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2024-05-02 07:06:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006254 2850 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens protein kinase C, delta (PRKCD), transcript variant 1,
mRNA.
ACCESSION NM_006254
VERSION NM_006254.3 GI:47157323
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2850)
AUTHORS Gentilin,E., Tagliati,F., Filieri,C., Mole,D., Minoia,M., Rosaria
Ambrosio,M., Degli Uberti,E.C. and Zatelli,M.C.
TITLE miR-26a plays an important role in cell cycle regulation in
ACTH-secreting pituitary adenomas by modulating protein kinase
Cdelta
JOURNAL Endocrinology 154 (5), 1690-1700 (2013)
PUBMED 23525216
REMARK GeneRIF: miR-26a and related pathways, such as PRKCD, play an
important role in cell cycle control of ACTH pituitary cells,
opening new therapeutic possibilities for the treatment of
persistent/recurrent Cushing's disease.
REFERENCE 2 (bases 1 to 2850)
AUTHORS Kuehn,H.S., Niemela,J.E., Rangel-Santos,A., Zhang,M., Pittaluga,S.,
Stoddard,J.L., Hussey,A.A., Evbuomwan,M.O., Priel,D.A., Kuhns,D.B.,
Park,C.L., Fleisher,T.A., Uzel,G. and Oliveira,J.B.
TITLE Loss-of-function of the protein kinase C delta (PKCdelta) causes a
B-cell lymphoproliferative syndrome in humans
JOURNAL Blood 121 (16), 3117-3125 (2013)
PUBMED 23430113
REMARK GeneRIF: Homozygous PRKCD mutation results in B-cell
hyperproliferation and defective apoptosis with consequent
lymphocyte accumulation and autoantibody production in humans, and
disrupts natural killer cell function.
REFERENCE 3 (bases 1 to 2850)
AUTHORS Wu,Z.X., Zhao,M., Xia,L., Yu,Y., Shen,S.M., Han,S.F., Li,H.,
Wang,T.D., Chen,G.Q. and Wang,L.S.
TITLE PKCdelta enhances C/EBPalpha degradation via inducing its
phosphorylation and cytoplasmic translocation
JOURNAL Biochem. Biophys. Res. Commun. 433 (2), 220-225 (2013)
PUBMED 23473759
REMARK GeneRIF: activated PKCdelta induce phosphorylation of C/EBPalpha,
which led to cytoplasmic translocation, inactivation and
degradation of C/EBPalpha
REFERENCE 4 (bases 1 to 2850)
AUTHORS Byrne,G., Freeley,M., Feighery,C., Whelan,A. and Long,A.
TITLE Protein kinase C delta is a substrate of tissue transglutaminase
and a novel autoantigen in coeliac disease
JOURNAL Clin. Immunol. 147 (1), 1-8 (2013)
PUBMED 23454274
REMARK GeneRIF: Data suggest that a subset of patients with coeliac
disease produce autoantibodies against PKCdelta and that this
response may stem from a tTG-PKCdelta substrate interaction.
REFERENCE 5 (bases 1 to 2850)
AUTHORS Larroque-Cardoso,P., Swiader,A., Ingueneau,C., Negre-Salvayre,A.,
Elbaz,M., Reyland,M.E., Salvayre,R. and Vindis,C.
TITLE Role of protein kinase C delta in ER stress and apoptosis induced
by oxidized LDL in human vascular smooth muscle cells
JOURNAL Cell Death Dis 4, E520 (2013)
PUBMED 23449456
REMARK GeneRIF: PKC delta activation mediated by oxLDL through reactive
oxygen species production and that PKC delta plays a crucial role
in the regulation of oxLDLinduced apoptosis mainly through the
IRE1a/JNK pathway of ER stress.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2850)
AUTHORS Kasahara,K., Chida,K., Tsunenaga,M., Kohno,Y., Ikuta,T. and
Kuroki,T.
TITLE Identification of lamin B2 as a substrate of protein kinase C in
BALB/MK-2 mouse keratinocytes
JOURNAL J. Biol. Chem. 266 (30), 20018-20023 (1991)
PUBMED 1939065
REFERENCE 7 (bases 1 to 2850)
AUTHORS Mellor,H. and Proud,C.G.
TITLE A synthetic peptide substrate for initiation factor-2 kinases
JOURNAL Biochem. Biophys. Res. Commun. 178 (2), 430-437 (1991)
PUBMED 1677563
REFERENCE 8 (bases 1 to 2850)
AUTHORS Bouvier,M., Guilbault,N. and Bonin,H.
