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2024-04-19 17:49:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006154 5760 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens neural precursor cell expressed, developmentally
down-regulated 4, E3 ubiquitin protein ligase (NEDD4), transcript
variant 1, mRNA.
ACCESSION NM_006154
VERSION NM_006154.2 GI:114520608
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5760)
AUTHORS Jahanshad N, Rajagopalan P, Hua X, Hibar DP, Nir TM, Toga AW, Jack
CR Jr, Saykin AJ, Green RC, Weiner MW, Medland SE, Montgomery GW,
Hansell NK, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ and
Thompson PM.
CONSRTM Alzheimer's Disease Neuroimaging Initiative
TITLE Genome-wide scan of healthy human connectome discovers SPON1 gene
variant influencing dementia severity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (12), 4768-4773 (2013)
PUBMED 23471985
REFERENCE 2 (bases 1 to 5760)
AUTHORS Fan,C.D., Lum,M.A., Xu,C., Black,J.D. and Wang,X.
TITLE Ubiquitin-dependent regulation of phospho-AKT dynamics by the
ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1
response
JOURNAL J. Biol. Chem. 288 (3), 1674-1684 (2013)
PUBMED 23195959
REMARK GeneRIF: Ubiquitination of phosphoAKT by NEDD4-1 is coupled to AKT
activation at the plasma membrane by insulin-like growth factor-1
(IGF-1), which promotes phosphoAKT nuclear trafficking.
REFERENCE 3 (bases 1 to 5760)
AUTHORS Eide,P.W., Cekaite,L., Danielsen,S.A., Eilertsen,I.A., Kjenseth,A.,
Fykerud,T.A., Agesen,T.H., Bruun,J., Rivedal,E., Lothe,R.A. and
Leithe,E.
TITLE NEDD4 is overexpressed in colorectal cancer and promotes colonic
cell growth independently of the PI3K/PTEN/AKT pathway
JOURNAL Cell. Signal. 25 (1), 12-18 (2013)
PUBMED 22974840
REMARK GeneRIF: The expression of NEDD4 did not influence the PTEN
subcellular localization or protein level.
REFERENCE 4 (bases 1 to 5760)
AUTHORS Kwak,Y.D., Wang,B., Li,J.J., Wang,R., Deng,Q., Diao,S., Chen,Y.,
Xu,R., Masliah,E., Xu,H., Sung,J.J. and Liao,F.F.
TITLE Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades
IGF-1 receptor protein in neurodegeneration
JOURNAL J. Neurosci. 32 (32), 10971-10981 (2012)
PUBMED 22875931
REMARK GeneRIF: This study demonistrated that the first time that zinc can
induce IGF-1Rbeta protein degradation in neurons via NEDD4-mediated
ubiquitination and the subsequent UPS mechanism.
REFERENCE 5 (bases 1 to 5760)
AUTHORS Nethe,M., de Kreuk,B.J., Tauriello,D.V., Anthony,E.C., Snoek,B.,
Stumpel,T., Salinas,P.C., Maurice,M.M., Geerts,D., Deelder,A.M.,
Hensbergen,P.J. and Hordijk,P.L.
TITLE Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote
maturation of cell-cell contacts
JOURNAL J. Cell. Sci. 125 (PT 14), 3430-3442 (2012)
PUBMED 22467858
REMARK GeneRIF: Data reveal a novel Rac1-dependent signalling pathway
that, through Nedd4-mediated ubiquitylation of Dvl1, stimulates the
maturation of epithelial cell-cell contacts.
REFERENCE 6 (bases 1 to 5760)
AUTHORS Staub,O., Gautschi,I., Ishikawa,T., Breitschopf,K., Ciechanover,A.,
Schild,L. and Rotin,D.
