GGRNA Home | Help | Advanced search

2019-03-25 14:30:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005957               7150 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR),
            mRNA.
ACCESSION   NM_005957
VERSION     NM_005957.4  GI:260898771
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7150)
  AUTHORS   Wilson,C.P., McNulty,H., Ward,M., Strain,J.J., Trouton,T.G.,
            Hoeft,B.A., Weber,P., Roos,F.F., Horigan,G., McAnena,L. and
            Scott,J.M.
  TITLE     Blood pressure in treated hypertensive individuals with the MTHFR
            677TT genotype is responsive to intervention with riboflavin:
            findings of a targeted randomized trial
  JOURNAL   Hypertension 61 (6), 1302-1308 (2013)
   PUBMED   23608654
  REMARK    GeneRIF: riboflavin supplementation targeted at hypertensive
            individuals with the MTHFR 677TT genotype can decrease BP more
            effectively than treatment with current antihypertensive drugs
            only.
REFERENCE   2  (bases 1 to 7150)
  AUTHORS   Senhaji,N., Serbati,N., Diakite,B., Arazzakou,S., Hamzi,K.,
            Badre,W. and Nadifi,S.
  TITLE     Methylenetetrahydrofolate reductase C677T variant in Moroccan
            patients with inflammatory bowel disease
  JOURNAL   Gene 521 (1), 45-49 (2013)
   PUBMED   23542077
  REMARK    GeneRIF: the genetic risk for the inflammatory bowel disease is not
            modulated by MTHFR C677T polymorphism in Moroccan population
REFERENCE   3  (bases 1 to 7150)
  AUTHORS   Hinohara,Y., Naito,M., Okada,R., Yin,G., Higashibata,T., Tamura,T.,
            Kawai,S., Morita,E., Wakai,K., Matsuo,H., Mori,A. and Hamajima,N.
  TITLE     No association between MTHFR C677T and serum uric acid levels among
            Japanese with ABCG2 126QQ and SLC22A12 258WW
  JOURNAL   Nagoya J Med Sci 75 (1-2), 93-100 (2013)
   PUBMED   23544272
  REMARK    GeneRIF: Report no association between serum uric acid and MTHFR
            C677T genotype, after the influences of ABCG2 Q126X and SLC22A12
            W258X were removed.
REFERENCE   4  (bases 1 to 7150)
  AUTHORS   .
  TITLE     [Interrelationship between polymorphic markers of
            methylenetetrahydrofolate reductase gene and development of acute
            disturbance of brain circulation in families of patients with
            atrial fibrillation]
  JOURNAL   Kardiologiia 53 (3), 55-58 (2013)
   PUBMED   23548428
  REMARK    GeneRIF: Polymorphic marker CC of the MTHFR gene - genetic
            predictors of acute disturbance of brain circulation in families of
            patients with atrial fibrillation.
REFERENCE   5  (bases 1 to 7150)
  AUTHORS   de Carvalho,S.C., Muniz,M.T., Siqueira,M.D., Siqueira,E.R.,
            Gomes,A.V., Silva,K.A., Bezerra,L.C., D'Almeida,V., de
            Oliveira,C.P. and Pereira,L.M.
  TITLE     Plasmatic higher levels of homocysteine in non-alcoholic fatty
            liver disease (NAFLD)
  JOURNAL   Nutr J 12, 37 (2013)
   PUBMED   23547829
  REMARK    GeneRIF: There was no relation between liver steatosis with plasma
            homocysteine levels and MTHFR C677T and A1298C polymorphisms in
            patients with NAFLD from Northeast Brazil.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7150)
  AUTHORS   Chen,J., Giovannucci,E., Kelsey,K., Rimm,E.B., Stampfer,M.J.,
            Colditz,G.A., Spiegelman,D., Willett,W.C. and Hunter,D.J.
  TITLE     A methylenetetrahydrofolate reductase polymorphism and the risk of
            colorectal cancer
  JOURNAL   Cancer Res. 56 (21), 4862-4864 (1996)
   PUBMED   8895734
REFERENCE   7  (bases 1 to 7150)
  AUTHORS   Goyette,P., Frosst,P., Rosenblatt,D.S. and Rozen,R.
