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2024-04-26 05:17:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006092 4506 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens nucleotide-binding oligomerization domain containing 1
(NOD1), mRNA.
ACCESSION NM_006092
VERSION NM_006092.2 GI:194733754
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4506)
AUTHORS Plantinga,T.S., Fransen,J., Knevel,R., Netea,M.G., Zwerina,J.,
Helsen,M.M., van der Meer,J.W., van Riel,P.L., Schett,G., van der
Helm-van Mil,A.H., van den Berg,W.B. and Joosten,L.A.
TITLE Role of NOD1 polymorphism in susceptibility and clinical
progression of rheumatoid arthritis
JOURNAL Rheumatology (Oxford) 52 (5), 806-814 (2013)
PUBMED 23353647
REMARK GeneRIF: Genetic variation of human NOD1 protein is not associated
with rheumatoid arthritis susceptibility or severity.
REFERENCE 2 (bases 1 to 4506)
AUTHORS Allison,C.C., Ferrand,J., McLeod,L., Hassan,M.,
Kaparakis-Liaskos,M., Grubman,A., Bhathal,P.S., Dev,A., Sievert,W.,
Jenkins,B.J. and Ferrero,R.L.
TITLE Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in
gastric epithelial cells during Helicobacter pylori infection and
exacerbates disease severity
JOURNAL J. Immunol. 190 (7), 3706-3715 (2013)
PUBMED 23460743
REMARK GeneRIF: cross-talk between NOD1 and IFN-gamma signaling pathways
contribute to H. pylori-induced inflammatory responses, potentially
revealing a novel mechanism whereby virulent H. pylori strains
promote more severe disease.
REFERENCE 3 (bases 1 to 4506)
AUTHORS Ver Heul,A.M., Fowler,C.A., Ramaswamy,S. and Piper,R.C.
TITLE Ubiquitin regulates caspase recruitment domain-mediated signaling
by nucleotide-binding oligomerization domain-containing proteins
NOD1 and NOD2
JOURNAL J. Biol. Chem. 288 (10), 6890-6902 (2013)
PUBMED 23300079
REMARK GeneRIF: Data suggest that ubiquitin (Ub) binding provides a
negative feedback loop upon NOD1 and NOD2 (nucleotide-binding
oligomerization domain-containing proteins)-dependent activation of
receptor-interacting protein kinase 2 (RIP2).
REFERENCE 4 (bases 1 to 4506)
AUTHORS Chatterjee,D. and Chaudhuri,K.
TITLE Vibrio cholerae O395 outer membrane vesicles modulate intestinal
epithelial cells in a NOD1 protein-dependent manner and induce
dendritic cell-mediated Th2/Th17 cell responses
JOURNAL J. Biol. Chem. 288 (6), 4299-4309 (2013)
PUBMED 23275338
REMARK GeneRIF: Vibrio cholerae O395 outer membrane vesicles modulate
intestinal epithelial cells in a NOD1 protein-dependent manner and
induce dendritic cell-mediated Th2/Th17 cell responses.
REFERENCE 5 (bases 1 to 4506)
AUTHORS Zhou,Y.J., Zhou,H., Li,Y. and Song,Y.L.
TITLE NOD1 activation induces innate immune responses and insulin
resistance in human adipocytes
JOURNAL Diabetes Metab. 38 (6), 538-543 (2012)
PUBMED 23182460
REMARK GeneRIF: The present study aimed to determine the presence of NOD1
and NOD2 in human adipose cells as well as to assess their
functionality. NOD1 activation reduced insulin-induced glucose
uptake, leading to insulin resistance.
REFERENCE 6 (bases 1 to 4506)
AUTHORS Chu,Z.L., Pio,F., Xie,Z., Welsh,K., Krajewska,M., Krajewski,S.,
Godzik,A. and Reed,J.C.
TITLE A novel enhancer of the Apaf1 apoptosome involved in cytochrome
c-dependent caspase activation and apoptosis
JOURNAL J. Biol. Chem. 276 (12), 9239-9245 (2001)
PUBMED 11113115
REFERENCE 7 (bases 1 to 4506)
AUTHORS Inohara,N., Ogura,Y., Chen,F.F., Muto,A. and Nunez,G.
