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2024-04-24 19:31:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005894 2248 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens CD5 molecule-like (CD5L), mRNA.
ACCESSION NM_005894
VERSION NM_005894.2 GI:187608675
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2248)
AUTHORS Mori,M., Kimura,H., Iwamura,Y., Arai,S. and Miyazaki,T.
TITLE Modification of N-glycosylation modulates the secretion and
lipolytic function of apoptosis inhibitor of macrophage (AIM)
JOURNAL FEBS Lett. 586 (20), 3569-3574 (2012)
PUBMED 23236605
REMARK GeneRIF: N-glycosylation plays important roles in the secretion and
lipolytic function of AIM
REFERENCE 2 (bases 1 to 2248)
AUTHORS Miyazaki,T., Kurokawa,J. and Arai,S.
TITLE AIMing at metabolic syndrome. -Towards the development of novel
therapies for metabolic diseases via apoptosis inhibitor of
macrophage (AIM).-
JOURNAL Circ. J. 75 (11), 2522-2531 (2011)
PUBMED 21970839
REMARK GeneRIF: AIM is involved in the progression of MetS in both an
advancing and inhibitory fashion. Regulation of AIM could therefore
be therapeutically applicable for MetS.
Review article
REFERENCE 3 (bases 1 to 2248)
AUTHORS Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
Snippe,H., Hibberd,M.L. and Seielstad,M.
TITLE New genetic associations detected in a host response study to
hepatitis B vaccine
JOURNAL Genes Immun. 11 (3), 232-238 (2010)
PUBMED 20237496
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2248)
AUTHORS Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
Kamboh,M.I., Amouyel,P. and Lambert,J.C.
TITLE Transcriptomic and genetic studies identify IL-33 as a candidate
gene for Alzheimer's disease
JOURNAL Mol. Psychiatry 14 (11), 1004-1016 (2009)
PUBMED 19204726
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 2248)
AUTHORS Qu,P., Du,H., Li,Y. and Yan,C.
TITLE Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic
inflammation and adenocarcinoma in the lung
JOURNAL J. Immunol. 182 (3), 1648-1659 (2009)
PUBMED 19155514
REMARK GeneRIF: Dysregulation of myeloid cell populations by extracellular
transgene Api6 signaling leads to abnormal myelopoiesis and lung
cancer in bitransgenic mice.
REFERENCE 6 (bases 1 to 2248)
AUTHORS Anderson,N.L., Polanski,M., Pieper,R., Gatlin,T., Tirumalai,R.S.,
Conrads,T.P., Veenstra,T.D., Adkins,J.N., Pounds,J.G., Fagan,R. and
Lobley,A.
TITLE The human plasma proteome: a nonredundant list developed by
combination of four separate sources
JOURNAL Mol. Cell Proteomics 3 (4), 311-326 (2004)
PUBMED 14718574
REFERENCE 7 (bases 1 to 2248)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE 8 (bases 1 to 2248)
AUTHORS Tissot,J.D., Sanchez,J.C., Vuadens,F., Scherl,A., Schifferli,J.A.,
Hochstrasser,D.F., Schneider,P. and Duchosal,M.A.
TITLE IgM are associated to Sp alpha (CD5 antigen-like)
JOURNAL Electrophoresis 23 (7-8), 1203-1206 (2002)
PUBMED 11981870
REFERENCE 9 (bases 1 to 2248)
AUTHORS Gebe,J.A., Kiener,P.A., Ring,H.Z., Li,X., Francke,U. and Aruffo,A.
TITLE Molecular cloning, mapping to human chromosome 1 q21-q23, and cell
binding characteristics of Spalpha, a new member of the scavenger
receptor cysteine-rich (SRCR) family of proteins
JOURNAL J. Biol. Chem. 272 (10), 6151-6158 (1997)
PUBMED 9045627
REFERENCE 10 (bases 1 to 2248)
AUTHORS Tissot,J.D., Schifferli,J.A., Hochstrasser,D.F., Pasquali,C.,
Spertini,F., Clement,F., Frutiger,S., Paquet,N., Hughes,G.J. and
Schneider,P.
TITLE Two-dimensional polyacrylamide gel electrophoresis analysis of
cryoglobulins and identification of an IgM-associated peptide
JOURNAL J. Immunol. Methods 173 (1), 63-75 (1994)
PUBMED 8034987
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA957550.1, AK292040.1, AL139409.9 and U82812.1.
