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2024-04-18 21:29:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005957 7150 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR),
mRNA.
ACCESSION NM_005957
VERSION NM_005957.4 GI:260898771
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7150)
AUTHORS Wilson,C.P., McNulty,H., Ward,M., Strain,J.J., Trouton,T.G.,
Hoeft,B.A., Weber,P., Roos,F.F., Horigan,G., McAnena,L. and
Scott,J.M.
TITLE Blood pressure in treated hypertensive individuals with the MTHFR
677TT genotype is responsive to intervention with riboflavin:
findings of a targeted randomized trial
JOURNAL Hypertension 61 (6), 1302-1308 (2013)
PUBMED 23608654
REMARK GeneRIF: riboflavin supplementation targeted at hypertensive
individuals with the MTHFR 677TT genotype can decrease BP more
effectively than treatment with current antihypertensive drugs
only.
REFERENCE 2 (bases 1 to 7150)
AUTHORS Senhaji,N., Serbati,N., Diakite,B., Arazzakou,S., Hamzi,K.,
Badre,W. and Nadifi,S.
TITLE Methylenetetrahydrofolate reductase C677T variant in Moroccan
patients with inflammatory bowel disease
JOURNAL Gene 521 (1), 45-49 (2013)
PUBMED 23542077
REMARK GeneRIF: the genetic risk for the inflammatory bowel disease is not
modulated by MTHFR C677T polymorphism in Moroccan population
REFERENCE 3 (bases 1 to 7150)
AUTHORS Hinohara,Y., Naito,M., Okada,R., Yin,G., Higashibata,T., Tamura,T.,
Kawai,S., Morita,E., Wakai,K., Matsuo,H., Mori,A. and Hamajima,N.
TITLE No association between MTHFR C677T and serum uric acid levels among
Japanese with ABCG2 126QQ and SLC22A12 258WW
JOURNAL Nagoya J Med Sci 75 (1-2), 93-100 (2013)
PUBMED 23544272
REMARK GeneRIF: Report no association between serum uric acid and MTHFR
C677T genotype, after the influences of ABCG2 Q126X and SLC22A12
W258X were removed.
REFERENCE 4 (bases 1 to 7150)
AUTHORS .
TITLE [Interrelationship between polymorphic markers of
methylenetetrahydrofolate reductase gene and development of acute
disturbance of brain circulation in families of patients with
atrial fibrillation]
JOURNAL Kardiologiia 53 (3), 55-58 (2013)
PUBMED 23548428
REMARK GeneRIF: Polymorphic marker CC of the MTHFR gene - genetic
predictors of acute disturbance of brain circulation in families of
patients with atrial fibrillation.
REFERENCE 5 (bases 1 to 7150)
AUTHORS de Carvalho,S.C., Muniz,M.T., Siqueira,M.D., Siqueira,E.R.,
Gomes,A.V., Silva,K.A., Bezerra,L.C., D'Almeida,V., de
Oliveira,C.P. and Pereira,L.M.
TITLE Plasmatic higher levels of homocysteine in non-alcoholic fatty
liver disease (NAFLD)
JOURNAL Nutr J 12, 37 (2013)
PUBMED 23547829
REMARK GeneRIF: There was no relation between liver steatosis with plasma
homocysteine levels and MTHFR C677T and A1298C polymorphisms in
patients with NAFLD from Northeast Brazil.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 7150)
AUTHORS Chen,J., Giovannucci,E., Kelsey,K., Rimm,E.B., Stampfer,M.J.,
Colditz,G.A., Spiegelman,D., Willett,W.C. and Hunter,D.J.
TITLE A methylenetetrahydrofolate reductase polymorphism and the risk of
colorectal cancer
JOURNAL Cancer Res. 56 (21), 4862-4864 (1996)
PUBMED 8895734
REFERENCE 7 (bases 1 to 7150)
AUTHORS Goyette,P., Frosst,P., Rosenblatt,D.S. and Rozen,R.
