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2024-04-18 15:37:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005785 5277 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ring finger protein 41 (RNF41), transcript variant 1,
mRNA.
ACCESSION NM_005785
VERSION NM_005785.3 GI:338827613
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5277)
AUTHORS Zhou,A., Pan,D., Yang,X. and Zhou,J.
TITLE Overexpression of Nrdp1/FLRF sensitizes cells to oxidative stress
JOURNAL Biochem. Biophys. Res. Commun. 410 (4), 771-774 (2011)
PUBMED 21693106
REMARK GeneRIF: these data provide insights into understanding the
potential role of Nrdp1 in cell growth, apoptosis and oxidative
stress, and in the pathogenesis of Parkinson's disease.
REFERENCE 2 (bases 1 to 5277)
AUTHORS Fry,W.H., Simion,C., Sweeney,C. and Carraway,K.L. III.
TITLE Quantity control of the ErbB3 receptor tyrosine kinase at the
endoplasmic reticulum
JOURNAL Mol. Cell. Biol. 31 (14), 3009-3018 (2011)
PUBMED 21576364
REMARK GeneRIF: Data demonstrate that Nrdp1 preferentially associates with
the nascent form of ErbB3 to accelerate its degradation, and that
the two proteins colocalize at the endoplasmic reticulum.
REFERENCE 3 (bases 1 to 5277)
AUTHORS Wauman,J., De Ceuninck,L., Vanderroost,N., Lievens,S. and
Tavernier,J.
TITLE RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and
ectodomain shedding
JOURNAL J. Cell. Sci. 124 (PT 6), 921-932 (2011)
PUBMED 21378310
REMARK GeneRIF: RNF41 interacts with JAK2-associated cytokine receptor
complexes and modulates their cell surface exposure and signalling.
REFERENCE 4 (bases 1 to 5277)
AUTHORS Ingalla,E.Q., Miller,J.K., Wald,J.H., Workman,H.C., Kaur,R.P.,
Yen,L., Fry,W.H., Borowsky,A.D., Young,L.J., Sweeney,C. and
Carraway,K.L. III.
TITLE Post-transcriptional mechanisms contribute to the suppression of
the ErbB3 negative regulator protein Nrdp1 in mammary tumors
JOURNAL J. Biol. Chem. 285 (37), 28691-28697 (2010)
PUBMED 20628057
REMARK GeneRIF: Post-transcriptional mechanisms contribute to the
suppression of the ErbB3 negative regulator protein Nrdp1 in
mammary tumors.
REFERENCE 5 (bases 1 to 5277)
AUTHORS Chen,L., Siddiqui,S., Bose,S., Mooso,B., Asuncion,A., Bedolla,R.G.,
Vinall,R., Tepper,C.G., Gandour-Edwards,R., Shi,X., Lu,X.H.,
Siddiqui,J., Chinnaiyan,A.M., Mehra,R., Devere White,R.W.,
Carraway,K.L. III and Ghosh,P.M.
TITLE Nrdp1-mediated regulation of ErbB3 expression by the androgen
receptor in androgen-dependent but not castrate-resistant prostate
cancer cells
JOURNAL Cancer Res. 70 (14), 5994-6003 (2010)
PUBMED 20587519
REMARK GeneRIF: Observations point to a model of CRPC development in which
progression of PCa to castration resistance is associated with the
inability of AR to transcriptionally regulate Nrdp1, and predict
that inhibition of ErbB3 during AW may impair CRPC development.
REFERENCE 6 (bases 1 to 5277)
AUTHORS Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
TITLE Comprehensive proteomic analysis of human Par protein complexes
reveals an interconnected protein network
JOURNAL J. Biol. Chem. 279 (13), 12804-12811 (2004)
PUBMED 14676191
REFERENCE 7 (bases 1 to 5277)
AUTHORS Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
TITLE Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
pathway for triggering apoptosis
JOURNAL EMBO J. 23 (4), 800-810 (2004)
PUBMED 14765125
REMARK GeneRIF: Nrdp1 can be important in the initiation of apoptosis by
catalyzing ubiquitination and degradation of BRUCE.
REFERENCE 8 (bases 1 to 5277)
AUTHORS Qiu,X.B. and Goldberg,A.L.
TITLE Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and
degradation of the epidermal growth factor receptor family member,
ErbB3
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (23), 14843-14848 (2002)
PUBMED 12411582
REMARK Erratum:[Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17220.]
REFERENCE 9 (bases 1 to 5277)
AUTHORS Diamonti,A.J., Guy,P.M., Ivanof,C., Wong,K., Sweeney,C. and
Carraway,K.L. III.