TITLE Phorbol-ester-induced phosphorylation of the beta 2-adrenergic
receptor decreases its coupling to Gs
JOURNAL FEBS Lett. 279 (2), 243-248 (1991)
PUBMED 1848190
REFERENCE 9 (bases 1 to 2850)
AUTHORS Fackler,M.J., Civin,C.I., Sutherland,D.R., Baker,M.A. and May,W.S.
TITLE Activated protein kinase C directly phosphorylates the CD34 antigen
on hematopoietic cells
JOURNAL J. Biol. Chem. 265 (19), 11056-11061 (1990)
PUBMED 1694174
REFERENCE 10 (bases 1 to 2850)
AUTHORS Jakobovits,A., Rosenthal,A. and Capon,D.J.
TITLE Trans-activation of HIV-1 LTR-directed gene expression by tat
requires protein kinase C
JOURNAL EMBO J. 9 (4), 1165-1170 (1990)
PUBMED 2182321
REMARK Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC043350.1, L07861.1,
BE048101.1, CD369320.1 and AW293041.1.
On May 13, 2004 this sequence version replaced gi:31377781.
Summary: Protein kinase C (PKC) is a family of serine- and
threonine-specific protein kinases that can be activated by calcium
and the second messenger diacylglycerol. PKC family members
phosphorylate a wide variety of protein targets and are known to be
involved in diverse cellular signaling pathways. PKC family members
also serve as major receptors for phorbol esters, a class of tumor
promoters. Each member of the PKC family has a specific expression
profile and is believed to play distinct roles in cells. The
protein encoded by this gene is one of the PKC family members.
Studies both in human and mice demonstrate that this kinase is
involved in B cell signaling and in the regulation of growth,
apoptosis, and differentiation of a variety of cell types.
Alternatively spliced transcript variants encoding the same protein
have been observed. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. Both variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC043350.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-532 BC043350.1 20-551
533-1793 L07861.1 238-1498
1794-2185 BE048101.1 154-545
2186-2209 L07861.1 1891-1914
2210-2235 BE048101.1 570-595
2236-2770 CD369320.1 1-535 c
2771-2850 AW293041.1 1-80 c
FEATURES Location/Qualifiers
source 1..2850
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.31"
gene 1..2850
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="protein kinase C, delta"
/db_xref="GeneID:5580"
/db_xref="HGNC:9399"
/db_xref="MIM:176977"
exon 1..222
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
exon 223..334
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 273
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:75666392"
variation 274
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:80287513"
misc_feature 306..308
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="upstream in-frame stop codon"
exon 335..468
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
CDS 354..2384
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/EC_number="2.7.10.2"
/EC_number="2.7.11.13"
/note="protein kinase C delta VIII; tyrosine-protein
kinase PRKCD"
/codon_start=1
/product="protein kinase C delta type"
/protein_id="NP_006245.2"
/db_xref="GI:31377782"
/db_xref="CCDS:CCDS2870.1"
/db_xref="GeneID:5580"
/db_xref="HGNC:9399"
/db_xref="MIM:176977"
/translation="
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
"
misc_feature 495..497
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphotyrosine-containing
peptide; propagated from UniProtKB/Swiss-Prot (Q05655.2);
other site"
misc_feature 507..509
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01301"
misc_feature 537..539
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphotyrosine-containing
peptide; propagated from UniProtKB/Swiss-Prot (Q05655.2);
other site"
misc_feature 543..545
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01301"
misc_feature 552..554
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphotyrosine-containing
peptide; propagated from UniProtKB/Swiss-Prot (Q05655.2);
other site"
misc_feature 720..722
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphotyrosine-containing
peptide; propagated from UniProtKB/Swiss-Prot (Q05655.2);
other site"
misc_feature 741..743
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 816..818
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 816..818
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01301"
misc_feature 828..977
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="Protein kinase C conserved region 1 (C1) .
Cysteine-rich zinc binding domain. Some members of this
domain family bind phorbol esters and diacylglycerol, some
are reported to bind RasGTP. May occur in tandem
arrangement. Diacylglycerol (DAG) is a second...; Region:
C1; cd00029"
/db_xref="CDD:28911"
misc_feature order(828..830,867..869,876..878,918..920,927..929,
942..944,951..953,975..977)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="zinc binding sites [ion binding]; other site"
/db_xref="CDD:28911"
misc_feature order(849..851,858..863,888..908)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="putative DAG/PE binding site; other site"
/db_xref="CDD:28911"
misc_feature order(858..860,864..866)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="putative RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:28911"
misc_feature 912..914
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01301"
misc_feature 1005..1007
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1044..1193
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="Protein kinase C conserved region 1 (C1) .
