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2019-03-22 05:04:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006244               2766 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens protein phosphatase 2, regulatory subunit B', beta
            (PPP2R5B), mRNA.
ACCESSION   NM_006244
VERSION     NM_006244.3  GI:295148153
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2766)
  AUTHORS   Oberg,E.A., Nifoussi,S.K., Gingras,A.C. and Strack,S.
  TITLE     Selective proteasomal degradation of the B'beta subunit of protein
            phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15
  JOURNAL   J. Biol. Chem. 287 (52), 43378-43389 (2012)
   PUBMED   23135275
  REMARK    GeneRIF: KLHL15 can interact with the PP2A/B'beta heterotrimer, it
            only degrades B'beta, thus promoting exchange with other regulatory
            subunits.
REFERENCE   2  (bases 1 to 2766)
  AUTHORS   Brandt,N., Franke,K., Johannes,S., Buck,F., Harder,S., Hassel,B.,
            Nitsch,R. and Schumacher,S.
  TITLE     B56beta, a regulatory subunit of protein phosphatase 2A, interacts
            with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching
  JOURNAL   FASEB J. 22 (7), 2521-2533 (2008)
   PUBMED   18385213
REFERENCE   3  (bases 1 to 2766)
  AUTHORS   Letourneux,C., Rocher,G. and Porteu,F.
  TITLE     B56-containing PP2A dephosphorylate ERK and their activity is
            controlled by the early gene IEX-1 and ERK
  JOURNAL   EMBO J. 25 (4), 727-738 (2006)
   PUBMED   16456541
REFERENCE   4  (bases 1 to 2766)
  AUTHORS   Nakada,N., Kuroda,K. and Kawahara,E.
  TITLE     Protein phosphatase 2A regulatory subunit Bbeta promotes MAP
            kinase-mediated migration of A431 cells
  JOURNAL   Cell. Physiol. Biochem. 15 (1-4), 19-28 (2005)
   PUBMED   15665512
  REMARK    GeneRIF: PP2A-Bbeta promotes cell migration through the MAPK
            cascade.
REFERENCE   5  (bases 1 to 2766)
  AUTHORS   Dozier,C., Bonyadi,M., Baricault,L., Tonasso,L. and Darbon,J.M.
  TITLE     Regulation of Chk2 phosphorylation by interaction with protein
            phosphatase 2A via its B' regulatory subunit
  JOURNAL   Biol. Cell 96 (7), 509-517 (2004)
   PUBMED   15380617
REFERENCE   6  (bases 1 to 2766)
  AUTHORS   McCright,B., Rivers,A.M., Audlin,S. and Virshup,D.M.
  TITLE     The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
            encodes differentiation-induced phosphoproteins that target PP2A to
            both nucleus and cytoplasm
  JOURNAL   J. Biol. Chem. 271 (36), 22081-22089 (1996)
   PUBMED   8703017
REFERENCE   7  (bases 1 to 2766)
  AUTHORS   McCright,B., Brothman,A.R. and Virshup,D.M.
  TITLE     Assignment of human protein phosphatase 2A regulatory subunit genes
            b56alpha, b56beta, b56gamma, b56delta, and b56epsilon
            (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to
            chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12
  JOURNAL   Genomics 36 (1), 168-170 (1996)
   PUBMED   8812429
REFERENCE   8  (bases 1 to 2766)
  AUTHORS   Zolnierowicz,S., Van Hoof,C., Andjelkovic,N., Cron,P., Stevens,I.,
            Merlevede,W., Goris,J. and Hemmings,B.A.
  TITLE     The variable subunit associated with protein phosphatase 2A0
            defines a novel multimember family of regulatory subunits
  JOURNAL   Biochem. J. 317 (PT 1), 187-194 (1996)
   PUBMED   8694763
REFERENCE   9  (bases 1 to 2766)
  AUTHORS   McCright,B. and Virshup,D.M.
  TITLE     Identification of a new family of protein phosphatase 2A regulatory
            subunits
  JOURNAL   J. Biol. Chem. 270 (44), 26123-26128 (1995)
   PUBMED   7592815
REFERENCE   10 (bases 1 to 2766)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat. Genet. 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE883575.1, L42374.1,
            AP001187.5 and BM665417.1.
            On Apr 25, 2010 this sequence version replaced gi:30795206.
