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2024-04-24 23:46:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005778 3149 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens RNA binding motif protein 5 (RBM5), transcript variant
1, mRNA.
ACCESSION NM_005778
VERSION NM_005778.3 GI:354459373
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3149)
AUTHORS Jin,W., Niu,Z., Xu,D. and Li,X.
TITLE RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the
binding of U2AF65 to the polypyrimidine tract
JOURNAL FEBS Lett. 586 (21), 3852-3857 (2012)
PUBMED 23017209
REMARK GeneRIF: RBM5 promotes exon 4 skipping of AID pre-mRNA by competing
with the binding of U2AF65 to the polypyrimidine tract.
REFERENCE 2 (bases 1 to 3149)
AUTHORS Song,Z., Wu,P., Ji,P., Zhang,J., Gong,Q., Wu,J. and Shi,Y.
TITLE Solution structure of the second RRM domain of RBM5 and its unusual
binding characters for different RNA targets
JOURNAL Biochemistry 51 (33), 6667-6678 (2012)
PUBMED 22839758
REMARK GeneRIF: NMR data analysis of RBM5 RRM2 reveals several features of
protein-RNA interfaces. The most striking observation is the
presence of two preferred target RNA sequences, the sequences
[5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3'].
REFERENCE 3 (bases 1 to 3149)
AUTHORS Masilamani,T.J., Rintala-Maki,N.D., Wang,K. and Sutherland,L.C.
TITLE Downregulating activated epidermal growth factor receptor has no
effect on RBM5 expression
JOURNAL Chin. Med. J. 125 (13), 2378-2381 (2012)
PUBMED 22882865
REMARK GeneRIF: The results suggest that RBM5 expression is not directly
regulated by EGFR in non-smoker related lung adenocarinomas.
REFERENCE 4 (bases 1 to 3149)
AUTHORS Shao,C., Zhao,L., Wang,K., Xu,W., Zhang,J. and Yang,B.
TITLE The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell
growth and induces apoptosis
JOURNAL World J Surg Oncol 10, 160 (2012)
PUBMED 22866867
REMARK GeneRIF: RBM5 can inhibit the growth of lung cancer cells and
induce apoptosis both in vitro and in vivo.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3149)
AUTHORS Oh,J.J., Koegel,A.K., Phan,D.T., Razfar,A. and Slamon,D.J.
TITLE The two single nucleotide polymorphisms in the H37/RBM5 tumour
suppressor gene at 3p21.3 correlated with different subtypes of
non-small cell lung cancers
JOURNAL Lung Cancer 58 (1), 7-14 (2007)
PUBMED 17606309
REMARK GeneRIF: specific allele types at C1138T and C2185T single
nucleotide polymorphisms positions are correlated with different
histological subtypes of non-small cell lung cancer
REFERENCE 6 (bases 1 to 3149)
AUTHORS Sutherland,L.C., Edwards,S.E., Cable,H.C., Poirier,G.G.,
Miller,B.A., Cooper,C.S. and Williams,G.T.
TITLE LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis
JOURNAL Oncogene 19 (33), 3774-3781 (2000)
PUBMED 10949932
REFERENCE 7 (bases 1 to 3149)
AUTHORS Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
and Old,L.J.
TITLE Antigens recognized by autologous antibody in patients with
renal-cell carcinoma
JOURNAL Int. J. Cancer 83 (4), 456-464 (1999)
PUBMED 10508479
REFERENCE 8 (bases 1 to 3149)
AUTHORS Oh,J.J., Grosshans,D.R., Wong,S.G. and Slamon,D.J.
TITLE Identification of differentially expressed genes associated with
HER-2/neu overexpression in human breast cancer cells
JOURNAL Nucleic Acids Res. 27 (20), 4008-4017 (1999)
PUBMED 10497265
REFERENCE 9 (bases 1 to 3149)
AUTHORS Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
Elst,A., van der Veen,A.Y., Kok,K., Naylor,S.L. and Buys,C.H.
TITLE An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3,
a region frequently deleted in a variety of cancers
JOURNAL Genomics 60 (2), 238-240 (1999)
PUBMED 10486216
REFERENCE 10 (bases 1 to 3149)
AUTHORS Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
Elst,A., Voutsinas,G., Hulsbeek,M.M., Draaijers,T.G., Looman,M.W.,
Kok,K., Naylor,S.L. and Buys,C.H.