  TITLE     Seven novel mutations in the methylenetetrahydrofolate reductase
            gene and genotype/phenotype correlations in severe
            methylenetetrahydrofolate reductase deficiency
  JOURNAL   Am. J. Hum. Genet. 56 (5), 1052-1059 (1995)
   PUBMED   7726158
REFERENCE   8  (bases 1 to 7150)
  AUTHORS   Frosst,P., Blom,H.J., Milos,R., Goyette,P., Sheppard,C.A.,
            Matthews,R.G., Boers,G.J., den Heijer,M., Kluijtmans,L.A., van den
            Heuvel,L.P. et al.
  TITLE     A candidate genetic risk factor for vascular disease: a common
            mutation in methylenetetrahydrofolate reductase
  JOURNAL   Nat. Genet. 10 (1), 111-113 (1995)
   PUBMED   7647779
REFERENCE   9  (bases 1 to 7150)
  AUTHORS   Goyette,P., Sumner,J.S., Milos,R., Duncan,A.M., Rosenblatt,D.S.,
            Matthews,R.G. and Rozen,R.
  TITLE     Human methylenetetrahydrofolate reductase: isolation of cDNA
            mapping and mutation identification
  JOURNAL   Nat. Genet. 7 (4), 551 (1994)
   PUBMED   7951330
  REMARK    Correction to:[Nat Genet. 1994 Jun;7(2):195-200. PMID: 7920641]
REFERENCE   10 (bases 1 to 7150)
  AUTHORS   Goyette,P., Sumner,J.S., Milos,R., Duncan,A.M., Rosenblatt,D.S.,
            Matthews,R.G. and Rozen,R.
  TITLE     Human methylenetetrahydrofolate reductase: isolation of cDNA,
            mapping and mutation identification
  JOURNAL   Nat. Genet. 7 (2), 195-200 (1994)
   PUBMED   7920641
  REMARK    Erratum:[Nat Genet. 1994 Aug;7(4):551. PMID: 7951330]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY046560.1, AB209113.1,
            AL953897.6, AJ237672.1 and BC053509.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 9, 2009 this sequence version replaced gi:87239999.
            
            Summary: The protein encoded by this gene catalyzes the conversion
            of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a
            co-substrate for homocysteine remethylation to methionine. Genetic
            variation in this gene influences susceptibility to occlusive
            vascular disease, neural tube defects, colon cancer and acute
            leukemia, and mutations in this gene are associated with
            methylenetetrahydrofolate reductase deficiency.[provided by RefSeq,
            Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053509.1, AK312907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AY046560.1         818-1135
            319-1514            AB209113.1         357-1552
            1515-1534           AL953897.6         80424-80443         c
            1535-2413           AJ237672.1         1435-2313
            2414-3489           BC053509.1         2236-3311
            3490-4058           AL953897.6         74846-75414         c
            4059-4868           BC053509.1         3881-4690
            4869-6277           AB209113.1         3669-5077
            6278-6952           AL953897.6         71952-72626         c
            6953-7150           AB209113.1         5756-5953
FEATURES             Location/Qualifiers
     source          1..7150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.3"
     gene            1..7150
                     /gene="MTHFR"
                     /note="methylenetetrahydrofolate reductase (NAD(P)H)"
                     /db_xref="GeneID:4524"
                     /db_xref="HGNC:7436"
                     /db_xref="MIM:607093"
     exon            1..216
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    95..97
                     /gene="MTHFR"
                     /note="upstream in-frame stop codon"
     exon            217..465
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     CDS             230..2200
                     /gene="MTHFR"
                     /EC_number="1.5.1.20"
                     /note="5,10-methylenetetrahydrofolate reductase (NADPH)"
                     /codon_start=1
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="NP_005948.3"
                     /db_xref="GI:87240000"
                     /db_xref="CCDS:CCDS137.1"
                     /db_xref="GeneID:4524"
                     /db_xref="HGNC:7436"
                     /db_xref="MIM:607093"
                     /translation="
MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP
"
     misc_feature    281..283
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    287..289
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    290..292
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    305..307
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    314..316
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    317..319
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    326..328
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    329..331
                     /gene="MTHFR"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    392..1240
                     /gene="MTHFR"
                     /note="Methylenetetrahydrofolate reductase; Region: MTHFR;
                     pfam02219"
                     /db_xref="CDD:145399"
     misc_feature    407..1237
                     /gene="MTHFR"
                     /note="Methylenetetrahydrofolate reductase (MTHFR).