            
            Summary: The product of this gene belongs to the phosphatase 2A
            regulatory subunit B family. Protein phosphatase 2A is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes a beta isoform of the regulatory subunit B56 subfamily.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L42374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               BE883575.1         1-297
            298-2242            L42374.1           1-1945
            2243-2243           AP001187.5         139771-139771
            2244-2745           L42374.1           1947-2448
            2746-2766           BM665417.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2766
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2766
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /note="protein phosphatase 2, regulatory subunit B', beta"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:9310"
                     /db_xref="HPRD:09038"
                     /db_xref="MIM:601644"
     exon            1..358
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       3..4
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:371491676"
     variation       81
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372177928"
     variation       170
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:60798873"
     variation       211
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114383308"
     variation       214
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61024397"
     exon            359..821
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       408
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55943854"
     variation       432
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4930690"
     variation       441
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56163683"
     variation       488..489
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11404201"
     variation       489..490
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="a"
                     /replace="ggaa"
                     /db_xref="dbSNP:33981788"
     variation       502..505
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:369353409"
     variation       503
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:139876615"
     variation       512..513
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="cc"
                     /replace="gc"
                     /db_xref="dbSNP:56053333"
     variation       513..514
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:375310561"
     misc_feature    539..541
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /note="upstream in-frame stop codon"
     variation       590
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201468641"
     variation       596
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368858478"
     variation       617
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367971718"
     variation       619
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200592076"
     CDS             623..2116
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /note="serine/threonine protein phosphatase 2A, 56 kDa
                     regulatory subunit, beta isoform; protein phosphatase 2,
                     regulatory subunit B', beta isoform; PP2A B subunit
                     isoform B'-beta; PP2A B subunit isoform R5-beta; PP2A B
                     subunit isoform B56-beta; PP2A B subunit isoform
                     PR61-beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform"
                     /protein_id="NP_006235.1"
                     /db_xref="GI:5453952"
                     /db_xref="CCDS:CCDS8085.1"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:9310"
                     /db_xref="HPRD:09038"
                     /db_xref="MIM:601644"
                     /translation="
METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS
"
     misc_feature    680..682
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    815..1954
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); Region: B56; pfam01603"
                     /db_xref="CDD:190051"
     variation       641
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199949257"
     variation       655
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371904447"
     variation       657
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201904964"
     variation       673
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376524488"
     variation       749
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139878967"
     variation       750
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201162064"
     variation       763
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141617925"
     variation       805
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146202052"
     exon            822..1018
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       828
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375715449"
     variation       844
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200140478"
     variation       847
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140140368"
     variation       857
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201702050"
     variation       858
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142378216"
     variation       907
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150907158"
     variation       932..935
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace=""
                     /replace="cggg"
                     /db_xref="dbSNP:201085110"
     variation       952
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201191328"
     variation       965
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201218993"
     exon            1019..1120
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1048
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139405284"
     variation       1105
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117110422"
     exon            1121..1213
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1142
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147663616"
     variation       1143
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150933072"
     variation       1200
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200228197"
     exon            1214..1344
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     exon            1345..1404
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1360
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186585758"
     variation       1371
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142324941"
     exon            1405..1513
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1405
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144744216"
     variation       1410
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77695690"
     variation       1437
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147891521"
     variation       1460
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374703944"
     variation       1463
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148879767"
     STS             1479..1556
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="MARC_15219-15220:1012924404:3"
                     /db_xref="UniSTS:267789"
