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2024-04-27 08:08:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006080 5672 bp mRNA linear PRI 04-JUL-2013
DEFINITION Homo sapiens sema domain, immunoglobulin domain (Ig), short basic
domain, secreted, (semaphorin) 3A (SEMA3A), mRNA.
ACCESSION NM_006080
VERSION NM_006080.2 GI:100913215
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5672)
AUTHORS Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI,
Ripke S, Santangelo S and Sullivan PF.
CONSRTM Cross-Disorder Group of the Psychiatric Genomics Consortium
TITLE Identification of risk loci with shared effects on five major
psychiatric disorders: a genome-wide analysis
JOURNAL Lancet 381 (9875), 1371-1379 (2013)
PUBMED 23453885
REMARK Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE 2 (bases 1 to 5672)
AUTHORS Nakano,Y., Chayama,K., Ochi,H., Toshishige,M., Hayashida,Y.,
Miki,D., Hayes,C.N., Suzuki,H., Tokuyama,T., Oda,N., Suenari,K.,
Uchimura-Makita,Y., Kajihara,K., Sairaku,A., Motoda,C.,
Fujiwara,M., Watanabe,Y., Yoshida,Y., Ohkubo,K., Watanabe,I.,
Nogami,A., Hasegawa,K., Watanabe,H., Endo,N., Aiba,T., Shimizu,W.,
Ohno,S., Horie,M., Arihiro,K., Tashiro,S., Makita,N. and Kihara,Y.
TITLE A nonsynonymous polymorphism in semaphorin 3A as a risk factor for
human unexplained cardiac arrest with documented ventricular
fibrillation
JOURNAL PLoS Genet. 9 (4), E1003364 (2013)
PUBMED 23593010
REMARK GeneRIF: A high incidence of SEMA3A(I334V) in UCA patients and
inappropriate innervation patterning in their hearts implicate
involvement of the SEMA3A gene in the pathogenesis of UCA.
REFERENCE 3 (bases 1 to 5672)
AUTHORS Takagawa,S., Nakamura,F., Kumagai,K., Nagashima,Y., Goshima,Y. and
Saito,T.
TITLE Decreased semaphorin3A expression correlates with disease activity
and histological features of rheumatoid arthritis
JOURNAL BMC Musculoskelet Disord 14, 40 (2013)
PUBMED 23343469
REMARK GeneRIF: Reduction of Sema3A expression in rheumatoid arthritis
synovial tissues may contribute to pathogenesis of RA.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 5672)
AUTHORS Hanchate,N.K., Giacobini,P., Lhuillier,P., Parkash,J., Espy,C.,
Fouveaut,C., Leroy,C., Baron,S., Campagne,C., Vanacker,C.,
Collier,F., Cruaud,C., Meyer,V., Garcia-Pinero,A., Dewailly,D.,
Cortet-Rudelli,C., Gersak,K., Metz,C., Chabrier,G., Pugeat,M.,
Young,J., Hardelin,J.P., Prevot,V. and Dode,C.
TITLE SEMA3A, a gene involved in axonal pathfinding, is mutated in
patients with Kallmann syndrome
JOURNAL PLoS Genet. 8 (8), E1002896 (2012)
PUBMED 22927827
REMARK GeneRIF: Findings indicate that semaphorin-3A signaling
insufficiency contributes to the pathogenesis of Kallmann syndrome.
Nonsynonymous mutations in SEMA3A were found in 24 patients, all in
heterozygous state .
REFERENCE 5 (bases 1 to 5672)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 6 (bases 1 to 5672)
AUTHORS Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
TITLE Plexin-neuropilin-1 complexes form functional semaphorin-3A
receptors
JOURNAL Cell 99 (1), 59-69 (1999)
PUBMED 10520994
REFERENCE 7 (bases 1 to 5672)
AUTHORS Takahashi,T., Nakamura,F., Jin,Z., Kalb,R.G. and Strittmatter,S.M.
