays a critical role in
            the regulation of HCV RNA polymerase phosphorylation via the
            PDK1-PRK2 signaling pathway.
REFERENCE   4  (bases 1 to 6104)
  AUTHORS   Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm
            H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C,
            Heard-Costa NL, Hottenga JJ, Kuhnel B, Kumar V, Lagou V, Liang L,
            Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu
            N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ,
            Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus
            EJ, Dixon AL, Doring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi
            NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB,
            Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G,
            Hypponen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kuhn JP, Lai
            S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG,
            Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y,
            O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko
            I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN,
            Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan
            W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM,
            Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G,
            Wurtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma
            DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K,
            McCarthy MI, Meisinger C, Mooser V, Pietilainen KH, Schumann G,
            Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U,
            Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield
            JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M,
            Stefansson K, Vollenweider P, Volzke H, Schadt EE, Scott J,
            Jarvelin MR, Elliott P and Kooner JS.
  CONSRTM   Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes
            Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic
            Investigation of Anthropometric Traits (GIANT) Consortium; Global
            Lipids Genetics Consortium; Genetics of Liver Disease (GOLD)
            Consortium; International Consortium for Blood Pressure
            (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits
            Consortium (MAGIC)
  TITLE     Genome-wide association study identifies loci influencing
            concentrations of liver enzymes in plasma
  JOURNAL   Nat. Genet. 43 (11), 1131-1138 (2011)
   PUBMED   22001757
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6104)
  AUTHORS   Lachmann,S., Jevons,A., De Rycker,M., Casamassima,A., Radtke,S.,
            Collazos,A. and Parker,P.J.
  TITLE     Regulatory domain selectivity in the cell-type specific
            PKN-dependence of cell migration
  JOURNAL   PLoS ONE 6 (7), E21732 (2011)
   PUBMED   21754995
  REMARK    GeneRIF: PKN isoforms are not simply redundant in supporting
            migration, but appear to be linked through isoform specific
            regulatory domain properties to selective upstream signals. It
REFERENCE   6  (bases 1 to 6104)
  AUTHORS   Yu,W., Liu,J., Morrice,N.A. and Wettenhall,R.E.
  TITLE     Isolation and characterization of a structural homologue of human
            PRK2 from rat liver. Distinguishing substrate and lipid activator
            specificities
  JOURNAL   J. Biol. Chem. 272 (15), 10030-10034 (1997)
   PUBMED   9092545
REFERENCE   7  (bases 1 to 6104)
  AUTHORS   Vincent,S. and Settleman,J.
  TITLE     The PRK2 kinase is a potential effector target of both Rho and Rac
            GTPases and regulates actin cytoskeletal organization
  JOURNAL   Mol. Cell. Biol. 17 (4), 2247-2256 (1997)
   PUBMED   9121475
REFERENCE   8  (bases 1 to 6104)
  AUTHORS   Quilliam,L.A., Lambert,Q.T., Mickelson-Young,L.A., Westwick,J.K.,
            Sparks,A.B., Kay,B.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Der,C.J.
  TITLE     Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein
            and potential effector of Rho protein signaling
  JOURNAL   J. Biol. Chem. 271 (46), 28772-28776 (1996)
   PUBMED   8910519
REFERENCE   9  (bases 1 to 6104)
  AUTHORS   Palmer,R.H., Ridden,J. and Parker,P.J.
  TITLE     Cloning and expression patterns of two members of a novel
            protein-kinase-C-related kinase family
  JOURNAL   Eur. J. Biochem. 227 (1-2), 344-351 (1995)
   PUBMED   7851406
REFERENCE   10 (bases 1 to 6104)
  AUTHORS   Palmer,R.H., Ridden,J. and Parker,P.J.
  TITLE     Identification of multiple, novel, protein kinase C-related gene
            products
  JOURNAL   FEBS Lett. 356 (1), 5-8 (1994)
   PUBMED   7988719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA451427.1, U33052.1 and AL136381.12.