TITLE Regulation of stability and function of the epithelial Na+ channel
(ENaC) by ubiquitination
JOURNAL EMBO J. 16 (21), 6325-6336 (1997)
PUBMED 9351815
REFERENCE 7 (bases 1 to 5760)
AUTHORS Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
TITLE Interaction of WW domains with hematopoietic transcription factor
p45/NF-E2 and RNA polymerase II
JOURNAL J. Biol. Chem. 272 (39), 24105-24108 (1997)
PUBMED 9305852
REFERENCE 8 (bases 1 to 5760)
AUTHORS Hatakeyama,S., Jensen,J.P. and Weissman,A.M.
TITLE Subcellular localization and ubiquitin-conjugating enzyme (E2)
interactions of mammalian HECT family ubiquitin protein ligases
JOURNAL J. Biol. Chem. 272 (24), 15085-15092 (1997)
PUBMED 9182527
REFERENCE 9 (bases 1 to 5760)
AUTHORS Kumar,S., Harvey,K.F., Kinoshita,M., Copeland,N.G., Noda,M. and
Jenkins,N.A.
TITLE cDNA cloning, expression analysis, and mapping of the mouse Nedd4
gene
JOURNAL Genomics 40 (3), 435-443 (1997)
PUBMED 9073511
REMARK Erratum:[Genomics 1997 Aug 15;44(1):156]
REFERENCE 10 (bases 1 to 5760)
AUTHORS Imhof,M.O. and McDonnell,D.P.
TITLE Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent
activation of transcription by human progesterone and
glucocorticoid receptors
JOURNAL Mol. Cell. Biol. 16 (6), 2594-2605 (1996)
PUBMED 8649367
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
D42055.1, AL832063.1, AL833300.1 and AC009997.7.
On Sep 15, 2006 this sequence version replaced gi:38257154.
Transcript Variant: This variant (1) differs in the 5' UTR and
contains alternate exons in the 5' coding region, compared to
variant 2. This results in a shorter isoform (1) with a distinct
N-terminus, compared to isoform 2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC152452.1, AK304394.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-860 D42055.1 1-860
861-1108 AL832063.1 2121-2368
1109-2609 D42055.1 1109-2609
2610-2682 AL833300.1 3067-3139
2683-5760 AC009997.7 122042-125119 c
FEATURES Location/Qualifiers
source 1..5760
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q"
gene 1..5760
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="neural precursor cell expressed, developmentally
down-regulated 4, E3 ubiquitin protein ligase"
/db_xref="GeneID:4734"
/db_xref="HGNC:7727"
/db_xref="MIM:602278"
exon 1..127
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
CDS 83..2785
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/EC_number="6.3.2.-"
/note="isoform 1 is encoded by transcript variant 1;
receptor-potentiating factor 1; E3 ubiquitin-protein
ligase NEDD4; NEDD-4; cell proliferation-inducing gene 53
protein; neural precursor cell expressed developmentally
down-regulated protein 4"
/codon_start=1
/product="E3 ubiquitin-protein ligase NEDD4 isoform 1"
/protein_id="NP_006145.2"
/db_xref="GI:114520609"
/db_xref="CCDS:CCDS45265.1"
/db_xref="GeneID:4734"
/db_xref="HGNC:7727"
/db_xref="MIM:602278"
/translation="
MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
"
misc_feature 140..535
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="C2 domain present in the Human neural precursor
cell-expressed, developmentally down-regulated 4 (NEDD4)
and NEDD4-like (NEDD4L/NEDD42); Region: C2_NEDD4_NEDD4L;
cd04033"
/db_xref="CDD:175999"
misc_feature order(203..205,359..361,365..367,380..382)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:175999"
misc_feature 617..619
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 617..619
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03321"
misc_feature 617..619
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03457"
misc_feature 617..619
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:00977"
misc_feature 668..754
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(704..706,737..739)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 1133..1222