     variation       1501
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368200752"
     exon            1514..1567
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1518
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143547442"
     variation       1567
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139176991"
     exon            1568..1618
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1575
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375513129"
     variation       1579
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111449778"
     exon            1619..1738
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1619
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368393421"
     variation       1659
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371550514"
     variation       1696
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144621979"
     variation       1712
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138534603"
     variation       1713
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141499148"
     exon            1739..1866
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1791
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368921406"
     variation       1800
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75667682"
     exon            1867..1968
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1902
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369675898"
     variation       1909
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373704138"
     variation       1958
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201780164"
     exon            1969..2750
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /inference="alignment:Splign:1.39.8"
     variation       1975
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372785277"
     variation       1985
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146213589"
     variation       2030
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137914776"
     variation       2075
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192831260"
     variation       2095
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185359743"
     variation       2105
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368931364"
     variation       2159
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11558624"
     variation       2249
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142900024"
     variation       2395
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:67232843"
     STS             2432..2630
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="G33092"
                     /db_xref="UniSTS:80324"
     variation       2473
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151092418"
     STS             2510..2703
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="A002D23"
                     /db_xref="UniSTS:52097"
     STS             2510..2703
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="G19958"
                     /db_xref="UniSTS:52096"
     STS             2510..2669
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="RH11559"
                     /db_xref="UniSTS:31620"
     STS             2511..2692
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /standard_name="RH17836"
                     /db_xref="UniSTS:70958"
     variation       2549
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188478728"
     variation       2675
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111561429"
     variation       2696
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141065909"
     variation       2708
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192880468"
     polyA_signal    2729..2734
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
     polyA_site      2750
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; PR61B"
ORIGIN      
ggtggggggaggtgacttgatgtcatcctgagcagctgggcggcgggtgccggtgcgcacggagccgagccggggctcccgttgcgctgcaccgcgttgggtcggagtcccaggacttcagcggagatccgcgcgctgcgacggccggtgcagagcccgccgagcgcccagtcccggcccggggctgagttgggggcatgctctagccgcccccccggagcccgggagagaacccaggagcgccgccgcccagccccagcgccccgagcggaaccgctgcgaaggggccctgaacggccgtcgccctccctacgggcagcccccgggggttggcgaccgaagtctaggttttcgagaaagccagggtgggaaccctaactggactcttcgggacccccaggaaggatctgaggcctgagccatcctcctttctaccctgtctgccccccaggactgggcagttgcaggaggccctgggggggggcccaggactgtggttgtgccccccccccaaaggccggacaggatgggaccaagttagtctgtccagtctcacccagcacctcccaggcccagagagaacccccggggctctgaaagcttgccctgccgcctgaccgccatggagacgaagctgccccctgcaagcacccccactagcccctcctcccccgggctgtcgcctgtgcccccacccgacaaggtggacggcttctcccgccgttccctccgcagagcccggccccgccgctcccacagctcctctcagttccgctatcagagcaaccagcaagagctcacaccgctgcccctgctcaaagatgtgccggcttccgagctgcacgagctgctgagccggaagctggcccagtgtggggtgatgtttgacttcttggactgtgtggccgacctcaaggggaaggaggtgaagcgggcagccctcaacgagctggtggagtgtgtggggagcacccggggtgtcctcatcgagcccgtctacccagacatcatccgcatgatctcagtgaatatcttccggactctgccgcccagtgagaaccctgaatttgaccctgaagaggatgagcccaatcttgagccttcgtggccacacctgcagctggtatatgagtttttcctgcgtttcttggagagcccagacttccagccctccgtggccaagagatatgtggatcaaaagtttgtcctgatgctcctggagctatttgatagtgaggatccccgggagcgtgagtacctcaagaccatcctgcaccgggtctatggcaagttcctgggtctccgggcctacatccgcaaacagtgcaaccacatcttcctccggttcatctatgaattcgagcacttcaatggtgtggctgagctgctggagatcctaggaagcatcatcaatggctttgcgctgcccctgaagacggagcacaagcagttcctggttcgcgtcctgatccccctgcactctgtcaagtcgctgtctgtcttccatgcccagctggcatactgtgtggtgcagttcctggagaaggatgccactctgacagagcacgtgatccgggggctgctcaaatactggccaaaaacctgcacccagaaggaggtgatgtttctgggggagatggaagagattcttgatgtcatcgagccctcccagtttgtgaagatccaggagcccctttttaagcaggtggctcgctgtgtttccagcccccatttccaggttgcagagcgggctctgtatttctggaacaatgagtatatcctaagcctcattgaggacaactgccacactgtgctgcctgctgtgtttgggaccctctaccaagtctccaaggagcactggaaccaaaccatcgtatcactgatctacaatgtgctcaagaccttcatggagatgaatgggaagctgtttgatgagctcacagcctcctacaagctggaaaagcagcaggagcagcagaaggcccaggagcgtcaggagttatggcaaggtctggaggagctgcggctacgccggctacaggggacccagggggccaaggaggcccccctccagcggcttacaccccaggtggccgccagtgggggtcagagctagacagcacctcagaaggggaaaagctaaacccagagctgtcagtccctctatcccttctcctgtccaggggcccagagagaaacacacctacccctggccttgccagagtggcttctgaggactccctgcccagcccagctttcactggggggagacgaggagaggcaatggtggtcttggcaacagaatgctcagcccctcgtggcaggacttgacaagggcaagcttgaccaggaagctgccatcagggatcttcccctgccccgcaaagctaggctccagctgcaggcgggctcccaccctctgctcctggccttgggcaagggcactcagcgcctcgcctgcccctgccttggccaatgcgaggtccttccttatccccaccatggggtccatggtctatttattctcgcccagctcaccctctacacagacactgtcctgggtgcacactcctcccttccctcgctgtgtacttccttgtcccctttttatttattgggcagggggagggggagggcacaggcaagaagagattcacagtgtcctggggtaagggggggttcacagtaatcatggtctactcctctttccgtggctgggggtagacttaataaagagagaaattcaagaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5526 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5526 -> Molecular function: GO:0008601 [protein phosphatase type 2A regulator activity] evidence: IEA
            GeneID:5526 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
            GeneID:5526 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
            GeneID:5526 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:5526 -> Cellular component: GO:0000159 [protein phosphatase type 2A complex] evidence: IEA
            GeneID:5526 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
            GeneID:5526 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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