            On Jun 2, 2006 this sequence version replaced gi:5453973.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S75548.1, U33052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               DA451427.1         1-557
            558-3588            U33052.1           225-3255
            3589-6104           AL136381.12        896-3411            c
FEATURES             Location/Qualifiers
     source          1..6104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..6104
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="protein kinase N2"
                     /db_xref="GeneID:5586"
                     /db_xref="HGNC:9406"
                     /db_xref="HPRD:03972"
                     /db_xref="MIM:602549"
     exon            1..390
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       153
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201410349"
     misc_feature    169..171
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="upstream in-frame stop codon"
     variation       239
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:10713037"
     variation       241
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77280369"
     variation       308
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370061054"
     CDS             343..3297
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /EC_number="2.7.11.13"
                     /note="cardiolipin-activated protein kinase Pak2; protein
                     kinase C-like 2; protein-kinase C-related kinase 2; PKN
                     gamma"
                     /codon_start=1
                     /product="serine/threonine-protein kinase N2"
                     /protein_id="NP_006247.1"
                     /db_xref="GI:5453974"
                     /db_xref="CCDS:CCDS714.1"
                     /db_xref="GeneID:5586"
                     /db_xref="HGNC:9406"
                     /db_xref="HPRD:03972"
                     /db_xref="MIM:602549"
                     /translation="
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC
"
     misc_feature    472..699
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: REM 1"
     misc_feature    <535..>597
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="First Protein kinase C-related kinase homology
                     region 1 (HR1) Rho-binding domain of Protein Kinase N;
                     Region: HR1_PKN_1; cd11622"
                     /db_xref="CDD:212012"
     misc_feature    order(535..540,544..549,556..561,568..570,583..588,
                     592..594)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="putative Rho binding site 2 [polypeptide binding];
                     other site"
                     /db_xref="CDD:212012"
     misc_feature    670..672
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    691..696
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by caspase-3; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); cleavage site"
     misc_feature    691..693
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:02799"
     misc_feature    703..705
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); phosphorylation site"
     misc_feature    712..714
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); phosphorylation site"
     misc_feature    730..945
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="Second Protein kinase C-related kinase homology
                     region 1 (HR1) Rho-binding domain of Protein Kinase N2;
                     Region: HR1_PKN2_2; cd11631"
                     /db_xref="CDD:212021"
     misc_feature    739..981
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: REM 2"
     misc_feature    order(757..759,766..768,775..780,787..792,796..801,
                     808..813,817..822,880..885,892..894,901..906,913..915)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="putative Rho binding site 1 [polypeptide binding];
                     other site"
                     /db_xref="CDD:212021"
     misc_feature    order(781..786,790..795,802..807,811..816,823..828,
                     865..870,874..876)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="putative Rho binding site 2 [polypeptide binding];
                     other site"
                     /db_xref="CDD:212021"
     misc_feature    967..1188
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="Third Protein kinase C-related kinase homology
                     region 1 (HR1) Rho-binding domain of Protein Kinase N2;
                     Region: HR1_PKN2_3; cd11635"
                     /db_xref="CDD:212025"
     misc_feature    982..1227
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: REM 3"
     misc_feature    order(1000..1002,1009..1011,1018..1023,1030..1035,
                     1039..1044,1051..1056,1060..1065,1123..1128,1135..1137,
                     1144..1149,1156..1158)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="putative Rho binding site 1 [polypeptide binding];
                     other site"
                     /db_xref="CDD:212025"
     misc_feature    order(1024..1029,1033..1038,1045..1050,1054..1059,
                     1066..1071,1108..1113,1117..1119)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="putative Rho binding site 2 [polypeptide binding];
                     other site"
                     /db_xref="CDD:212025"
     misc_feature    1207..1209
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1246..1248
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    1258..1260
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    1420..1422
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    1426..1428
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    1486..1731
