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2019-03-24 20:24:22, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005865               2881 bp    mRNA    linear   PRI 14-APR-2013
DEFINITION  Homo sapiens protease, serine, 16 (thymus) (PRSS16), mRNA.
ACCESSION   NM_005865
VERSION     NM_005865.3  GI:257467637
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Kitazawa,M., Ohnuma,T., Takebayashi,Y., Shibata,N., Baba,H.,
            Ohi,K., Yasuda,Y., Nakamura,Y., Aleksic,B., Yoshimi,A., Okochi,T.,
            Ikeda,M., Naitoh,H., Hashimoto,R., Iwata,N., Ozaki,N., Takeda,M.
            and Arai,H.
  TITLE     No associations found between the genes situated at 6p22.1,
            HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with
            schizophrenia
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (4), 456-464
            (2012)
   PUBMED   22488895
  REMARK    GeneRIF: The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated
            with Japanese patients with schizophrenia.
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Girgenti,M.J., LoTurco,J.J. and Maher,B.J.
  TITLE     ZNF804a regulates expression of the schizophrenia-associated genes
            PRSS16, COMT, PDE4B, and DRD2
  JOURNAL   PLoS ONE 7 (2), E32404 (2012)
   PUBMED   22384243
  REMARK    GeneRIF: ZNF804a regulates expression of the
            schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Shi,J., Levinson,D.F., Duan,J., Sanders,A.R., Zheng,Y., Pe'er,I.,
            Dudbridge,F., Holmans,P.A., Whittemore,A.S., Mowry,B.J., Olincy,A.,
            Amin,F., Cloninger,C.R., Silverman,J.M., Buccola,N.G.,
            Byerley,W.F., Black,D.W., Crowe,R.R., Oksenberg,J.R., Mirel,D.B.,
            Kendler,K.S., Freedman,R. and Gejman,P.V.
  TITLE     Common variants on chromosome 6p22.1 are associated with
            schizophrenia
  JOURNAL   Nature 460 (7256), 753-757 (2009)
   PUBMED   19571809
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2881)
  AUTHORS   Stefansson,H., Ophoff,R.A., Steinberg,S., Andreassen,O.A.,
            Cichon,S., Rujescu,D., Werge,T., Pietilainen,O.P., Mors,O.,
            Mortensen,P.B., Sigurdsson,E., Gustafsson,O., Nyegaard,M.,
            Tuulio-Henriksson,A., Ingason,A., Hansen,T., Suvisaari,J.,
            Lonnqvist,J., Paunio,T., Borglum,A.D., Hartmann,A., Fink-Jensen,A.,
            Nordentoft,M., Hougaard,D., Norgaard-Pedersen,B., Bottcher,Y.,
            Olesen,J., Breuer,R., Moller,H.J., Giegling,I., Rasmussen,H.B.,
            Timm,S., Mattheisen,M., Bitter,I., Rethelyi,J.M.,
            Magnusdottir,B.B., Sigmundsson,T., Olason,P., Masson,G.,
            Gulcher,J.R., Haraldsson,M., Fossdal,R., Thorgeirsson,T.E.,
            Thorsteinsdottir,U., Ruggeri,M., Tosato,S., Franke,B.,
            Strengman,E., Kiemeney,L.A., Melle,I., Djurovic,S., Abramova,L.,
            Kaleda,V., Sanjuan,J., de Frutos,R., Bramon,E., Vassos,E.,
            Fraser,G., Ettinger,U., Picchioni,M., Walker,N., Toulopoulou,T.,
            Need,A.C., Ge,D., Yoon,J.L., Shianna,K.V., Freimer,N.B.,
            Cantor,R.M., Murray,R., Kong,A., Golimbet,V., Carracedo,A.,
            Arango,C., Costas,J., Jonsson,E.G., Terenius,L., Agartz,I.,
            Petursson,H., Nothen,M.M., Rietschel,M., Matthews,P.M., Muglia,P.,
            Peltonen,L., St Clair,D., Goldstein,D.B., Stefansson,K. and
            Collier,D.A.
  CONSRTM   Genetic Risk and Outcome in Psychosis (GROUP)
  TITLE     Common variants conferring risk of schizophrenia
  JOURNAL   Nature 460 (7256), 744-747 (2009)
   PUBMED   19571808
REFERENCE   5  (bases 1 to 2881)
  AUTHORS   Viken,M.K., Blomhoff,A., Olsson,M., Akselsen,H.E., Pociot,F.,
            Nerup,J., Kockum,I., Cambon-Thomsen,A., Thorsby,E., Undlien,D.E.
            and Lie,B.A.
