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2024-04-19 18:19:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005707 2866 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens programmed cell death 7 (PDCD7), mRNA.
ACCESSION NM_005707
VERSION NM_005707.1 GI:22027540
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2866)
AUTHORS Turunen,J.J., Will,C.L., Grote,M., Luhrmann,R. and Frilander,M.J.
TITLE The U11-48K protein contacts the 5' splice site of U12-type introns
and the U11-59K protein
JOURNAL Mol. Cell. Biol. 28 (10), 3548-3560 (2008)
PUBMED 18347052
REFERENCE 2 (bases 1 to 2866)
AUTHORS Boven,L.A., Noorbakhsh,F., Bouma,G., van der Zee,R., Vargas,D.L.,
Pardo,C., McArthur,J.C., Nottet,H.S. and Power,C.
TITLE Brain-derived human immunodeficiency virus-1 Tat exerts
differential effects on LTR transactivation and neuroimmune
activation
JOURNAL J. Neurovirol. 13 (2), 173-184 (2007)
PUBMED 17505986
REFERENCE 3 (bases 1 to 2866)
AUTHORS Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
Elbashir,S., Tuschl,T. and Luhrmann,R.
TITLE The human 18S U11/U12 snRNP contains a set of novel proteins not
found in the U2-dependent spliceosome
JOURNAL RNA 10 (6), 929-941 (2004)
PUBMED 15146077
REFERENCE 4 (bases 1 to 2866)
AUTHORS Park,E.J., Kim,J.H., Seong,R.H., Kim,C.G., Park,S.D. and Hong,S.H.
TITLE Characterization of a novel mouse cDNA, ES18, involved in apoptotic
cell death of T-cells
JOURNAL Nucleic Acids Res. 27 (6), 1524-1530 (1999)
PUBMED 10037816
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK096970.1, AC013553.14 and
BC016992.2.
Summary: This gene encodes a 59 kDa protein that is associated with
the U11 small nuclear ribonucleoprotein (snRNP), which is a
component of the minor U12-type spliceosome responsible for
catalyzing pre-mRNA splicing of U12-type introns. [provided by
RefSeq, Dec 2010].
##Evidence-Data-START##
Transcript exon combination :: AK096970.1, AK225816.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1179 AK096970.1 1-1179
1180-1180 AC013553.14 128974-128974 c
1181-1984 AK096970.1 1181-1984
1985-2866 BC016992.2 915-1796
FEATURES Location/Qualifiers
source 1..2866
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q22.31"
gene 1..2866
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/note="programmed cell death 7"
/db_xref="GeneID:10081"
/db_xref="HGNC:8767"
/db_xref="HPRD:09736"
/db_xref="MIM:608138"
exon 1..925
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/inference="alignment:Splign:1.39.8"
misc_feature 5..7
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/note="upstream in-frame stop codon"
CDS 56..1513
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/note="apoptosis-related protein ES18; U11/U12 snRNP 59K"
/codon_start=1
/product="programmed cell death protein 7"
/protein_id="NP_005698.1"
/db_xref="GI:22027541"
/db_xref="CCDS:CCDS10201.1"
/db_xref="GeneID:10081"
/db_xref="HGNC:8767"
/db_xref="HPRD:09736"
/db_xref="MIM:608138"
/translation="
MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWATAVKLH
"
exon 926..1064
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/inference="alignment:Splign:1.39.8"
exon 1065..1301
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/inference="alignment:Splign:1.39.8"
exon 1302..1389
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/inference="alignment:Splign:1.39.8"
exon 1390..2851
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/inference="alignment:Splign:1.39.8"
variation 1593
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="g"
/replace="t"
/db_xref="dbSNP:1801392"
STS 2497..2603
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 2502..2595
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2553..2636
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="L18426"
/db_xref="UniSTS:34648"
STS 2557..2627
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
variation 2561
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="a"
/replace="g"
/db_xref="dbSNP:3207488"
variation 2566
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206475"
variation 2573