Cysteine-rich zinc binding domain. Some members of this
domain family bind phorbol esters and diacylglycerol, some
are reported to bind RasGTP. May occur in tandem
arrangement. Diacylglycerol (DAG) is a second...; Region:
C1; cd00029"
/db_xref="CDD:28911"
misc_feature order(1044..1046,1083..1085,1092..1094,1134..1136,
1143..1145,1158..1160,1167..1169,1191..1193)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="zinc binding sites [ion binding]; other site"
/db_xref="CDD:28911"
misc_feature order(1065..1067,1074..1079,1104..1124)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="putative DAG/PE binding site; other site"
/db_xref="CDD:28911"
misc_feature order(1074..1076,1080..1082)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="putative RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:28911"
misc_feature 1248..1250
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1257..1259
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1263..1265
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1272..1274
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 1290..1292
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1290..1292
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01080"
misc_feature 1338..1343
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage, by caspase-3 (By similarity); propagated
from UniProtKB/Swiss-Prot (Q05655.2); cleavage site"
misc_feature 1353..1355
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01080"
misc_feature 1398..2162
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 1410..2357
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Novel Protein Kinase C delta; Region:
STKc_nPKC_delta; cd05620"
/db_xref="CDD:173710"
misc_feature order(1416..1430,1440..1442,1479..1481,1485..1487,
1584..1586,1632..1637,1641..1643,1653..1655,1659..1661,
1770..1772,1776..1778,1782..1787,1791..1793,1821..1826,
1833..1835,1875..1892,1971..1973,1989..1991,1998..2000)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="active site"
/db_xref="CDD:173710"
misc_feature order(1416..1427,1440..1442,1479..1481,1485..1487,
1542..1544,1632..1643,1650..1655,1782..1787,1791..1793,
1821..1826)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173710"
misc_feature order(1428..1430,1653..1655,1659..1661,1770..1772,
1776..1778,1782..1784,1833..1835,1875..1892,1971..1973,
1989..1991,1998..2000)
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173710"
misc_feature 1473..1475
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 1473..1475
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1821..1892
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173710"
misc_feature 1860..1862
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 1872..1874
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:08912"
misc_feature 1872..1874
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:15942"
misc_feature 1872..1874
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:16199"
misc_feature 1872..1874
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
misc_feature 1872..1874
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1893..1895
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01080"
misc_feature 2052..2054
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q05655.2); phosphorylation site"
misc_feature 2052..2054
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01301"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:08912"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:15942"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:16199"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01501"
misc_feature 2286..2288
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2313..2315
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 2325..2327
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 2331..2348
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173710"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:08912"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:15942"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:16199"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q05655.2); phosphorylation site"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01504"
misc_feature 2343..2345
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 360
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:76625562"
variation 374
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:373946656"
variation 375
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:368029897"
variation 397
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="g"
/db_xref="dbSNP:369358922"
variation 410
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:377115507"
variation 416
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:369037399"
variation 421
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:144572650"
variation 458
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:141615361"
exon 469..668
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 472
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:376358631"
variation 490
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:79959723"
variation 527
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:55719519"
variation 530
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:369306770"
variation 533
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230493"
variation 536
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:145203229"
variation 545
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:373034483"
variation 554
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:188610371"
variation 559
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:112659981"
variation 567
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="g"
/db_xref="dbSNP:151061939"
variation 624
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="g"
/db_xref="dbSNP:79725471"
exon 669..729
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 701
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:374573652"
variation 714
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:377558890"
variation 725
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:148137939"
variation 726
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:370069134"
variation 727
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:376476959"
exon 730..892
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 740