TITLE Seven novel mutations in the methylenetetrahydrofolate reductase
gene and genotype/phenotype correlations in severe
methylenetetrahydrofolate reductase deficiency
JOURNAL Am. J. Hum. Genet. 56 (5), 1052-1059 (1995)
PUBMED 7726158
REFERENCE 8 (bases 1 to 7150)
AUTHORS Frosst,P., Blom,H.J., Milos,R., Goyette,P., Sheppard,C.A.,
Matthews,R.G., Boers,G.J., den Heijer,M., Kluijtmans,L.A., van den
Heuvel,L.P. et al.
TITLE A candidate genetic risk factor for vascular disease: a common
mutation in methylenetetrahydrofolate reductase
JOURNAL Nat. Genet. 10 (1), 111-113 (1995)
PUBMED 7647779
REFERENCE 9 (bases 1 to 7150)
AUTHORS Goyette,P., Sumner,J.S., Milos,R., Duncan,A.M., Rosenblatt,D.S.,
Matthews,R.G. and Rozen,R.
TITLE Human methylenetetrahydrofolate reductase: isolation of cDNA
mapping and mutation identification
JOURNAL Nat. Genet. 7 (4), 551 (1994)
PUBMED 7951330
REMARK Correction to:[Nat Genet. 1994 Jun;7(2):195-200. PMID: 7920641]
REFERENCE 10 (bases 1 to 7150)
AUTHORS Goyette,P., Sumner,J.S., Milos,R., Duncan,A.M., Rosenblatt,D.S.,
Matthews,R.G. and Rozen,R.
TITLE Human methylenetetrahydrofolate reductase: isolation of cDNA,
mapping and mutation identification
JOURNAL Nat. Genet. 7 (2), 195-200 (1994)
PUBMED 7920641
REMARK Erratum:[Nat Genet. 1994 Aug;7(4):551. PMID: 7951330]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY046560.1, AB209113.1,
AL953897.6, AJ237672.1 and BC053509.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 9, 2009 this sequence version replaced gi:87239999.
Summary: The protein encoded by this gene catalyzes the conversion
of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a
co-substrate for homocysteine remethylation to methionine. Genetic
variation in this gene influences susceptibility to occlusive
vascular disease, neural tube defects, colon cancer and acute
leukemia, and mutations in this gene are associated with
methylenetetrahydrofolate reductase deficiency.[provided by RefSeq,
Oct 2009].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC053509.1, AK312907.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-318 AY046560.1 818-1135
319-1514 AB209113.1 357-1552
1515-1534 AL953897.6 80424-80443 c
1535-2413 AJ237672.1 1435-2313
2414-3489 BC053509.1 2236-3311
3490-4058 AL953897.6 74846-75414 c
4059-4868 BC053509.1 3881-4690
4869-6277 AB209113.1 3669-5077
6278-6952 AL953897.6 71952-72626 c
6953-7150 AB209113.1 5756-5953
FEATURES Location/Qualifiers
source 1..7150
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.3"
gene 1..7150
/gene="MTHFR"
/note="methylenetetrahydrofolate reductase (NAD(P)H)"
/db_xref="GeneID:4524"
/db_xref="HGNC:7436"
/db_xref="MIM:607093"
exon 1..216
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
misc_feature 95..97
/gene="MTHFR"
/note="upstream in-frame stop codon"
exon 217..465
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
CDS 230..2200
/gene="MTHFR"
/EC_number="1.5.1.20"
/note="5,10-methylenetetrahydrofolate reductase (NADPH)"
/codon_start=1
/product="methylenetetrahydrofolate reductase"
/protein_id="NP_005948.3"
/db_xref="GI:87240000"
/db_xref="CCDS:CCDS137.1"
/db_xref="GeneID:4524"
/db_xref="HGNC:7436"
/db_xref="MIM:607093"
/translation="
MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP
"
misc_feature 281..283
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 287..289
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 290..292
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 305..307
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 314..316
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 317..319
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 326..328
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 329..331
/gene="MTHFR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 392..1240
/gene="MTHFR"
/note="Methylenetetrahydrofolate reductase; Region: MTHFR;
pfam02219"
/db_xref="CDD:145399"
misc_feature 407..1237
/gene="MTHFR"
/note="Methylenetetrahydrofolate reductase (MTHFR).