TITLE A comparison of genomic structures and expression patterns of two
closely related flanking genes in a critical lung cancer region at
3p21.3
JOURNAL Eur. J. Hum. Genet. 7 (4), 478-486 (1999)
PUBMED 10352938
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB080737.1, AF091263.1,
DA776815.1, CN293007.1 and BM985111.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 26, 2011 this sequence version replaced gi:307219255.
Summary: This gene is a candidate tumor suppressor gene which
encodes a nuclear RNA binding protein that is a component of the
spliceosome A complex. The encoded protein plays a role in the
induction of cell cycle arrest and apoptosis through pre-mRNA
splicing of multiple target genes including the tumor suppressor
protein p53. This gene is located within the tumor suppressor
region 3p21.3, and may play a role in the inhibition of tumor
transformation and progression of several malignancies including
lung cancer. [provided by RefSeq, Oct 2011].
Transcript Variant: This variant (1) represents the longer
transcript and is protein coding.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF091263.1, BC002957.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-27 DB080737.1 1-27
28-1164 AF091263.1 1-1137
1165-1165 DA776815.1 386-386
1166-2211 AF091263.1 1139-2184
2212-2647 CN293007.1 137-572
2648-3149 BM985111.1 1-502 c
FEATURES Location/Qualifiers
source 1..3149
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.3"
gene 1..3149
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RNA binding motif protein 5"
/db_xref="GeneID:10181"
/db_xref="HGNC:9902"
/db_xref="HPRD:06052"
/db_xref="MIM:606884"
exon 1..122
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 85
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:189692292"
exon 123..192
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 142
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200704750"
misc_feature 158..160
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="upstream in-frame stop codon"
CDS 176..2623
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="putative tumor suppressor LUCA15; renal carcinoma
antigen NY-REN-9"
/codon_start=1
/product="RNA-binding protein 5"
/protein_id="NP_005769.1"
/db_xref="GI:5032031"
/db_xref="CCDS:CCDS2810.1"
/db_xref="GeneID:10181"
/db_xref="HGNC:9902"
/db_xref="HPRD:06052"
/db_xref="MIM:606884"
/translation="
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME
"
misc_feature 350..352
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 380..382
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 389..391
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 401..403
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature <446..>718
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RNA-binding proteins (RRM domain) [General function
prediction only]; Region: COG0724"
/db_xref="CDD:31068"
misc_feature 470..688
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(476..478,599..601,605..607)
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 719..805
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="Zn-finger in Ran binding protein and others;
Region: zf-RanBP; pfam00641"
/db_xref="CDD:201366"
misc_feature 869..1111
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(875..877,1001..1003,1007..1009)
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 1103..1111
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 1136..2602
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52756.2);
Region: Required for interaction with U2AF2"
misc_feature 1529..1780
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P52756.2);
Region: Sufficient for interaction with ACIN1, PRPF8,
SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200"
misc_feature 2033..2035
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2036..2038
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P52756.2); phosphorylation site"
misc_feature 2036..2038
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2045..2047
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P52756.2); phosphorylation site"
misc_feature 2045..2047
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2396..>2509
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/note="glycine rich nucleic binding domain; Region:
G_patch; smart00443"
/db_xref="CDD:197727"
exon 193..358
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 258
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:148224209"
variation 277
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146767621"
variation 292
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:113634040"
variation 302
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375214845"
variation 311
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369019054"
variation 312
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372517136"
variation 328
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139911215"
variation 336
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370608309"
variation 347
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:144273003"
exon 359..514
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 364
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:142145196"
variation 392
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201956265"
variation 396
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370431662"
variation 430
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144164147"
variation 435
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:143299571"
variation 441
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="c"
/db_xref="dbSNP:201825095"
variation 475
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:140669787"
variation 511
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145486184"
exon 515..584
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 547
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146743332"
variation 555
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139289182"
exon 585..658
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
exon 659..742
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 664