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:1135095"
variation 742
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:79252610"
variation 747
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:375221270"
variation 748
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200939049"
variation 758
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:200462015"
variation 770
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:56208295"
variation 799
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:74793932"
variation 811
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:370103982"
variation 833
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:371324177"
variation 845
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:187146419"
exon 893..924
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 920
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:150667829"
exon 925..1010
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 950
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:74558112"
variation 956
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:75794462"
variation 957
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:149165175"
variation 983
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:151199013"
variation 986
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:372745352"
variation 987
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:375512516"
variation 989
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200410934"
exon 1011..1140
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1016
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:137874318"
variation 1031
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:78938657"
variation 1043
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:55865871"
variation 1054
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:140841846"
variation 1068
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:369236318"
variation 1094
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:55709737"
variation 1095
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:144320413"
variation 1097
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:147545646"
exon 1141..1241
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1146
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:373245386"
variation 1171
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:377512214"
variation 1193
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:145324216"
variation 1199
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:372028715"
variation 1223
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:370808161"
exon 1242..1338
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1252
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:143488209"
variation 1268
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:201862364"
variation 1292
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:368866073"
variation 1301
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:138049008"
variation 1302
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:55929201"
variation 1313
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:143202454"
variation 1314
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:372047510"
exon 1339..1439
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1340
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:373073065"
variation 1344
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:140359417"
variation 1348
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:377377410"
variation 1354
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:34297342"
variation 1379
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:199752526"
variation 1396
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:33911937"
variation 1397
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:59688439"
variation 1434
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:369078144"
exon 1440..1613
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1472
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2230494"
variation 1477
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1056998"
variation 1509
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:374287889"
variation 1559
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:74485893"
variation 1565
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:200149825"
variation 1566
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:150331740"
variation 1581
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:34502209"
variation 1597
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:35181307"
exon 1614..1705
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1630
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="t"
/db_xref="dbSNP:372295257"
variation 1646
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:377107086"
variation 1652
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200890839"
variation 1683
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:372673092"
variation 1695
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="t"
/db_xref="dbSNP:141979341"
exon 1706..1768
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1715
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:41295962"
variation 1763
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:201154167"
exon 1769..1907
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1794
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:2306574"
variation 1800
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:35891605"
variation 1853
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:149751382"
variation 1900
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="c"
/db_xref="dbSNP:34971355"
variation 1904
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:148833677"
exon 1908..2096
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 1955
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:79490732"
variation 1970
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:375360762"
variation 2024
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:147601598"
variation 2044
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:146289210"
variation 2058
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:141992569"
variation 2059
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:138712106"
exon 2097..2225
