GGRNA Home | Help | Advanced search

2020-10-26 19:03:34, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005742               2344 bp    mRNA    linear   PRI 14-MAY-2013
DEFINITION  Homo sapiens protein disulfide isomerase family A, member 6
            (PDIA6), mRNA.
ACCESSION   NM_005742
VERSION     NM_005742.2  GI:38679894
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Huergo-Zapico,L., Gonzalez-Rodriguez,A.P., Contesti,J.,
            Gonzalez,E., Lopez-Soto,A., Fernandez-Guizan,A., Acebes-Huerta,A.,
            de Los Toyos,J.R., Lopez-Larrea,C., Groh,V., Spies,T. and
            Gonzalez,S.
  TITLE     Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic
            leukemia cells: association with soluble MICA shedding
  JOURNAL   Cancer Immunol. Immunother. 61 (8), 1201-1210 (2012)
   PUBMED   22215138
  REMARK    GeneRIF: levels of expression of ERp5 and GRP78 correlated with the
            level of expression of membrane-bound MICA in chronic lymphocytic
            leukemia patients.
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Zocchi,M.R., Catellani,S., Canevali,P., Tavella,S., Garuti,A.,
            Villaggio,B., Zunino,A., Gobbi,M., Fraternali-Orcioni,G., Kunkl,A.,
            Ravetti,J.L., Boero,S., Musso,A. and Poggi,A.
  TITLE     High ERp5/ADAM10 expression in lymph node microenvironment and
            impaired NKG2D ligands recognition in Hodgkin lymphomas
  JOURNAL   Blood 119 (6), 1479-1489 (2012)
   PUBMED   22167753
  REMARK    GeneRIF: Data show that the lymph node (LN) stroma displayed in
            situ high levels of transcription and expression of the
            disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase
            ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell
            membrane.
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Jessop,C.E., Watkins,R.H., Simmons,J.J., Tasab,M. and Bulleid,N.J.
  TITLE     Protein disulphide isomerase family members show distinct substrate
            specificity: P5 is targeted to BiP client proteins
  JOURNAL   J. Cell. Sci. 122 (PT 23), 4287-4295 (2009)
   PUBMED   19887585
  REMARK    GeneRIF: P5 forms a non-covalent complex with immunoglobulin heavy
            chain binding protein (BiP) and shows specificity towards BiP
            client proteins.
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Kaiser,B.K., Yim,D., Chow,I.T., Gonzalez,S., Dai,Z., Mann,H.H.,
            Strong,R.K., Groh,V. and Spies,T.
  TITLE     Disulphide-isomerase-enabled shedding of tumour-associated NKG2D
            ligands
  JOURNAL   Nature 447 (7143), 482-486 (2007)
   PUBMED   17495932
  REMARK    GeneRIF: Pharmacological inhibition of thioreductase activity and
            ERp5 gene silencing revealed that cell-surface ERp5 function is
            required for MICA shedding
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Chi,A., Valencia,J.C., Hu,Z.Z., Watabe,H., Yamaguchi,H.,
            Mangini,N.J., Huang,H., Canfield,V.A., Cheng,K.C., Yang,F., Abe,R.,
            Yamagishi,S., Shabanowitz,J., Hearing,V.J., Wu,C., Appella,E. and
            Hunt,D.F.
  TITLE     Proteomic and bioinformatic characterization of the biogenesis and
            function of melanosomes
  JOURNAL   J. Proteome Res. 5 (11), 3135-3144 (2006)
   PUBMED   17081065
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Basrur,V., Yang,F., Kushimoto,T., Higashimoto,Y., Yasumoto,K.,
            Valencia,J., Muller,J., Vieira,W.D., Watabe,H., Shabanowitz,J.,
            Hearing,V.J., Hunt,D.F. and Appella,E.
  TITLE     Proteomic analysis of early melanosomes: identification of novel
            melanosomal proteins
  JOURNAL   J. Proteome Res. 2 (1), 69-79 (2003)
   PUBMED   12643545
REFERENCE   8  (bases 1 to 2344)
  AUTHORS   Kikuchi,M., Doi,E., Tsujimoto,I., Horibe,T. and Tsujimoto,Y.
  TITLE     Functional analysis of human P5, a protein disulfide isomerase
            homologue
  JOURNAL   J. Biochem. 132 (3), 451-455 (2002)
   PUBMED   12204115
  REMARK    GeneRIF: observed to have peptide-binding ability, and chaperone
            activity was confirmed with rhodanese and citrate synthase as
            substrates, but not with D-glyceraldehyde-3-phosphate
            dehydrogenase, showing substrate specificity with respect to
            chaperone activity
REFERENCE   9  (bases 1 to 2344)
  AUTHORS   Hayano,T. and Kikuchi,M.