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:56783610"
variation 736
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112699450"
exon 743..803
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 802
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199972536"
exon 804..869
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
exon 870..1030
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 918
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369205859"
variation 925
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371504098"
variation 988
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374749250"
variation 1001
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112480552"
variation 1003
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202222023"
variation 1015
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:117321322"
exon 1031..1128
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1076
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145275102"
variation 1104
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201268838"
exon 1129..1216
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1138
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:138796501"
variation 1155
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146237025"
variation 1165
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061474"
variation 1183
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368640807"
variation 1186
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371984080"
variation 1203
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:371337648"
exon 1217..1294
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1255
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148691467"
variation 1265
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:200288461"
exon 1295..1367
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1324
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="t"
/db_xref="dbSNP:12163538"
variation 1357
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376849156"
variation 1359
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369922395"
exon 1368..1453
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1368
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:140191137"
variation 1382
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:112895164"
variation 1392
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147593355"
variation 1393
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:116604207"
variation 1419
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:377112362"
variation 1449
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:369465782"
variation 1452
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:138305114"
exon 1454..1538
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1496
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="c"
/db_xref="dbSNP:151182806"
variation 1507
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376882895"
variation 1513
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:371107399"
exon 1539..1630
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1597
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:368059260"
exon 1631..1792
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1660
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:188042950"
variation 1674
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:143236556"
variation 1702
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199934210"
variation 1709
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:142022998"
variation 1732
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:201548077"
variation 1744
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="t"
/db_xref="dbSNP:377289450"
exon 1793..1942
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1816
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:17849691"
variation 1817
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376263678"
variation 1881
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200794643"
variation 1911
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:138341530"
exon 1943..2014
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 1953
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:150564071"
variation 1962
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373551648"
variation 1969
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149757302"
exon 2015..2194
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 2055
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:112421212"
variation 2082
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377258178"
variation 2101
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:80289519"
exon 2195..2269
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 2212
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1138536"
variation 2229
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:12495050"
variation 2230
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142079101"
variation 2242
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368504461"
variation 2259
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:34058922"
exon 2270..2367
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 2359
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554989"
variation 2360
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145873632"
exon 2368..2497
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 2467
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="c"
/db_xref="dbSNP:142892066"
variation 2485
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376533995"
exon 2498..3131
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/inference="alignment:Splign:1.39.8"
variation 2508
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:148253572"
STS 2513..2748
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/standard_name="PMC22669P19"
/db_xref="UniSTS:272131"
variation 2538
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:2624827"
variation 2539
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="g"