5,10-Methylenetetrahydrofolate is reduced to
5-methyltetrahydrofolate by methylenetetrahydrofolate
reductase, a cytoplasmic, NAD(P)-dependent enzyme.
5-methyltetrahydrofolate is utilized by methionine
synthase...; Region: MTHFR; cd00537"
/db_xref="CDD:29637"
misc_feature order(512..514,608..610,695..703,749..754,812..814,
818..820,830..832,836..838,857..859,866..868,875..880,
905..907,911..913,1190..1192)
/gene="MTHFR"
/note="FAD binding site [chemical binding]; other site"
/db_xref="CDD:29637"
variation 346
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:2066470"
variation 432
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2066472"
exon 466..704
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 505
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45546035"
variation 574
/gene="MTHFR"
/replace="a"
/replace="c"
/db_xref="dbSNP:2066461"
variation 629
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45550133"
variation 646
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2066466"
exon 705..815
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
exon 816..1009
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 835
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306554"
STS 855..966
/gene="MTHFR"
/standard_name="PMC110766P1"
/db_xref="UniSTS:270198"
variation 890
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45438591"
variation 929
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45589033"
variation 955
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45459991"
variation 961
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45486194"
exon 1010..1260
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 1135
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306555"
variation 1147
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45498098"
exon 1261..1395
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 1285
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:2066462"
exon 1396..1576
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 1493
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45571736"
variation 1498
/gene="MTHFR"
/replace="g"
/replace="t"
/db_xref="dbSNP:3927589"
variation 1517
/gene="MTHFR"
/replace="a"
/replace="c"
/db_xref="dbSNP:72552099"
exon 1577..1759
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
exon 1760..1861
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 1784
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45496998"
variation 1785
/gene="MTHFR"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:45449298"
exon 1862..1981
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 1926
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2274974"
exon 1982..7150
/gene="MTHFR"
/inference="alignment:Splign:1.39.8"
variation 2010
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2274976"
variation 2188
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45572531"
variation 2241
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45482794"
variation 2743
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45625835"
variation 2854
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45451599"
variation 3270
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:45574135"
variation 3468