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 2123
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:77870723"
variation 2134
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:146302697"
variation 2135
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="g"
/db_xref="dbSNP:1075865"
variation 2197
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="g"
/replace="t"
/db_xref="dbSNP:74838104"
variation 2199
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="t"
/db_xref="dbSNP:66776335"
variation 2210
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:900495"
variation 2215
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="g"
/db_xref="dbSNP:34738769"
variation 2223
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:79000840"
exon 2226..2835
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/inference="alignment:Splign:1.39.8"
variation 2234
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:199634315"
variation 2279
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:56338517"
variation 2281
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:369041593"
variation 2287
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:142844487"
variation 2309
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:147565728"
variation 2333
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230497"
variation 2334
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:149202171"
variation 2355
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:148364495"
variation 2406
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="g"
/db_xref="dbSNP:372770730"
variation 2428
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="t"
/db_xref="dbSNP:115951896"
STS 2440..2607
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/standard_name="D2S2845"
/db_xref="UniSTS:9640"
variation 2522
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="c"
/replace="t"
/db_xref="dbSNP:59159087"
STS 2566..2727
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/standard_name="RH12466"
/db_xref="UniSTS:22662"
variation 2657..2658
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="at"
/db_xref="dbSNP:35020629"
variation 2658..2659
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="ta"
/db_xref="dbSNP:10600423"
STS 2676..2829
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/standard_name="A007D36"
/db_xref="UniSTS:36319"
variation 2755..2757
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/db_xref="dbSNP:370040136"
variation 2755
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace="a"
/replace="c"
/db_xref="dbSNP:201812873"
variation 2756..2757
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/replace="aaa"
/db_xref="dbSNP:72190282"
variation 2761..2762
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:67526185"
variation 2762..2763
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/db_xref="dbSNP:377467643"
variation 2765..2766
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/db_xref="dbSNP:376355691"
variation 2771..2772
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
/replace=""
/replace="a"
/db_xref="dbSNP:66942248"
polyA_signal 2814..2819
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
polyA_site 2835
/gene="PRKCD"
/gene_synonym="MAY1; nPKC-delta; PKCD"
ORIGIN
tcgcacttccgtgtgccgcggcgccggagcccgaggcggctgtagcccacatctcccgagcgacccccggcgcccgcccgccgcgcggaggcccgggccacacctcactggccgcttggcccatcccagtcagcgccgcgccgaaccccgtccgcgcgcgccggggagcggcgcccccgccgctgccgccgcgacccttggcgcctgcccctgcaacgggaggtctgcagggaactggccaggcaagggggcaggcccgtttctcctggtggttggtgcgttgtagcagcagcgggagccaggactaaggacaagcaggagctgggagccccagccccactgcaggccccaccatggcgccgttcctgcgcatcgccttcaactcctatgagctgggctccctgcaggccgaggacgaggcgaaccagcccttctgtgccgtgaagatgaaggaggcgctcagcacagagcgtgggaaaacactggtgcagaagaagccgaccatgtatcctgagtggaagtcgacgttcgatgcccacatctatgaggggcgcgtcatccagattgtgctaatgcgggcagcagaggagccagtgtctgaggtgaccgtgggtgtgtcggtgctggccgagcgctgcaagaagaacaatggcaaggctgagttctggctggacctgcagcctcaggccaaggtgttgatgtctgttcagtatttcctggaggacgtggattgcaaacagtctatgcgcagtgaggacgaggccaagttcccaacgatgaaccgccgcggagccatcaaacaggccaaaatccactacatcaagaaccatgagtttatcgccaccttctttgggcaacccaccttctgttctgtgtgcaaagactttgtctggggcctcaacaagcaaggctacaaatgcaggcaatgtaacgctgccatccacaagaaatgcatcgacaagatcatcggcagatgcactggcaccgcggccaacagccgggacactatattccagaaagaacgcttcaacatcgacatgccgcaccgcttcaaggttcacaactacatgagccccaccttctgtgaccactgcggcagcctgctctggggactggtgaagcagggattaaagtgtgaagactgcggcatgaatgtgcaccataaatgccgggagaaggtggccaacctctgcggcatcaaccagaagcttttggctgaggccttgaaccaagtcacccagagagcctcccggagatcagactcagcctcctcagagcctgttgggatatatcagggtttcgagaagaagaccggagttgctggggaggacatgcaagacaacagtgggacctacggcaagatctgggagggcagcagcaagtgcaacatcaacaacttcatcttccacaaggtcctgggcaaaggcagcttcgggaaggtgctgcttggagagctgaagggcagaggagagtactttgccatcaaggccctcaagaaggatgtggtcctgatcgacgacgacgtggagtgcaccatggttgagaagcgggtgctgacacttgccgcagagaatccctttctcacccacctcatctgcaccttccagaccaaggaccacctgttctttgtgatggagttcctcaacgggggggacctgatgtaccacatccaggacaaaggccgctttgaactctaccgtgccacgttttatgccgctgagataatgtgtggactgcagtttctacacagcaagggcatcatttacagggacctcaaactggacaatgtgctgctggaccgggatggccacatcaagattgccgactttgggatgtgcaaagagaacatattcggggagagccgggccagcaccttctgcggcacccctgactatatcgcccctgagatcctacagggcctgaagtacacattctctgtggactggtggtctttcggggtccttctgtacgagatgctcattggccagtcccccttccatggtgatgatgaggatgaactcttcgagtccatccgtgtggacacgccacattatccccgctggatcaccaaggagtccaaggacatcctggagaagctctttgaaagggaaccaaccaagaggctgggagtgaccggaaacatcaaaatccaccccttcttcaagaccataaactggactctgctggaaaagcggaggttggagccacctttcaggcccaaagtgaagtcacccagagactacagtaactttgaccaggagttcctgaacgagaaggcgcgcctctcctacagcgacaagaacctcatcgactccatggaccagtctgcattcgctggcttctcctttgtgaaccccaaattcgagcacctcctggaagattgaggttcctggacagatcaggctagccctgccctccacccacacctgcccgctccccacgataagcaccagtgggactgtggtgacttctgctgctggccccgcccctgcccccagagcgtccttggctgccgtctggccgggctctcatggtacttcctctgtgaactgtgtgtgaatctgcttttcctctgccttcggagggaaattgtaaatcctgtgtttcattacttgaatgtagttatctattgaaaatatatattatatacatagacatatatatatatataataggctgtatatattgctcagtagagaaaaaccatgggggactggtgatatgttgatctttttcaaaaaaatatatatatgacaaaaaaaaaaaaaaaggagcacaagctgtttgaaccaccaggtttatttgtgtgtctaaataaacaccaaatagtaccaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5580 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5580 -> Molecular function: GO:0004697 [protein kinase C activity] evidence: ISS
GeneID:5580 -> Molecular function: GO:0004699 [calcium-independent protein kinase C activity] evidence: TAS
GeneID:5580 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IEA