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: Necessary to rescue apical junction formation (By
                     similarity)"
     misc_feature    1510..1761
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="C2 domain in Protein kinase C-like (PKN) proteins;
                     Region: C2_PKN-like; cd08687"
                     /db_xref="CDD:176069"
     misc_feature    1945..1947
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    2086..2088
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2089..2091
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    2089..2091
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2224..2226
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); phosphorylation site"
     misc_feature    2233..2235
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16513.1); phosphorylation site"
     misc_feature    2245..2247
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2311..3282
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Protein Kinase N; Region: STKc_PKN; cd05589"
                     /db_xref="CDD:173680"
     misc_feature    2326..3090
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(2329..2343,2353..2355,2392..2394,2398..2400,
                     2503..2505,2551..2556,2560..2562,2572..2574,2578..2580,
                     2686..2688,2692..2694,2698..2703,2707..2709,2737..2742,
                     2749..2751,2791..2808,2887..2889,2905..2907,2914..2916)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="active site"
                     /db_xref="CDD:173680"
     misc_feature    order(2329..2334,2353..2355,2392..2394,2398..2400,
                     2503..2505,2551..2562,2572..2574,2698..2703,2707..2709,
                     2737..2742)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173680"
     misc_feature    order(2341..2343,2572..2574,2578..2580,2686..2688,
                     2692..2694,2698..2700,2749..2751,2791..2808,2887..2889,
                     2905..2907,2914..2916)
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173680"
     misc_feature    2440..2445
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by caspase-3; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); cleavage site"
     misc_feature    2440..2442
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:02799"
     misc_feature    2737..2808
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173680"
     misc_feature    2788..2790
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PDPK1; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); phosphorylation site"
     misc_feature    2788..2790
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03954"
     misc_feature    2788..2790
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05556"
     misc_feature    2788..2790
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3091..3273
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: Necessary for the catalytic activity"
     misc_feature    3193..3195
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03954"
     misc_feature    3193..3195
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05556"
     misc_feature    3214..3216
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:173680"
     misc_feature    3214..3216
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q16513.1); phosphorylation site"
     misc_feature    3214..3216
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3262..3279
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:173680"
     misc_feature    3274..3294
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q16513.1);
                     Region: Negatively regulates the responsiveness of the
                     catalytic activity by cardiolipin and is required for
                     optimal activation by the GTP-bound RhoA"
     variation       369
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372711172"
     exon            391..691
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       401
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369171613"
     variation       403
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370072062"
     variation       410
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375306359"
     variation       453
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377515876"
     variation       460
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199689449"
     variation       494
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200490316"
     variation       520
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201117208"
     variation       561
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368643241"
     variation       624
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12039846"
     variation       676
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372785607"
     exon            692..846
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       704
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201995133"
     variation       751
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369178376"
     variation       763
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:430600"
     exon            847..964
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       868
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376874389"
     variation       876
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369228973"
     variation       896
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202004408"
     variation       932
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35207128"
     exon            965..1110
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1077
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201013196"