TITLE An RBCC protein implicated in maintenance of steady-state
neuregulin receptor levels
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (5), 2866-2871 (2002)
PUBMED 11867753
REFERENCE 10 (bases 1 to 5277)
AUTHORS Abdullah,J.M., Li,X., Nachtman,R.G. and Jurecic,R.
TITLE FLRF, a novel evolutionarily conserved RING finger gene, is
differentially expressed in mouse fetal and adult hematopoietic
stem cells and progenitors
JOURNAL Blood Cells Mol. Dis. 27 (1), 320-333 (2001)
PUBMED 11358394
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB989647.1, BC036267.1 and
AC073896.41.
On Jun 30, 2011 this sequence version replaced gi:37588857.
Summary: This gene encodes an E3 ubiquitin ligase. The encoded
protein plays a role in type 1 cytokine receptor signaling by
controlling the balance between JAK2-associated cytokine receptor
degradation and ectodomain shedding. Alternative splicing results
in multiple transcript variants. [provided by RefSeq, Jun 2011].
Transcript Variant: This variant (1) encodes the longer isoform
(1). Variants 1, 3 and 4 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC036267.1, BX376497.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-610 CB989647.1 28-637
611-2116 BC036267.1 555-2060
2117-5277 AC073896.41 128118-131278
FEATURES Location/Qualifiers
source 1..5277
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.13"
gene 1..5277
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="ring finger protein 41"
/db_xref="GeneID:10193"
/db_xref="HGNC:18401"
/db_xref="HPRD:11520"
exon 1..172
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
variation 100..101
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="c"
/replace="g"
/db_xref="dbSNP:11548553"
variation 101
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="a"
/replace="c"
/db_xref="dbSNP:11548554"
exon 173..357
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
exon 358..470
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
misc_feature 375..377
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="upstream in-frame stop codon"
CDS 381..1334
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/EC_number="6.3.2.-"
/note="isoform 1 is encoded by transcript variant 1;
neuregulin receptor degradation protein-1; fetal liver
ring finger; E3 ubiquitin-protein ligase NRDP1"
/codon_start=1
/product="E3 ubiquitin-protein ligase NRDP1 isoform 1"
/protein_id="NP_005776.1"
/db_xref="GI:5032071"
/db_xref="CCDS:CCDS8909.1"
/db_xref="GeneID:10193"
/db_xref="HGNC:18401"
/db_xref="HPRD:11520"
/translation="
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
"
misc_feature 420..554
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 432..545
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region:
RING; cd00162"
/db_xref="CDD:238093"
misc_feature order(432..434,441..443,480..482,486..488,495..497,
504..506,537..539)
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="cross-brace motif; other site"
/db_xref="CDD:238093"
misc_feature 789..1325
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/note="USP8 interacting; Region: USP8_interact; pfam08941"
/db_xref="CDD:149875"
exon 471..742
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
exon 743..878
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
exon 879..982
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
exon 983..5277
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/inference="alignment:Splign:1.39.8"
variation 1037
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="a"
/replace="g"
/db_xref="dbSNP:703822"
STS 2598..3388
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="RNF41_1849"
/db_xref="UniSTS:280974"
STS 3061..3207
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="A002D43"
/db_xref="UniSTS:3098"
STS 3061..3207
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="G19966"
/db_xref="UniSTS:3099"
polyA_signal 3254..3259
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
polyA_site 3280
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
variation 3521