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="a"
/replace="t"
/db_xref="dbSNP:3207489"
variation 2606
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="c"
/replace="t"
/db_xref="dbSNP:3207492"
variation 2607
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206477"
variation 2614
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206478"
STS 2621..2748
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="D15S707E"
/db_xref="UniSTS:151611"
STS 2717..2819
/gene="PDCD7"
/gene_synonym="ES18; HES18"
/standard_name="SGC30454"
/db_xref="UniSTS:72749"
polyA_signal 2720..2725
/gene="PDCD7"
/gene_synonym="ES18; HES18"
polyA_site 2741
/gene="PDCD7"
/gene_synonym="ES18; HES18"
polyA_signal 2828..2833
/gene="PDCD7"
/gene_synonym="ES18; HES18"
polyA_site 2851
/gene="PDCD7"
/gene_synonym="ES18; HES18"
ORIGIN
ctcatgaggagccactcagattcctgtcacttctcaaagcatctccgtcgtgaacatggccctgccaccattcttcggccagggtcgcccaggcccaccgcccccgcagccgccgcctcctgctcctttcggctgtccgccaccgccgctgccctccccggctttcccgccgcctctcccccagcggcccggcccttttccgggggcctccgcccccttccttcagcctccgctggctctgcagccccgagcctccgcggaggcctcccgcggcggaggcggcgctggcgccttctacccggtgccaccaccgccgctgcctcctccgccgccccagtgtcggcccttcccggggaccgacgccggcgagcggccgcggccaccgcctcccggcccggggccgccctggagcccgcggtggcctgaggcgccgccgccgccggccgacgtgctcggggatgcggccctccaacgcctgcgcgaccggcagtggctggaggcggtgttcgggaccccgcggcgggcaggctgtccggtgccccagcgcacgcatgccgggcccagccttggcgaagtgcgcgcgcgattgctccgggctctgcgcctggtgcggcggctgcgcggcctgagccaggccctgcgcgaggccgaagccgacggcgcggcctgggtcctgctgtactcccagaccgcgccgctgcgcgcggaactggccgagcggctacagccgttgacccaggctgcctatgtgggcgaggcgcggaggaggctggagagggtccggcgccgccggctgcggcttcgcgagagggcccgggaacgcgaggccgagcgggaggcagaggccgcgcgggcagtggaacgcgagcaggagattgaccgctggagggtgaagtgtgtgcaggaggtggaggagaagaagcgggagcaggaactcaaagcagccgctgatggcgtactatctgaagtgaggaaaaaacaagcagataccaaaagaatggtggacattctacgggctttggagaaattgaggaaactgaggaaagaggctgcagcgaggaaaggggtctgtcctccagcctcagcagatgagacttttacgcatcatcttcagcgactgagaaaactcattaaaaagcgctctgaactgtatgaagctgaagagagagccctcagagttatgctagaaggagaacaagaggaagagaggaaaagagaattagaaaagaaacaaagaaaagaaaaagagaaaattttacttcagaaacgtgaaattgagtccaagttgtttggggatccagatgagttcccacttgctcacctcttggagcctttccgacagtattatctccaagccgagcactccctgccagcgctcatccagatcaggcatgattgggatcagtacctggtgccatccgatcatcccaaaggcaacttcgttccccaaggatgggtccttcccccgctccccagcaacgacatctgggcaactgctgttaagctgcattagtaaagatgctccaggagtgtggtccagccagcgctctttccagctgtaaatattagcgatggtgccatcttttgctgtagactaaactgcaacttctaaattccatgtggcattcccctaccctgaagttatgctttccttctgtgctctgtgctggccagaggtgcctcttgaatcagattaatgtggtttttcaggaaaggacttaggtgaactgaggtttttaccacaggcagtgaatgaccttggttcaccaaatttgcctctgttttgaggggcttggtccagagtgacttgttaatttactctaacttccttgtgtgttgatgggtaagtacactcaaacactgaatacaggtgtgtgatgggtagatttcacagcccttctactaatagtgagtgtgaaggcaagcttgatgcaaaacctcctgacctttcctacctgaagagccctttgacttctaggaagaaaggtcaaaaatgttatcttcagttgtgttaatcccagttttagtgcagcttaggaggctgctagttaggaagatggcagtggctgtaggctgggttgccagaaaagatggtggcctagtcttattattcagatggagaacttagaaaacctgaagagtacccaaattggattgtattttaatggacaatggctgtattttttccatgttagaaggatcctaatgaaagcacctgttatttttaagtttctaagggtctagttgttcagaatccccaaggatatttccctaacctcactcagtcacattgtaggagccagtgtagctatggaattatcttaggaactcaagcttctaaaactatccatgtagtcaaatctaggggaaaaagcaaataaaaatagtaaaatttggccgggcacagtggctcacgcctgtaatcccaacactttgggaggccgaggcgggccgatcacgaggtcaggagatcaaggccatcctggctaacacggtgaaaccctgtctctactaaaaatacaaaaaaatattagctgggcgtaggtggtgcacacctgtagtcccagctactggggaggctgaggcaggagaatggtgtaaaacccaggaggcagagcttgcagtgagccgagatcgcgccacggcactccagcctgggagacagagcaagactccgtctcaaaaaaaaaaaaagtaaaatttattttttatattcattaataaatgctgttgtgcttggagatgatcactcatataacatgtcatttttttggttctgttttggtttggtttttgccaattattttgttatatttccaaaaaactaaataaaaatcatttttattttttaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10081 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10081 -> Biological process: GO:0008380 [RNA splicing] evidence: IC
GeneID:10081 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: ISS
GeneID:10081 -> Cellular component: GO:0005689 [U12-type spliceosomal complex] evidence: IDA
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