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2024-04-23 21:04:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006006 2417 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16),
transcript variant 1, mRNA.
ACCESSION NM_006006
VERSION NM_006006.4 GI:66932930
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2417)
AUTHORS Jones,C., St-Jean,S., Frechette,I., Bergeron,D., Rivard,N. and
Boudreau,F.
TITLE Identification of a novel promyelocytic leukemia zinc-finger
isoform required for colorectal cancer cell growth and survival
JOURNAL Int. J. Cancer 133 (1), 58-66 (2013)
PUBMED 23280881
REMARK GeneRIF: The p65 PLZF isoform is crucial to maintain colorectal
cancer cell growth, adhesion and survival, and must occur
independently of the traditionally viewed transcriptional role of
PLZF in the course of these biological processes.
REFERENCE 2 (bases 1 to 2417)
AUTHORS Gerart,S., Siberil,S., Martin,E., Lenoir,C., Aguilar,C., Picard,C.,
Lantz,O., Fischer,A. and Latour,S.
TITLE Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic
propensity that is counterbalanced by XIAP
JOURNAL Blood 121 (4), 614-623 (2013)
PUBMED 23223428
REMARK GeneRIF: Our findings identify a previously unknown pathway of
regulation of innate-like T-cell homeostasis depending on XIAP and
PLZF.
REFERENCE 3 (bases 1 to 2417)
AUTHORS Jeon,Y.K., Go,H., Nam,S.J., Keam,B., Kim,T.M., Jung,K.C.,
Kang,H.J., Lee,D.S., Huh,J.R. and Park,S.H.
TITLE Expression of the promyelocytic leukemia zinc-finger in
T-lymphoblastic lymphoma and leukemia has strong implications for
their cellular origin and greater association with initial bone
marrow involvement
JOURNAL Mod. Pathol. 25 (9), 1236-1245 (2012)
PUBMED 22555178
REMARK GeneRIF: Expression of the promyelocytic leukemia zinc-finger in
T-lymphoblastic lymphoma and leukemia has strong implications for
their cellular origin and greater association with initial bone
marrow involvement.
REFERENCE 4 (bases 1 to 2417)
AUTHORS Hsu,Y.H., Chen,Y.C., Chen,T.H., Sue,Y.M., Cheng,T.H., Chen,J.R. and
Chen,C.H.
TITLE Far-infrared therapy induces the nuclear translocation of PLZF
which inhibits VEGF-induced proliferation in human umbilical vein
endothelial cells
JOURNAL PLoS ONE 7 (1), E30674 (2012)
PUBMED 22292015
REMARK GeneRIF: Far infrared rays induce the nuclear translocation of PLZF
which inhibits VEGF-induced proliferation in HUVECs.
REFERENCE 5 (bases 1 to 2417)
AUTHORS Eidson,M., Wahlstrom,J., Beaulieu,A.M., Zaidi,B., Carsons,S.E.,
Crow,P.K., Yuan,J., Wolchok,J.D., Horsthemke,B., Wieczorek,D. and
Sant'Angelo,D.B.
TITLE Altered development of NKT cells, gammadelta T cells, CD8 T cells
and NK cells in a PLZF deficient patient
JOURNAL PLoS ONE 6 (9), E24441 (2011)
PUBMED 21915328
REMARK GeneRIF: PLZF appears to control the development and/or function of
a wide variety of human lymphocytes that represent more than 10% of
the total PBMCs.
REFERENCE 6 (bases 1 to 2417)
AUTHORS Hong,S.H., David,G., Wong,C.W., Dejean,A. and Privalsky,M.L.
TITLE SMRT corepressor interacts with PLZF and with the PML-retinoic acid
receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated
with acute promyelocytic leukemia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (17), 9028-9033 (1997)
PUBMED 9256429
REFERENCE 7 (bases 1 to 2417)
AUTHORS Dong,S., Zhu,J., Reid,A., Strutt,P., Guidez,F., Zhong,H.J.,
Wang,Z.Y., Licht,J., Waxman,S., Chomienne,C., Chen,Z., Zelent,A.
and Chen,S.J.
TITLE Amino-terminal protein-protein interaction motif (POZ-domain) is
responsible for activities of the promyelocytic leukemia zinc
finger-retinoic acid receptor-alpha fusion protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3624-3629 (1996)
PUBMED 8622986
REFERENCE 8 (bases 1 to 2417)
AUTHORS Reid,A., Gould,A., Brand,N., Cook,M., Strutt,P., Li,J., Licht,J.,
Waxman,S., Krumlauf,R. and Zelent,A.