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(1175..1177,1208..1210)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 1352..1441
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(1394..1396,1427..1429)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 1508..1597
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(1550..1552,1583..1585)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 1709..2773
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="HECT domain; C-terminal catalytic domain of a
subclass of Ubiquitin-protein ligase (E3). It binds
specific ubiquitin-conjugating enzymes (E2), accepts
ubiquitin from E2, transfers ubiquitin to substrate lysine
side chains, and transfers additional...; Region: HECTc;
cd00078"
/db_xref="CDD:28959"
misc_feature order(1727..1729,1820..1822,1853..1855,2039..2041,
2558..2560,2663..2668,2675..2689,2747..2749,2768..2770)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="catalytic cleft [active]"
/db_xref="CDD:28959"
misc_feature 1781..2770
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="Domain Homologous to E6-AP Carboxyl Terminus with;
Region: HECTc; smart00119"
/db_xref="CDD:197523"
misc_feature order(2123..2125,2132..2137,2141..2146,2153..2155,
2168..2170,2174..2176,2186..2191,2192..2194,2210..2212,
2225..2227,2276..2278,2288..2290)
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/note="E2 interaction site; other site"
/db_xref="CDD:28959"
exon 128..201
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 202..280
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 281..319
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 320..373
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 374..424
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 425..486
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 487..589
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 590..756
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 757..874
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 875..1042
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1043..1108
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1109..1228
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1229..1429
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1430..1510
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1511..1565
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1566..1624
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1625..1690
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1691..1920
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 1921..2042
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2043..2113
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2114..2209
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2210..2283
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2284..2344
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2345..2404
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2405..2512
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
variation 2508
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1126740"
exon 2513..2609
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2610..2682
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
exon 2683..5760
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/inference="alignment:Splign:1.39.8"
variation 2994
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042477"
STS 3031..3147
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/standard_name="D15S1324"
/db_xref="UniSTS:8729"
STS 4052..4542
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/standard_name="RH25321"
/db_xref="UniSTS:75346"
variation 4748
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11550869"
variation 4895