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:915014"
variation 3490
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:868014"
variation 3567
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:45445997"
variation 4798
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:11559040"
variation 4869
/gene="MTHFR"
/replace="c"
/replace="g"
/db_xref="dbSNP:1537514"
variation 4883
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:34733339"
variation 5035
/gene="MTHFR"
/replace="g"
/replace="t"
/db_xref="dbSNP:1537515"
variation 5076
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:1537516"
variation 5165
/gene="MTHFR"
/replace="a"
/replace="c"
/db_xref="dbSNP:3820192"
variation 5178
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:3737966"
variation 5195..5196
/gene="MTHFR"
/replace=""
/replace="ag"
/db_xref="dbSNP:35562212"
variation 5488
/gene="MTHFR"
/replace="c"
/replace="t"
/db_xref="dbSNP:3737967"
variation 5501
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2184226"
STS 6002..6257
/gene="MTHFR"
/standard_name="A009L06"
/db_xref="UniSTS:61957"
STS 6002..6257
/gene="MTHFR"
/standard_name="G32638"
/db_xref="UniSTS:117221"
variation 6195
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:2184227"
variation 6667
/gene="MTHFR"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057624"
STS 6870..6974
/gene="MTHFR"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 7006..7075
/gene="MTHFR"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
polyA_signal 7131..7136
/gene="MTHFR"
ORIGIN
atgacgataaaggcacggcctccaacgagacctgtgggcacggccatgttgggggcggggcttccggtcacccgcgccggtggtttccgccctgtaggcccgcctctccagcaacctgacacctgcgccgcgccccttcactgcgttccccgcccctgcagcggccacagtggtgcggccggcggccgagcgttctgagtcacccgggactggaggtaggaacccagccatggtgaacgaagccagaggaaacagcagcctcaacccctgcttggagggcagtgccagcagtggcagtgagagctccaaagatagttcgagatgttccaccccgggcctggaccccgagcggcatgagagactccgggagaagatgaggcggcgattggaatctggtgacaagtggttctccctggaattcttccctcctcgaactgctgagggagctgtcaatctcatctcaaggtttgaccggatggcagcaggtggccccctctacatagacgtgacctggcacccagcaggtgaccctggctcagacaaggagacctcctccatgatgatcgccagcaccgccgtgaactactgtggcctggagaccatcctgcacatgacctgctgccgtcagcgcctggaggagatcacgggccatctgcacaaagctaagcagctgggcctgaagaacatcatggcgctgcggggagacccaataggtgaccagtgggaagaggaggagggaggcttcaactacgcagtggacctggtgaagcacatccgaagtgagtttggtgactactttgacatctgtgtggcaggttaccccaaaggccaccccgaagcagggagctttgaggctgacctgaagcacttgaaggagaaggtgtctgcgggagccgatttcatcatcacgcagcttttctttgaggctgacacattcttccgctttgtgaaggcatgcaccgacatgggcatcacttgccccatcgtccccgggatctttcccatccagggctaccactcccttcggcagcttgtgaagctgtccaagctggaggtgccacaggagatcaaggacgtgattgagccaatcaaagacaacgatgctgccatccgcaactatggcatcgagctggccgtgagcctgtgccaggagcttctggccagtggcttggtgccaggcctccacttctacaccctcaaccgcgagatggctaccacagaggtgctgaagcgcctggggatgtggactgaggaccccaggcgtcccctaccctgggctctcagcgcccaccccaagcgccgagaggaagatgtacgtcccatcttctgggcctccagaccaaagagttacatctaccgtacccaggagtgggacgagttccctaacggccgctggggcaattcctcttcccctgcctttggggagctgaaggactactacctcttctacctgaagagcaagtcccccaaggaggagctgctgaagatgtggggggaggagctgaccagtgaagaaagtgtctttgaagtcttcgttctttacctctcgggagaaccaaaccggaatggtcacaaagtgacttgcctgccctggaacgatgagcccctggcggctgagaccagcctgctgaaggaggagctgctgcgggtgaaccgccagggcatcctcaccatcaactcacagcccaacatcaacgggaagccgtcctccgaccccatcgtgggctggggccccagcgggggctatgtcttccagaaggcctacttagagtttttcacttcccgcgagacagcggaagcacttctgcaagtgctgaagaagtacgagctccgggttaattaccaccttgtcaatgtgaagggtgaaaacatcaccaatgcccctgaactgcagccgaatgctgtcacttggggcatcttccctgggcgagagatcatccagcccaccgtagtggatcccgtcagcttcatgttctggaaggacgaggcctttgccctgtggattgagcggtggggaaagctgtatgaggaggagtccccgtcccgcaccatcatccagtacatccacgacaactacttcctggtcaacctggtggacaatgacttcccactggacaactgcctctggcaggtggtggaagacacattggagcttctcaacaggcccacccagaatgcgagagaaacggaggctccatgaccctgcgtcctgacgccctgcgttggagccactcctgtcccgccttcctcctccacagtgctgcttctcttgggaactccactctccttcgtgtctctcccaccccggcctccactcccccacctgacaatggcagctagactggagtgaggcttccaggctcttcctggacctgagtcggccccacatgggaacctagtactctctgctctagccaggagtctgtgctcttttggtggggagcacttgcgtcctgcagaggaccacagtgggtggcacctcctgagaaggcgaggagagtggttgttgccaactaagccctcgaaccaaggcagcctccagagccagcctgggactcccagtgaacttacacttggagcccgtgcagtacaggcaaaacacgcaagggcatcaggcactggtggcatcgtagaagagatgtggcaaagtgctgtacccttccacctcctagaggtgggcagctgggccccacctacttgtgactgaaggggcacaccactgccctgcctgcccacttagccgtccatggcaccagccccctggatgggcattgggctgacacctaccatgctgctttttggcacagttgtctattctgagccttgagagaaaaagtgccccttaagggttgaaggcagtctgaacccttgtgcttggtggggctcgtggccttccccttttgcctggctgtggaggcctgatgctgccccgttccctgtcagaggctaagatgagatttgccagcacaggggccccagatctgcctgggcctgtgcagcagcccagcttcctggtgtatttttcaggtaggcccttgtcctgccagctgccttcctcatcccctcgtcctgtcccagaggttatctgcctggcctggctccccacgagtcacctgcaagccccagggcctgggggcagtgactggcaggtgcagatgggctgtttcgtgtagtggaagagcagcctgatggccaagggggtggacgcaattgtgggatgtcctctttactcccttcctggcctcactggctggggcagaggggcagccgctaggagagactgaaagcagcagctaggactgaggagtgggttttattgtccttcagagctcttcaagctgtcccctctgtcatcactccctggatgtgtggggcatggttccttccctgggaaggctaagttcagttctgttttttattctatgagaacaagtcacagctgcagctgggccccatgctctgccccaagcccccaaccccgcggtgctctggcggcttcctgtccactctcggggcccttggggcctggcttgctccagggtcttgggctactggcagctcctctccttgggctcctggctgccaggcgttggtgccacttcttaaaggcctggaaccagggaggagaggaaatgctattgttgtgggctttctccggggtctgtgctgtgcctgctagagcaacccctgtacccagctccttttgtccccagggcccctccctctgccccaagcagccagccagtcttgcctaggccaaatgcacaagctcagaatagatctgatggtgagctgggaagctgtactcagagcagagcaaatgagggagggggcgctcaggacccaggccctccatgggctagtgtgagtggcagccatgcctcatgccacaccttcttcgcaaactgatggaccgggtgggcctggcctgagctggggccacaaatcaaagcaagggctccagcatccagcctgtgtgttctgtaatggaactgaccccctcccctgaaaacgaaggggccccggggctggcaagcagggaaagctccacggtgcgtggctgtggcacagacttctggaaggctggctgagtggaatgcagggaagagggcagtacctgggaaaggacccacccatcttcctgctgctgtaactgctgagccactcgcagtcgcaggatccgctgccaccacgtctgccaggcccatctcaggtgccactccctgagctttggggacagttggcagagaaggcctcttgtgctcacgctcccccgcagtccccagcccttctgcctttctcccccgacactgctgcaccagagtgaaagggctatggcaagggggtgtcatctgaggagtattaagaatgcagattcctgggcctgtcccccaaggttttggagtcagtaggtccaagggccatacttttgagaggggtttgggttaagtatgaggtgaaatgggagatggtcagtgtggagaggggtgcacccactcaccagggtccgcaccagctgctctgccccttgggcatccacccagtgctgccatgccactgccaggcacctggcctgctgggaaccccgcagcccgtgaagcagtgcctcgaggcaccggcgctgcaggtacttcctcctgatggccaagagcatcgtgacccttcagggccagaaggagggcagagccatgggcctgggcctgcttttccaggatcctgcaggaacgagcactggccagagagggcccagctgtagccatggctcaggcaagcccctcagcccttgcccccatccctcggacccaccaaactgcacacacagctcctcttaccgtagcctccgtttatgggccttgctttgggctttgcaggctctgggctcagggctggagtgcgctcttggtccctggtccctcgtccacaggggcaggcctgggacccagctactctgtccaggccactgtggccagagctggaaggcagggcagagggaatgttccctgcaccctggaaaggggagttgagtcacaagaggttaaggtgggtccaggaaggcagctgctcttagtgcccgcctaggagttgagtacagtgaggagggtggaggaaggtgctgagcttagccttgtgccctgcccccatctccccaggcctccagcctctcccggctgcctgccgcccaaagagaaatcacaggggcggggcaggaatgcaaagtgttttctcagaacagctgaaacattccgaagagggaatggatggggagaatggtcaatacacataagaccgtgtcccaaggagctgatttccaggcccctgaggactggagaccgcttcacccctgcacttcagacaccgtttgtcccccggggcaaggtctccttactctgagcccaggccgttccccttggcttcctccgtccacccaggctgcactgcagtgatggcgcgggaggcaccagctctgtggcctgtgtccagcagctgcgggtctgaaggaatagccagagaggagcacctgaaccccatgggcttggacttcctggggccccgctgggatttcttcgctgctctagctggcaggacacatcccggcctcttccacccattcccccatgtggctgaagacattccaacaatggggtgggcccataatagttagccctcagtcagttcccggagcacagccctgggagggggctatttctctccccactgaaaacatttcaaagctgagttacttgtctgaggcctcatccctcggaagccgtctgactccagagtctgagcccccggctagtaccctatagagagggggctctccaaaggggctgctggggcatgtgtgcctgtggcagaaaagaggagaccctggaattcagcaccctgggtgccattcccagcgtttagtttctagaggcctcagtttctccatcagcttatgggatccttgtctttactgacaagaatggaatagaaatgtaaaagtactctgaaaagcaattgccctgtaacttatctagaaagaaaagaccctgagactccagaatctgctgttgccatagccccatatgtgtgaattctgcaactagccaaggctagttcctttcaattccatttaaaaaacaaaaaccagcaggtgtggtggctcatggcgtaatgggcctgcccaatgctttgggaggccaaggcaggtagatcgcttgagcccaggagtttgagacaagccctggcaacatagtgagatcccatttctacaaaaaaaaaaaaaaaaaaattagccgggtgtggtggcacacgcctgtagtctcagctactcaggtggctgaggtgggaggatcgtttgagccctggaggttgaggctgcagtgagctgtgatcgcaccactgcactctggcctgggcgacagagtgagacactgtctgagaacaaaaaacgactgaaaaaaaaaatcaccttagctttttctcttagaatcttctctaaaacgtattctttgtggcattctgaaataggattcatgatgatgcctgttgatcttagggacactacctcacctgccagtatctttggggctgtgtccttcaaggacatgtccccagactgctgtgcagtgtcattttttgtgtttggtttggtggtggcttcttcccccttgctaggctatcaacctcttatcaccacttgttggtgtcagaactaactgcttctggtctggagagggactgaccgatgcctttgggtagagagaattatgaaagaaattttggtatttttctactttatattttctgaggtttctgtaataagcatatttcacttttccaataagaaaaaaaaaaacttggcctggcgcggtggctcacacctgtaatcccagcactttgggaagtcgaggtgggaggatcacttgagttcaggagttcgagaccagcttgggcaatatggtgaaaccccgtctctactaaaaatacaaaaattagccaggcgtggtggcgtgcacttgtagtcccagctactcaggaagctgaggcgggagaatcacttgaacccgggaggcagaggttgcagtgagctgagatcactcctctgcttcagcctgggcaattgagccagactctgtctcaaaaataaacaaaaaaacttgac
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4524 -> Molecular function: GO:0004489 [methylenetetrahydrofolate reductase (NADPH) activity] evidence: TAS
GeneID:4524 -> Molecular function: GO:0072341 [modified amino acid binding] evidence: IDA
GeneID:4524 -> Biological process: GO:0006520 [cellular amino acid metabolic process] evidence: TAS
GeneID:4524 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
GeneID:4524 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
GeneID:4524 -> Biological process: GO:0008015 [blood circulation] evidence: TAS
GeneID:4524 -> Biological process: GO:0009086 [methionine biosynthetic process] evidence: IEA
GeneID:4524 -> Biological process: GO:0035999 [tetrahydrofolate interconversion] evidence: IEA
GeneID:4524 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:4524 -> Biological process: GO:0046655 [folic acid metabolic process] evidence: TAS
GeneID:4524 -> Biological process: GO:0050667 [homocysteine metabolic process] evidence: IDA
GeneID:4524 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005948 -> EC 1.5.1.20
by
@meso_cacase at
DBCLS
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