TITLE Semaphorins A and E act as antagonists of neuropilin-1 and agonists
of neuropilin-2 receptors
JOURNAL Nat. Neurosci. 1 (6), 487-493 (1998)
PUBMED 10196546
REFERENCE 8 (bases 1 to 5672)
AUTHORS Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
TITLE Neuropilin-2, a novel member of the neuropilin family, is a high
affinity receptor for the semaphorins Sema E and Sema IV but not
Sema III
JOURNAL Neuron 19 (3), 547-559 (1997)
PUBMED 9331348
REMARK Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE 9 (bases 1 to 5672)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE Murine semaphorin D/collapsin is a member of a diverse gene family
and creates domains inhibitory for axonal extension
JOURNAL Neuron 14 (5), 941-948 (1995)
PUBMED 7748561
REFERENCE 10 (bases 1 to 5672)
AUTHORS Kolodkin,A.L., Matthes,D.J. and Goodman,C.S.
TITLE The semaphorin genes encode a family of transmembrane and secreted
growth cone guidance molecules
JOURNAL Cell 75 (7), 1389-1399 (1993)
PUBMED 8269517
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX491494.1, BU186364.1,
DR002146.1, L26081.1, BM723807.1, AC006322.2 and CR748125.1.
This sequence is a reference standard in the RefSeqGene project.
On May 25, 2006 this sequence version replaced gi:5174672.
Summary: This gene is a member of the semaphorin family and encodes
a protein with an Ig-like C2-type (immunoglobulin-like) domain, a
PSI domain and a Sema domain. This secreted protein can function as
either a chemorepulsive agent, inhibiting axonal outgrowth, or as a
chemoattractive agent, stimulating the growth of apical dendrites.
In both cases, the protein is vital for normal neuronal pattern
development. Increased expression of this protein is associated
with schizophrenia and is seen in a variety of human tumor cell
lines. Also, aberrant release of this protein is associated with
the progression of Alzheimer's disease. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK289954.1, L26081.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-41 BX491494.1 35-75
42-105 BU186364.1 134-197
106-305 BX491494.1 143-342
306-901 DR002146.1 144-739
902-2465 L26081.1 602-2165
2466-2607 BM723807.1 430-571
2608-2816 L26081.1 2308-2516
2817-5111 AC006322.2 37834-40128
5112-5672 CR748125.1 1-561 c
FEATURES Location/Qualifiers
source 1..5672
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p12.1"
gene 1..5672
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="sema domain, immunoglobulin domain (Ig), short
basic domain, secreted, (semaphorin) 3A"
/db_xref="GeneID:10371"
/db_xref="HGNC:10723"
/db_xref="HPRD:04908"
/db_xref="MIM:603961"
exon 1..427
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
misc_feature 283..285
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="upstream in-frame stop codon"
CDS 316..2631
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="semaphorin L; semaphorin III; collapsin 1;
semaphorin-3A; semaphorin D"
/codon_start=1
/product="semaphorin-3A precursor"
/protein_id="NP_006071.1"
/db_xref="GI:5174673"
/db_xref="CCDS:CCDS5599.1"
/db_xref="GeneID:10371"
/db_xref="HGNC:10723"
/db_xref="HPRD:04908"
/db_xref="MIM:603961"
/translation="
MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV
"
sig_peptide 316..378
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
mat_peptide 379..2628
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/product="semaphorin-3A"
misc_feature 391..1869
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="The Sema domain, a protein interacting module, of
semaphorin 3A (Sema3A); Region: Sema_3A; cd11249"
/db_xref="CDD:200510"
misc_feature 484..1785
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="semaphorin domain; Region: Sema; smart00630"
/db_xref="CDD:197806"
misc_feature order(625..636,811..816,826..828,889..891,895..900,
919..921,949..951,958..963,967..969,982..984,1069..1071,