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201215909"
STS 5284..5417
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/standard_name="STS-D42055"
/db_xref="UniSTS:27953"
variation 5640
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1042471"
variation 5686
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1042472"
polyA_signal 5728..5733
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
polyA_site 5755
/gene="NEDD4"
/gene_synonym="NEDD4-1; RPF1"
ORIGIN
ctcccgcttctcctcctcctcctccacagttgcctgccctgggcgggggcgagcgcgtccggtttgctggaagcgttcggaaatggcaacttgcgcggtggaggtgttcgggctcctggaggacgaggaaaattcacgaattgtgagagtaagagttatagccggaataggccttgccaagaaggatatattgggagctagtgatccttacgtgagagtgacgttatatgacccaatgaatggagttcttacaagtgtgcaaacaaaaaccattaaaaagagtttgaatccaaagtggaatgaagaaatattattcagagttcatcctcagcagcaccggcttctttttgaagtgtttgacgaaaaccgattgacaagagatgatttcctaggtcaagtggatgttccactttatccattaccgacagaaaatccaagattggagagaccatatacatttaaggattttgttcttcatccaagaagtcacaaatcaagagttaaaggttatctgagactaaaaatgacttatttacctaaaaccagtggctcagaagatgataatgcagaacaggctgaggaattagagcctggctgggttgttttggaccaaccagatgctgcttgccatttgcagcaacaacaagaaccttctcctctacctccagggtgggaagagaggcaggatatccttggaaggacctattatgtaaaccatgaatctagaagaacacagtggaaaagaccaacccctcaggacaacctaacagatgctgagaatggcaacattcaactgcaagcacaacgtgcatttaccaccaggcggcagatatccgaggaaacagaaagtgttgacaaccgagagtcttccgagaactgggaaattataagagaagatgaagccaccatgtatagcaaccaggccttcccatcacctccaccgtcaagtaacttggatgttccaactcatcttgcagaagaattgaatgccagactcaccatttttggaaattcagccgtgagccagccagcatcgagctcaaatcattccagcagaagaggcagcttacaagcctatacttttgaggaacaacctacacttcctgtgcttttgcctacttcatctggattaccaccaggttgggaagaaaaacaagatgaaagaggaagatcatattatgtagatcacaattccagaacgactacttggacaaagcccactgtacaggccacagtggagaccagtcagctgacctcaagccagagttctgcaggccctcaatcacaagcctccaccagtgattcaggccagcaggtgacccagccatctgaaattgagcaaggattccttcctaaaggctgggaagtccggcatgcaccaaatgggaggcctttctttattgaccacaacactaaaaccaccacctgggaagatccaagattgaaaattccagcccatctgagaggaaagacatcacttgatacttccaatgatctagggcctttacctccaggatgggaagagagaactcacacagatggaagaatcttctacataaatcacaatataaaaagaacacaatgggaagatcctcggttggagaatgtagcaataactggaccagcagtgccctactccagggattacaaaagaaagtatgagttcttccgaagaaagttgaagaagcagaatgacattccaaacaaatttgaaatgaaacttcgccgagcaactgttcttgaagactcttaccggagaattatgggtgtcaagagagcagacttcctgaaggctcgactgtggattgagtttgatggtgaaaagggattggattatggaggagttgccagagaatggttcttcctgatctcaaaggaaatgtttaacccttattatgggttgtttgaatattctgctacggacaattataccctacagataaatccaaactctggattgtgtaacgaagatcacctctcttacttcaagtttattggtcgggtagctggaatggcagtttatcatggcaaactgttggatggttttttcatccgcccattttacaagatgatgcttcacaaaccaataacccttcatgatatggaatctgtggatagtgaatattacaattccctaagatggattcttgaaaatgacccaacagaattggacctcaggtttatcatagatgaagaactttttggacagacacatcaacatgagctgaaaaatggtggatcagaaatagttgtcaccaataagaacaaaaaggaatatatttatcttgtaatacaatggcgatttgtaaaccgaatccagaagcaaatggctgcttttaaagagggattctttgaactaataccacaggatctcatcaaaatttttgatgaaaatgaactagagcttcttatgtgtggactgggagatgttgatgtgaatgactggagggaacatacaaagtataaaaatggctacagtgcaaatcatcaggttatacagtggttttggaaggctgttttaatgatggattcagaaaaaagaataagattacttcagtttgtcactggcacatctcgggtgcctatgaatggatttgctgaactatacggttcaaatggaccacagtcatttacagttgaacagtggggtactcctgaaaagctgccaagagctcatacctgttttaatcgcctggacttgccaccttatgaatcatttgaagaattatgggataaacttcagatggcaattgaaaacacccagggctttgatggagttgattagattacaaataacaatctgtagtgtttttactgccatagttttataaccaaaatcttgacttaaaattttccggggaactactaaaatgtggccactgagtcttcccagatcttgaagaaaatcatataaaaagcatttgaagaaatagtacgacaacttatttttaatcacttttaaataatgtgttgcatttacacagttgtttcatgctgtctttagagttaggtgcctgcctaaagccaggcaccaccacacctggctttagagttcacacaataggatataagtcctgtatgacttaaatagtgaattttgtccttaacatttacctcttgtatagtatctgccaggcagttttttcttaaactactgagatgataactgtgaaatatttgtgatacgtgtcatgtgtgaaaagtttgatgcattttgagatggaaaactgaaatttggaaaaagaaatactttactattgagtaaactacaatatatttagtgctactcgcagctatttattattttgtagacctgccttatgcaccttactgcctagatttttgggaaaaaactttggaaagtgtgttacctatatttctagccaactaactcacagaaaaactgtttacttcttcactttcgaagtatttggcttttgttaatatgcagttttactaaacagatggttcataagacatgtgaagcaaattcatatttgcaatgggtaaaaagtattaaagcctttctcttgcctgcatatcctattgaccattggtatagtcatcactttttcatattttagtgtagttagaagaattccttcttcaaacattaaagatccacaaagcagtatttctaaatatgccttgaagaactaaatgaagtgtatagcacttgcctttactagatattctttacacttgtacaattatgtagtaaatgtatgtttacagggtttatcatgtttacagattaagctaatttctgtagtcgcatttttatatttttagtatcactctagtaaaaaaaccaaataatttgtttaaaataaccaaagagttgttataatgcataatttgtattaaatttattactatttcttatgccttttaaaatactgtttactatgaagacaatgtttttaattacaaatccagaattctgtaggcaaaatgctacagttcatatcttcctttaaccaaactgaagtacataaagaccatgtacatgtattcatcaaacgtttattgaatgctgcgtgcctagcgctgtgctatgctctggggtaagagttgtcagcttcagagaagctgagtcctgatcctcaaggaacttgcaaatgtgtctatgaatttgtaaaacaatcaaaagtaggcgtaagcagaataaggcaaaagggaaagtgttctaggttccagcacacctgcaaagataaagtgtgccaagactgtatttatatttcatacttatattgtttcatccttatattggaatgattatatagaaaatgctcttaaaaagattaaacctatttctcagtatggtatcttggtgatttaggaataattgtaaatatatgttacgaatcttcttaaatatatatatatacacaccctgtgagaactgtaaaaagtacctctggttcttggtttaagtttgttggggtataacatgatgagtactcattagcacctgatagaaatctgaaatgtgacagtagcaaaaccactttctactttccaaacaccacagcatcagcatggtttaggggaagcaattcacagattaatgtaccctgcgttttgtcttcaccattgtcaaccagcagtcaaggatgagcaccaggtatagtcctggtttgatatctcaccagccatgtgaactgaagcagcttacttaacctctctggattcatatttcttcatctgtcaaatgagagtaatcatgcccaccctcattgtcatgccagattgtcagaagttccagacagatgagaaagcaaaaagtactttgtaaagtgttatacaatcagaaggtgctttgtgctgaccgtcagattgtgtcaagtcaggtgtgcaaattgaccacactcccaaagaatcatttaaaagtaaagtgacttctaagagacaaggaagtaggaacatttctgatattaaatatataaataatatggatacacatgtgtatatctgtatatggatcttaccatcataattcattttcttcatatcagcaaagtaatagtaatgtgggccaatgcattttggaaatgtcctcattatgtagaatggaatgtgaaaattatttttgttaaaacaggattttgccacaattatttaaatattatgtttgtgaactatctaagcatgagaaaatacaaagctttctttgtatctggctgatactcatttggatgattctgtgactcatagaacatgatgttaaatgagaccagactcaactgccaccagtccccagctgcagaccttcatccccttcatctcccactaggggctcgtggtctggaagaaacatctatcaagcaacacagccccttatcccagatagaaaagtgtctcaaatgcattctactgcgggacagtcagtaggatcattttcataaagcaaggacatcatatgtttctagaaattacaagcatataactttagcctacaatctcttattaaaaatttttaacaaaattgtattacaaatgcatttcatcagaactcaaatttaaatggtgtttgttttgggtttttatttataatgctgaagttattccatataagtatcaagttaaacacaattcattttgattataaactatttgactttttaaaatcttctgacacagtaaatatatatatcaagattgatgtatcaaaatttattgcacactttaaagtgtaaaatcattttttaaaatcttgaatccacaaataaagttctattctgattttaaaaaacaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4734 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:4734 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4734 -> Molecular function: GO:0019871 [sodium channel inhibitor activity] evidence: IDA
GeneID:4734 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:4734 -> Molecular function: GO:0031698 [beta-2 adrenergic receptor binding] evidence: IDA
GeneID:4734 -> Molecular function: GO:0043130 [ubiquitin binding] evidence: IDA
GeneID:4734 -> Molecular function: GO:0050815 [phosphoserine binding] evidence: ISS
GeneID:4734 -> Molecular function: GO:0050816 [phosphothreonine binding] evidence: ISS
GeneID:4734 -> Molecular function: GO:0070063 [RNA polymerase binding] evidence: IPI
GeneID:4734 -> Molecular function: GO:0070064 [proline-rich region binding] evidence: IMP
GeneID:4734 -> Molecular function: GO:0070064 [proline-rich region binding] evidence: IPI
GeneID:4734 -> Biological process: GO:0002250 [adaptive immune response] evidence: IEA
GeneID:4734 -> Biological process: GO:0003151 [outflow tract morphogenesis] evidence: IEA
GeneID:4734 -> Biological process: GO:0003197 [endocardial cushion development] evidence: IEA
GeneID:4734 -> Biological process: GO:0006513 [protein monoubiquitination] evidence: IEA
GeneID:4734 -> Biological process: GO:0006622 [protein targeting to lysosome] evidence: IDA