  TITLE     Cloning and sequencing of the cDNA encoding human P5
  JOURNAL   Gene 164 (2), 377-378 (1995)
   PUBMED   7590364
REFERENCE   10 (bases 1 to 2344)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J. Infect. 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF979486.1, BC001312.1, AK127433.1 and BM511594.1.
            On Dec 4, 2003 this sequence version replaced gi:5031972.
            
            Summary: Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6,
            are endoplasmic reticulum (ER) resident proteins that catalyze
            formation, reduction, and isomerization of disulfide bonds in
            proteins and are thought to play a role in folding of
            disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed
            7590364]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001312.1, AK289428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BF979486.1         11-49
            40-1858             BC001312.1         1-1819
            1859-2326           AK127433.1         2215-2682
            2327-2344           BM511594.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2344
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="protein disulfide isomerase family A, member 6"
                     /db_xref="GeneID:10130"
                     /db_xref="HGNC:30168"
                     /db_xref="HPRD:07504"
                     /db_xref="MIM:611099"
     exon            1..157
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     CDS             139..1461
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase-associated 6;
                     thioredoxin domain containing 7 (protein disulfide
                     isomerase); protein disulfide isomerase-related protein;
                     endoplasmic reticulum protein 5; protein
                     disulfide-isomerase A6; protein disulfide isomerase P5;
                     thioredoxin domain-containing protein 7; ER protein 5"
                     /codon_start=1
                     /product="protein disulfide-isomerase A6 precursor"
                     /protein_id="NP_005733.1"
                     /db_xref="GI:5031973"
                     /db_xref="CCDS:CCDS1675.1"
                     /db_xref="GeneID:10130"
                     /db_xref="HGNC:30168"
                     /db_xref="HPRD:07504"
                     /db_xref="MIM:611099"
                     /translation="
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
"
     sig_peptide     139..195
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     196..1458
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /product="Protein disulfide-isomerase A6"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15084.1)"
     misc_feature    214..522
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="PDIa family, P5 subfamily; composed of eukaryotic
                     proteins similar to human P5, a PDI-related protein with a
                     domain structure of aa'b (where a and a' are redox active
                     TRX domains and b is a redox inactive TRX-like domain).
                     Like PDI, P5 is located in the...; Region: PDI_a_P5;
                     cd03001"
                     /db_xref="CDD:48550"
     misc_feature    order(301..303,310..312,490..492)
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:48550"
     misc_feature    304..306
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Contributes to redox potential value (By
                     similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    307..309
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Contributes to redox potential value (By
                     similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    490..492
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Lowers pKa of C-terminal Cys of first active site
                     (By similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    622..936
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="PDIa family, P5 subfamily; composed of eukaryotic
                     proteins similar to human P5, a PDI-related protein with a
                     domain structure of aa'b (where a and a' are redox active
                     TRX domains and b is a redox inactive TRX-like domain).
                     Like PDI, P5 is located in the...; Region: PDI_a_P5;
                     cd03001"
                     /db_xref="CDD:48550"
     misc_feature    order(706..708,715..717,904..906)
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:48550"
     misc_feature    709..711
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Contributes to redox potential value (By
                     similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    712..714
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Contributes to redox potential value (By
                     similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    904..906
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Lowers pKa of C-terminal Cys of second active site
                     (By similarity); propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); other site"
     misc_feature    961..1350
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /note="P5 family, C-terminal redox inactive TRX-like
                     domain; P5 is a protein disulfide isomerase (PDI)-related
                     protein with a domain structure of aa'b (where a and a'
                     are redox active TRX domains and b is a redox inactive
                     TRX-like domain). Like PDI, P5 is...; Region: P5_C;
                     cd02983"
                     /db_xref="CDD:48532"
     misc_feature    1420..1422
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15084.1); phosphorylation site"
     misc_feature    1420..1422
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
     misc_feature    1447..1458
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15084.1);
                     Region: Prevents secretion from ER (Potential)"
     exon            158..299
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       237
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4758"
     variation       280
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200167111"
     exon            300..357
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     exon            358..484