                     5,10-Methylenetetrahydrofolate is reduced to
                     5-methyltetrahydrofolate by methylenetetrahydrofolate
                     reductase, a cytoplasmic, NAD(P)-dependent enzyme.
                     5-methyltetrahydrofolate is utilized by methionine
                     synthase...; Region: MTHFR; cd00537"
                     /db_xref="CDD:29637"
     misc_feature    order(512..514,608..610,695..703,749..754,812..814,
                     818..820,830..832,836..838,857..859,866..868,875..880,
                     905..907,911..913,1190..1192)
                     /gene="MTHFR"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:29637"
     variation       346
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2066470"
     variation       432
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2066472"
     exon            466..704
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       505
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45546035"
     variation       574
                     /gene="MTHFR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2066461"
     variation       629
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45550133"
     variation       646
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2066466"
     exon            705..815
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     exon            816..1009
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       835
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306554"
     STS             855..966
                     /gene="MTHFR"
                     /standard_name="PMC110766P1"
                     /db_xref="UniSTS:270198"
     variation       890
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45438591"
     variation       929
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45589033"
     variation       955
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45459991"
     variation       961
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45486194"
     exon            1010..1260
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       1135
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306555"
     variation       1147
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45498098"
     exon            1261..1395
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       1285
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2066462"
     exon            1396..1576
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       1493
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45571736"
     variation       1498
                     /gene="MTHFR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3927589"
     variation       1517
                     /gene="MTHFR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:72552099"
     exon            1577..1759
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     exon            1760..1861
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       1784
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45496998"
     variation       1785
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:45449298"
     exon            1862..1981
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       1926
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274974"
     exon            1982..7150
                     /gene="MTHFR"
                     /inference="alignment:Splign:1.39.8"
     variation       2010
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274976"
     variation       2188
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45572531"