GeneID:4734 -> Biological process: GO:0007041 [lysosomal transport] evidence: IDA
GeneID:4734 -> Biological process: GO:0007528 [neuromuscular junction development] evidence: IEA
GeneID:4734 -> Biological process: GO:0010766 [negative regulation of sodium ion transport] evidence: IDA
GeneID:4734 -> Biological process: GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] evidence: IMP
GeneID:4734 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP
GeneID:4734 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:4734 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:4734 -> Biological process: GO:0019089 [transmission of virus] evidence: IMP
GeneID:4734 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:4734 -> Biological process: GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] evidence: ISS
GeneID:4734 -> Biological process: GO:0031175 [neuron projection development] evidence: IEP
GeneID:4734 -> Biological process: GO:0031623 [receptor internalization] evidence: IDA
GeneID:4734 -> Biological process: GO:0032801 [receptor catabolic process] evidence: IDA
GeneID:4734 -> Biological process: GO:0034644 [cellular response to UV] evidence: IMP
GeneID:4734 -> Biological process: GO:0034765 [regulation of ion transmembrane transport] evidence: IDA
GeneID:4734 -> Biological process: GO:0042110 [T cell activation] evidence: IEA
GeneID:4734 -> Biological process: GO:0042391 [regulation of membrane potential] evidence: IDA
GeneID:4734 -> Biological process: GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:4734 -> Biological process: GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IMP
GeneID:4734 -> Biological process: GO:0042921 [glucocorticoid receptor signaling pathway] evidence: IDA
GeneID:4734 -> Biological process: GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] evidence: IMP
GeneID:4734 -> Biological process: GO:0044111 [development involved in symbiotic interaction] evidence: IMP
GeneID:4734 -> Biological process: GO:0045732 [positive regulation of protein catabolic process] evidence: IDA
GeneID:4734 -> Biological process: GO:0046824 [positive regulation of nucleocytoplasmic transport] evidence: IDA
GeneID:4734 -> Biological process: GO:0048514 [blood vessel morphogenesis] evidence: IEA
GeneID:4734 -> Biological process: GO:0048814 [regulation of dendrite morphogenesis] evidence: ISS
GeneID:4734 -> Biological process: GO:0050807 [regulation of synapse organization] evidence: IEA
GeneID:4734 -> Biological process: GO:0050847 [progesterone receptor signaling pathway] evidence: IDA
GeneID:4734 -> Biological process: GO:0051592 [response to calcium ion] evidence: TAS
GeneID:4734 -> Biological process: GO:0070534 [protein K63-linked ubiquitination] evidence: ISS
GeneID:4734 -> Biological process: GO:1901016 [regulation of potassium ion transmembrane transporter activity] evidence: IDA
GeneID:4734 -> Cellular component: GO:0000151 [ubiquitin ligase complex] evidence: ISS
GeneID:4734 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:4734 -> Cellular component: GO:0005634 [nucleus] evidence: IBA
GeneID:4734 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4734 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:4734 -> Cellular component: GO:0005829 [cytosol] evidence: ISS
GeneID:4734 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4734 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:4734 -> Cellular component: GO:0005886 [plasma membrane] evidence: IMP
GeneID:4734 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
GeneID:4734 -> Cellular component: GO:0016327 [apicolateral plasma membrane] evidence: TAS
GeneID:4734 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_006145 -> EC 6.3.2.-
by
@meso_cacase at
DBCLS
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