  TITLE     Reproducible association with type 1 diabetes in the extended class
            I region of the major histocompatibility complex
  JOURNAL   Genes Immun. 10 (4), 323-333 (2009)
   PUBMED   19295542
  REMARK    GeneRIF: our results identify PRSS16 and BTN3A2, two genes thought
            to play important roles in regulating the immune response, as
            potentially novel susceptibility genes for Type I diabetes.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 2881)
  AUTHORS   Luther,C., Wienhold,W., Oehlmann,R., Heinemann,M.K., Melms,A. and
            Tolosa,E.
  TITLE     Alternatively spliced transcripts of the thymus-specific protease
            PRSS16 are differentially expressed in human thymus
  JOURNAL   Genes Immun. 6 (1), 1-7 (2005)
   PUBMED   15592422
REFERENCE   7  (bases 1 to 2881)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 2881)
  AUTHORS   Lie,B.A., Akselsen,H.E., Bowlus,C.L., Gruen,J.R., Thorsby,E. and
            Undlien,D.E.
  TITLE     Polymorphisms in the gene encoding thymus-specific serine protease
            in the extended HLA complex: a potential candidate gene for
            autoimmune and HLA-associated diseases
  JOURNAL   Genes Immun. 3 (5), 306-312 (2002)
   PUBMED   12140752
  REMARK    GeneRIF: The gene encoding thymus-specific serine protease (PRSS16)
            maps to the extended HLA complex, which harbours several genes
            predisposing for autoimmune diseases.
REFERENCE   9  (bases 1 to 2881)
  AUTHORS   Bowlus,C.L., Ahn,J., Chu,T. and Gruen,J.R.
  TITLE     Cloning of a novel MHC-encoded serine peptidase highly expressed by
            cortical epithelial cells of the thymus
  JOURNAL   Cell. Immunol. 196 (2), 80-86 (1999)
   PUBMED   10527559
REFERENCE   10 (bases 1 to 2881)
  AUTHORS   Gruen,J.R., Nalabolu,S.R., Chu,T.W., Bowlus,C., Fan,W.F.,
            Goei,V.L., Wei,H., Sivakamasundari,R., Liu,Y., Xu,H.X., Parimoo,S.,
            Nallur,G., Ajioka,R., Shukla,H., Bray-Ward,P., Pan,J. and
            Weissman,S.M.
  TITLE     A transcription map of the major histocompatibility complex (MHC)
            class I region
  JOURNAL   Genomics 36 (1), 70-85 (1996)
   PUBMED   8812418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314037.1, AF052514.1,
            AK093590.1 and BG119060.1.
            On Sep 9, 2009 this sequence version replaced gi:21396490.
            
            Summary: This gene encodes a serine protease expressed exclusively
            in the thymus. It is thought to play a role in the alternative
            antigen presenting pathway used by cortical thymic epithelial cells
            during the positive selection of T cells. The gene is found in the
            large histone gene cluster on chromosome 6, near the major
            histocompatibility complex (MHC) class I region. A second
            transcript variant has been described, but its full length nature
            has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314037.1, AF052514.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               AK314037.1         1-550
            551-1232            AF052514.1         548-1229
            1233-1747           AK093590.1         1122-1636
            1748-2505           AF052514.1         1745-2502
            2506-2726           AK093590.1         2395-2615
            2727-2881           BG119060.1         290-444
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21"
     gene            1..2881
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="protease, serine, 16 (thymus)"
                     /db_xref="GeneID:10279"
                     /db_xref="HGNC:9480"
                     /db_xref="HPRD:06205"
                     /db_xref="MIM:607169"
     exon            1..85
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     CDS             16..1560
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="thymus specific serine peptidase; serine protease
                     16"
                     /codon_start=1
                     /product="thymus-specific serine protease"
                     /protein_id="NP_005856.1"
                     /db_xref="GI:5031993"
                     /db_xref="CCDS:CCDS4623.1"
                     /db_xref="GeneID:10279"
                     /db_xref="HGNC:9480"
                     /db_xref="HPRD:06205"
                     /db_xref="MIM:607169"
                     /translation="
MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDGQTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV
"
     misc_feature    205..1497
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="Serine carboxypeptidase S28; Region: Peptidase_S28;
                     pfam05577"
                     /db_xref="CDD:114307"
     variation       21
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146400295"
     variation       22
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138254301"
     variation       77
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149623864"
     exon            86..252
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       100
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144485144"
     variation       134
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114674760"
     variation       141
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185312781"
     variation       144
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145018357"
     variation       156
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374589944"
     variation       180
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368859680"
     variation       195
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372265510"
     variation       202
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147127802"
     variation       225
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140318437"
     variation       239
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150849072"
     exon            253..352
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       267
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139981185"
     variation       307
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375923335"
     variation       326
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:5030965"
     variation       350
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375736451"
