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2024-04-19 19:10:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006142 1336 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens stratifin (SFN), mRNA.
ACCESSION NM_006142
VERSION NM_006142.3 GI:45238846
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1336)
AUTHORS Yeo,K.S., Mohidin,T.B. and Ng,C.C.
TITLE Epstein-Barr virus-encoded latent membrane protein-1 upregulates
14-3-3sigma and Reprimo to confer G(2)/M phase cell cycle arrest
JOURNAL C. R. Biol. 335 (12), 713-721 (2012)
PUBMED 23312294
REMARK GeneRIF: study concludes that LMP-1 may induce cell cycle arrest at
G(2)/M progression via upregulation of 14-3-3sigma and Reprimo
REFERENCE 2 (bases 1 to 1336)
AUTHORS Butt,A.Q., Ahmed,S., Maratha,A. and Miggin,S.M.
TITLE 14-3-3epsilon and 14-3-3sigma inhibit Toll-like receptor
(TLR)-mediated proinflammatory cytokine induction
JOURNAL J. Biol. Chem. 287 (46), 38665-38679 (2012)
PUBMED 22984265
REMARK GeneRIF: 14-3-3epsilon and 14-3-3sigma inhibit Toll-like receptor
(TLR)-mediated proinflammatory cytokine induction
REFERENCE 3 (bases 1 to 1336)
AUTHORS Rose,R., Rose,M. and Ottmann,C.
TITLE Identification and structural characterization of two 14-3-3
binding sites in the human peptidylarginine deiminase type VI
JOURNAL J. Struct. Biol. 180 (1), 65-72 (2012)
PUBMED 22634725
REMARK GeneRIF: Crystallographic determination of 14-3-3-sigma binding
sites in the human peptidylarginine deiminase type VI.
REFERENCE 4 (bases 1 to 1336)
AUTHORS Chavez-Munoz,C., Hartwell,R., Jalili,R.B., Jafarnejad,S.M., Lai,A.,
Nabai,L., Ghaffari,A., Hojabrpour,P., Kanaan,N., Duronio,V.,
Guns,E., Cherkasov,A. and Ghahary,A.
TITLE SPARC/SFN interaction, suppresses type I collagen in dermal
fibroblasts
JOURNAL J. Cell. Biochem. 113 (8), 2622-2632 (2012)
PUBMED 22422640
REMARK GeneRIF: Data show that SFN and SPARC form a complex thereby
controlling the type I collagen synthesis and expression in
fibroblasts.
REFERENCE 5 (bases 1 to 1336)
AUTHORS Thanasopoulou,A., Xanthopoulou,A.G., Anagnostopoulos,A.K.,
Konstantakou,E.G., Margaritis,L.H., Papassideri,I.S.,
Stravopodis,D.J., Tsangaris,G.T. and Anastasiadou,E.
TITLE Silencing of CCDC6 reduces the expression of 14-3-3sigma in
colorectal carcinoma cells
JOURNAL Anticancer Res. 32 (3), 907-913 (2012)
PUBMED 22399611
REMARK GeneRIF: down-regulation of 14-3-3sigma in the absence of CCDC6
demonstrated their direct association and supports the notion that
CCDC6 contributes to cancer development, possibly through malignant
pathways involving 14-3-3sigma
REFERENCE 6 (bases 1 to 1336)
AUTHORS Chan,T.A., Hermeking,H., Lengauer,C., Kinzler,K.W. and
Vogelstein,B.
TITLE 14-3-3Sigma is required to prevent mitotic catastrophe after DNA
damage
JOURNAL Nature 401 (6753), 616-620 (1999)
PUBMED 10524633
REFERENCE 7 (bases 1 to 1336)
AUTHORS Hermeking,H., Lengauer,C., Polyak,K., He,T.C., Zhang,L.,
Thiagalingam,S., Kinzler,K.W. and Vogelstein,B.
TITLE 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
JOURNAL Mol. Cell 1 (1), 3-11 (1997)
PUBMED 9659898
REFERENCE 8 (bases 1 to 1336)
AUTHORS Leffers,H., Madsen,P., Rasmussen,H.H., Honore,B., Andersen,A.H.,
Walbum,E., Vandekerckhove,J. and Celis,J.E.
TITLE Molecular cloning and expression of the transformation sensitive
epithelial marker stratifin. A member of a protein family that has
been involved in the protein kinase C signalling pathway
JOURNAL J. Mol. Biol. 231 (4), 982-998 (1993)
PUBMED 8515476
REFERENCE 9 (bases 1 to 1336)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
REFERENCE 10 (bases 1 to 1336)
AUTHORS Prasad,G.L., Valverius,E.M., McDuffie,E. and Cooper,H.L.