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="a"
/replace="g"
/db_xref="dbSNP:773654"
STS 3799..3901
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 3844..4263
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D10S16"
/db_xref="UniSTS:155756"
STS 3878..4284
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 3878..3980
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 3883..4276
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3883..3972
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3938..4331
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
STS 3952..4131
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
variation 3982
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="c"
/replace="t"
/db_xref="dbSNP:773655"
STS 4027..4201
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="L17971"
/db_xref="UniSTS:43966"
variation 4045
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="a"
/replace="g"
/db_xref="dbSNP:773656"
STS 4189..4284
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
variation 4586
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
/replace="a"
/replace="g"
/db_xref="dbSNP:773657"
polyA_site 5277
/gene="RNF41"
/gene_synonym="FLRF; NRDP1; SBBI03"
ORIGIN
aaaggatccgtctgaggcggcgacgagtggtaggagtcttctttcccctccttcccctttcccttcccttcccgggagaggctgggacccggcaccagggcagtactgtggccgctgcggcctcagctccgactgggtcaggttgcggagactccaggccgcttccagggcgagtactcctgattgtgacatcacattcatcccctgggcgatggagcttgtcactgggaaggaatactcagtcggagaatagccaacaagatgggttactgggagaatctcttcagtggcactgagtggaggcatcagggggttggagccttgtgaacagggaacctgccccccaacacttggaaggacctgggtttcagtgatgagacatggggtatgatgtaacccgtttccagggggatgttgacgaagatcttatctgccctatttgcagtggagtcttggaggagccagtacaggcacctcattgtgaacatgctttctgcaacgcctgcatcacccagtggttctctcagcaacagacatgtccagtggaccgtagtgttgtgacggtcgcccatctgcgcccagtacctcggatcatgcggaacatgttgtcaaagctgcagattgcctgtgacaacgctgtgttcggctgtagtgccgttgtccggcttgacaacctcatgtctcacctcagcgactgtgagcacaacccgaagcggcctgtgacctgtgaacagggctgtggcctggagatgcccaaagatgagctgcccaaccataactgcattaagcacctgcgctcagtggtacagcagcagcagacacgcatcgcagagctggagaagacgtcagctgaacacaaacaccagctggcggagcagaagcgagacatccagctgctaaaggcatacatgcgtgcaatccgcagtgtcaaccccaaccttcagaacctggaggagacaattgaatacaacgagatcctagagtgggtgaactcccttcagccagcaagagtgacccgctggggagggatgatctcgactcctgatgctgtgctccaggctgtaatcaagcgctccctggtggagagtggctgtcctgcttctattgtcaacgagctgattgaaaatgcccacgagcgtagctggccccagggtctggccacactagagactagacagatgaaccgacgctactatgagaactacgtggccaagcgcatccctggcaagcaggctgttgtcgtgatggcctgtgagaaccagcacatgggggatgacatggtgcaagagccaggccttgtcatgatatttgcgcatggcgtggaagagatataagagaactcgactggctatcaggaagagatggaaatcagaaaatcccatcactccagcagctgggacctgagtcctacccaccattcttaatactgtggcttatacctgagccacacatctccctgcccttctggcactgaagggccttggggtagtttgctcagcctttcaggtgggaaacccagatttcctccctttgccatattcccctaaaatgtctataaattatcagtctgggtgggaaagcccccacctccatccattttcctgcttagggtccctggttccagttattttcagaaagcacaaagagattcaatttccctggaggatcaggacagaggaaggaatctctaatcgtccctctcctccaaaaccagggaatcagagcagtcaggcctgttgactctaagcagcagacatcctgaagaaatggtaagggtggagccaaatctctagaaataagtagtgaggccgttaattggccatcactgatggcccttagggaaagactggacctctgtgccaagcagtatccctgttcagcccaccttaaaggtgtaggcacccactgggtctaccagtatgcaggttgggatactgaaaatttccagatgagctcttctttcctacaagttttcataattagggaatgccagggtttagggtaggggttaatctgttgggggttgatgtgtttagcaagaagctactcctagcttttgctaaaatatggttggcactgcctcttgtggcacaggccataattgttccatagacccctctctagccctgtgactgtagttagttactttgataattttctttggccattgtttgtttatatttcacaaactccacctactgcccccccccctcttttttttaagaatggcctgatcatggctatctcagccacattgttggcaatttaatttatttacttcctttttttttttttaagaaaggaaaaaagaaaaaaaaatcaaacttgaaacttttcttttgatgttcctattgtgggggttctggatagggtgggacagggatgggggtgtgttttatattttttccttttcagcacaacctttggctttaatataggaagagccaagggagtcctcggctgaacttacgatatctgccccaaacctctgtaaccccaactgaaatgaggagcttcctctcttcctgtgaaggatatgacagtccagcatcgatgcctgtgccctctggaaaaatttcctcctagcccttccagggccttatcataaaactctggatttagagtattcattttgaaggcaactcccccttccccaagtttccttggagctgtatagctgggttctaagcttcaccatgcaaatcagaaattttatctctaagtacaggctgtgccgtgtctcacccacacccccctggggacttcagttccatttcaggttacctggggtataccttgatccctagagtgactggcagagtaagagaaggggagagataataggtgtgattattttaatatggaggtgggagtgtggttggagatagaaaggctcctccccaccatgtaatggcttcctctcagaattttattccaggctagcttgctgcaggtctgggtagttggatcatggctccactgggattggggtggaaagcttgaggggagtagggttccagctctgggacattgtgctcaggaatttgaaaacgctgctatacttactctggttactacatttcttccactcccctttcccctacctgccttaaccaaggctcatactgtcctgtccttaccctcagatggagccaggaagctcagtgaaaggcttccctaccctttgcactagtgtctctgcaggttgctggttgtgttgtatgtgctgttccatggtgttgactgcactaataataaaccttttactcaactctctaaattcttcagcattactccctttcttgagaaggtttcccctctgcttttgcctttctctcaccttaattccctttcttccttactttgttacctacccttatcttagtgctaacttctctttcaggaggatgtctgggagtagtgtgcacttcacagctgctttcccatgtaccctcctgcattcttccctcctatctcctgttctgtagcagccaaagctctctagtgatctgaactgtgtgcttcccagggtctgcctttatcctaaattccatgtcttccctgagtggtcctgagtttttgggataatttctacagaagatatgtatatatctttttcctttgtcccacaagcaactttgctttagaatctagaattcctttgcaggcagagaagtctctacctcccagtgtttcctagctaagaacgtaaatgtgaggagggaaatgtacttgcagaggtttcataattatttacttataaaaatagtcttcatagccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggtgggtggatcacaaggtcaggagttcgagaccatcctggctaacacagtgaaaccccgtctctactaaaaatacaaaaaattagccgggcgtggtggcaggcacctgtagtcccagctacttaggaggctgaggcaggagaatggcgtgaacccgggaggcagagcttgcagtgagcagagattgggccactgcattccagcctgggcgacagagcaaggctccgtctaaaaaaaaaaaaaaaaaaaaaagtcttcataggccgggcacggtggctcacgtctgtaatcccagcactttgggaggccaaggtgggtggatcacaacgtcaggagatcgagaccatcctggctaacatggtgaaaccctgtctctactaaaaatataaataaattagccggacaggcgcctgtcctcccagctactcaggaggctgaggcaggagaatggtgtgaacctgggaggcggagcttgcagtgagctgagatcacgccactgcactccagcctgggcaacagagcaagactccgtctcaaaaaaaaaaaaaaaaaaaccagtcttcataagtatttgctgctacctttccctgtcataagaaaaaggatagccagacatggtgggacgccactatgatcccagctccttggaaggctaaggcacaagaatcgcttgaacctgggaggtggaggttgcagtgagctgagatcatgccactgcactccagcctggtgacagagcaagagcctgtctcaaaaaaaaaaaagaaaagaaaagaaaaagggatatcttttcctcctcccagaagtttgttttaaatttgagcatttatcatgcacctgatgtaaacctaatagtactcttgatactctagtggcttgaaaaaaaaaaaaaaggcatttctgtgctgagtctgcgcttctatgcacacaaggtatgtttataaaatactgataagcatgtcacagtatagagcataagaggcaatgtatgtatcctagtgacattagcagtgcttttccccccttaaactcctttaaaattacttttagaacttgctgctcattcttgtgaatgttatgaatggtgtcatattgtccttttacagaagatacgatttttagaaacaaatattcattgaatgtctgccctgtgagatactcactagagtgaacatgaggaggcttatgtagcaaaatggcacctacctgcaaagaacttagtccctaatggagatgaatatataataagggatcataaatgtgctaagtggatttactagtaatatgtgagccaaggacgataaagctcctgattctgatgggtatcaggaaaggcttttcaggaagtgttacttgttataggtcagaggtcagcaaactacaggttacaaccccactgcctgcttttgtaaaaaactttattggaatacagttatgcccacttgtttata
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10193 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:10193 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS
GeneID:10193 -> Molecular function: GO:0005128 [erythropoietin receptor binding] evidence: IEA
GeneID:10193 -> Molecular function: GO:0005135 [interleukin-3 receptor binding] evidence: IEA
GeneID:10193 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10193 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:10193 -> Molecular function: GO:0031386 [protein tag] evidence: IEA
GeneID:10193 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IDA
GeneID:10193 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:10193 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IMP
GeneID:10193 -> Biological process: GO:0043408 [regulation of MAPK cascade] evidence: IDA
GeneID:10193 -> Biological process: GO:0045619 [regulation of lymphocyte differentiation] evidence: IEA
GeneID:10193 -> Biological process: GO:0045637 [regulation of myeloid cell differentiation] evidence: IEA
GeneID:10193 -> Biological process: GO:0051896 [regulation of protein kinase B signaling cascade] evidence: IDA
GeneID:10193 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IDA
GeneID:10193 -> Biological process: GO:2000377 [regulation of reactive oxygen species metabolic process] evidence: IMP
GeneID:10193 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005776 -> EC 6.3.2.-
by
@meso_cacase at
DBCLS
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