/db_xref="dbSNP:2624828"
variation 2542
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141267714"
variation 2543
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190757140"
variation 2557
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:182960900"
variation 2560
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139773311"
variation 2622..2623
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace=""
/replace="ga"
/db_xref="dbSNP:112672304"
variation 2646
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374884720"
STS 2734..2928
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/standard_name="IB431"
/db_xref="UniSTS:72908"
STS 2779..2930
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/standard_name="D3S3180"
/db_xref="UniSTS:153505"
variation 2816
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:370954464"
STS 2846..2993
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/standard_name="RH77698"
/db_xref="UniSTS:34804"
STS 2869..3120
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/standard_name="RH24950"
/db_xref="UniSTS:90462"
variation 2869
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="c"
/replace="t"
/db_xref="dbSNP:188484883"
variation 2942
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="a"
/replace="g"
/db_xref="dbSNP:14834"
variation 3044
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
/replace="g"
/replace="t"
/db_xref="dbSNP:145825068"
polyA_site 3131
/gene="RBM5"
/gene_synonym="G15; H37; LUCA15; RMB5"
ORIGIN
aagcgtgaggtactgtgggtaggagacggccgtcggcggaggcgccattttgtgtagccgccgaaccttgttggaggttctggggcgcagaaccgctactgctgcttcggtctctccttgggaaaaaataaaatttgaaccttttggagctgtgtgctaaatcttcagtgggacaatgggttcagacaaaagagtgagtagaacagagcgtagtggaagatacggttccatcatagacagggatgaccgtgatgagcgtgaatcccgaagcaggcggagggactcagattacaaaagatctagtgatgatcggaggggtgatagatatgatgactaccgagactatgacagtccagagagagagcgtgaaagaaggaacagtgaccgatccgaagatggctaccattcagatggtgactatggtgagcacgactataggcatgacatcagtgacgagagggagagcaagaccatcatgctgcgcggccttcccatcaccatcacagagagcgatattcgagaaatgatggagtccttcgaaggccctcagcctgcggatgtgaggctgatgaagaggaaaacaggtgtaagccgtggtttcgccttcgtggagttttatcacttgcaagatgctaccagctggatggaagccaatcagaaaaagttggtgattcaaggaaagcacattgcaatgcattatagcaatcccagacctaagtttgaagattggctttgtaacaagtgctgccttaacaatttcaggaaaagactaaaatgcttccgatgtggagcagacaagtttgactctgaacaggaagtgcctcctggaaccacagagtcggttcagtctgtggattactactgtgatacgatcattcttcggaacatagctccgcacactgtggtggattccatcatgacagcactgtctccttacgcgtctttagctgtcaataacatccgcctcataaaagacaaacagacccagcagaacagaggcttcgcatttgtgcagctgtcctctgcaatggatgcttctcagctgcttcagatattacagagtctccatcctcctttgaaaattgatggcaaaactattggggttgattttgcaaaaagtgccagaaaagacttggtcctctcagatggtaaccgcgtcagcgctttctctgtagctagtacggctattgctgctgctcagtggtcatccacccagtctcaaagtggtgaaggaggcagtgttgactacagttatctgcaaccaggtcaagatggctatgcccaatatgctcagtattcacaggattatcagcagttttatcaacaacaagctggaggattggaatctgatgcatcatctgcatcaggcacagcagtgaccaccacctcagcggctgtagtgtcccagagtcctcagctgtataatcaaacctccaatccacctggctctccgactgaggaagcacagcctagcactagcacaagtacacaggccccagccgcttcccctactggtgtagttcctggtaccaaatatgcagtacctgacacgtccacttaccagtatgatgaatcttcaggatattactatgatccgacaacagggctctattatgaccccaactcgcaatactactataattccttgacccagcagtacctttactgggatggggaaaaagagacctacgtgccagctgcagagtctagctcccaccagcagtcgggcctgcctcctgcaaaagaggggaaagagaagaaggagaaacccaagagcaaaacagcccagcagattgccaaagacatggaacgctgggctaagagtttgaataagcagaaagaaaactttaaaaatagctttcagcctgtcaattccttgagggaagaagaaaggagagaatctgctgcagcagacgctggctttgctctctttgagaagaagggagccttagctgaaaggcagcagctcatcccagaattggtgcgaaatggagatgaggagaatcccctcaaaaggggtctggttgctgcttacagtggtgacagtgacaatgaggaggagctggtggagagacttgagagtgaggaagagaagctagctgactggaagaagatggcctgtctgctctgccggcgccagttcccgaacaaagatgccctagtcaggcaccagcaactctcagaccttcacaagcaaaacatggacatctatcgacgatccaggctgagcgagcaggagctggaagccttggagctaagggagagagagatgaaataccgagaccgagctgcagaaagacgggagaagtacggcattccagaacctccagagcccaagcgcaagaagcagtttgatgccggcactgtgaattacgagcaacccaccaaagatggcattgaccacagtaacattggcaacaagatgctgcaggccatgggctggcgggaaggctctggcttgggacgaaagtgtcaaggcattacggctcccattgaggctcaagttcggctaaagggagctggcctaggagccaaaggcagcgcatatggtttgtcgggcgccgattcctacaaagatgctgtccggaaagccatgtttgcccggttcactgagatggagtgagagagagagagagagagagatgacaaggagcacaagaagtggtccatctcccgaattcgctgttaccgcctgtctctttaagggcatgccttgtgctgttaatagatcttagggtgaaccacttcattctgcagggttctccctcccaccttaaagaagttccccttatgtgggttgcctggtgaatggccttccttcccgccagagggcttgtgaacagaccggagaggacagtggattgtttatactccagtgtacatagtgtaatgtagcgtgtttacatgtgtagcctatgttgtggtccatcagcccctcacattcctaggggtttgagatgctgtaggtggtatgtgacaccaaagccacctctgtcatttgttgtgatgtcttttcttggcaaaagccttgtgtatatttgtatattacacatttgtacagaattttggaagattttcagtctagttgccaaatctggctcctttacaaaagaaataccttgagaaatgggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10181 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:10181 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:10181 -> Molecular function: GO:0003723 [RNA binding] evidence: TAS
GeneID:10181 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
GeneID:10181 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10181 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:10181 -> Biological process: GO:0000245 [spliceosomal complex assembly] evidence: IDA
GeneID:10181 -> Biological process: GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] evidence: IDA
GeneID:10181 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS
GeneID:10181 -> Biological process: GO:0006396 [RNA processing] evidence: TAS
GeneID:10181 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10181 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: TAS
GeneID:10181 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS
GeneID:10181 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:10181 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
GeneID:10181 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS
GeneID:10181 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10181 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:10181 -> Cellular component: GO:0005681 [spliceosomal complex] evidence: TAS
GeneID:10181 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
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