     variation       2241
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45482794"
     variation       2743
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45625835"
     variation       2854
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45451599"
     variation       3270
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45574135"
     variation       3468
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:915014"
     variation       3490
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:868014"
     variation       3567
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45445997"
     variation       4798
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11559040"
     variation       4869
                     /gene="MTHFR"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1537514"
     variation       4883
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34733339"
     variation       5035
                     /gene="MTHFR"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1537515"
     variation       5076
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1537516"
     variation       5165
                     /gene="MTHFR"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3820192"
     variation       5178
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3737966"
     variation       5195..5196
                     /gene="MTHFR"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:35562212"
     variation       5488
                     /gene="MTHFR"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3737967"
     variation       5501
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2184226"
     STS             6002..6257
                     /gene="MTHFR"
                     /standard_name="A009L06"
                     /db_xref="UniSTS:61957"
     STS             6002..6257
                     /gene="MTHFR"
                     /standard_name="G32638"
                     /db_xref="UniSTS:117221"
     variation       6195
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2184227"
     variation       6667
                     /gene="MTHFR"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1057624"
     STS             6870..6974
                     /gene="MTHFR"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             7006..7075
                     /gene="MTHFR"
                     /standard_name="D1S1423"
                     /db_xref="UniSTS:149619"
     polyA_signal    7131..7136
                     /gene="MTHFR"
ORIGIN      
atgacgataaaggcacggcctccaacgagacctgtgggcacggccatgttgggggcggggcttccggtcacccgcgccggtggtttccgccctgtaggcccgcctctccagcaacctgacacctgcgccgcgccccttcactgcgttccccgcccctgcagcggccacagtggtgcggccggcggccgagcgttctgagtcacccgggactggaggtaggaacccagccatggtgaacgaagccagaggaaacagcagcctcaacccctgcttggagggcagtgccagcagtggcagtgagagctccaaagatagttcgagatgttccaccccgggcctggaccccgagcggcatgagagactccgggagaagatgaggcggcgattggaatctggtgacaagtggttctccctggaattcttccctcctcgaactgctgagggagctgtcaatctcatctcaaggtttgaccggatggcagcaggtggccccctctacatagacgtgacctggcacccagcaggtgaccctggctcagacaaggagacctcctccatgatgatcgccagcaccgccgtgaactactgtggcctggagaccatcctgcacatgacctgctgccgtcagcgcctggaggagatcacgggccatctgcacaaagctaagcagctgggcctgaagaacatcatggcgctgcggggagacccaataggtgaccagtgggaagaggaggagggaggcttcaactacgcagtggacctggtgaagcacatccgaagtgagtttggtgactactttgacatctgtgtggcaggttaccccaaaggccaccccgaagcagggagctttgaggctgacctgaagcacttgaaggagaaggtgtctgcgggagccgatttcatcatcacgcagcttttctttgaggctgacacattcttccgctttgtgaaggcatgcaccgacatgggcatcacttgccccatcgtccccgggatctttcccatccagggctaccactcccttcggcagcttgtgaagctgtccaagctggaggtgccacaggagatcaaggacgtgattgagccaatcaaagacaacgatgctgccatccgcaactatggcatcgagctggccgtgagcctgtgccaggagcttctggccagtggcttggtgccaggcctccacttctacaccctcaaccgcgagatggctaccacagaggtgctgaagcgcctggggatgtggactgaggaccccaggcgtcccctaccctgggctctcagcgcccaccccaagcgccgagaggaagatgtacgtcccatcttctgggcctccagaccaaagagttacatctaccgtacccaggagtgggacgagttccctaacggccgctggggcaattcctcttcccctgcctttggggagctgaaggactactacctcttctacctgaagagcaagtcccccaaggaggagctgctgaagatgtggggggaggagctgaccagtgaagaaagtgtctttgaagtcttcgttctttacctctcgggagaaccaaaccggaatggtcacaaagtgacttgcctgccctggaacgatgagcccctggcggctgagaccagcctgctgaaggaggagctgctgcgggtgaaccgccagggcatcctcaccatcaactcacagcccaacatcaacgggaagccgtcctccgaccccatcgtgggctggggccccagcgggggctatgtcttccagaaggcctacttagagtttttcacttcccgcgagacagcggaagcacttctgcaagtgctgaagaagtacgagctccgggttaattaccaccttgtcaatgtgaagggtgaaaacatcaccaatgcccctgaactgcagccgaatgctgtcacttggggcatcttccctgggcgagagatcatccagcccaccgtagtggatcccgtcagcttcatgttctggaaggacgaggcctttgccctgtggattgagcggtggggaaagctgtatgaggaggagtccccgtcccgcaccatcatccagtacatccacgacaactacttcctggtcaacctggtggacaatgacttcccactggacaactgcctctggcaggtggtggaagacacattggagcttctcaacaggcccacccagaatgcgagagaaacggaggctccatgaccctgcgtcctgacgccctgcgttggagccactcctgtcccgccttcctcctccacagtgctgcttctcttgggaactccactctccttcgtgtctctcccaccccggcctccactcccccacctgacaatggcagctagactggagtgaggcttccaggctcttcctggacctgagtcggccccacatgggaacctagtactctctgctctagccaggagtctgtgctcttttggtggggagcacttgcgtcctgcagaggaccacagtgggtggcacctcctgagaaggcgaggagagtggttgttgccaactaagccctcgaaccaaggcagcctccagagccagcctgggactcccagtgaacttacacttggagcccgtgcagtacaggcaaaacacgcaagggcatcaggcactggtggcatcgtagaagagatgtggcaaagtgctgtacccttccacctcctagaggtgggcagctgggccccacctacttgtgactgaaggggcacaccactgccctgcctgcccacttagccgtccatggcaccagccccctggatgggcattgggctgacacctaccatgctgctttttggcacagttgtctattctgagccttgagagaaaaagtgccccttaagggttgaaggcagtctgaacccttgtgcttggtggggctcgtggccttccccttttgcctggctgtggaggcctgatgctgccccgttccctgtcagaggctaagatgagatttgccagcacaggggccccagatctgcctgggcctgtgcagcagcccagcttcctggtgtatttttcaggtaggcccttgtcctgccagctgccttcctcatcccctcgtcctgtcccagaggttatctgcctggcctggctccccacgagtcacctgcaagccccagggcctgggggcagtgactggcaggtgcagatgggctgtttcgtgtagtggaagagcagcctgatggccaagggggtggacgcaattgtgggatgtcctctttactcccttcctggcctcactggctggggcagaggggcagccgctaggagagactgaaagcagcagctaggactgaggagtgggttttattgtccttcagagctcttcaagctgtcccctctgtcatcactccctggatgtgtggggcatggttccttccctgggaaggctaagttcagttctgttttttattctatgagaacaagtcacagctgcagctgggccccatgctctgccccaagcccccaaccccgcggtgctctggcggcttcctgtccactctcggggcccttggggcctggcttgctccagggtcttgggctactggcagctcctctccttgggctcctggctgccaggcgttggtgccacttcttaaaggcctggaaccagggaggagaggaaatgctattgttgtgggctttctccggggtctgtgctgtgcctgctagagcaacccctgtacccagctccttttgtccccagggcccctccctctgccccaagcagccagccagtcttgcctaggccaaatgcacaagctcagaatagatctgatggtgagctgggaagctgtactcagagcagagcaaatgagggagggggcgctcaggacccaggccctccatgggctagtgtgagtggcagccatgcctcatgccacaccttcttcgcaaactgatggaccgggtgggcctggcctgagctggggccacaaatcaaagcaagggctccagcatccagcctgtgtgttctgtaatggaactgaccccctcccctgaaaacgaaggggccccggggctggcaagcagggaaagctccacggtgcgtggctgtggcacagacttctggaaggctggctgagtggaatgcagggaagagggcagtacctgggaaaggacccacccatcttcctgctgctgtaactgctgagccactcgcagtcgcaggatccgctgccaccacgtctgccaggcccatctcaggtgccactccctgagctttggggacagttggcagagaaggcctcttgtgctcacgctcccccgcagtccccagcccttctgcctttctcccccgacactgctgcaccagagtgaaagggctatggcaagggggtgtcatctgaggagtattaagaatgcagattcctgggcctgtcccccaaggttttggagtcagtaggtccaagggccatacttttgagaggggtttgggttaagtatgaggtgaaatgggagatggtcagtgtggagaggggtgcacccactcaccagggtccgcaccagctgctctgccccttgggcatccacccagtgctgccatgccactgccaggcacctggcctgctgggaaccccgcagcccgtgaagcagtgcctcgaggcaccggcgctgcaggtacttcctcctgatggccaagagcatcgtgacccttcagggccagaaggagggcagagccatgggcctgggcctgcttttccaggatcctgcaggaacgagcactggccagagagggcccagctgtagccatggctcaggcaagcccctcagcccttgcccccatccctcggacccaccaaactgcacacacagctcctcttaccgtagcctccgtttatgggccttgctttgggctttgcaggctctgggctcagggctggagtgcgctcttggtccctggtccctcgtccacaggggcaggcctgggacccagctactctgtccaggccactgtggccagagctggaaggcagggcagagggaatgttccctgcaccctggaaaggggagttgagtcacaagaggttaaggtgggtccaggaaggcagctgctcttagtgcccgcctaggagttgagtacagtgaggagggtggaggaaggtgctgagcttagccttgtgccctgcccccatctccccaggcctccagcctctcccggctgcctgccgcccaaagagaaatcacaggggcggggcaggaatgcaaagtgttttctcagaacagctgaaacattccgaagagggaatggatggggagaatggtcaatacacataagaccgtgtcccaaggagctgatttccaggcccctgaggactggagaccgcttcacccctgcacttcagacaccgtttgtcccccggggcaaggtctccttactctgagcccaggccgttccccttggcttcctccgtccacccaggctgcactgcagtgatggcgcgggaggcaccagctctgtggcctgtgtccagcagctgcgggtctgaaggaatagccagagaggagcacctgaaccccatgggcttggacttcctggggccccgctgggatttcttcgctgctctagctggcaggacacatcccggcctcttccacccattcccccatgtggctgaagacattccaacaatggggtgggcccataatagttagccctcagtcagttcccggagcacagccctgggagggggctatttctctccccactgaaaacatttcaaagctgagttacttgtctgaggcctcatccctcggaagccgtctgactccagagtctgagcccccggctagtaccctatagagagggggctctccaaaggggctgctggggcatgtgtgcctgtggcagaaaagaggagaccctggaattcagcaccctgggtgccattcccagcgtttagtttctagaggcctcagtttctccatcagcttatgggatccttgtctttactgacaagaatggaatagaaatgtaaaagtactctgaaaagcaattgccctgtaacttatctagaaagaaaagaccctgagactccagaatctgctgttgccatagccccatatgtgtgaattctgcaactagccaaggctagttcctttcaattccatttaaaaaacaaaaaccagcaggtgtggtggctcatggcgtaatgggcctgcccaatgctttgggaggccaaggcaggtagatcgcttgagcccaggagtttgagacaagccctggcaacatagtgagatcccatttctacaaaaaaaaaaaaaaaaaaattagccgggtgtggtggcacacgcctgtagtctcagctactcaggtggctgaggtgggaggatcgtttgagccctggaggttgaggctgcagtgagctgtgatcgcaccactgcactctggcctgggcgacagagtgagacactgtctgagaacaaaaaacgactgaaaaaaaaaatcaccttagctttttctcttagaatcttctctaaaacgtattctttgtggcattctgaaataggattcatgatgatgcctgttgatcttagggacactacctcacctgccagtatctttggggctgtgtccttcaaggacatgtccccagactgctgtgcagtgtcattttttgtgtttggtttggtggtggcttcttcccccttgctaggctatcaacctcttatcaccacttgttggtgtcagaactaactgcttctggtctggagagggactgaccgatgcctttgggtagagagaattatgaaagaaattttggtatttttctactttatattttctgaggtttctgtaataagcatatttcacttttccaataagaaaaaaaaaaacttggcctggcgcggtggctcacacctgtaatcccagcactttgggaagtcgaggtgggaggatcacttgagttcaggagttcgagaccagcttgggcaatatggtgaaaccccgtctctactaaaaatacaaaaattagccaggcgtggtggcgtgcacttgtagtcccagctactcaggaagctgaggcgggagaatcacttgaacccgggaggcagaggttgcagtgagctgagatcactcctctgcttcagcctgggcaattgagccagactctgtctcaaaaataaacaaaaaaacttgac
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4524 -> Molecular function: GO:0004489 [methylenetetrahydrofolate reductase (NADPH) activity] evidence: TAS
            GeneID:4524 -> Molecular function: GO:0072341 [modified amino acid binding] evidence: IDA
            GeneID:4524 -> Biological process: GO:0006520 [cellular amino acid metabolic process] evidence: TAS
            GeneID:4524 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
            GeneID:4524 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
            GeneID:4524 -> Biological process: GO:0008015 [blood circulation] evidence: TAS
            GeneID:4524 -> Biological process: GO:0009086 [methionine biosynthetic process] evidence: IEA
            GeneID:4524 -> Biological process: GO:0035999 [tetrahydrofolate interconversion] evidence: IEA
            GeneID:4524 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:4524 -> Biological process: GO:0046655 [folic acid metabolic process] evidence: TAS
            GeneID:4524 -> Biological process: GO:0050667 [homocysteine metabolic process] evidence: IDA
            GeneID:4524 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005948 -> EC 1.5.1.20

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.