TITLE Complementary DNA cloning of a novel epithelial cell marker
protein, HME1, that may be down-regulated in neoplastic mammary
cells
JOURNAL Cell Growth Differ. 3 (8), 507-513 (1992)
PUBMED 1390337
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AF029082.1 and BC001550.1.
On Mar 8, 2004 this sequence version replaced gi:30102938.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: BC023552.2 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1189 AF029082.1 1-1189
1190-1336 BC001550.1 1076-1222
FEATURES Location/Qualifiers
source 1..1336
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.11"
gene 1..1336
/gene="SFN"
/gene_synonym="YWHAS"
/note="stratifin"
/db_xref="GeneID:2810"
/db_xref="HGNC:10773"
/db_xref="HPRD:03185"
/db_xref="MIM:601290"
exon 1..1315
/gene="SFN"
/gene_synonym="YWHAS"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="t"
/db_xref="dbSNP:372187333"
misc_feature 39..41
/gene="SFN"
/gene_synonym="YWHAS"
/note="upstream in-frame stop codon"
variation 44
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:374076427"
variation 51
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:374491178"
STS 56..334
/gene="SFN"
/gene_synonym="YWHAS"
/standard_name="PMC18556P3"
/db_xref="UniSTS:271693"
CDS 72..818
/gene="SFN"
/gene_synonym="YWHAS"
/note="14-3-3 sigma; epithelial cell marker protein 1"
/codon_start=1
/product="14-3-3 protein sigma"
/protein_id="NP_006133.1"
/db_xref="GI:5454052"
/db_xref="CCDS:CCDS288.1"
/db_xref="GeneID:2810"
/db_xref="HGNC:10773"
/db_xref="HPRD:03185"
/db_xref="MIM:601290"
/translation="
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
"
misc_feature 72..773
/gene="SFN"
/gene_synonym="YWHAS"
/note="14-3-3 sigma, an isoform of 14-3-3 protein; Region:
14-3-3_sigma; cd10019"
/db_xref="CDD:206756"
misc_feature order(84..86,96..98,105..110,114..116,123..125,144..146,
243..245,252..254,264..266,309..314,318..323,330..335,
342..344)
/gene="SFN"
/gene_synonym="YWHAS"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:206756"
misc_feature 84..86
/gene="SFN"
/gene_synonym="YWHAS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P31947.1); phosphorylation site"
misc_feature order(216..221,237..239,435..437,456..461,591..596,
603..605,615..617,747..749,759..761)
/gene="SFN"
/gene_synonym="YWHAS"
/note="peptide binding site [polypeptide binding]; other
site"
/db_xref="CDD:206756"
misc_feature 237..239
/gene="SFN"
/gene_synonym="YWHAS"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphoserine on interacting
protein; propagated from UniProtKB/Swiss-Prot (P31947.1);
other site"
misc_feature 456..458
/gene="SFN"
/gene_synonym="YWHAS"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with phosphoserine on interacting
protein; propagated from UniProtKB/Swiss-Prot (P31947.1);
other site"
misc_feature order(675..677,681..683,687..689)
/gene="SFN"
/gene_synonym="YWHAS"
/note="putative phospho-independent ligand binding site;
other site"
/db_xref="CDD:206756"
misc_feature 813..815
/gene="SFN"
/gene_synonym="YWHAS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P31947.1); phosphorylation site"
variation 158
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:142676288"
variation 162
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:368467494"
variation 165
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:187432842"
variation 170
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:375058896"
STS 174..335
/gene="SFN"
/gene_synonym="YWHAS"
/standard_name="PMC18556P2"
/db_xref="UniSTS:271692"
variation 208
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:77608477"
variation 296
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:368074999"
variation 364
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:375382073"
variation 366
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:138537988"
variation 387
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="c"
/db_xref="dbSNP:371597532"
variation 399
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:150754661"
variation 414
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:375934637"
variation 457
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:368924622"
variation 465
/gene="SFN"
/gene_synonym="YWHAS"
/replace="g"
/replace="t"
/db_xref="dbSNP:201166719"
variation 517
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:78707984"
variation 536
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542705"
variation 539
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:61749358"
variation 554
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:149812347"
variation 564
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="t"
/db_xref="dbSNP:77755255"
variation 571
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:75914997"
variation 576
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:202094692"
variation 692
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542704"
variation 766
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:79984509"
variation 773
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:377228666"
variation 776
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:142332741"
variation 777
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:369790436"
variation 787
/gene="SFN"
/gene_synonym="YWHAS"
/replace="g"
/replace="t"
/db_xref="dbSNP:376687682"
variation 808
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:191803556"