TITLE Leukemia translocation gene, PLZF, is expressed with a speckled
nuclear pattern in early hematopoietic progenitors
JOURNAL Blood 86 (12), 4544-4552 (1995)
PUBMED 8541544
REFERENCE 9 (bases 1 to 2417)
AUTHORS Chen,S.J., Zelent,A., Tong,J.H., Yu,H.Q., Wang,Z.Y., Derre,J.,
Berger,R., Waxman,S. and Chen,Z.
TITLE Rearrangements of the retinoic acid receptor alpha and
promyelocytic leukemia zinc finger genes resulting from
t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
JOURNAL J. Clin. Invest. 91 (5), 2260-2267 (1993)
PUBMED 8387545
REFERENCE 10 (bases 1 to 2417)
AUTHORS Chen,Z., Brand,N.J., Chen,A., Chen,S.J., Tong,J.H., Wang,Z.Y.,
Waxman,S. and Zelent,A.
TITLE Fusion between a novel Kruppel-like zinc finger gene and the
retinoic acid receptor-alpha locus due to a variant t(11;17)
translocation associated with acute promyelocytic leukaemia
JOURNAL EMBO J. 12 (3), 1161-1167 (1993)
PUBMED 8384553
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX648973.1, BC029812.1 and
BM969145.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 3, 2005 this sequence version replaced gi:31543978.
Summary: This gene is a member of the Krueppel C2H2-type
zinc-finger protein family and encodes a zinc finger transcription
factor that contains nine Kruppel-type zinc finger domains at the
carboxyl terminus. This protein is located in the nucleus, is
involved in cell cycle progression, and interacts with a histone
deacetylase. Specific instances of aberrant gene rearrangement at
this locus have been associated with acute promyelocytic leukemia
(APL). Alternate transcriptional splice variants have been
characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX648973.1, BC029812.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-18 BX648973.1 118-135
19-2373 BC029812.1 1-2355
2374-2417 BM969145.1 6-49 c
FEATURES Location/Qualifiers
source 1..2417
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.1"
gene 1..2417
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="zinc finger and BTB domain containing 16"
/db_xref="GeneID:7704"
/db_xref="HGNC:12930"
/db_xref="HPRD:11762"
/db_xref="MIM:176797"
exon 1..174
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 110
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:117941637"
variation 147
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:373387180"
exon 175..1532
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 215
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371858413"
misc_feature 247..249
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="upstream in-frame stop codon"
variation 254
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="t"
/db_xref="dbSNP:371403983"
variation 264
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:200061176"
CDS 265..2286
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="zinc finger protein 145 (Kruppel-like, expressed in
promyelocytic leukemia); zinc finger protein PLZF"
/codon_start=1
/product="zinc finger and BTB domain-containing protein
16"
/protein_id="NP_005997.2"
/db_xref="GI:21359888"
/db_xref="CCDS:CCDS8367.1"
/db_xref="GeneID:7704"
/db_xref="HGNC:12930"
/db_xref="HPRD:11762"
/db_xref="MIM:176797"
/translation="
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
"
misc_feature 337..630
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="BTB/POZ domain; Region: BTB; pfam00651"
/db_xref="CDD:201372"
misc_feature 988..990
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/experiment="experimental evidence, no additional details
recorded"
/note="sumoylation site; modified site"
/db_xref="HPRD:03554"
misc_feature 1444..1449
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form PLZF-RAR-alpha
oncogene; propagated from UniProtKB/Swiss-Prot (Q05516.2);
other site"
misc_feature <1606..2025
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="FOG: Zn-finger [General function prediction only];
Region: COG5048"
/db_xref="CDD:34653"
misc_feature 1645..1713
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="C2H2-type zinc finger; Region: zf-C2H2_6;
pfam13912"
/db_xref="CDD:206083"
misc_feature 1816..1884
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1858..1929
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1945..2016
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 2029..2094
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
variation 308
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368808235"
variation 309
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:114873121"
variation 314..315
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace=""
/replace="cc"
/db_xref="dbSNP:4020462"
variation 317
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:200118587"
variation 321
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:142115592"
variation 354
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:150708066"
STS 387..601
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/db_xref="UniSTS:99119"
variation 409
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:200926841"
variation 471
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201372671"
variation 526
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:112754090"
variation 552
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373752900"
variation 582
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:367557148"
variation 597
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:200027612"
variation 662
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:370480903"
variation 663
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:35616762"
variation 673
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368029529"
variation 678
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147951342"
variation 690
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:149620068"
variation 700
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:116000851"
variation 706
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368725888"
variation 721
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:200811309"
variation 753