     exon            353..482
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       360
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200804935"
     variation       384
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376298678"
     variation       385
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149942995"
     variation       423
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199723551"
     variation       425
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367792034"
     variation       461
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145240806"
     exon            483..606
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       488..489
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35193701"
     variation       503
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367779428"
     variation       506
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372674948"
     variation       509..510
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35505122"
     variation       534..536
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="ctc"
                     /db_xref="dbSNP:145433670"
     exon            607..684
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       626
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35466700"
     variation       644
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368386726"
     variation       665
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199924462"
     exon            685..732
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       703
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369039018"
     variation       705
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200343894"
     exon            733..1023
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       735
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145057645"
     variation       785
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373693994"
     variation       802
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201036521"
     variation       825
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376394921"
     variation       834
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370382383"
     variation       840
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374127733"
     variation       875
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367668932"
     variation       877
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199812226"
     variation       878
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201412510"
     variation       921
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376340080"
     variation       930
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370172983"
     variation       936
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34132190"
     variation       976
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374424134"
     variation       977..978
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:374906013"
     variation       980
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201343810"
     variation       998
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368893993"
     exon            1024..1165
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       1071
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199666358"
     variation       1127
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140528789"
     variation       1153
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376962461"
     variation       1158
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191407230"
     exon            1166..1345
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       1166
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145885657"
     variation       1200
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368818262"
     variation       1216
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372392587"
     variation       1233
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1062834"
     variation       1255
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199614851"
     variation       1272
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148977056"
     variation       1282
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143725538"
     variation       1290
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141944192"
     variation       1298
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201267315"
     exon            1346..1491
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     variation       1384
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371863087"
     variation       1398
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375471259"
     variation       1417
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369828855"
     variation       1418
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150255818"
     variation       1486
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138897744"
     exon            1492..2865
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:1.39.8"
     STS             1506..1705
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /standard_name="RH103917"
                     /db_xref="UniSTS:98242"
     variation       1531..1545
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="aaggagagccagatt"
                     /db_xref="dbSNP:141138864"
     variation       1531
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="aaggagagccagatt"
                     /db_xref="dbSNP:5030663"
     variation       1535..1549
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="agagccagattaagg"
                     /db_xref="dbSNP:371606222"
     variation       1535
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143492910"
     variation       1535
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="agagccagattaagg"
                     /db_xref="dbSNP:75688361"
     variation       1536
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147170589"
     variation       1537
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140280737"
     variation       1538
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201493618"
     variation       1539
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199705677"