GeneID:5580 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5580 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5580 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IPI
GeneID:5580 -> Molecular function: GO:0008047 [enzyme activator activity] evidence: IDA
GeneID:5580 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:5580 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:5580 -> Molecular function: GO:0043560 [insulin receptor substrate binding] evidence: ISS
GeneID:5580 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5580 -> Molecular function: GO:0070976 [TIR domain binding] evidence: IEA
GeneID:5580 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:5580 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:5580 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:5580 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5580 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:5580 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:5580 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:5580 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:5580 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS
GeneID:5580 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5580 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0009408 [response to heat] evidence: IEA
GeneID:5580 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA
GeneID:5580 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
GeneID:5580 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5580 -> Biological process: GO:0010469 [regulation of receptor activity] evidence: TAS
GeneID:5580 -> Biological process: GO:0014070 [response to organic cyclic compound] evidence: IEA
GeneID:5580 -> Biological process: GO:0015810 [aspartate transport] evidence: IEA
GeneID:5580 -> Biological process: GO:0016064 [immunoglobulin mediated immune response] evidence: IEA
GeneID:5580 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5580 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5580 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:5580 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0023021 [termination of signal transduction] evidence: IMP
GeneID:5580 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5580 -> Biological process: GO:0030837 [negative regulation of actin filament polymerization] evidence: ISS
GeneID:5580 -> Biological process: GO:0032091 [negative regulation of protein binding] evidence: TAS
GeneID:5580 -> Biological process: GO:0032613 [interleukin-10 production] evidence: IEA
GeneID:5580 -> Biological process: GO:0032615 [interleukin-12 production] evidence: IEA
GeneID:5580 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IEA
GeneID:5580 -> Biological process: GO:0032930 [positive regulation of superoxide anion generation] evidence: IMP
GeneID:5580 -> Biological process: GO:0032963 [collagen metabolic process] evidence: IEA
GeneID:5580 -> Biological process: GO:0034351 [negative regulation of glial cell apoptotic process] evidence: IMP
GeneID:5580 -> Biological process: GO:0035307 [positive regulation of protein dephosphorylation] evidence: IMP
GeneID:5580 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
GeneID:5580 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
GeneID:5580 -> Biological process: GO:0042100 [B cell proliferation] evidence: IEA
GeneID:5580 -> Biological process: GO:0042119 [neutrophil activation] evidence: IDA
GeneID:5580 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IEA
GeneID:5580 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:5580 -> Biological process: GO:0042542 [response to hydrogen peroxide] evidence: IEA
GeneID:5580 -> Biological process: GO:0042742 [defense response to bacterium] evidence: ISS
GeneID:5580 -> Biological process: GO:0043200 [response to amino acid stimulus] evidence: IEA
GeneID:5580 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IEA
GeneID:5580 -> Biological process: GO:0043407 [negative regulation of MAP kinase activity] evidence: IMP
GeneID:5580 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5580 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:5580 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IEA
GeneID:5580 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: ISS
GeneID:5580 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IEA
GeneID:5580 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: IC
GeneID:5580 -> Biological process: GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] evidence: ISS
GeneID:5580 -> Biological process: GO:0050821 [protein stabilization] evidence: NAS
GeneID:5580 -> Biological process: GO:0051490 [negative regulation of filopodium assembly] evidence: ISS
GeneID:5580 -> Biological process: GO:0060333 [interferon-gamma-mediated signaling pathway] evidence: TAS
GeneID:5580 -> Biological process: GO:0090331 [negative regulation of platelet aggregation] evidence: ISS
GeneID:5580 -> Biological process: GO:0090398 [cellular senescence] evidence: IMP
GeneID:5580 -> Biological process: GO:1900163 [positive regulation of phospholipid scramblase activity] evidence: IMP
GeneID:5580 -> Biological process: GO:2000304 [positive regulation of ceramide biosynthetic process] evidence: IMP
GeneID:5580 -> Biological process: GO:2000753 [positive regulation of glucosylceramide catabolic process] evidence: IMP
GeneID:5580 -> Biological process: GO:2000755 [positive regulation of sphingomyelin catabolic process] evidence: IMP
GeneID:5580 -> Biological process: GO:2001022 [positive regulation of response to DNA damage stimulus] evidence: IMP
GeneID:5580 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5580 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5580 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5580 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:5580 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:5580 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:5580 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5580 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:5580 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5580 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IEA
GeneID:5580 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
GeneID:5580 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_006245 -> EC 2.7.10.2
NP_006245 -> EC 2.7.11.13
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.