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     exon            485..591
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       564
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4799"
     exon            592..722
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       633
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2276679"
     exon            723..837
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       779
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4807"
     variation       823
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11545887"
     exon            838..978
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       905
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1804106"
     exon            979..1063
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1064..1136
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1137..1295
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1296..1392
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       1328
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11545888"
     exon            1393..2328
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /inference="alignment:Splign:1.39.8"
     variation       1496
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14337"
     variation       1543
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11545886"
     STS             1659..1801
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /standard_name="RH11818"
                     /db_xref="UniSTS:53905"
     variation       1680
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804107"
     STS             1702..1828
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /standard_name="SGC31703"
                     /db_xref="UniSTS:51040"
     variation       1768
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804105"
     variation       1771
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3208276"
     STS             1991..2179
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /standard_name="RH70399"
                     /db_xref="UniSTS:57524"
     variation       2143
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060002"
     variation       2145
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060005"
     variation       2179
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060011"
     variation       2264
                     /gene="PDIA6"
                     /gene_synonym="ERP5; P5; TXNDC7"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11489"
ORIGIN      
ggcccgcccccgcgcggccgcccctcggaccaccggactggcctggggcgggacgtgggcgcgggggcgcggcgtgcggcacgctgcagggctgaagcggcggcggcggtggggactgcacgtagcccggcgctcggcatggctctcctggtgctcggtctggtgagctgtaccttctttctggcagtgaatggtctgtattcctctagtgatgatgtgatcgaattaactccatcgaatttcaaccgagaagttattcagagtgatagtttgtggcttgtagaattctatgctccatggtgtggtcactgtcaaagattaacaccagaatggaagaaagcagcaactgcattaaaagatgttgtcaaagttggtgcagttgatgcagataagcatcattccctaggaggtcagtatggtgttcagggatttcctaccattaagatttttggatccaacaaaaacagaccagaagattaccaaggtggcagaactggtgaagccattgtagatgctgcgctgagtgctctgcgccagctcgtgaaggatcgcctcgggggacggagcggaggatacagttctggaaaacaaggcagaagtgatagttcaagtaagaaggatgtgattgagctgacagacgacagctttgataagaatgttctggacagtgaagatgtttggatggttgagttctatgctccttggtgtggacactgcaaaaacctagagccagagtgggctgccgcagcttcagaagtaaaagagcagacgaaaggaaaagtgaaactggcagctgtggatgctacagtcaatcaggttctggcctcccgatacgggattagaggatttcctacaatcaagatatttcagaaaggcgagtctcctgtggattatgacggtgggcggacaagatccgacatcgtgtcccgggcccttgatttgttttctgataacgccccacctcctgagctgcttgagattatcaacgaggacattgccaagaggacgtgtgaggagcaccagctctgtgttgtggctgtgctgccccatatccttgatactggagctgcaggcagaaattcttatctggaagttcttctgaagttggcagacaaatacaaaaagaaaatgtgggggtggctgtggacagaagctggagcccagtctgaacttgagaccgcgttggggattggagggtttgggtaccccgccatggccgccatcaatgcacgcaagatgaaatttgctctgctaaaaggctccttcagtgagcaaggcatcaacgagtttctcagggagctctcttttgggcgtggctccacggcacctgtaggaggcggggctttccctaccatcgttgagagagagccttgggacggcagggatggcgagcttcccgtggaggatgacattgacctcagtgatgtggagcttgatgacttagggaaagatgagttgtgagagccacaacagaggcttcagaccattttcttttcttgggagccagtggatttttccagcagtgaagggacattctctacactcagatgactctaccagtggccttttaaccaagaagtagtacttgattggtcatttgaaaacactgcaacagtgaacttttgcatctcaagaaaacattgaaaaattctatgaattgttgtagccggtgaattgagtcgtattctgtcacataatattttgaagaaaacttggctgtcgaaacatttttctctctgactgctgcttgaatgttcttggaggctgtttcttatgtatgggttttttttaatgtgatcccttcatttgaatattaatggctttttccattaaagaataaaatattttggacaatgccgataaatgtatgaagttagtatccacatcataaattcagagtgatgtttagcagtaaatcaatattttgaagtgatacacagatgtctttcctccccacaaacttttttaaacaaaaaacaagacctcttttctttagatggtgccacctatgcccaccacaacagagattttacatggaaaccgggctcagtgagaactgatttcctgcccaatatttgtctttgggctgtctctagtgactaattattaaggaatctagctggttatacagttcaaggctttctatgttgttaatgaacctcaaaatagccgttaagacatgaaatacagcagcaggttaccaatgcgaacaggtagttcgcatttatgtaaaacattcagaaaatgaagttttgaatttgttggaacattcaaaggacttgagagcattttattgtaacttaaaaaaataaatacaactgtcactaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10130 -> Molecular function: GO:0003756 [protein disulfide isomerase activity] evidence: IEA
            GeneID:10130 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10130 -> Molecular function: GO:0009055 [electron carrier activity] evidence: IEA
            GeneID:10130 -> Molecular function: GO:0015035 [protein disulfide oxidoreductase activity] evidence: IEA
            GeneID:10130 -> Biological process: GO:0006457 [protein folding] evidence: TAS
            GeneID:10130 -> Biological process: GO:0006662 [glycerol ether metabolic process] evidence: IEA
            GeneID:10130 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
            GeneID:10130 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
            GeneID:10130 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:10130 -> Biological process: GO:0045454 [cell redox homeostasis] evidence: IEA
            GeneID:10130 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: TAS
            GeneID:10130 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: IEA
            GeneID:10130 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
            GeneID:10130 -> Cellular component: GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] evidence: IDA
            GeneID:10130 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:10130 -> Cellular component: GO:0042470 [melanosome] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005733 -> EC 5.3.4.1

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.