     variation       1540
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142712601"
     variation       1541
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200987021"
     variation       1543
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144604424"
     variation       1553
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368262432"
     variation       1628
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142829853"
     variation       1660
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146063903"
     variation       1690
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3734578"
     variation       1700
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190153998"
     variation       1708
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3734577"
     variation       1830
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:5030953"
     variation       1933
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3734576"
     variation       1973
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141891269"
     variation       2017
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192968631"
     variation       2120
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184847039"
     variation       2126
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:188561309"
     variation       2127
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180706651"
     variation       2180
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5030954"
     variation       2344..2347
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="tctc"
                     /db_xref="dbSNP:373601841"
     variation       2433..2435
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="tcta"
                     /db_xref="dbSNP:35237909"
     variation       2436
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199522641"
     variation       2440..2441
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="atct"
                     /db_xref="dbSNP:70981152"
     STS             2454..2649
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /standard_name="RH36539"
                     /db_xref="UniSTS:8123"
     variation       2525..2526
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:200311156"
     variation       2588
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146267002"
     variation       2594
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185140362"
     polyA_signal    2678..2683
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
     polyA_site      2716
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
     variation       2780
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58265076"
     variation       2862
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189220208"
     polyA_site      2865
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
ORIGIN      
agagtcccgaacaccatggccgtctggcttgcccagtggctgggccctctgctcttggtttccctctggggactcttggctccagcctcccttcttaggcgcctgggtgagcacattcagcagtttcaggagagctctgcccagggcctgggcctgagcctggggccaggtgctgcagccctcccaaaagtggggtggctggagcaactgctggaccccttcaacgtgtccgacagacgatccttcctacagcgttactgggtgaatgaccaacattgggttggccaggatggacccatattcctgcatctagggggtgagggcagccttgggcctggctcagtgatgagaggccatcccgcagccttggccccagcctggggcgccctggtgataagcctggaacacagattttatggcctgagtatacctgctggaggcctggaaatggcccagctccgcttcttgtccagccgccttgcgctggctgatgtggtctctgcccgcctggcactttcccgcctctttaacatctcctcctccagcccctggatctgcttcggaggctcctatgccggctccttggccgcctgggcccggctgaagttcccccatctcattttcgcgtcggtcgcctcctccgccccggtgcgggccgtgctggatttctccgagtataatgacgtggtatcccgaagcctaatgagcaccgcgatcggcgggtccctggagtgccgggcggcggtgtccgtcgccttcgctgaagtggagcggcggctgcgctcgggtggggcggctcaagcagcattgcggacggagctgagcgcttgcgggcccctgggccgcgctgaaaaccaggcggagctgttgggggcgctgcaggcactggtgggaggtgtagtgcagtatgatgggcagacgggagcgccgctaagcgtgcgacagctctgcggacttctcctcgggggcgggggcaaccgcagccactccacgccctactgcgggcttcgtcgggcggtgcagattgtcttgcacagcctgggccagaagtgtttaagcttttcccgagcagagacagtggcacagctgaggagcacagaacctcaactgtctggtgtgggtgaccggcagtggttgtatcagacatgtaccgagttcggcttctatgtcacctgtgagaatcccagatgtcctttctcccagctcccagcactgccctcccagctagacctatgtgagcaggtgtttgggctctcagccttgtcagtagcccaggctgtggctcagacgaactcctactacggtggccagacccctggggctaacaaagtgctgtttgttaatggggacacagacccctggcatgtgctaagtgtaacacaggctttaggatcctcagaatcaactcttcttatccgcactggctcccactgcttggacatggcacctgagaggccctcagactcccccagcctccgcctagggcgccagaacatcttccagcagctacagacctggctcaagctggcaaaggagagccagattaagggtgaagtctgaatctcataccctttccactccctgcatggtcacctcagtcctggacatacttgttcactgaacaaaagaaagcagcttgttttgaaagaagaaactcccaggaattggaattcagcacctgttccgcacgtaattggcatgtgtctgcaaacatccttattcccaacttaaagtgctttattgcagagagttatggaaatataagtggatgattattctcattgtaaatattggtattttgaatgttaaatgtcaaacaaatgtgacttatgctggtgccctcgccctgctgatcagattctggttcaaattctgccactccagctcctgggttaggggctttgctgtaagtttctttttctggactttagatcctgaacctgtccttgcttctcagtttctctcactgtacccctttccctcagtctcttcctctctctttcccctgtcactatttgtctttctaatctccttctgtttctctgaatatcttcatttctatctctgtgtttctgtctatttctctgtttatctttctgtccttcaatctgtgtttttgtttctggctctccgtcagtgtctttttctctcctctctctcttgctctgccatggctatttccactgctctatttctgactctcatttttggtctctgtgtgtctcctagtcactttctttctcactctgtctctgtctctatttctgtctctcctctgctgtgtcctcaatctctctgtctccctgaggctctatttctgtctctcctctgctgtgtcctcaatctctctgtctccctgaggctctatttctgtctctgatgctcttcttctgtgtctctatttctcttcctgtcacttaatcttttccttctctatctctcttatttagtcttccttccacacccttcactcaccatcttttcccacaatcaaatatcactccctggtacttccagcttccaactctagggattcatgattctggtggagattccttcttccagggcctgggaggatagggctaatcccaagggtgcctgcttaggctatgttagctgtgacaggaacctgccatagatttgcactgttctttcctaaagatcaattattttcagcaataaatacttctcagctttttgtatgtctttgtatgcacagagatggtagttttagagttttatccagtttcatatttccttgtgggtaagaggcaacctcctcatgctgtcataccaaagtcaatctccactacactttagttctgcctgttcttgatctttatataaatggaaacttgcagtataaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10279 -> Molecular function: GO:0008236 [serine-type peptidase activity] evidence: NAS
            GeneID:10279 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:10279 -> Biological process: GO:0030163 [protein catabolic process] evidence: NAS
            GeneID:10279 -> Cellular component: GO:0005764 [lysosome] evidence: IDA
            GeneID:10279 -> Cellular component: GO:0005768 [endosome] evidence: IDA
            GeneID:10279 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA

by @meso_cacase at DBCLS
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