TITLE Human Nod1 confers responsiveness to bacterial lipopolysaccharides
JOURNAL J. Biol. Chem. 276 (4), 2551-2554 (2001)
PUBMED 11058605
REFERENCE 8 (bases 1 to 4506)
AUTHORS Inohara,N., Koseki,T., Lin,J., del Peso,L., Lucas,P.C., Chen,F.F.,
Ogura,Y. and Nunez,G.
TITLE An induced proximity model for NF-kappa B activation in the
Nod1/RICK and RIP signaling pathways
JOURNAL J. Biol. Chem. 275 (36), 27823-27831 (2000)
PUBMED 10880512
REFERENCE 9 (bases 1 to 4506)
AUTHORS Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
TITLE Nod1, an Apaf-1-like activator of caspase-9 and nuclear
factor-kappaB
JOURNAL J. Biol. Chem. 274 (21), 14560-14567 (1999)
PUBMED 10329646
REFERENCE 10 (bases 1 to 4506)
AUTHORS Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
Glucksmann,M.A. and DiStefano,P.S.
TITLE Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
member that activates NF-kappaB
JOURNAL J. Biol. Chem. 274 (19), 12955-12958 (1999)
PUBMED 10224040
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CV569884.1, BC040339.1,
AF113925.1 and AA845215.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 31, 2008 this sequence version replaced gi:5174616.
Summary: This gene encodes a member of the NOD (nucleotide-binding
oligomerization domain) family. This member is a cytosolic protein.
It contains an N-terminal caspase recruitment domain (CARD), a
centrally located nucleotide-binding domain (NBD), and 10 tandem
leucine-rich repeats (LRRs) in its C terminus. The CARD is involved
in apoptotic signaling, LRRs participate in protein-protein
interactions, and mutations in the NBD may affect the process of
oligomerization and subsequent function of the LRR domain. This
protein is an intracellular pattern-recognition receptor (PRR) that
initiates inflammation in response to a subset of bacteria through
the detection of bacterial diaminopimelic acid. Multiple
alternatively spliced transcript variants differring in the 5' UTR
have been described, but the full-length nature of these variants
has not been determined. [provided by RefSeq, Oct 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC040339.1, AF126484.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-621 CV569884.1 1-621
622-1413 BC040339.1 537-1328
1414-4460 AF113925.1 1315-4361
4461-4506 AA845215.1 1-46 c
FEATURES Location/Qualifiers
source 1..4506
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p15-p14"
gene 1..4506
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="nucleotide-binding oligomerization domain
containing 1"
/db_xref="GeneID:10392"
/db_xref="HGNC:16390"
/db_xref="HPRD:05815"
/db_xref="MIM:605980"
exon 1..172
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
variation 128
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2709798"
variation 139
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743332"
exon 173..313
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 314..402
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
variation 341
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:5743335"
variation 364
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743336"
exon 403..724
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
misc_feature 503..505
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="upstream in-frame stop codon"
CDS 524..3385
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="NLR family, CARD domain containing 1;
nucleotide-binding oligomerization domain, leucine rich
repeat and CARD domain containing 1; caspase recruitment
domain family, member 4; caspase recruitment
domain-containing protein 4"
/codon_start=1
/product="nucleotide-binding oligomerization
domain-containing protein 1"
/protein_id="NP_006083.1"
/db_xref="GI:5174617"
/db_xref="CCDS:CCDS5427.1"
/db_xref="GeneID:10392"
/db_xref="HGNC:16390"
/db_xref="HPRD:05815"
/db_xref="MIM:605980"
/translation="
MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF
"
misc_feature 584..838
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="Caspase activation and recruitment domain similar
to that found in NOD1; Region: CARD_NOD1_CARD4; cd08324"
/db_xref="CDD:176738"
misc_feature order(599..601,608..613,620..631,635..643,647..649,
659..661,782..784,791..796,800..826,830..835)
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:176738"
misc_feature 1103..>1396
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="ATPases associated with a variety of cellular
activities; Region: AAA; smart00382"