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:141895562"
variation 754
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:372617173"
variation 775
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:374962005"
variation 801
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368971745"
variation 829
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:111746546"
variation 865
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:111515613"
variation 928
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:373854559"
variation 936
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35784831"
variation 965
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:377612552"
variation 1040
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147732000"
variation 1044
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:149153164"
variation 1077
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:200225387"
variation 1125
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:373185527"
STS 1152..1271
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/standard_name="ZNF145"
/db_xref="UniSTS:36228"
variation 1187
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:199676604"
variation 1203
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:143295857"
variation 1234
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:377294039"
variation 1269
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:113757018"
variation 1270
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:140433448"
variation 1286
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:188510268"
variation 1293
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:145655784"
variation 1294
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373798357"
variation 1300
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:376003797"
variation 1311
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:200705288"
variation 1335
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:138118636"
variation 1336
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:142709090"
variation 1376
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:370641059"
variation 1396
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:374279135"
variation 1422
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116451759"
variation 1426
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:144726594"
variation 1435
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:368196682"
variation 1437
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:371963458"
variation 1440
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:138594849"
variation 1447
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:149262112"
variation 1464
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:207472352"
variation 1499
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368472066"
variation 1512
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116066082"
exon 1533..1630
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1543
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371953230"
variation 1557
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:375573362"
variation 1560
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:148436647"
variation 1582
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:141621748"
variation 1605
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:369917864"
exon 1631..1717
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1643
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147151121"
variation 1662
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:116547293"
variation 1677
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:202099154"
exon 1718..1888
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 1731
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:140189842"
variation 1741
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:375570317"
variation 1767
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:145667225"
variation 1776
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:117928729"
variation 1792
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:143447302"
variation 1806
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:147709798"
variation 1878
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:139901986"
exon 1889..2056
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
STS 1890..2052
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/db_xref="UniSTS:99223"
variation 1890
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:111400906"
variation 1944
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:145751819"
variation 1953
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:370528130"
variation 1963
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="c"
/db_xref="dbSNP:115957435"
variation 1987
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:145635689"
variation 2003
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047222"
exon 2057..2407
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/inference="alignment:Splign:1.39.8"
variation 2113
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:121434606"
variation 2127
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:376061668"
variation 2133
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:202060139"
variation 2241
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201532309"
variation 2259
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:114107235"
variation 2260
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="t"
/db_xref="dbSNP:370636939"
variation 2296
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:377609979"
variation 2299
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:371293614"
variation 2301
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:3088357"
variation 2302
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:368652898"
variation 2307
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:201739085"
variation 2310
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:115496918"