     variation       1079..1080
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34602652"
     exon            1111..1327
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1118
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375574349"
     variation       1144
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368591525"
     variation       1160
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148288884"
     variation       1161
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201690209"
     variation       1182
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373700833"
     variation       1187
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:66931534"
     variation       1203
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368171924"
     variation       1220
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371630794"
     variation       1271
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373232178"
     variation       1284
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374860858"
     variation       1289
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111704755"
     variation       1314
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368519297"
     variation       1321
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9651072"
     exon            1328..1513
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1360..1361
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34708108"
     variation       1365
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201111346"
     variation       1398
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201865794"
     variation       1423
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368676500"
     variation       1433
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200726637"
     variation       1454
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187178031"
     variation       1469
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373814749"
     variation       1473
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376395087"
     variation       1484
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371274223"
     variation       1488..1490
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="tct"
                     /db_xref="dbSNP:201679232"
     exon            1514..1623
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1547
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373098773"
     variation       1589
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377562198"
     exon            1624..1767
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1716
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56365263"
     variation       1722
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367724153"
     exon            1768..1843
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1821
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147713481"
     exon            1844..2018
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       1845
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200022569"
     variation       1934
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368860135"
     variation       1953
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201758727"
     variation       1963
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201149414"
     variation       1969
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376245572"
     variation       1972
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369266668"
     variation       1974
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191397480"
     variation       1984
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373758248"
     variation       1986
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376747132"
     variation       2003
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369398098"
     variation       2010
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373479229"
     exon            2019..2145
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2019
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:786906"
     variation       2074
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373655576"
     variation       2081
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377246617"
     exon            2146..2276
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2205
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372278347"
     variation       2226
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200217727"
     variation       2227
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368473517"
     variation       2246
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371912104"
     exon            2277..2352
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2278
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373058309"
     variation       2286
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201749502"
     variation       2306
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12085658"
     variation       2310
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373212914"
     variation       2312
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376189560"
     variation       2352
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6671949"
     exon            2353..2444
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2356
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200476994"
     variation       2379
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377511914"
     variation       2437
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371052905"
     exon            2445..2621