/db_xref="CDD:197690"
misc_feature 1112..1624
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="NACHT domain; Region: NACHT; pfam05729"
/db_xref="CDD:191357"
misc_feature 2417..2491
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 1"
misc_feature 2549..3346
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
(RI)-like subfamily. LRRs are 20-29 residue sequence
motifs present in many proteins that participate in
protein-protein interactions and have different functions
and cellular locations. LRRs correspond...; Region:
LRR_RI; cl15309"
/db_xref="CDD:199167"
misc_feature order(2552..2554,2561..2563,2567..2569,2576..2578,
2582..2584,2639..2641,2645..2647,2654..2656,2660..2662,
2711..2713,2720..2722,2726..2728,2735..2737,2741..2743,
2795..2797,2804..2806,2810..2812,2819..2821,2825..2827,
2879..2881,2888..2890,2894..2896,2903..2905,2909..2911,
2963..2965,2972..2974,2978..2980,2987..2989,2993..2995,
3047..3049,3056..3058,3062..3064,3071..3073,3077..3079,
3131..3133,3140..3142,3146..3148,3155..3157,3161..3163,
3215..3217,3224..3226,3230..3232,3239..3241,3245..3247,
3299..3301,3308..3310,3314..3316,3323..3325,3329..3331)
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="Leucine-rich repeats; other site"
/db_xref="CDD:29015"
misc_feature order(2570..2575,2732..2734,2900..2902,2984..2986,
3152..3154,3227..3229,3233..3235,3311..3313)
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/note="Substrate binding site [chemical binding]; other
site"
/db_xref="CDD:29015"
misc_feature 2627..2698
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 2"
misc_feature 2702..2773
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 3"
misc_feature 2786..2857
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 4"
misc_feature 2870..2941
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 5"
misc_feature 3038..3109
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 6"
misc_feature 3122..3196
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 7"
misc_feature 3206..3277
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 8"
misc_feature 3290..3361
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y239.1);
Region: LRR 9"
variation 679
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2075818"
exon 725..899
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 900..2724
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
variation 925
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:72551109"
variation 958
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:5743340"
variation 1004..1006
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551114"
variation 1006
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2235099"
variation 1009
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551112"
variation 1093
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551108"
variation 1095
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72470547"
variation 1140
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551110"
variation 1164..1166
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551111"
variation 1176..1178
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:72551113"
variation 1319
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2075820"
variation 1366
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743341"
variation 1414
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3020208"
variation 1569
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72551107"
variation 1583..1585
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:72551104"
variation 1584..1586
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:72551106"
variation 1632
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:72551105"
variation 1637
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5743342"
variation 1858
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743343"
variation 1863
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2975634"
variation 2184
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743344"
variation 2245
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2075821"
STS 2307..2682
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/standard_name="NOD1"
/db_xref="UniSTS:503630"
variation 2335
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:3020209"
variation 2336
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743345"
variation 2351
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5743346"