1141..1155,1159..1161,1504..1506,1516..1518,1525..1527)
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="putative plexin binding site [polypeptide binding];
other site"
/db_xref="CDD:200510"
misc_feature order(1072..1077,1081..1083,1090..1098,1198..1200,
1207..1212,1216..1218,1222..1224,1234..1236,1303..1326,
1402..1413,1543..1545,1588..1590)
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:200510"
misc_feature 1861..>1971
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="domain found in Plexins, Semaphorins and Integrins;
Region: PSI; smart00423"
/db_xref="CDD:197717"
misc_feature 2053..2325
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="Immunoglobulin (Ig)-like domain of class III
semaphorin; Region: Ig_Semaphorin_classIII; cd05871"
/db_xref="CDD:143279"
misc_feature 2074..2316
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="Immunoglobulin V-set domain; Region: V-set;
pfam07686"
/db_xref="CDD:203725"
misc_feature order(2089..2091,2224..2226)
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143279"
exon 428..585
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 586..648
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 649..768
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 769..862
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 863..982
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 983..1125
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
variation 1020
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="c"
/replace="t"
/db_xref="dbSNP:34541339"
variation 1101
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="c"
/replace="t"
/db_xref="dbSNP:34652029"
exon 1126..1240
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 1241..1310
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
variation 1254
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="a"
/replace="g"
/db_xref="dbSNP:35078268"
exon 1311..1455
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 1456..1675
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 1676..1767
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 1768..1809
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 1810..1967
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
variation 1878
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="c"
/replace="g"
/db_xref="dbSNP:10487865"
exon 1968..2032
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 2033..2175
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
exon 2176..5659
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/inference="alignment:Splign:1.39.8"
STS 2192..2897
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/standard_name="SEMA3A_v396"
/db_xref="UniSTS:277698"
STS 2306..2535
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/standard_name="SEMIII"
/db_xref="UniSTS:32126"
STS 2394..2607
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/standard_name="RH69031"
/db_xref="UniSTS:62231"
variation 2466
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="a"
/replace="g"
/db_xref="dbSNP:797821"
STS 3767..3941
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/standard_name="SHGC-53494"
/db_xref="UniSTS:1610"
variation 3767
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="c"
/replace="t"
/db_xref="dbSNP:797822"
variation 4176
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/replace="a"
/replace="c"
/db_xref="dbSNP:1052343"
polyA_site 4686
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
STS 5390..5644
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
/standard_name="SHGC-56119"
/db_xref="UniSTS:74775"
polyA_site 5659
/gene="SEMA3A"
/gene_synonym="coll-1; COLL1; HH16; Hsema-I; Hsema-III;
SEMA1; SEMAD; SEMAIII; SEMAL; SemD"
ORIGIN