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2448
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368655957"
     variation       2471
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371286273"
     variation       2478
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199566133"
     variation       2485
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375403448"
     variation       2508
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367761410"
     variation       2595
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200519077"
     exon            2622..2684
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2679
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369174463"
     exon            2685..2761
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2731
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373246980"
     exon            2762..2904
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2869
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369061418"
     exon            2905..3012
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       2985
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76430567"
     variation       3001
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370637742"
     exon            3013..3093
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     variation       3037
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374663309"
     variation       3051
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368751411"
     variation       3067
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201403675"
     variation       3070
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370300406"
     variation       3092
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188265897"
     exon            3094..6104
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /inference="alignment:Splign:1.39.8"
     STS             3125..3744
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /standard_name="PRKCL2__5581"
                     /db_xref="UniSTS:463828"
     variation       3185
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200518024"
     variation       3194
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368185560"
     variation       3195
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193170277"
     variation       3204
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377094068"
     variation       3231
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371640614"
     variation       3242
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200905692"
     variation       3243
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374868325"
     variation       3289
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184754507"
     STS             3331..3464
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /standard_name="SHGC-75118"
                     /db_xref="UniSTS:79360"
     variation       3339
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372351771"
     STS             3359..3490
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /standard_name="RH47567"
                     /db_xref="UniSTS:65714"
     variation       3397..3399
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="ttg"
                     /db_xref="dbSNP:148906887"
     variation       3399..3401
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="gtt"
                     /db_xref="dbSNP:374016964"
     variation       3418
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187904669"
     variation       3456..3458
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="aag"
                     /db_xref="dbSNP:3831022"
     variation       3497
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76669528"
     variation       3518
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147551533"
     variation       3539
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141963409"
     variation       3561
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145835594"
     variation       3595
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11541543"
     variation       3676
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151165483"
     variation       3715
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:191409712"
     variation       3759..3760
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199950121"
     variation       3766..3767
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:142129138"
     variation       3766
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183934392"
     variation       3767
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:57445331"
     variation       3768..3769
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:61703221"
     variation       3821
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79463875"
     variation       3837
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181363261"
     variation       3878
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150349508"
     variation       3997
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11541544"
     variation       4017
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61118957"
     variation       4041
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138057302"
     variation       4148
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:115260590"
     variation       4163
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375207517"
     variation       4176
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12027005"
     variation       4233
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76442107"
     variation       4252