On May 7, 2008 this sequence version replaced gi:5174410.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U82812.1, BC033586.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025083, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-79 DA957550.1 1-79
80-1218 AK292040.1 1-1139
1219-2057 AL139409.9 24904-25742 c
2058-2248 U82812.1 1975-2165
FEATURES Location/Qualifiers
source 1..2248
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21-q23"
gene 1..2248
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="CD5 molecule-like"
/db_xref="GeneID:922"
/db_xref="HGNC:1690"
/db_xref="HPRD:03997"
/db_xref="MIM:602592"
exon 1..171
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
misc_feature 75..77
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="upstream in-frame stop codon"
CDS 144..1187
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="apoptosis inhibitor 6; CD5 antigen-like (scavenger
receptor cysteine rich family); CT-2; igM-associated
peptide"
/codon_start=1
/product="CD5 antigen-like precursor"
/protein_id="NP_005885.1"
/db_xref="GI:5174411"
/db_xref="CCDS:CCDS1171.1"
/db_xref="GeneID:922"
/db_xref="HGNC:1690"
/db_xref="HPRD:03997"
/db_xref="MIM:602592"
/translation="
MALLFSLILAICTRPGFLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG
"
sig_peptide 144..200
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O43866.1)"
mat_peptide 201..1184
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/product="CD5 antigen-like"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O43866.1)"
misc_feature 213..515
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="Scavenger receptor Cys-rich; Region: SR;
smart00202"
/db_xref="CDD:197572"
misc_feature 555..857
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="Scavenger receptor Cys-rich; Region: SR;
smart00202"
/db_xref="CDD:197572"
misc_feature 873..1181
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="Scavenger receptor Cys-rich; Region: SR;
smart00202"
/db_xref="CDD:197572"
exon 172..198
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
misc_feature <192..>1030
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/note="annotated region of clone"
exon 199..519
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
variation 257
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804957"
variation 494
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:11537583"
exon 520..861
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
exon 862..1182
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
variation 1171
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/replace="g"
/replace="t"
/db_xref="dbSNP:200945512"
exon 1183..2237
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/inference="alignment:Splign:1.39.8"
variation 1343
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804958"
variation 1363
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/replace="a"
/replace="t"
/db_xref="dbSNP:1048086"
STS 1383..1510
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/standard_name="RH12832"
/db_xref="UniSTS:57724"
polyA_signal 1597..1602
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
STS 1627..1879
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/standard_name="D1S3339"
/db_xref="UniSTS:22555"
polyA_site 1637
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
STS 1723..1868
/gene="CD5L"
/gene_synonym="AIM; API6; PRO229; SP-ALPHA; Spalpha"
/standard_name="D1S3558"
/db_xref="UniSTS:81465"
ORIGIN
gatcatctgataatgctttgcctgcactcaggacctgtctttgtccctcctcttaacatacttgcagctaaaactaaatattgctgcttggggacctccttctagccttaaatttcagctcatcaccttcacctgccttggtcatggctctgctattctccttgatccttgccatttgcaccagacctggattcctagcgtctccatctggagtgcggctggtggggggcctccaccgctgtgaagggcgggtggaggtggaacagaaaggccagtggggcaccgtgtgtgatgacggctgggacattaaggacgtggctgtgttgtgccgggagctgggctgtggagctgccagcggaacccctagtggtattttgtatgagccaccagcagaaaaagagcaaaaggtcctcatccaatcagtcagttgcacaggaacagaagatacattggctcagtgtgagcaagaagaagtttatgattgttcacatgatgaagatgctggggcatcgtgtgagaacccagagagctctttctccccagtcccagagggtgtcaggctggctgacggccctgggcattgcaagggacgcgtggaagtgaagcaccagaaccagtggtataccgtgtgccagacaggctggagcctccgggccgcaaaggtggtgtgccggcagctgggatgtgggagggctgtactgactcaaaaacgctgcaacaagcatgcctatggccgaaaacccatctggctgagccagatgtcatgctcaggacgagaagcaacccttcaggattgcccttctgggccttgggggaagaacacctgcaaccatgatgaagacacgtgggtcgaatgtgaagatccctttgacttgagactagtaggaggagacaacctctgctctgggcgactggaggtgctgcacaagggcgtatggggctctgtctgtgatgacaactggggagaaaaggaggaccaggtggtatgcaagcaactgggctgtgggaagtccctctctccctccttcagagaccggaaatgctatggccctggggttggccgcatctggctggataatgttcgttgctcaggggaggagcagtccctggagcagtgccagcacagattttgggggtttcacgactgcacccaccaggaagatgtggctgtcatctgctcaggatagtatcctggtgttgcttgacctggcccccctggccccgcctgccctctgcttgttctcctgagccctgattatcctcatactcattctggggctcaggcttgagccactactccctcatcccctcaggagtctgaacactgggcttatgccttactctcagggacaagcagcccccattgctgcctgtagatgtgagctgttgagttccctcttgctggggaagatgagcttccatgtatcctgtgctcaaccctgaccctttgacactggttctggcctttcctgccttttctcaagctgcctggaatcctcaaacctgtcactttggtcagatgtgcagaccattactaaggtctatgtctgcaaacattactaatctaggtcctattactaatctatgtctgcaaacattaaaggaatgaaacaatgaaaggaacatttgaaagaaaatgtgggtagacaatttcttgcaacttgggggaaagtttagaattcttttgattggactactttttttttttttcctcaagcttcaggtgaccacaatagcaacacctccctattctgttatttcttagtgtaggtagacaattctttcaggagcagagcagcgtcctataatcctagaccttttcatgacgtgtaaaaaatgatgtttcatcctctgattgccccaataaaaatctttgttgtccatccctatacaacctgccaacatggttgacatttaatgagaggaatgtcaaaaatacattttactttattcaaagaaaaatatattggttactgggaaaaggtcaagaaagaggcagaaagagatcagggagggctaaagttgtgtcttatgccaagcgaaagtgaaaaatatcattttcactttatcaactgagactttggggcctgtaagcttgaggcaagacagaaataagagaatcaagacttgattgtaaaaattgacaactttagattctgaggctaggctgagtacttattatacggctacatttacacatttacacttatctaataaatcagatttcacagtctcaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:922 -> Molecular function: GO:0005044 [scavenger receptor activity] evidence: IEA
GeneID:922 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:922 -> Biological process: GO:0006968 [cellular defense response] evidence: TAS
GeneID:922 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS
GeneID:922 -> Cellular component: GO:0005615 [extracellular space] evidence: TAS
GeneID:922 -> Cellular component: GO:0016020 [membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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