variation 2433
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5743347"
exon 2725..2808
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 2809..2892
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 2893..2976
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 2977..3060
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 3061..3144
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 3145..3228
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 3229..3312
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
exon 3313..4496
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/inference="alignment:Splign:1.39.8"
variation 3604
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743372"
STS 3665..4481
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/standard_name="CARD4_3524"
/db_xref="UniSTS:462080"
variation 3678
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5743373"
variation 3767
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5743374"
STS 4336..4471
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/standard_name="STS-R02588"
/db_xref="UniSTS:7022"
variation 4461
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:963804"
polyA_signal 4473..4478
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
polyA_site 4496
/gene="NOD1"
/gene_synonym="CARD4; CLR7.1; NLRC1"
ORIGIN
gttccgggcccgcgaggcagccgccccggtcctgcccctccctcgcgctactgcgggagcagcgtcctcccgggccacggcgcttcccggccccggcgtccccggaccatggcgctctccgggctcttctctagctctcagcggctgcgaagtctgtaaacctggtggccaagtgattgtaagtcaggagactttccttcggtttctgcctttgatggcaagaggtggagattgtggcggcgattacagaaaacatctgggaagacaagttgctgtttttatgggaatcgcaggcttggaagagacagaagcaattccagaaataaattggaaattgaagatttaaacaatgttgttttaaaatattctaacttcaaagaatgatgccagaaacttaaaaaggggctgcgcagagtagcaggggccctggagggcgcggcctgaatcctgattgcccttctgctgagaggacacacgcagctgaagatgaatttgggaaaagtagccgcttgctactttaactatggaagagcagggccacagtgagatggaaataatcccatcagagtctcacccccacattcaattactgaaaagcaatcgggaacttctggtcactcacatccgcaatactcagtgtctggtggacaacttgctgaagaatgactacttctcggccgaagatgcggagattgtgtgtgcctgccccacccagcctgacaaggtccgcaaaattctggacctggtacagagcaagggcgaggaggtgtccgagttcttcctctacttgctccagcaactcgcagatgcctacgtggacctcaggccttggctgctggagatcggcttctccccttccctgctcactcagagcaaagtcgtggtcaacactgacccagtgagcaggtatacccagcagctgcgacaccatctgggccgtgactccaagttcgtgctgtgctatgcccagaaggaggagctgctgctggaggagatctacatggacaccatcatggagctggttggcttcagcaatgagagcctgggcagcctgaacagcctggcctgcctcctggaccacaccaccggcatcctcaatgagcagggtgagaccatcttcatcctgggtgatgctggggtgggcaagtccatgctgctacagcggctgcagagcctctgggccacgggccggctagacgcaggggtcaaattcttcttccactttcgctgccgcatgttcagctgcttcaaggaaagtgacaggctgtgtctgcaggacctgctcttcaagcactactgctacccagagcgggaccccgaggaggtgtttgccttcctgctgcgcttcccccacgtggccctcttcaccttcgatggcctggacgagctgcactcggacttggacctgagccgcgtgcctgacagctcctgcccctgggagcctgcccaccccctggtcttgctggccaacctgctcagtgggaagctgctcaagggggctagcaagctgctcacagcccgcacaggcatcgaggtcccgcgccagttcctgcggaagaaggtgcttctccggggcttctcccccagccacctgcgcgcctatgccaggaggatgttccccgagcgggccctgcaggaccgcctgctgagccagctggaggccaaccccaacctctgcagcctgtgctctgtgcccctcttctgctggatcatcttccggtgcttccagcacttccgtgctgcctttgaaggctcaccacagctgcccgactgcacgatgaccctgacagatgtcttcctcctggtcactgaggtccatctgaacaggatgcagcccagcagcctggtgcagcggaacacacgcagcccagtggagaccctccacgccggccgggacactctgtgctcgctggggcaggtggcccaccggggcatggagaagagcctctttgtcttcacccaggaggaggtgcaggcctccgggctgcaggagagagacatgcagctgggcttcctgcgggctttgccggagctgggccccgggggtgaccagcagtcctatgagtttttccacctcaccctccaggccttctttacagccttcttcctcgtgctggacgacagggtgggcactcaggagctgctcaggttcttccaggagtggatgccccctgcgggggcagcgaccacgtcctgctatcctcccttcctcccgttccagtgcctgcagggcagtggtccggcgcgggaagacctcttcaagaacaaggatcacttccagttcaccaacctcttcctgtgcgggctgttgtccaaagccaaacagaaactcctgcggcatctggtgcccgcggcagccctgaggagaaagcgcaaggccctgtgggcacacctgttttccagcctgcggggctacctgaagagcctgccccgcgttcaggtcgaaagcttcaaccaggtgcaggccatgcccacgttcatctggatgctgcgctgcatctacgagacacagagccagaaggtggggcagctggcggccaggggcatctgcgccaactacctcaagctgacctactgcaacgcctgctcggccgactgcagcgccctctccttcgtcctgcatcacttccccaagcggctggccctagacctagacaacaacaatctcaacgactacggcgtgcgggagctgcagccctgcttcagccgcctcactgttctcagactcagcgtaaaccagatcactgacggtggggtaaaggtgctaagcgaagagctgaccaaatacaaaattgtgacctatttgggtttatacaacaaccagatcaccgatgtcggagccaggtacgtcaccaaaatcctggatgaatgcaaaggcctcacgcatcttaaactgggaaaaaacaaaataacaagtgaaggagggaagtatctcgccctggctgtgaagaacagcaaatcaatctctgaggttgggatgtggggcaatcaagttggggatgaaggagcaaaagccttcgcagaggctctgcggaaccaccccagcttgaccaccctgagtcttgcgtccaacggcatctccacagaaggaggaaagagccttgcgagggccctgcagcagaacacgtctctagaaatactgtggctgacccaaaatgaactcaacgatgaagtggcagagagtttggcagaaatgttgaaagtcaaccagacgttaaagcatttatggcttatccagaatcagatcacagctaaggggactgcccagctggcagatgcgttacagagcaacactggcataacagagatttgcctaaatggaaacctgataaaaccagaggaggccaaagtctatgaagatgagaagcggattatctgtttctgagaggatgctttcctgttcatggggtttttgccctggagcctcagcagcaaatgccactctgggcagtcttttgtgtcagtgtcttaaaggggcctgcgcaggcgggactatcaggagtccactgcctccatgatgcaagccagcttcctgtgcagaaggtctggtcggcaaactccctaagtacccgctacaattctgcagaaaaagaatgtgtcttgcgagctgttgtagttacagtaaatacactgtgaagagactttattgcctattataattatttttatctgaagctagaggaataaagctgtgagcaaacagaggaggccagcctcacctcattccaacacctgccatagggaccaacgggagcgagttggtcaccgctcttttcattgaagagttgaggatgtggcacaaagttggtgccaagcttcttgaataaaacgtgtttgatggattagtattatacctgaaatattttcttccttctcagcactttcccatgtattgatactggtcccacttcacagctggagacaccggagtatgtgcagtgtgggatttgactcctccaaggttttgtggaaagttaatgtcaaggaaaggatgcaccacgggcttttaattttaatcctggagtctcactgtctgctggcaaagatagagaatgccctcagctcttagctggtctaagaatgacgatgccttcaaaatgctgcttccactcagggcttctcctctgctaggctaccctcctctagaaggctgagtaccatgggctacagtgtctggccttgggaagaagtgattctgtccctccaaagaaatagggcatggcttgcccctgtggccctggcatccaaatggctgcttttgtctcccttacctcgtgaagaggggaagtctcttcctgcctcccaagcagctgaagggtgactaaacgggcgccaagactcaggggatcggctgggaactgggccagcagagcatgttggacaccccccaccatggtgggcttgtggtggctgctccatgagggtgggggtgatactactagatcacttgtcctcttgccagctcatttgttaataaaatactgaaaacactcttaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10392 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10392 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:10392 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: TAS
GeneID:10392 -> Molecular function: GO:0042802 [identical protein binding] evidence: IDA
GeneID:10392 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:10392 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:10392 -> Molecular function: GO:0042834 [peptidoglycan binding] evidence: TAS
GeneID:10392 -> Molecular function: GO:0050700 [CARD domain binding] evidence: IDA
GeneID:10392 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:10392 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0002606 [positive regulation of dendritic cell antigen processing and presentation] evidence: ISS
GeneID:10392 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:10392 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IDA
GeneID:10392 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:10392 -> Biological process: GO:0006952 [defense response] evidence: TAS
GeneID:10392 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
GeneID:10392 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:10392 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
GeneID:10392 -> Biological process: GO:0009595 [detection of biotic stimulus] evidence: TAS
GeneID:10392 -> Biological process: GO:0016045 [detection of bacterium] evidence: IDA
GeneID:10392 -> Biological process: GO:0032755 [positive regulation of interleukin-6 production] evidence: IEA
GeneID:10392 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: IEA
GeneID:10392 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IDA
GeneID:10392 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:10392 -> Biological process: GO:0042228 [interleukin-8 biosynthetic process] evidence: IDA
GeneID:10392 -> Biological process: GO:0042742 [defense response to bacterium] evidence: IDA
GeneID:10392 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA
GeneID:10392 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:10392 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IEA
GeneID:10392 -> Biological process: GO:0050830 [defense response to Gram-positive bacterium] evidence: IEA
GeneID:10392 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:10392 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: TAS
GeneID:10392 -> Biological process: GO:0051259 [protein oligomerization] evidence: TAS
GeneID:10392 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:10392 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IEA
GeneID:10392 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
GeneID:10392 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:10392 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:10392 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:10392 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IDA
GeneID:10392 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
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