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184959864"
     variation       4431
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201266373"
     variation       4532
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370300351"
     variation       4619
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76107017"
     variation       4749
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:74392918"
     variation       4844
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79294200"
     variation       4986
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149526423"
     variation       5065
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373003994"
     variation       5086
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:71778817"
     variation       5109
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189841196"
     variation       5206
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144889137"
     variation       5221..5222
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:71693414"
     variation       5235
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181568060"
     variation       5259
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186252655"
     variation       5289
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:786912"
     variation       5290
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138185887"
     variation       5311
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34982854"
     variation       5346..5348
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="aga"
                     /db_xref="dbSNP:201147667"
     variation       5397
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370415100"
     variation       5409
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11800810"
     variation       5413
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146070743"
     variation       5437
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148737509"
     variation       5481..5484
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="tgta"
                     /db_xref="dbSNP:200537391"
     variation       5484..5487
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace=""
                     /replace="atgt"
                     /db_xref="dbSNP:376692067"
     variation       5595
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141492534"
     polyA_signal    5625..5630
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
     polyA_site      5654
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
     polyA_signal    5752..5757
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
     polyA_site      5771
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
     variation       6013
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371031954"
     variation       6059
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191056745"
     polyA_signal    6085..6090
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
     variation       6101
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376458970"
     polyA_site      6104
                     /gene="PKN2"
                     /gene_synonym="Pak-2; PAK2; PRK2; PRKCL2; PRO2042"
ORIGIN      
acagccaaatggtgcgacaggaggagctgcagccgcggccgcagcgcccgcacggagaggcttgaggcggctcctggcgtcgcccagagggagcgactagacgaacagtccggtgagggcggcgagaggaagcccgctacgagtgccctagctccccgccgctctcgatgaaccggacggaataagccgcgcctccagcaggggctgcgcctccatgaatccctagttgtttttttttttttctttctctcccctctcctcacccccaccccgagccccgtcccgccttctcccttcgccagaggcggccgcgtccaggtgcggagtccataccggagcgcaatggcgtccaaccccgaacggggggagattctgctcacggaactgcagggggattcccgaagtcttccgttttctgagaatgtgagtgctgttcaaaaattagacttttcagatacaatggtgcagcagaaattggatgatatcaaggatcgaattaagagagaaataaggaaagaactgaaaatcaaagaaggagctgaaaatctgaggaaagtcacaacagataaaaaaagtttggcttatgtagacaacattttgaaaaaatcaaataaaaaattagaagaactacatcacaagctgcaggaattaaatgcacatattgttgtatcagatccagaagatattacagattgcccaaggactccagatactccaaataatgaccctcgttgttctactagcaacaatagattgaaggccttacaaaaacaattggatatagaacttaaagtaaaacaaggtgcagagaatatgatacagatgtattcaaatggatcttcaaaggatcggaaactccatggtacagctcagcaactgctccaggacagcaagacaaaaatagaagtcatacgaatgcagattcttcaggcagtccagactaatgaattggcttttgataatgcaaaacctgtgataagtcctcttgaacttcggatggaagaattaaggcatcattttaggatagagtttgcagtagcagaaggtgcaaagaatgtaatgaaattacttggctcaggaaaagtaacagacagaaaagcactttcagaagctcaagcaagatttaatgaatcaagtcagaagttggaccttttaaagtattcattagagcaaagattaaacgaagtccccaagaatcatcccaaaagcaggattattattgaagaactttcacttgttgctgcatcaccaacactaagtccacgtcaaagtatgatatctacgcaaaatcaatatagtacactatccaaaccagcagcactaacaggtactttggaagttcgtcttatgggctgccaagatatcctagagaatgtccctggacggtcaaaagcaacatcagttgcactgcctggttggagtccaagtgaaaccagatcatctttcatgagcagaacgagtaaaagtaaaagcggaagtagtcgaaatcttctaaaaaccgatgacttgtccaatgatgtctgtgctgttttgaagctcgataatactgtggttggccaaactagctggaaacccatttccaatcagtcatgggaccagaagtttacactggaactggacaggtcacgtgaactggaaatttcagtttattggcgtgattggcggtctctgtgtgctgtaaaatttctgaggttagaagattttttagacaaccaacggcatggcatgtgtctctatttggaaccacagggtactttatttgcagaggttaccttttttaatccagttattgaaagaagaccaaaacttcaaagacaaaagaaaattttttcaaagcaacaaggcaaaacatttctcagagctcctcaaatgaatattaatattgccacttggggaaggctagtaagaagagctattcctacagtaaatcattctggcaccttcagccctcaagctcctgtgcctactacagtgccagtggttgatgtacgcatccctcaactagcacctccagctagtgattctacagtaaccaaattggactttgatcttgagcctgaacctcctccagccccaccacgagcttcttctcttggagaaatagatgaatcttctgaattaagagttttggatataccaggacaggattcagagactgtttttgatattcagaatgacagaaatagtatacttccaaaatctcaatctgaatacaagcctgatactcctcagtcaggcctagaatatagtggtattcaagaacttgaggacagaagatctcagcaaaggtttcagtttaatctacaagatttcaggtgttgtgctgtcttgggaagaggacattttggaaaggtgcttttagctgaatataaaaacacaaatgagatgtttgctataaaagccttaaagaaaggagatattgtggctcgagatgaagtagacagcctgatgtgtgaaaaaagaatttttgaaactgtgaatagtgtaaggcatccctttttggtgaacctttttgcatgtttccaaaccaaagagcatgtttgctttgtaatggaatatgctgccggtggggacctaatgatgcacattcatactgatgtcttttctgaaccaagagctgtattttatgctgcttgtgtagttcttgggttgcagtatttacatgaacacaaaattgtttatagagatttgaaattggataacttattgctagatacagagggctttgtgaaaattgctgattttggtctttgcaaagaaggaatgggatatggagatagaacaagcacattttgtggcactcctgaatttcttgccccagaagtattaacagaaacttcttatacaagggctgtagattggtggggccttggcgtgcttatatatgaaatgcttgttggtgagtctccctttcctggtgatgatgaagaggaagtttttgacagtattgtaaatgatgaagtaaggtatccaaggttcttatctacagaagccatttctataatgagaaggctgttaagaagaaatcctgaacggcgccttggggctagcgagaaagatgcagaggatgtaaaaaagcacccatttttccggctaattgattggagcgctctgatggacaaaaaagtaaagccaccatttatacctaccataagaggacgagaagatgttagtaattttgatgatgaatttacctcagaagcacctattctgactccacctcgagaaccaaggatactttcggaagaggagcaggaaatgttcagagattttgactacattgctgattggtgttaagttgctagacactgcgaaaccaagctgactcacaagaagacctcttaaaaatagcaacccttcatttgctctctgtgccaccaatagcttctgagttttttgttgttgttgtttttattgaaacacgtgaagatttgtttaaaagtaccattctaatacttcttcaaaagtggctcctcattgtacttcagcgtaaatatgagcactggaaacagtttcatggagtttaagttgagtgaacatcggccatgaaaatccatcacgaatacttttggatcaatagtctatttttaaaaagaaagaaaaaaaccacttttttatagtccctagctttgccatatgcccgccttaagtggaaggaaagttaatcacttaactatgttttataaaaagaaaaaagggcttggaatgctattactgttcacacaaagtatgattctgtttgaataaggcaaatgctcctttttttaaaaaaaaagacattactgtaatatcaaaaaccgtggcagtttgtatacaactcggggcttgattttttttaaaaaaacagaatgaattgatgtcttattttataaatgttctatatttattaggagaaaactttatattgccttttttatcaatcatgtaacaggcttatagctttccaacagagctgcttgccaaacaattttttttgtttattaaacagtgctgaaacaaacaggatcagcatttacttaagatgttaagaatgaggacttttaatcagccgaaccaagatattgttacctgtatgcattcccaaagtctagatgctcagtatgttcagtcatatctttcagaatcagtgaaccgattaccctttttttggtattcactctacatctgccaacctagttcaccttggttttgtgtctgctgtagaagggaaccataacttggttaaaccgtagggattatcattgtatacatgctgtgaacatgtatatgtgcaagttttaatgtattctatgttgtaggcttattatttaattttaccacttcatcacttttgtacagtggccaagcagacacctcaaactccagcatttacattaagtgcatttgtacattttaggccactggatccagattttatattggcagttattgagggcaaaagcaatatattgtaacagaatgtataaatatttttgataaaacagtctatattttattaaaaaatgaattataacactaaagctgtacctcaaaagtctcaaaaataatttgatgaaatattttatacaactcttcaaaggatccgtctgtggctttttatactcttttagggttgtctttttacaaaccatgactttccacttgcctgtagttttttgtttgttttggtttggtttgattttatatttttttctcctaatctatgactttattgttttttcttagtttagtaatagcatctttgatcctgtgcttagcatgttagggtcattatacctcaggaatagcaagctgttaagtaaccatactgaattaactatttaattacagtgagctcatctcttaaaaattgttcaggtgtaaatcttatgagaaacatgaaaaagcacactgatttatggagagttgagctaaaaacatttataaatatttgctgggatgttttagcatcttttcattgtactctgagaacaattaaaattgtccagagatcatttatattaccttccaaattgtttattacccaagatcctttgggagaaaatcttatagaatgggggaacaatatgtggtttaaagttattttaaaatgccagttaatttcctcggcaaaggacaatagaggaacttagcttaattgtctggctttaatttaaactgtgttaatacaacattaaaataaaacactaaatacttttgaggtacagtctgctcacttttttggttctcaaatagcaaagaaagtaatgtctaaaataggctcttagcattaaaaactgacagcatttcgtaactacacagtgtacagaatttttttttaattgaagtcaatcactaaaaaaattagaaggcagggtctatttacacaattaagctgaagaaagcactaattttttgtagtttaaaatatatatatattttagtcagatttaaaattttaagctttatagagtgtaaatatattttgctattactgtatgtgtatgtgactgctcaagcactttgtaaagaaattaggatattttagaatggtacactatgcattcaaatgaaatgtgcctttcactatgtcattctaagaaaacaagtgttttttgcagtcataaattatcacaaatgcacaaattaaagtctatatagattgaaatttgtaactttggttttaagtattctttccttttagaaacttcctaatgattaaaatatactttaacttttctgtgttcaaaatctcaaagactaattaactttaataaacattcttgcaagtactttttgtcctagtgaaggcttaaaaccatgaacattcagagcaaactgtccacttcattgggaataatgggaaaagtttgtattctgctcctgtaaggtcagtagcatcttttatttgaagcatatttatggactgcttactgtgtatagatactgagaataggaagtttttttttttaaagcaacaaaatgttgatgaatgaagaacagcctgttttaattaagatgcaagcaccagtattgtatgtacttttctcttgtttgaggttagcttattttaatttaggacctggcttctcaaaaaggcaaatgaataaaacagaatactagta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5586 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
            GeneID:5586 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:5586 -> Molecular function: GO:0004697 [protein kinase C activity] evidence: IEA
            GeneID:5586 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5586 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5586 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IDA
            GeneID:5586 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5586 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:5586 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:5586 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5586 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:5586 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:5586 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
            GeneID:5586 -> Biological process: GO:0010631 [epithelial cell migration] evidence: IDA
            GeneID:5586 -> Biological process: GO:0032467 [positive regulation of cytokinesis] evidence: IMP
            GeneID:5586 -> Biological process: GO:0043297 [apical junction assembly] evidence: IMP
            GeneID:5586 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IMP
            GeneID:5586 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:5586 -> Biological process: GO:2000145 [regulation of cell motility] evidence: IMP
            GeneID:5586 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5586 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5586 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
            GeneID:5586 -> Cellular component: GO:0016020 [membrane] evidence: IEA
            GeneID:5586 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
            GeneID:5586 -> Cellular component: GO:0030496 [midbody] evidence: IDA
            GeneID:5586 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IDA
            GeneID:5586 -> Cellular component: GO:0043296 [apical junction complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_006247 -> EC 2.7.11.13

by @meso_cacase at DBCLS
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