variation 2311
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="a"
/replace="g"
/db_xref="dbSNP:373656983"
variation 2318
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="g"
/replace="t"
/db_xref="dbSNP:111960851"
variation 2335
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:374340897"
variation 2346
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="t"
/db_xref="dbSNP:58686003"
polyA_signal 2365..2370
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
polyA_site 2379
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/experiment="experimental evidence, no additional details
recorded"
variation 2380..2381
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace=""
/replace="a"
/db_xref="dbSNP:113522699"
variation 2392
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/replace="c"
/replace="g"
/db_xref="dbSNP:11214915"
polyA_site 2404
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
ORIGIN
gcagcagagaggagttgagggcgatgagagcgggtactgcgaactgccgggcgatgctgtcgctgccgccgtgatacggagagcaacagttccccagcaacacccctccccgacacaggcacacaccccccgacaggcacgcacacccaccccacagtgcccggctcggctgcgcctcctctattggcccaggaagcccacccagccccgccacgcagagcccagaaggaaagaaagcctcatgcctgagccgaggggagcaccatggatctgacaaaaatgggcatgatccagctgcagaaccctagccaccccacggggctactgtgcaaggccaaccagatgcggctggccgggactttgtgcgatgtggtcatcatggtggacagccaggagttccacgcccaccggacggtgctggcctgcaccagcaagatgtttgagatcctcttccaccgcaatagtcaacactatactttggacttcctctcgccaaagaccttccagcagattctggagtatgcatatacagccacgctgcaagccaaggcggaggacctggatgacctgctgtatgcggccgagatcctggagatcgagtacctggaggaacagtgcctgaagatgctggagaccatccaggcctcagacgacaatgacacggaggccaccatggccgatggcggggccgaggaagaagaggaccgcaaggctcggtacctcaagaacatcttcatctcgaagcattccagcgaggagagtgggtatgccagtgtggctggacagagcctccctgggcccatggtggaccagagcccttcagtctccacttcatttggtctttcagccatgagtcccaccaaggctgcagtggacagtttgatgaccataggacagtctctcctgcagggaactcttcagccacctgcagggcccgaggagccaactctggctgggggtgggcggcaccctggggtggctgaggtgaagacggagatgatgcaggtggatgaggtgcccagccaggacagccctggggcagccgagtccagcatctcaggagggatgggggacaaggttgaggaaagaggcaaagaggggcctgggaccccgactcgaagcagcgtcatcaccagtgctagggagctacactatgggcgagaggagagtgccgagcaggtgccacccccagctgaggctggccaggcccccactggccgacctgagcacccagcacccccgcctgagaagcatctgggcatctactccgtgttgcccaaccacaaggctgacgctgtattgagcatgccgtcttccgtgacctctggcctccacgtgcagcctgccctggctgtctccatggacttcagcacctatggggggctgctgccccagggcttcatccagagggagctgttcagcaagctgggggagctggctgtgggcatgaagtcagagagccggaccatcggagagcagtgcagcgtgtgtggggtcgagcttcctgataacgaggctgtggagcagcacaggaagctgcacagtgggatgaagacgtacgggtgcgagctctgcgggaagcggttcctggatagtttgcggctgagaatgcacttactggctcattcagcgggtgccaaagcctttgtctgtgatcagtgcggtgcacagttttcgaaggaggatgccctggagacacacaggcagacccatactggcactgacatggccgtcttctgtctgctgtgtgggaagcgcttccaggcgcagagcgcactgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgcagtgagtgcaaccgcaccttccccagccacacggctctcaaacgccacctgcgctcacatacaggcgaccacccctacgagtgtgagttctgtggcagctgcttccgggatgagagcacactcaagagccacaaacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggcaagaagttcagcctcaagcatcagctggagacgcactatagggtgcacacaggtgagaagccctttgagtgtaagctctgccaccagcgctcccgggactactcggccatgatcaagcacctgagaacgcacaacggcgcctcgccctaccagtgcaccatctgcacagagtactgccccagcctctcctccatgcagaagcacatgaagggccacaagcccgaggagatcccgcccgactggaggatagagaagacgtacctctacctgtgctatgtgtgaagggaggcccgcggcggtggagccgagcggggagccaggaaagaagagttggagtgagatgaaggaaggactatgacaaataaaaaaggaaaagaaaaaaaaaaacagaaggaaaaggaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7704 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:7704 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:7704 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7704 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:7704 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:7704 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:7704 -> Biological process: GO:0001823 [mesonephros development] evidence: ISS
GeneID:7704 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:7704 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:7704 -> Biological process: GO:0007417 [central nervous system development] evidence: ISS
GeneID:7704 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:7704 -> Biological process: GO:0009880 [embryonic pattern specification] evidence: IEA
GeneID:7704 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
GeneID:7704 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IEA
GeneID:7704 -> Biological process: GO:0030097 [hemopoiesis] evidence: IDA
GeneID:7704 -> Biological process: GO:0030097 [hemopoiesis] evidence: TAS
GeneID:7704 -> Biological process: GO:0030099 [myeloid cell differentiation] evidence: TAS
GeneID:7704 -> Biological process: GO:0032332 [positive regulation of chondrocyte differentiation] evidence: IMP
GeneID:7704 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA
GeneID:7704 -> Biological process: GO:0035136 [forelimb morphogenesis] evidence: IEA
GeneID:7704 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:7704 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: IMP
GeneID:7704 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: ISS
GeneID:7704 -> Biological process: GO:0045778 [positive regulation of ossification] evidence: IDA
GeneID:7704 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7704 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: NAS
GeneID:7704 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7704 -> Biological process: GO:0048133 [male germ-line stem cell division] evidence: IEA
GeneID:7704 -> Biological process: GO:0051216 [cartilage development] evidence: IDA
GeneID:7704 -> Biological process: GO:0061036 [positive regulation of cartilage development] evidence: IDA
GeneID:7704 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016604 [nuclear body] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016605 [PML body] evidence: IDA
GeneID:7704 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA
GeneID:7704 -> Cellular component: GO:0017053 [transcriptional repressor complex] evidence: IDA
by
@meso_cacase at
DBCLS
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