variation 819
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="g"
/db_xref="dbSNP:373594101"
variation 834
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:113302181"
variation 836
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:80013205"
variation 837
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:75343738"
STS 930..1308
/gene="SFN"
/gene_synonym="YWHAS"
/standard_name="PMC18556P1"
/db_xref="UniSTS:271691"
STS 948..1290
/gene="SFN"
/gene_synonym="YWHAS"
/standard_name="G06573"
/db_xref="UniSTS:43664"
variation 1022
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:182906629"
variation 1051
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:187708887"
STS 1117..1253
/gene="SFN"
/gene_synonym="YWHAS"
/standard_name="SHGC-74449"
/db_xref="UniSTS:33176"
variation 1189..1190
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="ac"
/db_xref="dbSNP:3065004"
variation 1190..1195
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="gtgtgt"
/db_xref="dbSNP:143285617"
variation 1211..1214
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="tgtg"
/db_xref="dbSNP:71718437"
variation 1213..1216
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="tgtg"
/db_xref="dbSNP:57297594"
variation 1214..1215
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="gt"
/db_xref="dbSNP:71692099"
variation 1215..1216
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="tg"
/replace="tgtgtg"
/db_xref="dbSNP:67867832"
variation 1216..1217
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="gt"
/replace="gtgt"
/replace="gtgtgtgt"
/db_xref="dbSNP:66719503"
variation 1217..1218
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="tg"
/db_xref="dbSNP:71700336"
variation 1221
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3208129"
variation 1223
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:112547702"
variation 1224..1225
/gene="SFN"
/gene_synonym="YWHAS"
/replace=""
/replace="gc"
/db_xref="dbSNP:367565202"
variation 1249
/gene="SFN"
/gene_synonym="YWHAS"
/replace="a"
/replace="g"
/db_xref="dbSNP:189757868"
variation 1250
/gene="SFN"
/gene_synonym="YWHAS"
/replace="c"
/replace="t"
/db_xref="dbSNP:1060331"
ORIGIN
gagagacacagagtccggcattggtcccaggcagcagttagcccgccgcccgcctgtgtgtccccagagccatggagagagccagtctgatccagaaggccaagctggcagagcaggccgaacgctatgaggacatggcagccttcatgaaaggcgccgtggagaagggcgaggagctctcctgcgaagagcgaaacctgctctcagtagcctataagaacgtggtgggcggccagagggctgcctggagggtgctgtccagtattgagcagaaaagcaacgaggagggctcggaggagaaggggcccgaggtgcgtgagtaccgggagaaggtggagactgagctccagggcgtgtgcgacaccgtgctgggcctgctggacagccacctcatcaaggaggccggggacgccgagagccgggtcttctacctgaagatgaagggtgactactaccgctacctggccgaggtggccaccggtgacgacaagaagcgcatcattgactcagcccggtcagcctaccaggaggccatggacatcagcaagaaggagatgccgcccaccaaccccatccgcctgggcctggccctgaacttttccgtcttccactacgagatcgccaacagccccgaggaggccatctctctggccaagaccactttcgacgaggccatggctgatctgcacaccctcagcgaggactcctacaaagacagcaccctcatcatgcagctgctgcgagacaacctgacactgtggacggccgacaacgccggggaagaggggggcgaggctccccaggagccccagagctgagtgttgcccgccaccgccccgccctgccccctccagtcccccaccctgccgagaggactagtatggggtgggaggccccacccttctcccctaggcgctgttcttgctccaaagggctccgtggagagggactggcagagctgaggccacctggggctggggatcccactcttcttgcagctgttgagcgcacctaaccactggtcatgcccccacccctgctctccgcacccgcttcctcccgaccccaggaccaggctacttctcccctcctcttgcctccctcctgcccctgctgcctctgatcgtaggaattgaggagtgtcccgccttgtggctgagaactggacagtggcaggggctggagatgggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcgcgcgcgccagtgcaagaccgagattgagggaaagcatgtctgctgggtgtgaccatgtttcctctcaataaagttcccctgtgacactcaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2810 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2810 -> Molecular function: GO:0008426 [protein kinase C inhibitor activity] evidence: TAS
GeneID:2810 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:2810 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IEA
GeneID:2810 -> Molecular function: GO:0051219 [phosphoprotein binding] evidence: IEA
GeneID:2810 -> Biological process: GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
GeneID:2810 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IDA
GeneID:2810 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: TAS
GeneID:2810 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:2810 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:2810 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:2810 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:2810 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:2810 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:2810 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IEA
GeneID:2810 -> Biological process: GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:2810 -> Biological process: GO:0043616 [keratinocyte proliferation] evidence: IEA
GeneID:2810 -> Biological process: GO:0046827 [positive regulation of protein export from nucleus] evidence: IEA
GeneID:2810 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:2810 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
GeneID:2810 -> Cellular component: GO:0005615 [extracellular space] evidence: TAS
GeneID:2810 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:2810 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2810 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:2810 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: TAS
by
@meso_cacase at
DBCLS
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