aagcaccactgcagcagaccttgttaattttttttttttttctttccacacaacagttgtgcctcattatccggtgcctggctcggaatttttttttttttttttctttttggagggtttgaagtttctgtgcttcagtgactgttacagaagaagaggtgttagtgttgccatgaggtcttgattgtctgcatttatgaatgaaactgacctaaatcacctgttacctccagtttccagattgtttgaacttctctggccgcacaatacaggaaggaagactaaagcagcaaagggacctacagcgtctgcagcatgggctggttaactaggattgtctgtcttttctggggagtattacttacagcaagagcaaactatcagaatgggaagaacaatgtgccaaggctgaaattatcctacaaagaaatgttggaatccaacaatgtgatcactttcaatggcttggccaacagctccagttatcataccttccttttggatgaggaacggagtaggctgtatgttggagcaaaggatcacatattttcattcgacctggttaatatcaaggattttcaaaagattgtgtggccagtatcttacaccagaagagatgaatgcaagtgggctggaaaagacatcctgaaagaatgtgctaatttcatcaaggtacttaaggcatataatcagactcacttgtacgcctgtggaacgggggcttttcatccaatttgcacctacattgaaattggacatcatcctgaggacaatatttttaagctggagaactcacattttgaaaacggccgtgggaagagtccatatgaccctaagctgctgacagcatcccttttaatagatggagaattatactctggaactgcagctgattttatggggcgagactttgctatcttccgaactcttgggcaccaccacccaatcaggacagagcagcatgattccaggtggctcaatgatccaaagttcattagtgcccacctcatctcagagagtgacaatcctgaagatgacaaagtatactttttcttccgtgaaaatgcaatagatggagaacactctggaaaagctactcacgctagaataggtcagatatgcaagaatgactttggagggcacagaagtctggtgaataaatggacaacattcctcaaagctcgtctgatttgctcagtgccaggtccaaatggcattgacactcattttgatgaactgcaggatgtattcctaatgaactttaaagatcctaaaaatccagttgtatatggagtgtttacgacttccagtaacattttcaagggatcagccgtgtgtatgtatagcatgagtgatgtgagaagggtgttccttggtccatatgcccacagggatggacccaactatcaatgggtgccttatcaaggaagagtcccctatccacggccaggaacttgtcccagcaaaacatttggtggttttgactctacaaaggaccttcctgatgatgttataacctttgcaagaagtcatccagccatgtacaatccagtgtttcctatgaacaatcgcccaatagtgatcaaaacggatgtaaattatcaatttacacaaattgtcgtagaccgagtggatgcagaagatggacagtatgatgttatgtttatcggaacagatgttgggaccgttcttaaagtagtttcaattcctaaggagacttggtatgatttagaagaggttctgctggaagaaatgacagtttttcgggaaccgactgctatttcagcaatggagctttccactaagcagcaacaactatatattggttcaacggctggggttgcccagctccctttacaccggtgtgatatttacgggaaagcgtgtgctgagtgttgcctcgcccgagacccttactgtgcttgggatggttctgcatgttctcgctattttcccactgcaaagagacgcacaagacgacaagatataagaaatggagacccactgactcactgttcagacttacaccatgataatcaccatggccacagccctgaagagagaatcatctatggtgtagagaatagtagcacatttttggaatgcagtccgaagtcgcagagagcgctggtctattggcaattccagaggcgaaatgaagagcgaaaagaagagatcagagtggatgatcatatcatcaggacagatcaaggccttctgctacgtagtctacaacagaaggattcaggcaattacctctgccatgcggtggaacatgggttcatacaaactcttcttaaggtaaccctggaagtcattgacacagagcatttggaagaacttcttcataaagatgatgatggagatggctctaagaccaaagaaatgtccaatagcatgacacctagccagaaggtctggtacagagacttcatgcagctcatcaaccaccccaatctcaacacaatggatgagttctgtgaacaagtttggaaaagggaccgaaaacaacgtcggcaaaggccaggacataccccagggaacagtaacaaatggaagcacttacaagaaaataagaaaggtagaaacaggaggacccacgaatttgagagggcacccaggagtgtctgagctgcattacctctagaaacctcaaacaagtagaaacttgcctagacaataactggaaaaacaaatgcaatatacatgaacttttttcatggcattatgtggatgtttacaatggtgggaaattcagctgagttccaccaattataaattaaatccatgagtaactttcctaataggctttttttcctaataccaccacctaacagagaacacaggtgaatgcagatgttcactttagcagacttaatgtttcctatgagatttcactgtacaggtttgtctttcttctttgcctgagaaataaaaatgtcatttgccatattgccatctaaaggagaaaaactgcatcagcaaagccattgtattgaactaaaagtttaaaatgaactgcatggatttactaagctgatgaatattccaaaacgtggttggattcaaggatatattttgtctaccggccctcatgtttgtatgtacttgaggagtaaaatgagtaaaatgatactgaatgaaatgttctgtggaaatattaaaaaaaaaaaaaaacataagccatccatcatccagaagaaaaatggaatacactgatctactactgatgtcttctttcagctttgatctaaagatgtattttattaaaactataatttaaatgtaccatgaaaaatatgcagtaaaaattagttgttttctaagctagagtaggatttgtcttacaattattgtgctatgtagtttttgttttaaaaattccaatggtgtgctgctttctttggacattttattttcaattctataagagggatagatgacattgttctagaaacacatatacatcattaagagtgaatctctaaaaccaggatataaattatgctttatttctctgagaaaatcaaacaaatggaagctgttcacacctccccttctttaagcattatctaaattaatttttacttgcataatgttcttagaaaaaaaaacagaacatttaagcaggaaaaaaggaagaaacaagttgatttttaagtgcattttactataatgaatcaatgaagggaaaaggaactgcatatttcatgaaaataataagcattgtcttaatatactgttaatagaaaatgtgtcttaattccgtgcttgaatccctgcatgatatttgagactaagatctctcttatgattctaccaagaattatatctgtgtcacttaatttttttaaaagagagagatcaataactattcagagcaacatgttaaaggcaaagtttccaatcatttacatctgtatcaggtgcctcttacctttccttatttaagacaattatttgtacaagaaacacatgactcttttcatatcaatgggagggacttttctacaaagtattttccaggatgcaacccacatttaaacaatgtaaaattctttgtttcctgcaacaacttacaaaataaggtaaaagactaaaattcaagatttgcttccttcattgtcctaagacgattcgttgagaatcactgactttgagatatttaaaactttcagcattatactgtggtttcttttgcactgcactcacctattcaggactcctcccccaggttcctcatcatgcacaaaaatgcaaagaaaacatcttattagtaattaatgaagcaacattgaaattctaactctagctgtctttggattctaattaactcagcatcaatttctcacctcagactacagtgaatttttatttcctatcagctgaaatatttcacagatggaagctcatgtttcagttttaatgactgccttgaataaacaagttgttgccacttgtttcaaacaaaagcctaaaaataatctacattcaattttaggctccattgactaatatggtgttgcttttggaagtactgtatatcctcacatggaagccaaattgttaaattatttgaaggacacaccactgtacagaaagtagtgtttcaaatataaatcgaagaacaaagagtgctccaaaaaataggtcattcttttattttcataaagtatctaaactgtactaacattcagtgttgtgtttcattctaaatttgcagctgaaataaatttatttgcgatagcagaaatatcttattattcatcctcagaaataaaggatttgaagggatagagattatatgataaatttatagaagactttcagaatttgaatgcattttgtttagtgttatgaaatgacaatagaaaaaagtctcgacttcaattaaaagttacacaaacaaacaaatctacaggcatgtctttatataccatcaggtctaagttttcaaagaaaattgtagatataacttgcagataactcattacagtcataatctctgcccatgtgtattgagagggggcagtttgcacgaaaaagaattattggcccatttaataattcagctttaaatagactttgtcatatgcatgaatcatcagagatgaaactgtttgagagactcatgtgaccttacgaaaattacaacagcagtcttaaagtatgaaaaagatgcatcacagcagagacattatggcccagttgatatcaaatgtaaaatgtaaatgcatgtaaatgcacacttcattttatgtattatttagtaatttgcagtggtatgtgtttaatatttttgctacctacacattaggcaaaaaaaagatgtaaataatttgggagaaaaagaggaagaacagtgtaaaataaaactttctataagtactccatttcaatgtgttcaacatcatcctaaaaggcaagattttcccacgcaggtgacaaggtggtttatgtactatttaagggcggaaggtgcgtgcccgttcaataagcatgttttttgccaggtaggaaatatgttccatatctttacttatcattgcatttcagatgggaactagaaaaactggagagaaaaatgtaatgaaactgctgctgtaaattattccttttagcatgtattcacttgctaaatacacatttcttcaaaataaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10371 -> Molecular function: GO:0004872 [receptor activity] evidence: IEA
GeneID:10371 -> Molecular function: GO:0045499 [chemorepellent activity] evidence: TAS
GeneID:10371 -> Biological process: GO:0001764 [neuron migration] evidence: ISS
GeneID:10371 -> Biological process: GO:0002027 [regulation of heart rate] evidence: IEA
GeneID:10371 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10371 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:10371 -> Biological process: GO:0007413 [axonal fasciculation] evidence: IEA
GeneID:10371 -> Biological process: GO:0010633 [negative regulation of epithelial cell migration] evidence: IEA
GeneID:10371 -> Biological process: GO:0021675 [nerve development] evidence: ISS
GeneID:10371 -> Biological process: GO:0021772 [olfactory bulb development] evidence: IMP
GeneID:10371 -> Biological process: GO:0048485 [sympathetic nervous system development] evidence: ISS
GeneID:10371 -> Biological process: GO:0048485 [sympathetic nervous system development] evidence: TAS
GeneID:10371 -> Biological process: GO:0048813 [dendrite morphogenesis] evidence: IEA
GeneID:10371 -> Biological process: GO:0048841 [regulation of axon extension involved in axon guidance] evidence: IDA
GeneID:10371 -> Biological process: GO:0048843 [negative regulation of axon extension involved in axon guidance] evidence: IEA
GeneID:10371 -> Biological process: GO:0048846 [axon extension involved in axon guidance] evidence: ISS
GeneID:10371 -> Biological process: GO:0048880 [sensory system development] evidence: TAS
GeneID:10371 -> Biological process: GO:0060385 [axonogenesis involved in innervation] evidence: ISS
GeneID:10371 -> Biological process: GO:0060666 [dichotomous subdivision of terminal units involved in salivary gland branching] evidence: IEA
GeneID:10371 -> Biological process: GO:0071526 [semaphorin-plexin signaling pathway] evidence: TAS
GeneID:10371 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:10371 -> Cellular component: GO:0016020 [membrane] evidence: IEA
GeneID:10371 -> Cellular component: GO:0030424 [axon] evidence: IEA
GeneID:10371 -> Cellular component: GO:0030425 [dendrite] evidence: IEA
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